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1. 发明申请

WO2003099377A1 SELECTIVE NERVE FIBER STIMULATION FOR TREATING HEART CONDITIONS 审中-公开
标题翻译：选择性神经纤维刺激治疗心脏病症
公开(公告)号：WO2003099377A1
公开(公告)日：2003-12-04
申请号：PCT/IL2003/000431
申请日：2003-05-23
申请人： BIOCONTROL MEDICAL LTD. , AYAL, Shai , BEN EZRA, Omry , BEN DAVID, Tamir , GROSS, Yossi , COHEN, Ehud
发明人： AYAL, Shai , BEN EZRA, Omry , BEN DAVID, Tamir , GROSS, Yossi , COHEN, Ehud
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus for treating a subject (31) includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of the subject (31), and a heart rate sensor (24), configured to detect a heart rate of the subject (31), and to generate a heart rate signal responsive thereto. The apparatus also includes a control unit (20), adapted to receive the heart rate signal, and, responsive to determining that the heart rate is greater than a threshold value, which threshold value is greater than a normal heart rate, drive the electrode device (40) to apply a current to the vagus nerve (36), and configure the current so as to reduce the heart rate of the subject (31).
摘要翻译：用于治疗受试者（31）的装置包括适于联接到受试者（31）的迷走神经（36）的电极装置（40）和心率传感器（24），其被配置为检测心脏对象（31），并且响应于此产生心率信号。该装置还包括适于接收心率信号的控制单元（20），并且响应于确定心率大于阈值，该阈值大于正常心率，驱动电极装置（40）将电流施加到迷走神经（36），并配置电流以降低被检体（31）的心率。

2. 发明申请

WO2004103455A2 SELECTIVE NERVE FIBER STIMULATION FOR TREATING HEART CONDITIONS 审中-公开
标题翻译：选择性神经纤维刺激心脏治疗
公开(公告)号：WO2004103455A2
公开(公告)日：2004-12-02
申请号：PCT/IL2004/000440
申请日：2004-05-23
申请人： BIOCONTROL MEDICAL LTD. , BEN DAVID, Tamir , AYAL, Shai , BEN EZRA, Omry , COHEN, Ehud
发明人： BEN DAVID, Tamir , AYAL, Shai , BEN EZRA, Omry , COHEN, Ehud
IPC分类号： A61N
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus (18) is provided that includes an electrode device (40), adapted to be coupled to a vagus nerve (36) of a subject (31), and a control unit (20), adapted to drive the electrode device (40) to apply to the vagus nerve (36) a current that reduces heart rate variability of the subject (31). Also provided is a method comprising applying to a vagus nerve (36) of a subject (31) a current that reduces heart rate variability of the subject (31).
摘要翻译：提供了一种装置（18），其包括适于联接到受试者（31）的迷走神经（36）的电极装置（40）和适于驱动电极装置（40）的控制单元（20）将迷走神经（36）应用于减少受试者的心率变异性的电流（31）。还提供了一种方法，包括向受试者（31）的迷走神经（36）施加减少受试者（31）的心率变异性的电流。

3. 发明申请

WO2004110549A2 APPLICATIONS OF VAGAL STIMULATION 审中-公开
标题翻译： VAGAL刺激的应用
公开(公告)号：WO2004110549A2
公开(公告)日：2004-12-23
申请号：PCT/IL2004/000495
申请日：2004-06-10
申请人： BIOCONTROL MEDICAL LTD. , BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir , DABBY, Ron
发明人： BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir , DABBY, Ron
IPC分类号： A61N
CPC分类号： A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： A method is provided for treating a subject (30) suffering from atrial fibrillation (AF), including administering a drug for treating the AF to the subject (30); applying a current to a site of the subject selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30); and configuring the current to increase vagal tone of the subject (30), so as to treat the AF. For some applications, configuring the current includes configuring the current so as to enhance an efficacy of the drug.
摘要翻译：提供一种治疗患有房颤（AF）的受试者（30）的方法，包括给予对象（30）治疗AF的药物; 对从所述受试者（30）的迷走神经（24），所述受试者（30）的心外膜脂肪垫，所述受试者（30）的肺静脉构成的列表中应用电流，受试者（30）的颈动脉，受试者（30）的颈动脉窦，受试者（30）的腔静脉和受试者（30）的颈内静脉; 以及配置电流以增加受试者（30）的迷走神经张力，以便治疗房颤。对于一些应用，配置电流包括配置电流以提高药物的功效。

4. 发明申请

WO2004110550A2 VAGAL STIMULATION FOR ANTI-EMBOLIC THERAPY 审中-公开
标题翻译： VAGAL刺激抗肿瘤治疗
公开(公告)号：WO2004110550A2
公开(公告)日：2004-12-23
申请号：PCT/IL2004/000496
申请日：2004-06-10
申请人： BIOCONTROL MEDICAL LTD. , BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir
发明人： BEN EZRA, Omry , COHEN, Ehud , BEN DAVID, Tamir
IPC分类号： A61N
CPC分类号： A61N1/0556 , A61B5/4035 , A61N1/36114 , A61N1/3621 , A61N1/395 , A61N1/3962
摘要： Apparatus (20) for treating a subject (30) suffering from spontaneous atrial fibrillation includes an electrode device (22), adapted to be coupled to a site of the subject (30) selected from the list consisting of: a vagus nerve (24) of the subject (30), an epicardial fat pad of the subject (30), a pulmonary vein of the subject (30), a carotid artery of the subject (30), a carotid sinus of the subject (30), a vena cava vein of the subject (30), and an internal jugular vein of the subject (30), and a control unit (32), adapted to drive the electrode device (22) to apply an electrical current to the site, and to configure the current to maintain the spontaneous AF for at least about 24 hours, so as to modify blood flow within the atria and reduce risk of thromboembolic events.
摘要翻译：用于治疗患有自发性心房颤动的受试者（30）的装置（20）包括电极装置（22），其适于耦合到选自以下的列表中的受试者（30）的位置：迷走神经（24）受试者（30）的心外膜脂肪垫，受试者（30）的肺静脉，受试者（30）的颈动脉，受试者（30）的颈动脉窦，体外受试者（30）的静脉和静脉内部的颈内静脉和控制单元（32），其适于驱动电极装置（22）向该部位施加电流，并且配置目前为了维持自发性AF至少约24小时，以便改变心房内的血流量并降低血栓栓塞事件的风险。

5. 发明申请

WO2010035271A1 DEVICES AND METHODS FOR CONTROL OF BLOOD PRESSURE 审中-公开
标题翻译：用于控制血压的装置和方法
公开(公告)号：WO2010035271A1
公开(公告)日：2010-04-01
申请号：PCT/IL2009/000932
申请日：2009-09-29
申请人： VASCULAR DYNAMICS INC. , GROSS, Yossi , AVNERI, Itzik , BEN EZRA, Omry , WEISBERG, Ori , GEFEN, Raanan
发明人： GROSS, Yossi , AVNERI, Itzik , BEN EZRA, Omry , WEISBERG, Ori , GEFEN, Raanan
IPC分类号： A61B5/22
CPC分类号： A61B5/021 , A61B5/022 , A61B5/6862 , A61B5/6876
摘要： Apparatus is provided for reducing hypertension of a subject. A selective circumferential pressure applicator (60) includes at least two surfaces (61) that increase baroreceptor activity of the subject, by applying pressure to an artery (20) of the subject at two or more respective non-contiguous regions around the circumference of the artery, at a longitudinal site of the artery, such that between the non-contiguous regions, at the longitudinal site (a) there is at least one region (22) of the artery that is more relaxed than in the absence of the device, and (b) there is at least one region (21) of the artery that is more tense than in the absence of the device. A joint (63) couples the surfaces to each other. For at least a portion of the subject's cardiac cycle, the joint does not to contact the subject's artery. Other applications are also provided.
摘要翻译：提供用于减少受试者的高血压的装置。选择性周向压力施加器（60）包括至少两个增加受试者压力感受器活性的表面（61），所述至少两个表面（61）通过在受试者的动脉（20）周围的两个或更多个相邻的非连续区域周围施加压力动脉，在动脉的纵向位置处，使得在不连续区域之间，在纵向位置（a）处，与没有装置相比，动脉的至少一个区域（22）比较松弛，和（b）动脉的至少一个区域（21）比不存在装置时更紧张。接头（63）将表面彼此连接。对于受试者心脏周期的至少一部分，关节不接触受试者的动脉。还提供其他应用。

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