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1. 发明申请

WO2010105261A2 FLEXIBLE NEURAL LOCALIZATION DEVICES AND METHODS 审中-公开
标题翻译：灵活的神经定位设备和方法
公开(公告)号：WO2010105261A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/027323
申请日：2010-03-15
申请人： BAXANO, INC. , WALLACE, Michael, P. , SUN, Benjamin, Kao-Shing , SHEINBERG, Michael , BLEICH, Jeffery, L. , SCHMITZ, Gregory, P. , LEGUIDLEGUID, Roy , SCHNIEDERMAN, Gary, A.
发明人： WALLACE, Michael, P. , SUN, Benjamin, Kao-Shing , SHEINBERG, Michael , BLEICH, Jeffery, L. , SCHMITZ, Gregory, P. , LEGUIDLEGUID, Roy , SCHNIEDERMAN, Gary, A.
IPC分类号： A61B17/00 , A61B17/56 , A61N1/05 , A61B5/04 , A61B5/0488
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/0488 , A61B5/1107 , A61B5/4519 , A61B5/4893 , A61B5/6852 , A61B5/6855 , A61B17/149 , A61B17/1671 , A61B17/1757 , A61B17/7092 , A61B17/8897 , A61B2562/0209 , A61B2562/0261 , A61B2562/043 , A61B2562/046 , A61N1/0553
摘要： Described herein are devices, systems and methods for determining if a nerve is nearby a device or portion of a device. The neural stimulation tools described herein are configured to be flexible and low-profile, so that they can be used within body regions that may be tortuous or difficult to reach, such as within a compressed or partially occluded neural foramen. In most cases, these tools described herein are ribbon-shaped and adapted to be manipulated bimanually, for example, by applying force to the ends of the devices from separate locations outside of the patient's body. Thus, in some of the exemplary neural localization devices described herein, the distal end region of the device are configured to couple to the proximal end of a guidewire. One or more surfaces of the devices may include an electrode or multi-polar network of electrodes configured to stimulate only nerves within a predetermined distance of a particular face of the device.
摘要翻译：本文描述了用于确定神经是否在设备或设备的一部分附近的装置，系统和方法。本文所述的神经刺激工具被配置为柔性和低轮廓，使得它们可以在可能曲折或难以到达的身体区域内使用，例如在压缩或部分闭塞的神经孔内。在大多数情况下，这里描述的这些工具是带状的并且适于双手操作，例如通过从患者身体外部的分离位置向装置的端部施加力。因此，在本文所述的一些示例性神经定位装置中，装置的远端区域被配置为耦合到导丝的近端。器件的一个或多个表面可以包括电极或多极电极网络，其被配置为仅在装置的特定面部的预定距离内刺激神经。

2. 发明申请

WO2008070867A2 TISSUE REMOVAL DEVICES AND METHODS 审中-公开
标题翻译：组织去除装置和方法
公开(公告)号：WO2008070867A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/086872
申请日：2007-12-07
申请人： BAXANO, INC. , BLEICH, Jeffery, L. , BLEAM, Jefferey , SPISAK, Steven, A. , SCHMITZ, Gregory , LEGUIDLEGUID, Roy , LEGUIDLEGUIDE, Ronald , CATORNA, Nestor, C. , WALLACE, Michael, P.
发明人： BLEICH, Jeffery, L. , BLEAM, Jefferey , SPISAK, Steven, A. , SCHMITZ, Gregory , LEGUIDLEGUID, Roy , LEGUIDLEGUIDE, Ronald , CATORNA, Nestor, C. , WALLACE, Michael, P.
IPC分类号： A61B17/32
CPC分类号： A61B17/3207 , A61B17/149 , A61B17/320016 , A61B17/32002 , A61B2017/00261 , A61B2017/320004 , A61B2017/320008 , A61B2017/32006
摘要： A device for modifying tissue in a patient may include: an elongate body having a rigid proximal portion and a flexible distal portion having first and second major surfaces; a proximal handle coupled with the proximal portion of the body; one or more tissue modifying members disposed along the first major surface of the distal portion of the body; a guidewire coupled with and extending from the distal portion of the body; and a distal handle removably coupleable with the guidewire outside the patient.
摘要翻译：用于修改患者组织的装置可以包括：细长体，其具有刚性近端部分和具有第一和第二主表面的柔性远端部分; 与所述主体的近侧部分联接的近侧手柄; 沿着身体远端部分的第一主表面设置的一个或多个组织修改构件; 与所述主体的所述远端部分连接并从所述远端部分延伸的导丝; 以及远离手柄，其可拆卸地与患者外部的导丝连接。

3. 发明申请

WO2010009093A3 TISSUE MODIFICATION DEVICES 审中-公开
标题翻译：组织修改设备
公开(公告)号：WO2010009093A3
公开(公告)日：2010-05-14
申请号：PCT/US2009050492
申请日：2009-07-14
申请人： BAXANO INC , WALLACE MICHAEL P , GARABEDIAN ROBERT , SCHMITZ GREGORY P , BLEICH JEFFREY L , CANTORNA NESTOR C , LEGUIDLEGUID RONALD , LEGUIDLEGUID ROY , SHEINBERG MICHAEL
发明人： WALLACE MICHAEL P , GARABEDIAN ROBERT , SCHMITZ GREGORY P , BLEICH JEFFREY L , CANTORNA NESTOR C , LEGUIDLEGUID RONALD , LEGUIDLEGUID ROY , SHEINBERG MICHAEL
IPC分类号： A61B17/56 , A61B17/66
CPC分类号： A61B17/1671 , A61B17/149 , A61B17/1659 , A61B17/320016 , A61B17/32002 , A61B17/3207 , A61B2017/00261 , A61B2017/320004 , A61B2017/320008 , A61B2017/32006 , A61B2017/32008 , A61B2090/3925 , A61B2090/3954 , A61B2090/3966
摘要： Described herein are elongate devices for modifying tissue having a plurality of flexibly connected and rungs or links, and methods of using them, including methods of using them to decompress stenotic spinal tissue. These devices may be included as part of a system for modifying tissue. In general, these devices include a plurality of blades positioned on (or forme from) rungs that are flexibly connected and may be separated by one or more spacers. The rungs are typically wider than they are long (e.g., rectangular). The rungs may be arranged, ladder like, and may be connected by a flexible connector substrate or between two or more cables. Different sized rungs may be used, or rungs with different cutting properties. In some variations the tissue modification devices may have a non-linear axial shape, or may be converted from a first axial shape to a second axial shape.
摘要翻译：本文描述的是用于修改具有多个柔性连接和梯级或链节的组织的细长装置，以及使用它们的方法，包括使用它们来减压狭窄的脊髓组织的方法。可以将这些装置作为用于修改组织的系统的一部分。通常，这些装置包括位于（或形成）梯级的多个叶片，所述叶片被柔性地连接并且可被一个或多个间隔件隔开。梯级通常比它们长（例如，矩形）宽。梯级可以布置成梯子，并且可以通过柔性连接器基板或两根或更多根电缆连接。可以使用不同尺寸的梯级，或者具有不同切割性能的梯级。在一些变型中，组织改变装置可以具有非线性轴向形状，或者可以从第一轴向形状转换成第二轴向形状。

4. 发明申请

WO2010105261A3 FLEXIBLE NEURAL LOCALIZATION DEVICES AND METHODS 审中-公开
标题翻译：灵活的神经定位设备和方法
公开(公告)号：WO2010105261A3
公开(公告)日：2011-02-10
申请号：PCT/US2010027323
申请日：2010-03-15
申请人： BAXANO INC , WALLACE MICHAEL P , SUN BENJAMIN KAO-SHING , SHEINBERG MICHAEL , BLEICH JEFFERY L , SCHMITZ GREGORY P , LEGUIDLEGUID ROY , SCHNIEDERMAN GARY A
发明人： WALLACE MICHAEL P , SUN BENJAMIN KAO-SHING , SHEINBERG MICHAEL , BLEICH JEFFERY L , SCHMITZ GREGORY P , LEGUIDLEGUID ROY , SCHNIEDERMAN GARY A
IPC分类号： A61B17/00 , A61B5/04 , A61B5/0488 , A61B17/56 , A61N1/05
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/0488 , A61B5/1107 , A61B5/4519 , A61B5/4893 , A61B5/6852 , A61B5/6855 , A61B17/149 , A61B17/1671 , A61B17/1757 , A61B17/7092 , A61B17/8897 , A61B2562/0209 , A61B2562/0261 , A61B2562/043 , A61B2562/046 , A61N1/0553
摘要： Described herein are devices, systems and methods for determining if a nerve is nearby a device or portion of a device. The neural stimulation tools described herein are configured to be flexible and low-profile, so that they can be used within body regions that may be tortuous or difficult to reach, such as within a compressed or partially occluded neural foramen. In most cases, these tools described herein are ribbon-shaped and adapted to be manipulated bimanually, for example, by applying force to the ends of the devices from separate locations outside of the patient's body. Thus, in some of the exemplary neural localization devices described herein, the distal end region of the device are configured to couple to the proximal end of a guidewire. One or more surfaces of the devices may include an electrode or multi-polar network of electrodes configured to stimulate only nerves within a predetermined distance of a particular face of the device.
摘要翻译：本文描述了用于确定神经是否在设备或设备的一部分附近的装置，系统和方法。本文所述的神经刺激工具被配置为柔性和低轮廓，使得它们可以在可能曲折或难以到达的身体区域内使用，例如在压缩或部分闭塞的神经孔内。在大多数情况下，这里描述的这些工具是带状的并且适于双手操作，例如通过从患者身体外部的分离位置向装置的端部施加力。因此，在本文所述的一些示例性神经定位装置中，装置的远端区域被配置为耦合到导丝的近端。器件的一个或多个表面可以包括电极或多极电极网络，其被配置为仅在装置的特定面部的预定距离内刺激神经。

5. 发明申请

WO2010129525A2 TISSUE MODIFICATION DEVICES AND METHODS 审中-公开
标题翻译：组织修改设备和方法
公开(公告)号：WO2010129525A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033508
申请日：2010-05-04
申请人： BAXANO, INC. , WALLACE, Michael, P. , GARABEDIAN, Robert , CANTORNA, Nestor, C. , BLEICH, Jeffery, L. , LEGUIDLEGUID, Roy , LEGUIDLEGUID, Ronald
发明人： WALLACE, Michael, P. , GARABEDIAN, Robert , CANTORNA, Nestor, C. , BLEICH, Jeffery, L. , LEGUIDLEGUID, Roy , LEGUIDLEGUID, Ronald
IPC分类号： A61B17/32 , A61B17/14 , A61B17/56
CPC分类号： A61B17/320016 , A61B17/149 , A61B17/1659 , A61B17/1671 , A61B17/32 , A61B17/320725 , A61B18/08 , A61B90/03 , A61B2017/00867 , A61B2017/320004 , A61B2017/320008 , A61B2017/320028 , A61B2017/320052 , A61B2017/32006 , A61B2090/08021
摘要： Described herein are devices, systems and methods for cutting tissue in a patient. In some embodiments, a tissue modification region of a device includes a pair of flexible elongate cutting members extending along the length of the tissue modification region. Each elongate cutting member may be configured to cut a discrete trough into tissue to a depth that is greater than the thickness of the cutting member. In some embodiments, the device includes a spacer. The spacer may be sized and configured to operate in one of two modes. A first mode, in which the spacer is coupled to the cutting members such that it holds a portion of each of the two cutting members a distance from one another, and a second mode, in which at least a portion of the spacer is moved away from a cutting member to allow the cutting members to cut further into tissue.
摘要翻译：这里描述了用于切割患者组织的装置，系统和方法。在一些实施例中，装置的组织修改区域包括沿着组织修改区域的长度延伸的一对柔性细长切割构件。每个细长的切割构件可以被配置成将离散的槽切割成组织到比切割构件的厚度大的深度。在一些实施例中，该装置包括间隔件。间隔件的尺寸和构造可以以两种模式之一来操作。第一模式，其中间隔件联接到切割构件，使得其将两个切割构件中的每一个的一部分保持彼此的距离，以及第二模式，其中至少一部分间隔件移开从切割构件允许切割构件进一步切割成组织。

6. 发明申请

WO2007106740A3 METHODS AND APPARATUS FOR TISSUE MODIFICATION 审中-公开
标题翻译：用于组织修饰的方法和装置
公开(公告)号：WO2007106740A3
公开(公告)日：2008-11-06
申请号：PCT/US2007063679
申请日：2007-03-09
申请人： BAXANO INC , BLEICH JEFFERY L , SAADAT VAHID , SPISAK STEVEN A , ASHLEY JOHN , LEGUIDLEGUID ROY , BLEAM JEFFEREY , LEGUIDLEGUID RONALD , DREWS MIKE , HVALKA EDWIN J
发明人： BLEICH JEFFERY L , SAADAT VAHID , SPISAK STEVEN A , ASHLEY JOHN , LEGUIDLEGUID ROY , BLEAM JEFFEREY , LEGUIDLEGUID RONALD , DREWS MIKE , HVALKA EDWIN J
IPC分类号： A61B17/32 , A61B17/14
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/0218 , A61B17/1626 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B17/8861 , A61B17/8897 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： Apparatus for modifying tissue in a patient may include: an elongate, at least partially flexible body having a proximal portion and a distal portion; a tissue modifying member disposed along one side of the body; an atraumatic surface located adjacent the tissue modifying member; an actuator coupled with the tissue modifying member and extending to the proximal portion of the body; and means at or near the proximal and distal portions of the elongate body for facilitating application of tensioning and/or anchoring force to urge the tissue modifying member against the target tissue. In some embodiments, a flexible portion of the elongate body may be configured to extend through an intervertebral foramen of the patient's spine while the proximal and distal portions of the device extend out of the patient, and the tissue modifying member may be configured to remove soft tissue and/or bone to treat or alleviate spinal stenosis.
摘要翻译：用于修改患者组织的装置可以包括：具有近端部分和远端部分的细长的，至少部分柔性的主体; 组织修改构件，其沿身体的一侧设置; 位于组织修饰构件附近的无创表面; 与所述组织修改构件联接并延伸到所述主体的近侧部分的致动器; 以及在细长体的近端和远端部分附近的装置，用于便于施加张力和/或锚定力以促使组织修饰构件抵抗靶组织。在一些实施例中，细长体的柔性部分可构造成延伸穿过患者脊柱的椎间孔，同时该装置的近端部分和远端部分延伸出患者，并且组织修改部件可被构造成去除软组织和/或骨以治疗或减轻脊柱狭窄。

7. 发明申请

WO2008042793A3 ARTICULATING TISSUE CUTTING DEVICE 审中-公开
标题翻译：组织切割装置
公开(公告)号：WO2008042793A3
公开(公告)日：2008-07-03
申请号：PCT/US2007079939
申请日：2007-09-28
申请人： BAXANO INC , SCHMITZ GREGORY , BLEICH JEFFERY L , MILLER ERIC C
发明人： SCHMITZ GREGORY , BLEICH JEFFERY L , MILLER ERIC C
IPC分类号： A61B17/00
CPC分类号： A61B17/1611 , A61B17/1604 , A61B17/1659 , A61B17/1671 , A61B18/14 , A61B2017/003
摘要： A device for cutting ligament and/or bone tissue in a lateral recess and/or an intervertebral foramen of a spine of a patient to treat spinal stenosis may include: an elongate shaft having a rigid proximal portion and a distal portion articulatable relative to the proximal portion; a handle coupled with the proximal portion of the shaft; a tissue cutter disposed on one side of the distal portion of the shaft; a first actuator coupling the handle with the tissue cutter fo activating the tissue cutter to cut tissue; and a second actuator coupling the handle with the distal portion for articulating the distal portion relative to the proximal portion. In some embodiments, the distal portion of the shaft may be configured to pass at least partway into an intervertebral foramen of the patient's spine.
摘要翻译：用于切割患者脊柱的侧向凹部和/或椎间孔中的韧带和/或骨组织以治疗脊柱狭窄的装置可以包括：细长轴，其具有刚性近端部分和远端部分，其可相对于近端一部分; 与所述轴的近侧部分联接的手柄; 设置在所述轴的远端部分的一侧上的组织切割器; 将所述手柄与所述组织切割器联接的第一致动器，用于激活所述组织切割器以切割组织; 以及第二致动器，其将所述手柄与所述远端部分联接，用于相对于所述近端部分铰接所述远侧部分。在一些实施例中，轴的远端部分可以构造成至少中途地通过患者脊柱的椎间孔。

8. 发明申请

WO2008016886A9 TISSUE CUTTING DEVICES AND METHODS 审中-公开
标题翻译：组织切割装置和方法
公开(公告)号：WO2008016886A9
公开(公告)日：2008-03-27
申请号：PCT/US2007074770
申请日：2007-07-30
申请人： BAXANO INC , SCHMITZ GREGORY , BLEAM JEFFEREY , LEGUIDLEGUID ROY , BLEICH JEFFERY L , SMITH SCOTT M
发明人： SCHMITZ GREGORY , BLEAM JEFFEREY , LEGUIDLEGUID ROY , BLEICH JEFFERY L , SMITH SCOTT M
IPC分类号： A61B17/32
CPC分类号： A61B17/1604 , A61B17/1671 , A61B17/320016 , A61B17/32002 , A61B17/320068 , A61B17/320783 , A61B2017/00261 , A61B2017/003 , A61B2017/2901 , A61B2017/2902 , A61B2017/2905 , A61B2017/32006
摘要： A device for cutting tissue in a human body may include an elongate shaft having a proximal portion and a distal portion, at least one translatable blade disposed along one side of the distal portion of the shaft, and at least one actuator coupled with the at least one translatable blade and extending to the proximal portion of the shaft, wherein the actuator is configured to translate the blade to cut tissue. In various embodiments, various components of the device may have dimensions that facilitate passing a portion of the device into or through a small space and also facilitate and/or enhance the device's tissue cutting abilies.
摘要翻译：用于在人体中切割组织的装置可以包括具有近端部分和远侧部分的细长轴，至少一个沿着轴的远端部分的一侧设置的可平移刀片，以及至少一个致动器，一个可平移的叶片并且延伸到所述轴的近端部分，其中所述致动器构造成将所述叶片平移到切割的组织。在各种实施例中，装置的各种部件可以具有便于将装置的一部分通入或穿过小空间的尺寸，并且还促进和/或增强装置的组织切割装置。

9. 发明申请

WO2008016886A2 TISSUE CUTTING DEVICES AND METHODS 审中-公开
标题翻译：组织切割装置和方法
公开(公告)号：WO2008016886A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/074770
申请日：2007-07-30
申请人： BAXANO, INC. , SCHMITZ, Gregory , BLEAM, Jefferey , LEGUIDLEGUID, Roy , BLEICH, Jeffery, L. , SMITH, Scott, M.
发明人： SCHMITZ, Gregory , BLEAM, Jefferey , LEGUIDLEGUID, Roy , BLEICH, Jeffery, L. , SMITH, Scott, M.
IPC分类号： A61B17/32
CPC分类号： A61B17/1604 , A61B17/1671 , A61B17/320016 , A61B17/32002 , A61B17/320068 , A61B17/320783 , A61B2017/00261 , A61B2017/003 , A61B2017/2901 , A61B2017/2902 , A61B2017/2905 , A61B2017/32006
摘要： A device for cutting tissue in a human body may include an elongate shaft having a proximal portion and a distal portion, at least one translatable blade disposed along one side of the distal portion of the shaft, and at least one actuator coupled with the at least one translatable blade and extending to the proximal portion of the shaft, wherein the actuator is configured to translate the blade to cut tissue. In various embodiments, various components of the device may have dimensions that facilitate passing a portion of the device into or through a small space and also facilitate and/or enhance the device's tissue cutting abilies.
摘要翻译：用于在人体内切割组织的装置可以包括具有近侧部分和远侧部分的细长轴，沿轴的远侧部分的一侧布置的至少一个平移刀片，以及在至少一个致动器，其与所述至少一个平移叶片联接并且延伸至所述轴的所述近侧部分，其中所述致动器构造成平移所述叶片以切割组织。在各种实施例中，装置的各种部件可具有便于使装置的一部分进入或穿过小空间并且还促进和/或增强装置的组织切割小样的尺寸。

10. 发明申请

WO2007106740A2 METHODS AND APPARATUS FOR TISSUE MODIFICATION 审中-公开
标题翻译：用于组织修饰的方法和装置
公开(公告)号：WO2007106740A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/063679
申请日：2007-03-09
申请人： BAXANO, INC. , BLEICH, Jeffery, L. , SAADAT, Vahid , SPISAK, Steven, A. , ASHLEY, John , LEGUIDLEGUID, Roy , BLEAM, Jefferey , LEGUIDLEGUID, Ronald , DREWS, Mike , HLVAKA, Edwin, J.
发明人： BLEICH, Jeffery, L. , SAADAT, Vahid , SPISAK, Steven, A. , ASHLEY, John , LEGUIDLEGUID, Roy , BLEAM, Jefferey , LEGUIDLEGUID, Ronald , DREWS, Mike , HLVAKA, Edwin, J.
IPC分类号： A61B17/58
CPC分类号： A61B17/1659 , A61B17/00234 , A61B17/02 , A61B17/0218 , A61B17/1626 , A61B17/1671 , A61B17/1757 , A61B17/320016 , A61B17/32002 , A61B17/3421 , A61B17/8861 , A61B17/8897 , A61B2017/00261 , A61B2017/00867 , A61B2017/32006 , A61B2017/3488 , A61B2090/08021
摘要： Apparatus for modifying tissue in a patient may include: an elongate, at least partially flexible body having a proximal portion and a distal portion; a tissue modifying member disposed along one side of the body; an atraumatic surface located adjacent the tissue modifying member; an actuator coupled with the tissue modifying member and extending to the proximal portion of the body; and means at or near the proximal and distal portions of the elongate body for facilitating application of tensioning and/or anchoring force to urge the tissue modifying member against the target tissue. In some embodiments, a flexible portion of the elongate body may be configured to extend through an intervertebral foramen of the patient's spine while the proximal and distal portions of the device extend out of the patient, and the tissue modifying member may be configured to remove soft tissue and/or bone to treat or alleviate spinal stenosis.
摘要翻译：用于修改患者组织的装置可以包括：具有近端部分和远端部分的细长的，至少部分柔性的主体; 组织修改构件，其沿身体的一侧设置; 位于组织修饰构件附近的无创表面; 与所述组织修改构件联接并延伸到所述主体的近侧部分的致动器; 以及在细长体的近端和远端部分附近的装置，用于便于施加张力和/或锚定力以促使组织修饰构件抵抗靶组织。在一些实施例中，细长体的柔性部分可构造成延伸穿过患者脊柱的椎间孔，同时该装置的近端部分和远端部分延伸出患者，并且组织修改部件可被构造成去除软组织和/或骨以治疗或减轻脊柱狭窄。

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