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1. 发明申请

WO1997021726A1 AGENTS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：促进骨形成的药剂
公开(公告)号：WO1997021726A1
公开(公告)日：1997-06-19
申请号：PCT/EP1996005380
申请日：1996-12-06
申请人： ROUSSEL UCLAF , KITAMURA, Kazuyuki , KOMIYAMA, Osamu , INAZU, Mizuho , BARON, Roland , GADEK, Thomas , KNOLLE, Jochen , STILZ, Han-Ulrich , WEHNER, Volkmar , MCDOWELL, Robert, S.
发明人： ROUSSEL UCLAF
IPC分类号： C07K07/06
CPC分类号： C07K5/0821 , A61K38/04 , A61K38/05 , A61K38/07 , A61K38/12 , A61K38/1703 , A61K38/39 , C07C271/22 , C07C279/08 , C07C279/20 , C07K5/0202 , C07K5/0817 , C07K5/1019 , C07K5/1024 , C07K14/46 , C07K14/745 , C07K14/78
摘要： The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by general formula (IX) and so on, as well as a biologically acceptable salt thereof, wherein R16 represents -N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents -NH-, -O- or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
摘要翻译：本发明提供骨形成促进剂，骨形成治疗方法及骨形成促进剂的制备方法。用于骨形成的促进剂，其包含分子中含有氨基酸序列ArgGlyAsp的丝氨酸蛋白酶，抑制素，肽或多肽中的至少一种，例如由Gly-Arg-Gly-Asp-Ser表示的肽或由通式式（IX）等，以及其生物可接受的盐，其中R 16表示-N（R 20）2（R 20表示氢原子或C 1 -C 4烷基），R 17表示氢原子或C1- C4烷基，R18表示氢原子，C1-C4烷基等，R19表示OH，NH2等，Y表示-NH-，-O-或直接键，a表示1-3，b 表示1或2，c表示0或1，d表示0或1。

2. 发明申请

WO1993001280A1 INHIBITION OF PROTON PUMP IN OSTEOCLAST CELLS 审中-公开
标题翻译：原子泵在OSTEOCLAST细胞中的抑制作用
公开(公告)号：WO1993001280A1
公开(公告)日：1993-01-21
申请号：PCT/US1992005498
申请日：1992-07-07
申请人： BARON, Roland
IPC分类号： C12N09/14
CPC分类号： C12N9/16 , A61K35/32 , A61K2300/00
摘要： The present invention relates to a uniquely identified ATP dependent proton (H )-pump in osteoclast membranes which is sensitive to both vanadate and NEM and which contains one or more immunologically distinct subunit(s) not found in other proton pumps, and which is highly sensitive to nitrate. The invention also teaches a method for the introduction of suitable therapeutic agents into the aforesaid uniquely identified proton (H )-pump in osteoclast membranes in order to treat the effect of osteopenia and other bone and joint diseases with increased osteoclastic activity (Arthritis, Paget's disease, Hypercalcemia).
摘要翻译：本发明涉及在破骨细胞膜中独特鉴定的ATP依赖性质子（H +）泵，其对钒酸盐和NEM敏感，并且其含有在其它质子泵中未见的一个或多个免疫学上不同的亚基，以及这对硝酸盐非常敏感。本发明还教导了一种在破骨细胞膜中将合适的治疗剂引入上述唯一鉴定的质子（H +）泵中的方法，以便治疗骨质减少和其他骨和关节疾病与破骨细胞活性增加的作用（关节炎，佩吉特氏病，高钙血症）。

3. 发明申请

WO0217858A3 ROLE OF FOSB IN BONE FORMATION 审中-公开
标题翻译： FOSB在骨形成中的作用
公开(公告)号：WO0217858A3
公开(公告)日：2003-01-30
申请号：PCT/US0141890
申请日：2001-08-28
申请人： UNIV YALE , BARON ROLAND E , SIMS NATALIE , SABATAKOS GEORGIOS , NESTLER ERIC , CHEN JINGSHAN , KELZ MAX
发明人： BARON ROLAND E , SIMS NATALIE , SABATAKOS GEORGIOS , NESTLER ERIC , CHEN JINGSHAN , KELZ MAX
IPC分类号： G01N33/48 , A01K67/027 , A61K31/00 , A61K45/00 , A61K48/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07H21/04 , C12N5/06 , C12N15/09 , C12N15/63 , C12N15/74 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N1/30 , G01N33/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/035 , A61K31/00 , A61K48/00 , G01N33/6893
摘要： The present invention is based on the discovery that overexpression of DELTA FosB leads to bone formation and that DELTA FosB expression inhibits adipogenesis. The present invention provides methods of identifying agents that modulate bone formation and adipogenesis. Moreover, the present invention provides methods for identifying genes that are modulated by DELTA FosB, osteogenesis, and adipogenesis.
摘要翻译：本发明基于以下发现：DELTA FosB的过度表达导致骨形成，并且DELTA FosB表达抑制脂肪形成。本发明提供鉴定调节骨形成和脂肪形成的药剂的方法。此外，本发明提供用于鉴定由DELTA FosB，成骨和脂肪形成调节的基因的方法。

4. 发明申请

WO2002081745A2 GENES INVOLVED IN OSTEOGENESIS, AND METHODS OF USE 审中-公开
标题翻译：基因参与OSTEOGENESIS和使用方法
公开(公告)号：WO2002081745A2
公开(公告)日：2002-10-17
申请号：PCT/IB2002/002211
申请日：2002-04-05
申请人： AVENTIS PHARMA S.A. , GARCIA, Teresa , ROMAN ROMAN, Sergio , BARON, Roland , CALL, Katherine , THEILHABER, Joachim , CONNOLLY, Timothy , JACKSON, Amanda , BUSHNELL, Steven, E. , RAWADI, Georges
发明人： GARCIA, Teresa , ROMAN ROMAN, Sergio , BARON, Roland , CALL, Katherine , THEILHABER, Joachim , CONNOLLY, Timothy , JACKSON, Amanda , BUSHNELL, Steven, E. , RAWADI, Georges
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C12N2799/021 , G01N2500/20
摘要： The present invention relates to methods of diagnosis, therapy, and screening of new therapeutic compounds in the field of osteogenesis, based on the differential expression observed for the genes of the invention, represented by SEQ ID N° 1 to SEQ ID N° 150, or SEQ ID N° 151, 152 or 153, or SEQ ID N° 154 to SEQ ID N° 196, or SEQ ID N° 197 to SEQ ID N°210, or SEQ ID N°211 to SEQ ID N° 229, or SEQ ID N° 230 to SEQ ID N° 234, or SEQ ID N° 235 to SEQ ID N° 245.
摘要翻译：本发明涉及基于由SEQ ID NO：1至SEQ ID NO：150表示的本发明基因所观察到的差异表达，在成骨领域中新治疗化合物的诊断，治疗和筛选方法，或SEQ ID NO：151,152或153，或SEQ ID NO.14 154至SEQ ID NO：196，或SEQ ID NO：197至SEQ ID NO：210，或SEQ ID NO：211至SEQ ID NO：229; 或SEQ ID N DEG 230至SEQ ID N DEG 234，或SEQ ID N DEG 235至SEQ ID N DEG 245。

5. 发明申请

WO0217858A9 ROLE OF FOSB IN BONE FORMATION 审中-公开
标题翻译： FOSB在骨形成中的作用
公开(公告)号：WO0217858A9
公开(公告)日：2003-07-17
申请号：PCT/US0141890
申请日：2001-08-28
申请人： UNIV YALE , BARON ROLAND E , SIMS NATALIE , SABATAKOS GEORGIOS , NESTLER ERIC , CHEN JINGSHAN , KELZ MAX
发明人： BARON ROLAND E , SIMS NATALIE , SABATAKOS GEORGIOS , NESTLER ERIC , CHEN JINGSHAN , KELZ MAX
IPC分类号： G01N33/48 , A01K67/027 , A61K31/00 , A61K45/00 , A61K48/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07H21/04 , C12N5/06 , C12N15/09 , C12N15/63 , C12N15/74 , C12Q1/00 , C12Q1/02 , C12Q1/68 , G01N1/30 , G01N33/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/035 , A61K31/00 , A61K48/00 , G01N33/6893
摘要： The present invention is based on the discovery that overexpression of DELTA FosB leads to bone formation and that DELTA FosB expression inhibits adipogenesis. The present invention provides methods of identifying agents that modulate bone formation and adipogenesis. Moreover, the present invention provides methods for identifying genes that are modulated by DELTA FosB, osteogenesis, and adipogenesis.
摘要翻译：本发明基于以下发现：DELTA FosB的过度表达导致骨形成并且DELTA FosB表达抑制脂肪形成。本发明提供了鉴定调节骨形成和脂肪生成的试剂的方法。此外，本发明提供了用于鉴定由ΔFosB，骨生成和脂肪生成调节的基因的方法。

6. 发明申请

WO2002081745A3 GENES INVOLVED IN OSTEOGENESIS, AND METHODS OF USE 审中-公开
公开(公告)号：WO2002081745A3
公开(公告)日：2002-10-17
申请号：PCT/IB2002/002211
申请日：2002-04-05
申请人： PROSKELIA PHARMACEUTICALS , GARCIA, Teresa , ROMAN ROMAN, Sergio , BARON, Roland , CALL, Katherine , THEILHABER, Joachim , CONNOLLY, Timothy , JACKSON, Amanda , BUSHNELL, Steven, E. , RAWADI, Georges
发明人： GARCIA, Teresa , ROMAN ROMAN, Sergio , BARON, Roland , CALL, Katherine , THEILHABER, Joachim , CONNOLLY, Timothy , JACKSON, Amanda , BUSHNELL, Steven, E. , RAWADI, Georges
IPC分类号： C12Q1/68
摘要： The present invention relates to methods of diagnosis, therapy, and screening of new therapeutic compounds in the field of osteogenesis, based on the differential expression observed for the genes of the invention, represented by SEQ ID N° 1 to SEQ ID N° 150, or SEQ ID N° 151, 152 or 153, or SEQ ID N° 154 to SEQ ID N° 196, or SEQ ID N° 197 to SEQ ID N°210, or SEQ ID N°211 to SEQ ID N° 229, or SEQ ID N° 230 to SEQ ID N° 234, or SEQ ID N° 235 to SEQ ID N° 245.

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