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1. 发明申请

WO2004028624A3 NERVE STIMULATION FOR TREATING SPASTICITY, TREMOR, MUSCLE WEAKNESS, AND OTHER MOTOR DISORDERS 审中-公开
标题翻译：神经刺激治疗弹性，有力，肌肉无力和其他运动障碍
公开(公告)号：WO2004028624A3
公开(公告)日：2004-04-29
申请号：PCT/IL0300765
申请日：2003-09-24
申请人： BIOCONTROL MEDICAL LTD , AYAL SHAI , COHEN EHUD , DABBY RON
发明人： AYAL SHAI , COHEN EHUD , DABBY RON
IPC分类号： A61N1/18 , A61N1/34 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36021 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36071 , A61N1/37205
摘要： A method for treating spasticity of a subject is provided, including driving a current into a nerve of the subject that includes one or more sensory fibers, and configuring the current so as to inhibit propagation of action potentials in one or more of the sensory fibers, so as to treat the spasticity. In a preferred embodiment, the sensory fibers include one or more Ia sensory fibers, and configuring the current includes configuring the current so as to inhibit propagation of the action potentials in at least one of the Ia sensory fibers.
摘要翻译：提供了用于治疗受试者痉挛状态的方法，包括将电流驱入包括一种或多种感觉纤维的受试者的神经中，并且配置电流以抑制动作电位在一种或多种感觉纤维中的传播，以治疗痉挛。在优选实施方案中，感觉纤维包括一种或多种Ia感觉纤维，并且配置电流包括配置电流以抑制动作电位在至少一种Ia感觉纤维中的传播。

2. 发明申请

WO2004103455A3 SELECTIVE NERVE FIBER STIMULATION FOR HEART TREATMENT 审中-公开
标题翻译：选择性神经纤维刺激心脏治疗
公开(公告)号：WO2004103455A3
公开(公告)日：2005-01-06
申请号：PCT/IL2004000440
申请日：2004-05-23
申请人： BIOCONTROL MEDICAL LTD , BEN DAVID TAMIR , AYAL SHAI , BEN EZRA OMRY , COHEN EHUD
发明人： BEN DAVID TAMIR , AYAL SHAI , BEN EZRA OMRY , COHEN EHUD
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus (18) is provided that includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of a subject (31), and a control unit (20), adapted to drive the electrode device (40) to apply to the vagus nerve (36) a current that reduces heart rate variability of the subject (31). Also provided is a method comprising applying to a vagus nerve (36) of a subject (31) a current that reduces heart rate variability of the subject (31).
摘要翻译：提供了一种装置（18），其包括适于联接到受试者（31）的迷走神经（36）的电极装置（40）和适于驱动电极装置（40）的控制单元（20）将迷走神经（36）应用于减少受试者的心率变异性的电流（31）。还提供了一种方法，包括向受试者（31）的迷走神经（36）施加减少受试者（31）的心率变异性的电流。

3. 发明申请

WO2004103455A2 SELECTIVE NERVE FIBER STIMULATION FOR TREATING HEART CONDITIONS 审中-公开
标题翻译：选择性神经纤维刺激心脏治疗
公开(公告)号：WO2004103455A2
公开(公告)日：2004-12-02
申请号：PCT/IL2004/000440
申请日：2004-05-23
申请人： BIOCONTROL MEDICAL LTD. , BEN DAVID, Tamir , AYAL, Shai , BEN EZRA, Omry , COHEN, Ehud
发明人： BEN DAVID, Tamir , AYAL, Shai , BEN EZRA, Omry , COHEN, Ehud
IPC分类号： A61N
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus (18) is provided that includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of a subject (31), and a control unit (20), adapted to drive the electrode device (40) to apply to the vagus nerve (36) a current that reduces heart rate variability of the subject (31). Also provided is a method comprising applying to a vagus nerve (36) of a subject (31) a current that reduces heart rate variability of the subject (31).
摘要翻译：提供了一种装置（18），其包括适于联接到受试者（31）的迷走神经（36）的电极装置（40）和适于驱动电极装置（40）的控制单元（20）将迷走神经（36）应用于减少受试者的心率变异性的电流（31）。还提供了一种方法，包括向受试者（31）的迷走神经（36）施加减少受试者（31）的心率变异性的电流。

4. 发明申请

WO2003099373A2 ELECTRODE ASSEMBLY FOR NERVE CONTROL 审中-公开
标题翻译：电极组件用于神经控制
公开(公告)号：WO2003099373A2
公开(公告)日：2003-12-04
申请号：PCT/IL2003/000430
申请日：2003-05-23
申请人： BIOCONTROL MEDICAL LTD. , AYAL, Shai , BETSER, Nir , GROSS, Yossi , COHEN, Ehud
发明人： AYAL, Shai , BETSER, Nir , GROSS, Yossi , COHEN, Ehud
IPC分类号： A61N
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus (20) is provided for applying current to a nerve (30). A cathode (40) is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve (30) and to apply a cathodic current to the nerve (30). A primary inhibiting anode (42) is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve (30) and to apply a primary anodal current to the nerve (30). A secondary inhibiting anode (44) is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve (30) and to apply a secondary anodal current to the nerve (30), the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.
摘要翻译：提供设备（20）用于向神经（30）施加电流。阴极（40）适于放置在神经（30）的阴极纵向位置附近并施加阴极电流至神经（30）。主抑制阳极（42）适于放置在神经（30）的主要阳极纵向部位附近，并将主阳极电流施加到神经（30）。辅助抑制阳极（44）适于放置在神经（30）的次级阳极纵向位置附近，并将次要阳极电流施加到神经（30），次级阳极纵向位置更靠近原始阳极纵向位置比阴极纵向位置。

5. 发明申请

WO02058782A8 METHOD AND APPARATUS FOR SELECTIVE CONTROL OF NERVE FIBERS 审中-公开
标题翻译：用于选择性控制神经纤维的方法和装置
公开(公告)号：WO02058782A8
公开(公告)日：2004-05-27
申请号：PCT/IL0200070
申请日：2002-01-23
申请人： BIOCONTROL MEDICAL BCM LTD , COHEN EHUD , AYAL SHAI
发明人： COHEN EHUD , AYAL SHAI
IPC分类号： A61N1/34 , A61N1/36 , A61N1/18
CPC分类号： A61N1/36071
摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device (10) to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers.
摘要翻译：一种通过使用三极电极装置（10）选择性地阻止穿过神经束的身体产生的动作电位的传播来产生单向动作电位以用作具有身体产生动作的碰撞块的疼痛控制的方法和装置代表小直径感觉纤维疼痛感的潜力。

6. 发明申请

WO2002058782A3 METHOD AND APPARATUS FOR SELECTIVE CONTROL OF NERVE FIBERS 审中-公开
公开(公告)号：WO2002058782A3
公开(公告)日：2002-08-01
申请号：PCT/IL2002/000070
申请日：2002-01-23
申请人： BIOCONTROL MEDICAL BCM LTD. , COHEN, Ehud , AYAL, Shai
发明人： COHEN, Ehud , AYAL, Shai
IPC分类号： A61N1/18
摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device (10) to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers.

7. 发明申请

WO2002058782A2 METHOD AND APPARATUS FOR SELECTIVE CONTROL OF NERVE FIBERS 审中-公开
标题翻译：用于选择性控制神经纤维的方法和装置
公开(公告)号：WO2002058782A2
公开(公告)日：2002-08-01
申请号：PCT/IL2002/000070
申请日：2002-01-23
申请人： BIOCONTROL MEDICAL BCM LTD. , COHEN, Ehud , AYAL, Shai
发明人： COHEN, Ehud , AYAL, Shai
IPC分类号： A61N
CPC分类号： A61N1/36071
摘要： A method and apparatus particularly useful for pain control by selectively blocking the propagation of body-generated action potentials travelling through a nerve bundle by using a tripolar electrode device to generate unidirectional action potentials to serve as collision blocks with the body-generated action potentials representing pain sensations in the small-diameter sensory fibers. In the described preferred embodiments there are a plurality of electrode devices spaced along the length of the nerve bundle which are sequentially actuated with delays corresponding to the velocity of propagation of the body-generated action potentials through the large-diameter fibers to produce a "green wave" effect which minimizes undesired anodal blocking of the large-diameter fibers while maximizing the collision blocking of the small-diameter fibers.
摘要翻译：通过使用三极电极装置选择性地阻断穿过神经束的身体产生的动作电位的传播，产生单向动作电位以用作代表疼痛的身体产生的动作电位的碰撞块来特别有用的疼痛控制方法和装置小直径感觉纤维的感觉。在所描述的优选实施例中，存在沿着神经束的长度间隔开的多个电极装置，其依次通过大直径纤维的身体产生的动作电位的传播速度的延迟而被启动，以产生“绿色波“效应，其最大限度地减小了大直径纤维的不希望的阳极阻塞，同时最大限度地发挥了小直径纤维的碰撞阻塞。

8. 发明申请

WO2004028624A2 NERVE STIMULATION FOR TREATING SPASTICITY, TREMOR, MUSCLE WEAKNESS, AND OTHER MOTOR DISORDERS 审中-公开
标题翻译：神经刺激治疗痉挛，颤抖，肌肉疲劳及其他电机疾病
公开(公告)号：WO2004028624A2
公开(公告)日：2004-04-08
申请号：PCT/IL2003/000765
申请日：2003-09-24
申请人： BIOCONTROL MEDICAL LTD. , AYAL, Shai , COHEN, Ehud , DABBY, Ron
发明人： AYAL, Shai , COHEN, Ehud , DABBY, Ron
IPC分类号： A61N1/18
CPC分类号： A61N1/36021 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36071 , A61N1/37205
摘要： A method for treating spasticity of a subject is provided, including driving a current into a nerve of the subject that includes one or more sensory fibers, and configuring the current so as to inhibit propagation of action potentials in one or more of the sensory fibers, so as to treat the spasticity. In a preferred embodiment, the sensory fibers include one or more Ia sensory fibers, and configuring the current includes configuring the current so as to inhibit propagation of the action potentials in at least one of the Ia sensory fibers.
摘要翻译：提供了一种用于治疗受试者痉挛状态的方法，包括将电流驱动到包含一种或多种感觉纤维的受试者的神经中，并且配置电流以便抑制一种或多种感觉纤维中的动作电位的传播，以治疗痉挛。在优选实施方案中，感觉纤维包括一种或多种Ia感官纤维，并且配置电流包括配置电流，以便抑制在Ia感觉纤维中的至少一种中的动作电位的传播。

9. 发明申请

WO2003099377A1 SELECTIVE NERVE FIBER STIMULATION FOR TREATING HEART CONDITIONS 审中-公开
标题翻译：选择性神经纤维刺激治疗心脏病症
公开(公告)号：WO2003099377A1
公开(公告)日：2003-12-04
申请号：PCT/IL2003/000431
申请日：2003-05-23
申请人： BIOCONTROL MEDICAL LTD. , AYAL, Shai , BEN EZRA, Omry , BEN DAVID, Tamir , GROSS, Yossi , COHEN, Ehud
发明人： AYAL, Shai , BEN EZRA, Omry , BEN DAVID, Tamir , GROSS, Yossi , COHEN, Ehud
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus for treating a subject (31) includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of the subject (31), and a heart rate sensor (24), configured to detect a heart rate of the subject (31), and to generate a heart rate signal responsive thereto. The apparatus also includes a control unit (20), adapted to receive the heart rate signal, and, responsive to determining that the heart rate is greater than a threshold value, which threshold value is greater than a normal heart rate, drive the electrode device (40) to apply a current to the vagus nerve (36), and configure the current so as to reduce the heart rate of the subject (31).
摘要翻译：用于治疗受试者（31）的装置包括适于联接到受试者（31）的迷走神经（36）的电极装置（40）和心率传感器（24），其被配置为检测心脏对象（31），并且响应于此产生心率信号。该装置还包括适于接收心率信号的控制单元（20），并且响应于确定心率大于阈值，该阈值大于正常心率，驱动电极装置（40）将电流施加到迷走神经（36），并配置电流以降低被检体（31）的心率。

10. 发明申请

WO2003099373A3 ELECTRODE ASSEMBLY FOR NERVE CONTROL 审中-公开
公开(公告)号：WO2003099373A3
公开(公告)日：2003-12-04
申请号：PCT/IL2003/000430
申请日：2003-05-23
申请人： BIOCONTROL MEDICAL LTD. , AYAL, Shai , BETSER, Nir , GROSS, Yossi , COHEN, Ehud
发明人： AYAL, Shai , BETSER, Nir , GROSS, Yossi , COHEN, Ehud
IPC分类号： A61N1/05
摘要： Apparatus (20) is provided for applying current to a nerve (30). A cathode (40) is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve (30) and to apply a cathodic current to the nerve (30). A primary inhibiting anode (42) is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve (30) and to apply a primary anodal current to the nerve (30). A secondary inhibiting anode (44) is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve (30) and to apply a secondary anodal current to the nerve (30), the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.

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