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1. 发明申请

WO2009014372A3 DISPERSIBLE TABLET COMPRISING COATED DRUG-CONTAINING PARTICLES AND METHOD FOR THE PREPARATION THEREOF 审中-公开
标题翻译：包含含有包裹药物的颗粒的不均匀片剂及其制备方法
公开(公告)号：WO2009014372A3
公开(公告)日：2009-03-19
申请号：PCT/KR2008004298
申请日：2008-07-23
申请人： AMOREPACIFIC CORP , SHIN KWANG HYUN , BIN SUNG AH , KIM KYOUNG KOOK , BAE JOON HO , KIM JUNG JU
发明人： SHIN KWANG HYUN , BIN SUNG AH , KIM KYOUNG KOOK , BAE JOON HO , KIM JUNG JU
IPC分类号： A61K9/28 , A61K9/24 , A61K9/30 , A61K31/44
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/2027 , A61K9/2054 , A61K9/5026 , A61K31/7048
摘要： The present invention relates to a dispersible tablet comprising a plurality of a coated drug-containing particles and a method for preparing said dispersible tablet. The inventive dispersible tablet comprising (a) a plurality of a drug-containing particle having a coating layer on the surface thereof; (b) a binding agent for protecting the coating layer; and (c) a pharmaceutically acceptable excipient, is capable of: maintaining a suitable hardness to prevent from the breakage thereof during the packing, circulating or storing period; enhancing the patient compliance through masking the drug bitterness; and disintegrating and dispersing rapidly enough to be easily administered to young children or old people having difficulty in swallowing a conventional oral formulation.
摘要翻译：本发明涉及包含多个涂覆药物的颗粒的分散片和一种制备所述分散片的方法。本发明的分散片包含（a）在其表面上具有涂层的多个含药颗粒; （b）用于保护涂层的粘合剂; 和（c）药学上可接受的赋形剂，能够：在包装，循环或储存期间保持合适的硬度以防止其破裂; 通过掩盖药物的苦味来增强患者的依从性; 并迅速分散和分散，容易地对难以吞咽常规口服制剂的幼儿或老年人施用。

2. 发明申请

WO2009014372A2 DISPERSIBLE TABLET COMPRISING COATED DRUG-CONTAINING PARTICLES AND METHOD FOR THE PREPARATION THEREOF 审中-公开
标题翻译：包含涂覆的含药物颗粒的分散片剂及其制备方法
公开(公告)号：WO2009014372A2
公开(公告)日：2009-01-29
申请号：PCT/KR2008/004298
申请日：2008-07-23
申请人： AMOREPACIFIC CORPORATION , SHIN, Kwang Hyun , BIN, Sung Ah , KIM, Kyoung Kook , BAE, Joon Ho , KIM, Jung Ju
发明人： SHIN, Kwang Hyun , BIN, Sung Ah , KIM, Kyoung Kook , BAE, Joon Ho , KIM, Jung Ju
IPC分类号： A61K9/28
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/2027 , A61K9/2054 , A61K9/5026 , A61K31/7048
摘要： The present invention relates to a dispersible tablet comprising a plurality of a coated drug-containing particles and a method for preparing said dispersible tablet. The inventive dispersible tablet comprising (a) a plurality of a drug-containing particle having a coating layer on the surface thereof; (b) a binding agent for protecting the coating layer; and (c) a pharmaceutically acceptable excipient, is capable of: maintaining a suitable hardness to prevent from the breakage thereof during the packing, circulating or storing period; enhancing the patient compliance through masking the drug bitterness; and disintegrating and dispersing rapidly enough to be easily administered to young children or old people having difficulty in swallowing a conventional oral formulation.
摘要翻译：本发明涉及包含多种包衣的含药物颗粒的可分散片剂以及制备所述可分散片剂的方法。本发明的分散片包含（a）多个在其表面上具有涂层的含药颗粒; （b）用于保护涂层的粘合剂; 和（c）药学上可接受的赋形剂能够：在包装，循环或储存期间保持合适的硬度以防止其破裂; 通过掩盖药物苦味提高患者依从性; 并迅速崩解和分散，以便容易地给吞咽常规口服制剂困难的幼儿或老年人服用。

3. 发明申请

WO2013032210A3 BIOMEMBRANE PERMEABLE COMPOSITION 审中-公开
标题翻译：生物膜渗透性组合物
公开(公告)号：WO2013032210A3
公开(公告)日：2013-05-10
申请号：PCT/KR2012006868
申请日：2012-08-28
申请人： AMOREPACIFIC CORP , JANG JI HYE , KIM JAE KWAN , PARK JIN WOO , BAE JOON HO
发明人： JANG JI HYE , KIM JAE KWAN , PARK JIN WOO , BAE JOON HO
IPC分类号： A61K38/00 , A61K47/42 , C07K7/08 , C12N15/09
CPC分类号： C07K7/08 , C07K2319/33
摘要： The present invention relates to a biomembrane permeable composition including: a transfer target material; and a low molecular weight protamine including an amino acid having a sequence identifier number 1 or 2.
摘要翻译：本发明涉及生物膜可渗透组合物，其包括：转移靶材料; 和含有序列识别符号1或2的氨基酸的低分子量鱼精蛋白。

4. 发明申请

WO2010053337A3 SLOW-RELEASE PARTICLE AND A PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：缓释颗粒及其生产方法
公开(公告)号：WO2010053337A3
公开(公告)日：2010-09-10
申请号：PCT/KR2009006590
申请日：2009-11-10
申请人： AMOREPACIFIC CORP , SHIN KWANG-HYUN , KIM JAEKWAN , JUN JAI-IL , HONG DEOK-KI , BAE JOON-HO
发明人： SHIN KWANG-HYUN , KIM JAEKWAN , JUN JAI-IL , HONG DEOK-KI , BAE JOON-HO
IPC分类号： A61K9/16 , A61K47/48
CPC分类号： A61K9/5047 , A61K9/5026 , A61K9/5042
摘要： The present invention relates to a slow-release particle comprising: a matrix having a pharmacologically active component; and a slow-release layer having a substance which forms a slow-release stratum on the matrix. The slow-release particle of the present invention not only allows control of the dual release of drugs of an effective kind but can also exhibit outstanding elution characteristics even when a small amount of coating substance is used.
摘要翻译：本发明涉及缓释颗粒，其包含：具有药理活性成分的基质; 以及具有在基质上形成缓释层的物质的缓释层。本发明的缓释颗粒不仅可以控制有效种类的药物的双重释放，而且即使使用少量的包衣物质也能显示出优异的洗脱特性。

5. 发明申请

WO2008100107A1 CONTROLLED-RELEASE PREPARATION CONTAINING CILOSTAZOL AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：含有西兰坦的控制释放制剂及其制备方法
公开(公告)号：WO2008100107A1
公开(公告)日：2008-08-21
申请号：PCT/KR2008/000902
申请日：2008-02-15
申请人： AMOREPACIFIC CORPORATION , PACIFIC PHARMACEUTICAL CO., LTD. , PARK, Jin Woo , SHIN, Kwang Hyun , BIN, Sung Ah , LEE, Hyeok , BAE, Joon Ho , JEON, Do Yong
发明人： PARK, Jin Woo , SHIN, Kwang Hyun , BIN, Sung Ah , LEE, Hyeok , BAE, Joon Ho , JEON, Do Yong
IPC分类号： A61K9/22 , A61K9/20 , A61K47/34 , A61K9/36 , A61K31/47
CPC分类号： A61K9/0065 , A61K9/2031 , A61K9/2054 , A61K31/4709
摘要： The present invention relates to a controlled-release formulation comprising cilostazol and a method for preparing said formultion. The inventive controlled-release formulation comprising cilostazol or a pharmaceutically acceptable salt thereof, a solubilizing agent, a swelling agent, a swell-controlling agent and a gas generating material has advantages in that it maintains a constant cilostazol level in the blood through a slow release while it resides in the stomach and intestines over a long period of time, thereby increasing the absorption of cilostazol in the small intestine, the major absorption site of cilostazol, as well as minimizing adverse effects caused by rapid release and making it easy for a patient to take the drug.
摘要翻译：本发明涉及包含西洛他唑的控释制剂及其制备方法。包含西洛他唑或其药学上可接受的盐，增溶剂，溶胀剂，溶胀控制剂和气体发生材料的本发明的控制释放制剂具有以下优点：其通过缓慢释放维持血液中恒定的西洛他唑水平而长时间存在于胃和肠中，从而增加西洛他唑的主要吸收部位小肠西洛他唑的吸收，同时减少由快速释放引起的不良反应，使病人容易服用药物

6. 发明申请

WO2006101321A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：新化合物，其异构体，或其药学上可接受的盐作为VANILLOID受体拮抗剂; 和含有它们的药物组合物
公开(公告)号：WO2006101321A1
公开(公告)日：2006-09-28
申请号：PCT/KR2006/000988
申请日：2006-03-17
申请人： AMOREPACIFIC CORPORATION , SUH, Young-Ger , KIM, Hee-Doo , PARK, Hyeung-Geun , OH, Uh Taek , LEE, Yong-Sil , PARK, Seol Rin , RYU, Chong Hyon , PARK, Young-Ho , SHIN, Song Seok , KIM, Sun-Young , KIM, Jin Kwan , JEONG, Yeon Su , LEE, Ki-Wha , CHOI, Jin Kyu , LIM, Kyung Min , KOH, Hyun Ju , MOH, Joo Hyun , KIM, Sung-Il , BAE, Joon Ho
发明人： SUH, Young-Ger , KIM, Hee-Doo , PARK, Hyeung-Geun , OH, Uh Taek , LEE, Yong-Sil , PARK, Seol Rin , RYU, Chong Hyon , PARK, Young-Ho , SHIN, Song Seok , KIM, Sun-Young , KIM, Jin Kwan , JEONG, Yeon Su , LEE, Ki-Wha , CHOI, Jin Kyu , LIM, Kyung Min , KOH, Hyun Ju , MOH, Joo Hyun , KIM, Sung-Il , BAE, Joon Ho
IPC分类号： C07C275/24 , A61K31/17
CPC分类号： C07C275/24 , C07C311/08 , C07C311/11 , C07C323/62 , C07D211/46 , C07D295/088 , C07D295/155 , C07D309/12 , C07F7/0818
摘要： This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receotor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
摘要翻译：本发明涉及新化合物，其异构体或其药学上可接受的盐作为香草素受体（Vanilloid Receotor 1; VR1; TRPV1）拮抗剂; 和含有该组合物的药物组合物。本发明提供了用于预防或治疗诸如疼痛，偏头痛，关节痛，神经痛，神经病，神经损伤，皮肤病，尿膀胱过敏症，肠易激综合征，粪便紧急性，呼吸障碍，皮肤刺激，眼睛或粘膜，胃十二指肠溃疡，炎症性疾病，耳疾病和心脏病。

7. 发明申请

WO2011139101A3 METHOD FOR PRODUCING THE SOLID PHASE OF A WATER-INSOLUBLE GEL COMPOSITION AND A WATER-INSOLUBLE GEL PRODUCED THEREBY 审中-公开
标题翻译：生产水不溶性凝胶组合物的固体相的方法和生产水不溶性凝胶
公开(公告)号：WO2011139101A3
公开(公告)日：2012-03-22
申请号：PCT/KR2011003352
申请日：2011-05-04
申请人： AMOREPACIFIC CORP , AH YOUNG CHANG , LEE JIN HEE , JUNG JU A , BAE JOON HO
发明人： AH YOUNG CHANG , LEE JIN HEE , JUNG JU A
IPC分类号： A61K9/06 , A61K9/32 , A61K47/30
CPC分类号： A61K9/06
摘要： Disclosed is a method for producing a water-insoluble gel composition comprising the steps of: producing a composition by introducing water, an auxiliary dispersing agent, a water-soluble polymer, a pH adjuster and a cross-linking agent; and removing the water and the auxiliary dispersing agent from the composition produced in the above step. The method allows a water-insoluble gel composition of outstanding quality to be produced efficiently. Also disclosed is a water-insoluble gel composition produced by means of the method for producing the water-insoluble gel composition.
摘要翻译：本发明公开了一种水不溶性凝胶组合物的制造方法，包括以下步骤：通过引入水，辅助分散剂，水溶性聚合物，pH调节剂和交联剂来制备组合物; 并从上述步骤中制备的组合物中除去水和辅助分散剂。该方法能够有效地生产出优质的水不溶性凝胶组合物。还公开了通过生产水不溶性凝胶组合物的方法制备的水不溶性凝胶组合物。

8. 发明申请

WO2010053335A3 METHOD FOR PRODUCING POWDER CONTAINING NANOPARTICLES OF INSOLUBLE DRUG, POWDER PRODUCED THEREBY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 审中-公开
标题翻译：生产含有不溶性药物的纳米颗粒的粉末的方法，生产的粉末和含有它们的药物组合物
公开(公告)号：WO2010053335A3
公开(公告)日：2010-09-10
申请号：PCT/KR2009006585
申请日：2009-11-10
申请人： AMOREPACIFIC CORP , BAE JOON-HO , LEE HYEOK , HONG DEOK-KI , LEE JONG-HWI
发明人： BAE JOON-HO , LEE HYEOK , HONG DEOK-KI , LEE JONG-HWI
IPC分类号： A61K9/16 , A61K47/48
CPC分类号： A61K9/146 , A61K9/1694 , A61K9/19
摘要： The present invention relates to a production method for a powder containing nanoparticles of an insoluble drug, a powder produced thereby, and a pharmaceutical composition containing the same. The method comprises the steps of: providing a uniformly dispersed solution of an insoluble drug which has been formed into nanoparticles in the presence of a surface stabilizer; mixing the uniformly dispersed solution with a water-soluble dispersant solution; and drying the resulting mixed solution and thereby recovering a powder. When the powder containing the nanoparticles of the insoluble drug obtained by the method of the present invention is again dispersed in an aqueous solution, the insoluble drug retains a particle size in the nano scale while the solubility and the dissolution rate of the drug are increased, thereby providing enhanced bioavailability. Consequently, the present invention can be used effectively in the development of otherwise insoluble drug preparations for oral or parenteral administration.
摘要翻译：本发明涉及一种含有不溶性药物的纳米颗粒的粉末的生产方法，由此制备的粉末和含有它的药物组合物。该方法包括以下步骤：提供在表面稳定剂存在下已形成纳米颗粒的不溶性药物的均匀分散溶液; 将均匀分散的溶液与水溶性分散剂溶液混合; 并干燥得到的混合溶液，从而回收粉末。当通过本发明方法获得的含有不溶性药物的纳米颗粒的粉末再次分散在水溶液中时，不溶性药物保持纳米级的粒径，同时药物的溶解度和溶解速率增加，从而提供增强的生物利用度。因此，本发明可以有效地用于开发用于口服或肠胃外给药的其它不溶性药物制剂。

9. 发明申请

WO2008100106A1 CONTROLLED RELEASE PREPARATION CONTAINING CILOSTAZOLAND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：含有CILOSTAZOLAND过程的控制释放制剂的制备
公开(公告)号：WO2008100106A1
公开(公告)日：2008-08-21
申请号：PCT/KR2008/000901
申请日：2008-02-15
申请人： AMOREPACIFIC CORPORATION , PACIFIC PHARMACEUTICAL CO., LTD. , PARK, Jin Woo , SHIN, Kwang Hyun , KWON, Min Jung , BAE, Joon Ho , JEON, Do Yong
发明人： PARK, Jin Woo , SHIN, Kwang Hyun , KWON, Min Jung , BAE, Joon Ho , JEON, Do Yong
IPC分类号： A61K9/10
CPC分类号： A61K9/2054 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/205 , A61K9/2077 , A61K31/4709
摘要： A controlled release preparation which comprises particles containing cilostazol or its pharmaceutically acceptable salt dispersed in a solubilizing agent and an erodible material encasing said particles which is capable of forming a hydrogel, can maintain a constant level of cilostazol in the blood through its slow release during its prolonged residence time in the stomach and intestines, thereby minimizing adverse effects caused by rapid release of the drug or solubilizing agent.
摘要翻译：包含分散在增溶剂中的含有西洛他唑或其药学上可接受的盐的颗粒的控制释放制剂和包含能形成水凝胶的所述颗粒的可侵蚀材料可以通过其中缓慢释放来维持血液中恒定水平的西洛他唑在胃和肠中延长停留时间，从而最小化药物或增溶剂快速释放引起的不良反应。

10. 发明申请

WO2006019280A1 A COMPOSITION CONTAINING A THIOUREA DERIVATIVE FOR PREVENTING OR TREATING PRURITIC OR IRRITANT SKIN DISEASES 审中-公开
标题翻译：含有THIURURA衍生物的组合物，用于预防或治疗原始或刺激性皮肤疾病
公开(公告)号：WO2006019280A1
公开(公告)日：2006-02-23
申请号：PCT/KR2005/002735
申请日：2005-08-19
申请人： AMOREPACIFIC CORPORATION , KOH, Hyun Ju , CHOI, Jin Kyu , JEONG, Yeon Su , LIM, Kyung Min , MOH, Joo-Hyun , BAE, Joon Ho , KIM, Dae Kwon , KIM, Kwang Mi , LEE, Chang Hoon , JOO, Yung Hyup , SHIN, Song Seok , PARK, Young-Ho , SIM, Young Chul
发明人： KOH, Hyun Ju , CHOI, Jin Kyu , JEONG, Yeon Su , LIM, Kyung Min , MOH, Joo-Hyun , BAE, Joon Ho , KIM, Dae Kwon , KIM, Kwang Mi , LEE, Chang Hoon , JOO, Yung Hyup , SHIN, Song Seok , PARK, Young-Ho , SIM, Young Chul
IPC分类号： A61K31/64
CPC分类号： A61K31/64
摘要： Disclosed herein is a composition for preventing or treating pruritic or irritant skin diseases which comprises, as a vanilloid receptor antagonist, a thiourea derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, together with a pharmaceutically acceptable carrier.
摘要翻译：本文公开了一种用于预防或治疗瘙痒或刺激性皮肤病的组合物，其包含作为香草素受体拮抗剂的硫脲衍生物，其药学上可接受的盐，其水合物或其溶剂合物，以及药学上可接受的载体。

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