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1. 发明申请

WO1996017860A1 NEW DIPEPTIDE P-AMIDINOBENZYLAMIDES WITH N-TERMINAL SULFONYL OR AMINOSULFONYL RADICALS 审中-公开
标题翻译：具有N-末端磺酰OR NEW二肽P AMIDINOBENZYLAMIDE AMINOSULFONYLRESTEN
公开(公告)号：WO1996017860A1
公开(公告)日：1996-06-13
申请号：PCT/EP1995004646
申请日：1995-11-25
申请人： BASF AKTIENGESELLSCHAFT , BÖHM, Hans, Joachim , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried , ZIERKE, Thomas
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07K05/06
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06043 , C07K5/06078 , C07K5/06113
摘要： The invention pertains to compounds of formula (I), wherein R , A and B are as indicated in the description, and to their preparation. The new compounds can be used for combatting diseases.
摘要翻译：是式（I）化合物，其中R <1>，A和B具有在说明书中给出的含义，并且它们的生产。的新的化合物适于防治疾病。

2. 发明申请

WO1995035309A1 NEW THROMBIN INHIBITORS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新凝血酶抑制剂，生产和使用
公开(公告)号：WO1995035309A1
公开(公告)日：1995-12-28
申请号：PCT/EP1995002135
申请日：1995-06-06
申请人： BASF AKTIENGESELLSCHAFT , BÖHM, Hans-Joachim , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07K05/06
CPC分类号： C07K5/0812 , A61K38/00 , A61K47/64 , C07D205/04 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06026 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/06113
摘要： Compounds having the formula (I) are disclosed, in which the substituents have the meanings given in the description, as well as their salts with physiologically acceptable acids and their stereoisomers, and intermediate products for producing the same. These compounds are useful for treating diseases.
摘要翻译：它将与生理上相容的酸和它们的式（I）和它们的盐的化合物，其中取代基具有本说明书中给出的含义的立体异构体进行说明。接着中间体公开了用于它们的制备。所述化合物适于防治疾病。

3. 发明申请

WO1996024609A1 THROMBIN INHIBITORS 审中-公开
标题翻译：凝血酶抑制剂
公开(公告)号：WO1996024609A1
公开(公告)日：1996-08-15
申请号：PCT/EP1996000472
申请日：1996-02-06
申请人： BASF AKTIENGESELLSCHAFT , SEITZ, Werner , MACK, Helmut , ZIERKE, Thomas , BÖHM, Hans-Joachim , HÖFFKEN, Hans, Wolfgang , KOSER, Stefan , PFEIFFER, Thomas , HORNBERGER, Wilfried
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07K05/06
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/0606 , C07K5/06078 , C07K5/06113 , C07K5/06191
摘要： The invention concerns thrombin inhibitors of formula (I), wherein R , A, B, and D have the meanings given in the description, and intermediate products for the preparation thereof. The compounds of formula (I) are suitable for combating diseases.
摘要翻译：有式凝血酶抑制剂（I）其中，R <1>中，A，B和D具有它们的制备方法在本说明书中给出的含义，以及描述的中间体。化合物（Ⅰ）适于防治的疾病。

4. 发明申请

WO1996025426A1 NOVEL DIPEPTIDE AMIDINES AS THROMBIN INHIBITORS 审中-公开
标题翻译： NEW二肽作为脒凝血酶抑制剂
公开(公告)号：WO1996025426A1
公开(公告)日：1996-08-22
申请号：PCT/EP1996000582
申请日：1996-02-12
申请人： BASF AKTIENGESELLSCHAFT , BÖHM, Hans-Joachim , HÖFFKEN, Hans, Wolfgang , HORNBERGER, Wilfried , KOSER, Stefan , MACK, Helmut , PFEIFFER, Thomas , SEITZ, Werner , ZIERKE, Thomas
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07K05/06
CPC分类号： C07D213/78 , C07D205/04 , C07D207/16 , C07D239/28 , C07D241/24 , C07D401/12 , C07K5/06165
摘要： The description relates to compounds of formula (I) in which A, B, D, R and R have the meanings given in the specification. The compounds are suitable for the treatment of diseases. The novel compounds are produced via compounds of the formula H2N-CH2-G-M in which G and M have the meanings given in claim 4.
摘要翻译：有式描述的化合物（I），其中A，B，D，R <1>和R <2>具有说明书中给出的含义。所述化合物适于防治疾病。新化合物经由式H2N-CH2-G-M，其中G和M如权利要求中所定义的化合物制备。4

5. 发明申请

WO1995015944A1 SUBSTITUTED CYCLOALKANECARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN ANTAGONISTS 审中-公开
标题翻译：取代环烷酸衍生物，生产与应用，内皮素拮抗剂
公开(公告)号：WO1995015944A1
公开(公告)日：1995-06-15
申请号：PCT/EP1994003914
申请日：1994-11-26
申请人： BASF AKTIENGESELLSCHAFT , ALBRECHT, Hans-Peter , BÖHM, Hans-Joachim , RASCHACK, Manfred , UNGER, Liliane , WERNET, Wolfgang
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07D209/18
CPC分类号： C07C205/56 , C07C62/06 , C07C62/18 , C07C62/38 , C07C69/757 , C07C229/46 , C07C229/50 , C07C235/34 , C07C2602/28 , C07D209/18
摘要： The invention describes compounds of formula (I), where A is an oxygen atom or a NH group; B is the radical -Zm-(CHQ)p-(CH=CH)q-(CH2)r-P, where Z is a -CO- group or -SO2-group, m is 0 or 1, p is 0, 1 or 2, q is 0, 1 or 2, r is 0, 1 or 2, Q is a hydrogen atom, a C1-4 alkyl radical, a carboxyl-, carboxamido- or carboxy-C1-4 alkyl group, and P is a hydrogen atom, an indolyl radical, or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkyl groups, and/or a C1-2 alkylenedioxy group; D is an amino-, hydroxy-, C1-4 alkoxy, C1-4 alkylamino-, aryl-C1-4 alkylenoxy- or aryl-C1-4 alkyleneamino, where the aryl radicals represent a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group; X is a C1-4 alkyl radical or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group; Y is a hydrogen atom, a C1-4 alkyl radical or a phenyl radical possibly substituted by 1-3-C1-4 alkyl radicals, halogen atoms, trifluoromethyl-, hydroxy-, C1-4 alkoxy-, C1-4 acyloxy-, amino-, C1-5 acylamino-, sulfonamido-, nitro-, C1-5 acyl-, carboxyl- or thio-C1-4 alkylene groups and/or a C1-2 alkylenedioxy group, or X and Y together represent a -(CH2)s group, where s is 3, 4 or 5, and 1 or 2 hydrogen atoms can be replaced by methyl groups, and n is 0 or 1, and possibly their salts with physiologically tolerable acids and bases. The compounds can be used to combat diseases.
摘要翻译：有式（I），其中A是氧原子或NH基团的发明中，B是基团-Zm-（CHQ）对 - （CH = CH）Q（CH 2）RP，其中Z是-CO - 或-SO 2基团，m是0或1，p是阿尔0，1或2，q为0，1或2，r是0，1或2，Q是氢原子，C 1-4 烷基，羧基，甲酰氨基，或羧基-C 1-4 - 烷基且P为氢原子或任选地被1-3个C 1-4烷基，卤素原子，三氟甲基，羟基，C 1-4烷氧基，C 1 -C 4-酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C 1-5酰基，羧基或硫代C 1-4 - 烷基基团和/或C1-2亚烷基二氧基取代的苯基或代表吲哚基团，D是氨基，羟基，C 1-4 - 烷氧基，C 1-4 - 烷基氨基，芳基-C 1-4 - 亚烷基或芳基-C 1-4亚烷基氨基，其中所述芳基任选被取代的1- 3个C 1-4烷基，卤素原子，三氟甲基，羟基，C 1-4 - 烷氧基，C 1-4 - 酰氧基，氨基，C 1-5酰氨基，磺 namido-，硝基，C 1-5酰基，羧基或硫代C1-4亚烷基基团和/或C 1-2 - 亚烷基二氧基取代的苯基，X表示C 1-4 - 烷基或任选被1个 -3 C 1-4烷基，卤素，三氟甲基，羟基，C 1-4烷氧基，C 1-4酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C1-5- 亚烷基硫基-C 1-4 - 酰基，羧基或和/或亚烷基二C1-2取代的苯基基团，Y表示氢原子，C 1-4烷基或任选地被1-3 C 1-4烷基的基团，卤原子甲基，三氟甲基，羟基，C 1-4 - 烷氧基，C 1-4 - 酰氧基，氨基，C 1-5酰氨基，磺酰氨基，硝基，C 1-5酰基，羧基或硫代C1 -4 - 亚烷基和/或C 1-2 - 亚烷基二氧基取代的苯基基团，或X和Y一起形成 - （CH 2）平均的小组，其中s是在其通过甲基基团1个或2个氢原子的数目3，4或5个可以被替换，并且n为数字0或1，和任选其盐与生理上可接受的酸或碱。所述化合物适于防治疾病。

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