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1. 发明申请

WO2010073159A1 ABLATION CONTROL DEVICE FOR REAL-TIME MONITORING OF TISSUE DISPLACEMENT IN REACTION TO A FORCE APPLIED 审中-公开
标题翻译：用于实时监测组织位移反应的力量控制装置
公开(公告)号：WO2010073159A1
公开(公告)日：2010-07-01
申请号：PCT/IB2009/055490
申请日：2009-12-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , PETRUZZELLO, John , ANAND, Ajay , ZHOU, Shiwei
发明人： PETRUZZELLO, John , ANAND, Ajay , ZHOU, Shiwei
IPC分类号： A61B8/08 , A61N7/02
CPC分类号： A61N7/02 , A61B8/08 , A61B18/18 , A61B18/20 , A61B2018/00904 , A61B2090/378
摘要： An ablation control device (110) configured for halting, in real time, ablation of body tissue at a current ablation point to achieve a predetermined lesion size upon halting includes a control section (120) configured for registering, with a characteristic curve, one or more values and halting the ablation based on the registering. The value or values are obtained from monitoring (115), for the current ablation point, displacement caused by force applied to the body tissue. In one embodiment, halting is performed upon detecting, by the monitoring and after a peak value of the monitored displacement has occurred, an endpoint value of the monitored displacement. In another embodiment, the endpoint value is determined prior to the detecting, and the determining is performed by the registering.
摘要翻译：消融控制装置（110）被配置为实时停止在当前消融点处的身体组织的消融以在停止时实现预定的病变尺寸，包括控制部分（120），其被配置为用特征曲线登记一个或更多的价值观，并根据注册停止消融。对于当前消融点，由施加到身体组织的力引起的位移，从监视（115）获得值或值。在一个实施例中，在通过监视检测到并且在所监视的位移的峰值发生之后检测到所监视的位移的端点值时执行停止。在另一个实施例中，在检测之前确定端点值，并且通过注册来执行确定。

2. 发明申请

WO2013001503A3 METHOD AND APPARATUS FOR AUTOMATED ULTRASONIC DOPPLER ANGLE AND FLOW VELOCITY ESTIMATION 审中-公开
标题翻译：自动超声多角度角和流速估计的方法与装置
公开(公告)号：WO2013001503A3
公开(公告)日：2013-03-28
申请号：PCT/IB2012053315
申请日：2012-06-29
申请人： KONINKL PHILIPS ELECTRONICS NV , GUPTA LALIT , ANAND AJAY , PETRUZZELLO JOHN , VAJINEPALLI PALLAVI , SISODIA RAJENDRA SINGH , FIRTION CELINE , RAMACHANDRAN GANESAN
发明人： GUPTA LALIT , ANAND AJAY , PETRUZZELLO JOHN , VAJINEPALLI PALLAVI , SISODIA RAJENDRA SINGH , FIRTION CELINE , RAMACHANDRAN GANESAN
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B8/4494 , A61B8/483 , A61B8/488 , A61B8/5223
摘要： Disclosed is an ultrasound device for measuring blood flow velocity in a blood vessel of a subject without imaging functionality in the device. The measurement depends upon reflections of a collimated beam of ultrasound from a subject's body part. Received electrical signals representative of the reflected ultrasound energy is used for generating a representation of blood flow at a plurality of predetermined locations in the volume and calculating a first blood flow velocity at each of the locations. The representation of flow is used for delineating the blood flow in the blood vessel in the volume. An angle calculating unit calculates the Doppler angle between the direction of the radiated collimated beam in the delineated blood flow at each point. A velocity calculator calculates a second blood flow velocity at the plurality of points based on the calculated first velocities and the calculated angle at the point.
摘要翻译：本发明公开了一种超声波装置，用于测量装置中没有成像功能的被检体的血管中的血流速度。测量取决于来自受试者身体部位的准直的超声波束的反射。代表反射的超声能量的接收的电信号用于产生体积中的多个预定位置处的血流的表示，并计算每个位置处的第一血流速度。流量的表示用于描绘体积中血管中的血流量。角度计算单元计算在每个点处描绘的血流中的辐射准直光束的方向之间的多普勒角度。速度计算器基于计算的第一速度和该点处的计算角度，计算多个点处的第二血流速度。

3. 发明申请

WO2013014647A1 ULTRASOUND PROBE, METHOD AND DEVICE FOR ACQUIRING A BLOOD FLOW SIGNAL OF AN ARTERY AND SYSTEM FOR MEASURING SYSTOLIC BLOOD PRESSURE 审中-公开
标题翻译：用于获取动脉血流信号的超声波探头，方法和装置以及用于测量同步血压的系统
公开(公告)号：WO2013014647A1
公开(公告)日：2013-01-31
申请号：PCT/IB2012/053852
申请日：2012-07-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZHONG, Jianyi , ANAND, Ajay , PETRUZZELLO, John , CHEN, Yinan , LU, Weijia
发明人： ZHONG, Jianyi , ANAND, Ajay , PETRUZZELLO, John , CHEN, Yinan , LU, Weijia
IPC分类号： A61B8/04 , A61B8/06
CPC分类号： A61B8/04 , A61B5/489 , A61B8/06 , A61B8/4236 , A61B8/4477 , A61B8/4483 , A61B8/488 , A61B8/5223
摘要： This invention provides an ultrasound probe, a device and method for acquiring a blood flow signal of an artery and a system for measuring systolic blood pressure. The ultrasound probe comprises a plurality of ultrasound transducers, wherein each of the plurality of ultrasound transducers is configured to obtain an echo signal by transmitting an ultrasonic wave, receiving an ultrasonic wave and transforming the received ultrasonic wave into the echo signal. The device for acquiring a blood flow signal of an artery comprises the ultrasound probe, wherein the ultrasound probe is intended to be attached to the exterior of the body. The device further comprises: a first deriving unit configured to derive, from each obtained echo signal, at least one Doppler signal, the at least one Doppler signal being associated with the ultrasound transducer obtaining the echo signal and being indicative of information about Doppler shift of the echo signal; a selecting unit configured to select a Doppler signal from the derived Doppler signals according to a predefined condition, the selected Doppler signal being indicative of the at least one characteristic of the blood flow in the artery of the body. In this way, the need for accurate localization of the artery by means of manual adjustment is eliminated on the proviso that the ultrasound probe is attached in such a way that the artery lies within the footprint of the ultrasound probe.
摘要翻译：本发明提供了一种用于获取动脉的血流信号的超声波探头，装置和方法以及用于测量收缩血压的系统。所述超声波探头包括多个超声换能器，其中，所述多个超声波换能器中的每一个被配置为通过发送超声波，接收超声波并将所接收的超声波变换为回波信号来获得回波信号。用于获取动脉的血流信号的装置包括超声波探头，其中超声波探头旨在附接到身体的外部。所述设备还包括：第一导出单元，被配置为从每个获得的回波信号中导出至少一个多普勒信号，所述至少一个多普勒信号与超声换能器相关联，获得回波信号并且指示有关多普勒频移的信息回波信号; 选择单元，被配置为根据预定义的条件从所述导出的多普勒信号中选择多普勒信号，所选择的多普勒信号指示所述身体的动脉中的血流的至少一个特征。以这种方式，消除了通过手动调节对动脉进行精确定位的需要，条件是超声波探头以使得动脉位于超声探头的占地面积内的方式附接。

4. 发明申请

WO2012085788A2 AUTOMATED DOPPLER VELOCIMETRY USING A LOW-COST TRANSDUCER. 审中-公开
标题翻译：使用低成本传感器的自动多普勒测速仪。
公开(公告)号：WO2012085788A2
公开(公告)日：2012-06-28
申请号：PCT/IB2011/055729
申请日：2011-12-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ANAND, Ajay , PETRUZZELLO, John , SISODIA, Rajendra Singh , GUPTA, Lalit , VAJINEPALLI, Pallavi , FIRTION, Celine
发明人： ANAND, Ajay , PETRUZZELLO, John , SISODIA, Rajendra Singh , GUPTA, Lalit , VAJINEPALLI, Pallavi , FIRTION, Celine
IPC分类号： A61B8/06
CPC分类号： A61B8/5223 , A61B5/489 , A61B8/06 , A61B8/0891 , A61B8/4427 , A61B8/4444 , A61B8/466 , A61B8/467 , A61B8/483 , A61B8/488 , A61B8/54 , A61B8/585
摘要： An automatic, stand-alone, hand-held ultrasound blood-vessel examination device (100)requires a reduced number of transducer elements (126) and presents a simplified user interface(136-140), without the need for displaying an image of any of the vessels. The probe, in one embodiment,acquires and examines a volume of interest (106), searches for a target vessel, tests the vessel for normality of blood flow, and reports the diagnosis, all automatically and without need for user intervention. In another embodiment, the probe finds a body vessel (108-112) in a volume, and extracts a clinical Doppler parameter, all automatically and without need for user intervention.
摘要翻译：自动，独立的手持式超声波血管检查装置（100）需要减少数量的换能器元件（126）并呈现简化的用户界面（136-140），而不需要显示任何的船只。在一个实施例中，探针获取和检查感兴趣的体积（106），搜索目标血管，测试血液的血流正常性并且自动报告诊断，并且不需要用户干预。在另一个实施例中，探针在体积中找到身体容器（108-112），并自动提取临床多普勒参数，并且不需要用户干预。

5. 发明申请

WO2008038182A3 ULTRASONIC DETERMINATION OF OPTICAL ABSORPTION COEFFICIENTS 审中-公开
公开(公告)号：WO2008038182A3
公开(公告)日：2008-04-03
申请号：PCT/IB2007/053763
申请日：2007-09-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SAVERY, David , JANKOVIC, Ladislav , ANAND, Ajay
发明人： SAVERY, David , JANKOVIC, Ladislav , ANAND, Ajay
IPC分类号： G01N29/24 , A61B5/00 , G01N21/17 , G01N21/47
摘要： The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (μa) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (ΔT(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (μeff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated. Finally, the desired optical absorption coefficient (μa) at a measuring location (r) can be determined from the light intensity and the temperature increase at this location.

6. 发明申请

WO2013001503A2 METHOD AND APPARATUS FOR AUTOMATED ULTRASONIC DOPPLER ANGLE AND FLOW VELOCITY ESTIMATION 审中-公开
标题翻译：用于自动超声波多普勒角度和流速估计的方法和设备
公开(公告)号：WO2013001503A2
公开(公告)日：2013-01-03
申请号：PCT/IB2012/053315
申请日：2012-06-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GUPTA, Lalit , ANAND, Ajay , PETRUZZELLO, John , VAJINEPALLI, Pallavi , SISODIA, Rajendra Singh , FIRTION, Celine , RAMACHANDRAN, Ganesan
发明人： GUPTA, Lalit , ANAND, Ajay , PETRUZZELLO, John , VAJINEPALLI, Pallavi , SISODIA, Rajendra Singh , FIRTION, Celine , RAMACHANDRAN, Ganesan
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B8/4494 , A61B8/483 , A61B8/488 , A61B8/5223
摘要： Disclosed is an ultrasound device for measuring blood flow velocity in a blood vessel of a subject without imaging functionality in the device. The measurement depends upon reflections of a collimated beam of ultrasound from a subject's body part. Received electrical signals representative of the reflected ultrasound energy is used for generating a representation of blood flow at a plurality of predetermined locations in the volume and calculating a first blood flow velocity at each of the locations. The representation of flow is used for delineating the blood flow in the blood vessel in the volume. An angle calculating unit calculates the Doppler angle between the direction of the radiated collimated beam in the delineated blood flow at each point. A velocity calculator calculates a second blood flow velocity at the plurality of points based on the calculated first velocities and the calculated angle at the point.
摘要翻译：公开了一种用于测量在装置中没有成像功能的对象的血管中的血流速度的超声设备。测量取决于来自对象身体部分的准直超声波束的反射。表示反射的超声能量的接收电信号被用于生成体积中的多个预定位置处的血流的表示并且计算每个位置处的第一血流速度。流量的表示用于描绘体积中血管中的血流量。角度计算单元计算在每个点处描绘的血流中辐射准直束的方向之间的多普勒角度。速度计算器基于计算出的第一速度和该点处计算的角度来计算多个点处的第二血流速度。

7. 发明申请

WO2012085788A3 AUTOMATED DOPPLER VELOCIMETRY USING A LOW-COST TRANSDUCER. 审中-公开
标题翻译：使用低成本传感器的自动多普勒速度测量。
公开(公告)号：WO2012085788A3
公开(公告)日：2012-08-23
申请号：PCT/IB2011055729
申请日：2011-12-16
申请人： KONINKL PHILIPS ELECTRONICS NV , ANAND AJAY , PETRUZZELLO JOHN , SISODIA RAJENDRA SINGH , GUPTA LALIT , VAJINEPALLI PALLAVI , FIRTION CELINE
发明人： ANAND AJAY , PETRUZZELLO JOHN , SISODIA RAJENDRA SINGH , GUPTA LALIT , VAJINEPALLI PALLAVI , FIRTION CELINE
IPC分类号： A61B8/06
CPC分类号： A61B8/5223 , A61B5/489 , A61B8/06 , A61B8/0891 , A61B8/4427 , A61B8/4444 , A61B8/466 , A61B8/467 , A61B8/483 , A61B8/488 , A61B8/54 , A61B8/585
摘要： An automatic, stand-alone, hand-held ultrasound blood-vessel examination device (100)requires a reduced number of transducer elements (126) and presents a simplified user interface(136-140), without the need for displaying an image of any of the vessels. The probe, in one embodiment,acquires and examines a volume of interest (106), searches for a target vessel, tests the vessel for normality of blood flow, and reports the diagnosis, all automatically and without need for user intervention. In another embodiment, the probe finds a body vessel (108-112) in a volume, and extracts a clinical Doppler parameter, all automatically and without need for user intervention.
摘要翻译：自动的，独立的手持式超声波血管检查装置（100）需要减少数量的换能器元件（126）并呈现简化的用户界面（136-140），而不需要显示任何的船只。在一个实施例中，探测器获取并检查感兴趣体积（106），搜索目标血管，检测血管的血流正常，并且报告诊断，全部自动且无需用户干预。在另一个实施例中，探头在一个体积中找到身体血管（108-112），并且全部自动提取临床多普勒参数，而不需要用户干预。

8. 发明申请

WO2010146532A3 IMAGING SYSTEM FOR IMAGING A VISCOELASTIC MEDIUM 审中-公开
标题翻译：用于成像粘贴介质的成像系统
公开(公告)号：WO2010146532A3
公开(公告)日：2012-01-19
申请号：PCT/IB2010052668
申请日：2010-06-15
申请人： KONINKL PHILIPS ELECTRONICS NV , SHAHZAD KHALID , ANAND AJAY , PETRUZZELLO JOHN , ZHOU SHIWEI , SUIJVER JAN FREDERIK
发明人： SHAHZAD KHALID , ANAND AJAY , PETRUZZELLO JOHN , ZHOU SHIWEI , SUIJVER JAN FREDERIK
IPC分类号： G10K11/30 , A61B8/00
CPC分类号： G10K11/30 , A61B5/0053 , A61B8/12 , A61B8/4281 , A61B8/445 , A61B18/1492 , A61B2090/378 , G01S15/8911
摘要： An imaging system for imaging a viscoelastic medium is disclosed. The imaging system comprises a variable refractive lens (4) and a transducer system (5) for generating acoustic radiation. The imaging system is operated to alternate between first and second operating modes. While the variable refractive lens is operated to alternate between a first configuration and a second configuration, the transducer is operated to alternate between generating acoustic radiation for displacing the viscoelastic medium and acoustic radiation for imaging the displacement of the viscoelastic medium. In embodiments the variable refractive lens is a fluid focus lens. Moreover, in embodiments, the imaging system is integrated with a catheter-based interaction modality, such as a tissue ablation modality.
摘要翻译：公开了一种用于对粘弹性介质进行成像的成像系统。成像系统包括可变折射透镜（4）和用于产生声辐射的换能器系统（5）。操作成像系统以在第一和第二操作模式之间交替。当可变折射透镜被操作以在第一配置和第二配置之间交替时，换能器被操作以在产生用于移动粘弹性介质的声辐射和用于成像粘弹介质的位移成像的声辐射之间交替。在实施例中，可变折射透镜是流体聚焦透镜。此外，在实施例中，成像系统与基于导管的相互作用模式（例如组织消融模态）整合。

9. 发明申请

WO2008038182A2 DETERMINATION OF OPTICAL ABSORPTION COEFFICIENTS 审中-公开
标题翻译：光学吸收系数的测定
公开(公告)号：WO2008038182A2
公开(公告)日：2008-04-03
申请号：PCT/IB2007053763
申请日：2007-09-18
申请人： KONINKL PHILIPS ELECTRONICS NV , SAVERY DAVID , JANKOVIC LADISLAV , ANAND AJAY
发明人： SAVERY DAVID , JANKOVIC LADISLAV , ANAND AJAY
IPC分类号： G01N29/24 , A61B5/00 , G01N21/17 , G01N21/47
CPC分类号： G01N29/2418 , A61B5/0059 , A61B5/0095 , A61B8/08 , G01N21/1702 , G01N21/4795 , G01N2021/1706 , G01N2291/02466 , G01N2291/02475
摘要： The invention relates to an examination apparatus and a method for the determination of optical coefficients, particularly of the optical absorption coefficient (µa) in an object (1) like the body of a patient. The apparatus comprises an ultrasonic scanner (20) for recording first and second pulse echoes before and after the object (1) has been illuminated with a heating light beam (11) from a (e.g. laser) light source (10). An evaluation unit (30) determines a map of temperature increase (?T(r)) caused by the heating light beam (11) inside the object (1) based on apparent displacements showing up between the second and first pulse echoes. Furthermore, the evaluation of locally adjacent temperature increases inside the object (1) allows to determine a map of the effective scattering coefficient (µeff(r)), from which the distribution of light intensity (I(r)) inside the object (1) can be calculated. Finally, the desired optical absorption coefficient (µa) at a measuring location (r) can be determined from the light intensity and the temperature increase at this location.
摘要翻译：本发明涉及一种用于确定像患者身体的物体（1）中的光学系数，特别是光学吸收系数（μa）的检查装置和方法。该装置包括用于在来自（例如激光）光源（10）的加热光束（11）照射物体（1）之前和之后记录第一和第二脉冲回波的超声波扫描器（20）。评估单元（30）基于在第二和第一脉冲回波之间显示的表观位移来确定由对象（1）内部的加热光束（11）引起的温度升高（ΔT（r））的映射。此外，物体（1）内的局部相邻温度升高的评估允许确定物体（1）内的光强度（I（r））的分布的有效散射系数（μeff（r））的映射）可以计算。最后，测量位置（r）所需的光学吸收系数（μa）可以从光强度和该位置的温度升高来确定。

10. 发明申请

WO2011161559A1 REAL-TIME MONITORING AND CONTROL OF HIFU THERAPY IN MULTIPLE DIMENSIONS 审中-公开
标题翻译： HIFU治疗多维度实时监测与控制
公开(公告)号：WO2011161559A1
公开(公告)日：2011-12-29
申请号：PCT/IB2011/051855
申请日：2011-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ANAND, Ajay , PETRUZZELLO, John , ZHOU, Shiwei , SETHURAMAN, Shriram
发明人： ANAND, Ajay , PETRUZZELLO, John , ZHOU, Shiwei , SETHURAMAN, Shriram
IPC分类号： A61N7/02 , A61B8/00
CPC分类号： A61N7/00 , A61B8/4488 , A61B8/485 , A61B2090/378 , A61N7/02 , A61N2007/0052 , A61N2007/0082 , A61N2007/0095
摘要： Energy is transferred (336) to cause a mechanical property of biological tissue to change, as in ablation. An effect of the transferring is examined in more than one spatial dimension to, for example, make an ablation halting decision for a treatment region, i.e., line (312)or layer (314), or for a location (316) within the region. Halting decisions can be based on lesion-central and/or lesion-peripheral longitudinal displacement of treated tissue evaluated in real time against a characteristic curve. Steering in the azimuthal and/or elevation direction is afforded by, for example, linear, or 2D, multi-channel ultrasound arrays for therapy and imaging. Protocols includable are region-wide scanning (SI 010) and location-by-location completion for both (HIFU) therapy and tracking (acoustic-radiation-forced-based) displacement of treated tissue. Fine, location- to-location monitoring can be used for relatively inhomogeneous tissue; whereas, quicker, sparser and more generalized monitoring (1 100, 1200) can be employed for relatively homogeneous tissue.
摘要翻译：转移能量（336）以使生物组织的机械性能发生变化，如消融。在多于一个空间维度中检查转移的效果，以便例如对处理区域（即，线路（312）或层（314））或区域（316）进行消融停止决定。暂停决定可以基于对特征曲线实时评估的处理组织的病变中心和/或病变周边纵向位移。方位角和/或仰角方向的转向由例如用于治疗和成像的线性或2D多通道超声阵列提供。可包括的协议是针对处理组织的（HIFU）治疗和跟踪（基于声辐射的强制）位移的区域扫描（SI 010）和位置逐个完成。精细的位置到位置监测可用于相对不均匀的组织; 而对于相对均匀的组织，可以采用更快，更稀疏和更广泛的监测（1100,1200）。

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