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1. 发明申请

WO2012030871A1 EXPANDABLE DEVICES 审中-公开
标题翻译：可扩展的设备
公开(公告)号：WO2012030871A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/049804
申请日：2011-08-30
申请人： CELONOVA BIOSCIENCES, INC. , DENISON, Andy, Edward , STALKER, Kent, C.b. , BATES, Mark
发明人： DENISON, Andy, Edward , STALKER, Kent, C.b. , BATES, Mark
IPC分类号： A61F2/90
CPC分类号： A61F2/89 , A61F2/04 , A61F2/82 , A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2230/0069
摘要： An expandable, bistable open cell design incorporates the following features: a first relatively stiff portion (152) having first and second ends and a first relatively flexible portion (154) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a first open area (156) of the stent structure; a second relatively stiff portion (158) having first and second ends and a second relatively flexible portion (160) connected to the first and second ends of the first relatively stiff portion, the first relatively stiff portion and the first relatively flexible portion substantially surrounding a second open area (162) of the stent structure; and an opening (1 10) formed through the first relatively stiff portion and the second relatively flexible portion such that the opening connects the first and second open areas, thereby creating first and second intermediate ends (152a, 152b) of the first relatively stiff portion and first and second intermediate ends (160a, 160b) of the second relatively flexible portion. The first intermediate end (152a) of the relatively stiff portion is connected to the first intermediate end (160a) of the relatively flexible portion so as to create a first inward apex (170), the second intermediate end (152b) of the relatively stiff portion is connected to the second intermediate end (160b) of the relatively flexible portion so as to create a second inward apex (172), and the stent structure is configured such that, in a collapsed configuration, the first inward apex (170) is in contact with the second inward apex (172) and, in an expanded configuration, the first inward apex is biased to move in a first circumferential direction and the second inward apex is biased to move in a second circumferential direction that is different than the first circumferential direction.
摘要翻译：可膨胀的双稳态开孔结构具有以下特征：具有第一和第二端的第一相对较硬的部分（152）和连接到第一相对刚性部分的第一和第二端的第一相对柔性部分（154），第一相对硬的部分和第一相对柔性部分基本上围绕支架结构的第一开口区域（156）; 具有第一和第二端部的第二相对刚性部分（158）和连接到第一相对刚性部分的第一和第二端部的第二相对柔性部分（160），第一相对刚性部分和第一相对柔性部分基本上围绕第二开放区域（162）; 以及通过所述第一相对刚性部分形成的开口（110）和所述第二相对柔性部分，使得所述开口连接所述第一和第二开口区域，从而形成所述第一相对刚性部分的第一和第二中间端（152a，152b）以及第二相对柔性部分的第一和第二中间端（160a，160b）。相对刚性部分的第一中间端（152a）连接到相对柔性部分的第一中间端（160a），以便产生第一内向顶点（170），第二中间端（152b）具有较硬的部分连接到相对柔性部分的第二中间端（160b），以便形成第二内向顶点（172），并且支架结构构造成使得在折叠构型中，第一向内顶点（170）是与第二内向顶点（172）接触，并且在膨胀构造中，第一向内顶点被偏压以在第一圆周方向上移动，并且第二内向顶点被偏压以在不同于第一内顶端的第二圆周方向上移动圆周方向。

2. 发明申请

WO2011065984A1 A MULTI-FUNCTION BOTTLE OPENER 审中-公开
标题翻译：多功能开瓶器
公开(公告)号：WO2011065984A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/023384
申请日：2010-02-05
申请人： BATES, Mark, R. , BATES, Leisa, Marie
发明人： BATES, Mark, R. , BATES, Leisa, Marie
IPC分类号： B67B7/44 , B67B7/04 , B67B7/18
CPC分类号： B67B7/0423 , B67B7/18 , B67B7/44
摘要： A specialized bottle opener provides a cap opener for opening screw tops, and a corkscrew attached to the cap opener, for opening traditional wine bottles sealed with corks. A lever arm, common to both tools, extends radially outward to provide torque when using either the cap opener or the corkscrew. The cap opener comprises a customizable ring and a pedestal having an interior cavity. Disposed on the inner surface of the cavity is one or more gripping members, such as vertical ridges, which serve to grip the cap and retain it within the cavity after the cap is removed from the bottle. After pouring the wine, the waiter may release the cap by accessing it through openings in the pedestal. Regardless of how a wine bottle is sealed, the multi-function bottle opener serves to maintain the sophisticated wine-drinking experience that consumers have come to expect.
摘要翻译：专门的开瓶器提供打开螺丝头的开盖器，以及连接在开瓶器上的开瓶器，用于打开用软木塞密封的传统葡萄酒瓶。两个工具共用的杠杆臂径向向外延伸，以便在使用开盖器或开瓶器时提供扭矩。开盖器包括可定制的环和具有内部空腔的基座。设置在空腔的内表面上的是一个或多个夹紧构件，例如垂直脊，其用于在帽从瓶中取出之后抓住帽并将其保持在腔内。浇酒后，服务员可以通过底座上的开口进入盖子来释放盖子。无论如何密封酒瓶，多功能开瓶器都能保持消费者所期待的复杂的饮酒体验。

3. 发明申请

WO2010042882A3 INVENTORY SPARING CATHETER SYSTEM 审中-公开
公开(公告)号：WO2010042882A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060259
申请日：2009-10-09
申请人： NEXEON MEDSYSTEMS, INC. , STALKER, Kent, C.B. , WHITFIELD, John, D. , BATES, Mark, C. , D'AQUANNI, Peter, J. , HABEGER, Jason, Andrew
发明人： STALKER, Kent, C.B. , WHITFIELD, John, D. , BATES, Mark, C. , D'AQUANNI, Peter, J. , HABEGER, Jason, Andrew
IPC分类号： A61M25/01 , A61M25/10 , A61M29/02 , A61F2/84 , A61M25/00
摘要： The application relates to a catheter system (200) having a changeable or adjustable working length. The catheter system can comprise a proximal end, a distal end, and a first axial lumen configured to receive a guidewire formed through, at least a portion of the catheter body (208). A first opening (206) can be formed through a portion of the catheter body and be in communication with the first lumen. The sheath (204) can be rotatable, axially movable, or otherwise changeable from at least a first position to a second position, wherein the sheath can substantially cover the first opening in the catheter body in the first position, and can substantially expose the first opening in the catheter body in the second position.

4. 发明申请

WO2010005575A2 NANOTUBE-REINFORCED BALLOONS FOR DELIVERING THERAPEUTIC AGENTS WITHIN OR BEYOND THE WALL OF BLOOD VESSELS, AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译：用于在血液瓶壁之间或之外递送治疗剂的纳米级增强型气泡，以及制造和使用它们的方法
公开(公告)号：WO2010005575A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/004006
申请日：2009-07-09
申请人： NEXEON MEDSYSTEMS, INC. , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M25/10 , A61K38/43 , A61K39/395 , A61K38/16
CPC分类号： A61L29/126 , A61K38/00 , A61L29/16 , A61L2300/602 , A61L2300/624 , A61L2400/12 , A61M25/10 , A61M25/104 , A61M2025/105 , A61M2025/1075 , A61M2025/1084 , A61M2025/1086
摘要： A dilatation catheter for delivering a therapeutic agent within a body lumen having a wall with a thickness is provided having a balloon having a flexible wall including a polymer with dispersed nanotubes and pores configured to close below a predefined pressure and to open at or above a predefined pressure. In some embodiments, an actuator is provided to controllably inflate the balloon with a fluid at a pressure sufficient to bring the flexible wall of the balloon into contact with at least a portion of the wall of the body lumen but below the predefined pressure, and to controllably increase the pressure of the fluid within the inflated balloon to at least the predefined pressure at a rate and with a force sufficient to deliver the therapeutic agent from the pores and through at least a portion of the thickness of the wall of the body lumen.
摘要翻译：提供了一种用于在具有厚度的壁的体腔内递送治疗剂的扩张导管，其具有球囊，所述球囊具有柔性壁，弹性壁包括具有分散的纳米管的聚合物和构造成接近低于预定压力的孔，并且在预定义压力。在一些实施例中，致动器被提供以用足以使气囊的柔性壁与体腔的至少一部分壁接触但低于预定压力的压力的流体可控制地膨胀气囊，并且可膨胀气囊内的流体的压力以足以从治疗剂输送治疗剂和通过体腔壁厚度的至少一部分的速度和速度将至少预定的压力增加至至少预定的压力。

5. 发明申请

WO2006122152A3 APPARATUS AND METHODS FOR RENAL STENTING 审中-公开
标题翻译：装置和方法进行手术
公开(公告)号：WO2006122152A3
公开(公告)日：2008-10-09
申请号：PCT/US2006017986
申请日：2006-05-09
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： The present invention provides and apparatus and methods for emboli removal and stenting within the renal arteries having a catheter system having a distal occlusion element, a stent deployment section, and an emboli removal lumen. The occlusion element is disposed at a predetermined distance from the stent deployment section specific for use in the renal artery, and is constructed to reduce the potential for perforation or jailing during stent deployment. The apparatus further includes an array of radio-opaque markers disposed on the stent delivery catheter to facilitate accurate stent deployment within a renal artery.
摘要翻译：本发明提供了用于在具有具有远端闭塞元件，支架展开部分和栓塞移除内腔的导管系统的肾动脉内的栓塞移除和支架置入的装置和方法。闭塞元件设置在与用于肾动脉中特异的支架展开部分预定的距离处，并且被构造成在支架展开期间减小穿孔或挂钩的可能性。该装置还包括设置在支架输送导管上的无线电不透明标记阵列，以便于肾动脉内准确的支架展开。

6. 发明申请

WO2007056058A3 RADIOPAQUE-BALLOON MICROCATHETER AND METHODS OF MANUFACTURE 审中-公开
公开(公告)号：WO2007056058A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/042804
申请日：2006-11-01
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M25/10 , B82B1/00 , B82B3/00
摘要： Microcatheters catheters are provided having balloons incorporating radiopaque nanoparticles. Optionally, carbon nanotubes dispersed within the shaft may be configured to react to electrical stimulation, thereby providing a steerable distal end region on the microcatheter. Methods of making the foregoing microcatheters also are provided.

7. 发明申请

WO2006041669A2 METHODS AND APPARATUS FOR TREATING INFARCTED REGIONS OF TISSUE FOLLOWING ACUTE MYOCARDIAL INFARCTION 审中-公开
标题翻译：治疗急性心肌梗死后组织感染区域的方法和装置
公开(公告)号：WO2006041669A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/034474
申请日：2005-09-23
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61M25/0084 , A61M2025/0002
摘要： Apparatus and methods are provided for treating an infarcted region of myocardium following acute myocardial infarction by reducing the rate of blood flow through infarcted region, and then injecting a solution containing stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment into the effected region so that the stem cells become embedded therein and promote tissue regeneration. In a first embodiment, delivery of the stem cells, endothelial progenitor cells or mediators of stem cell mobilization, migration and attachment is accomplished using a catheter that relies upon antegrade flow through the coronary artery and a flow control catheter placed in the coronary sinus. In an alternative embodiment, the delivery catheter delivers the stem cells in a retrograde manner through the coronary sinus, and the delivery catheter further comprises an occlusion balloon for controlling outflow through the coronary sinus ostium.
摘要翻译：提供了设备和方法，用于通过降低通过梗塞区域的血流量来治疗急性心肌梗塞后的心肌梗死区域，然后注入含有干细胞动员，迁移和附着的干细胞，内皮祖细胞或介质的溶液使干细胞嵌入其中并促进组织再生。在第一个实施方案中，干细胞移动，迁移和附着的干细胞，内皮祖细胞或介体的递送使用依赖于顺流过冠状动脉的导管和放置在冠状窦中的流量控制导管进行。在替代实施例中，输送导管以逆行方式通过冠状窦输送干细胞，并且输送导管还包括用于控制通过冠状窦口的流出的闭塞球囊。

8. 发明申请

WO2006020256A2 SYSTEMS AND METHODS FOR ATRAUMATIC IMPLANTATION OF BIO-ACTIVE AGENTS 审中-公开
标题翻译：用于生物活性剂的ATRAUMATIC植入物的系统和方法
公开(公告)号：WO2006020256A2
公开(公告)日：2006-02-23
申请号：PCT/US2005025470
申请日：2005-07-18
申请人： PARAGON INTELLECTUAL PROPERTIE , BATES MARK C
发明人： BATES MARK C
IPC分类号： A61M31/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/00398 , A61B2017/00871 , A61B2017/3411 , A61B2017/3484 , A61B2018/00392 , A61M5/3287
摘要： Methods and apparatus are provided for delivering a bioactive agent in a needle track formed in a target tissue mass, following formation of the needle track, by avoiding impingement of the agent against target tissue at high velocity or by using capillary action to draw the bioactive agent out of the needle during needle withdrawal. The apparatus comprises a catheter and a needle disposed within the catheter and configured to be selectively extended into the tissue mass to a predetermined depth, while dispensing the agent simultaneously with retraction of the needle along the needle track. Alternatively, or in addition, the needle may be configured to create a tissue space surrounding a distal or lateral surface of the needle, into which the bioactive agent to be infused.
摘要翻译：提供了方法和装置，用于在形成针迹后，在形成于靶组织块中的针迹中递送生物活性剂，方法是避免药物以高速度撞击目标组织，或通过使用毛细管作用来吸引生物活性剂拔针时出针。该装置包括导管和设置在导管内的针，并且被配置成选择性地延伸到组织块中至预定的深度，同时在沿着针轨缩回针的同时分配药剂。或者或另外，针可以被配置为产生围绕针的远侧或侧表面的组织空间，待注入的生物活性剂。

9. 发明申请

WO2005123044A2 IMPLANTABLE DEVICE FOR TREATING DISEASE STATES AND METHODS OF USING SAME 审中-公开
标题翻译：用于治疗疾病状态的可植入装置及其使用方法
公开(公告)号：WO2005123044A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/019934
申请日：2005-06-07
申请人： PARAGON INTELLECTUAL PROPERTIES, LLC , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61K9/22
CPC分类号： A61M31/002 , A61B17/12109 , A61B17/12172 , A61B17/12177 , A61B17/12181 , A61B17/1219 , A61B2017/00889 , A61F2/022 , A61F2/86 , A61L29/16 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/43 , A61L2300/45 , A61L2300/64 , A61M25/04
摘要： Methods and apparatus are provided for delivering drugs, gene vectors, naturally-occurring or synthetic hormones or proteins or other bioactive agents within a patient's vasculature. In a preferred embodiment, the apparatus comprises a material that elutes or secretes a bioactive agent and is held in place within the patient's vessel by an anchor. The material may comprise a biocompatible, and optionally, absorbable matrix, or a culture medium that sustains and nourishes stem cells, spleen cells or pancreatic islets or other beneficial cells. The anchor and material are sized and/or collapsible from a delivery configuration, in which the anchor and material may be delivered into the patient's vasculature within a delivery sheath, to a deployed configuration, wherein the anchor engages an interior wall of the patient's vessel. The apparatus of the invention may be temporarily or permanently implanted, and may in addition self reconfigure after a predetermined period of residency.
摘要翻译：提供了用于在患者的脉管系统内递送药物，基因载体，天然存在的或合成的激素或蛋白质或其他生物活性剂的方法和装置。在优选的实施方案中，该装置包括洗脱或分泌生物活性剂并通过锚固体保持在患者血管内的适当位置的材料。该材料可以包含生物相容性和任选的可吸收基质，或维持和滋养干细胞，脾细胞或胰岛或其它有益细胞的培养基。锚和材料的尺寸和/或可从输送构型定尺寸，其中锚固件和材料可以在输送护套内输送到患者的脉管系统中到展开构造，其中锚固件接合患者血管的内壁。本发明的装置可以暂时地或永久地植入，并且可以在预定的居住期间之后再重新配置。

10. 发明申请

WO2013142204A2 APPARATUS AND METHODS FOR FILTERING EMBOLI DURING PERCUTANEOUS AORTIC VALVE REPLACEMENT AND REPAIR PROCEDURES WITH FILTRATION SYSTEM COUPLED TO DISTAL END OF SHEATH 审中-公开
标题翻译：装置和方法，用于过滤动脉瓣置换和修复过程中的过滤与过滤系统相结合的远端
公开(公告)号：WO2013142204A2
公开(公告)日：2013-09-26
申请号：PCT/US2013/030943
申请日：2013-03-13
申请人： NEXEON MEDSYSTEMS, INC. , BATES, Mark, C.
发明人： BATES, Mark, C.
IPC分类号： A61F2/01 , G10D1/02
CPC分类号： A61F2/013 , A61F2/2427 , A61F2002/011
摘要： J Embodiments of the present invention provide apparatus and methods for embolic filtering during percutaneous valve replacement and repair procedures. Under one aspect, an apparatus comprises a sheath and a filter. The sheath has proximal and distal ends and a lumen therebetween. The distal end may be introduced into the aortic arch via the peripheral arteries and ascending aorta, while the proximal end may be disposed outside of the body. The lumen permits percutaneous aortic valve replacement or repair therethrough. The filter has a frame with an inlet and an outlet and an emboli-filtering mesh attached to the frame. The inlet is substantially spans the aortic arch in a region between the aortic valve and the great arteries. The outlet is coupled to the distal end of the sheath without leaving any gaps through which emboli could pass and without obstructing the lumen at the distal end of the sheath.
摘要翻译：本发明的实施例提供了在经皮瓣膜置换和修复过程期间用于栓塞过滤的装置和方法。在一个方面，一种装置包括护套和过滤器。护套具有近端和远端以及其间的管腔。远端可以通过外周动脉和升主动脉引入主动脉弓，而近端可以设置在身体的外部。管腔允许经皮主动脉瓣置换或修复。过滤器具有带入口和出口的框架，以及连接到框架的栓塞过滤网。入口基本跨过主动脉瓣和大动脉之间的区域中的主动脉弓。出口连接到护套的远端，而不留下任何间隙，栓塞通过该间隙，而不会阻塞鞘的远端处的内腔。

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