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1. 发明申请

WO2011161559A1 REAL-TIME MONITORING AND CONTROL OF HIFU THERAPY IN MULTIPLE DIMENSIONS 审中-公开
标题翻译： HIFU治疗多维度实时监测与控制
公开(公告)号：WO2011161559A1
公开(公告)日：2011-12-29
申请号：PCT/IB2011/051855
申请日：2011-04-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ANAND, Ajay , PETRUZZELLO, John , ZHOU, Shiwei , SETHURAMAN, Shriram
发明人： ANAND, Ajay , PETRUZZELLO, John , ZHOU, Shiwei , SETHURAMAN, Shriram
IPC分类号： A61N7/02 , A61B8/00
CPC分类号： A61N7/00 , A61B8/4488 , A61B8/485 , A61B2090/378 , A61N7/02 , A61N2007/0052 , A61N2007/0082 , A61N2007/0095
摘要： Energy is transferred (336) to cause a mechanical property of biological tissue to change, as in ablation. An effect of the transferring is examined in more than one spatial dimension to, for example, make an ablation halting decision for a treatment region, i.e., line (312)or layer (314), or for a location (316) within the region. Halting decisions can be based on lesion-central and/or lesion-peripheral longitudinal displacement of treated tissue evaluated in real time against a characteristic curve. Steering in the azimuthal and/or elevation direction is afforded by, for example, linear, or 2D, multi-channel ultrasound arrays for therapy and imaging. Protocols includable are region-wide scanning (SI 010) and location-by-location completion for both (HIFU) therapy and tracking (acoustic-radiation-forced-based) displacement of treated tissue. Fine, location- to-location monitoring can be used for relatively inhomogeneous tissue; whereas, quicker, sparser and more generalized monitoring (1 100, 1200) can be employed for relatively homogeneous tissue.
摘要翻译：转移能量（336）以使生物组织的机械性能发生变化，如消融。在多于一个空间维度中检查转移的效果，以便例如对处理区域（即，线路（312）或层（314））或区域（316）进行消融停止决定。暂停决定可以基于对特征曲线实时评估的处理组织的病变中心和/或病变周边纵向位移。方位角和/或仰角方向的转向由例如用于治疗和成像的线性或2D多通道超声阵列提供。可包括的协议是针对处理组织的（HIFU）治疗和跟踪（基于声辐射的强制）位移的区域扫描（SI 010）和位置逐个完成。精细的位置到位置监测可用于相对不均匀的组织; 而对于相对均匀的组织，可以采用更快，更稀疏和更广泛的监测（1100,1200）。

2. 发明申请

WO2010100573A1 TRANSURETHRAL ULTRASOUND PROBE FOR TREATMENT OF PROSTATE 审中-公开
标题翻译：用于治疗前列腺的超声超声探头
公开(公告)号：WO2010100573A1
公开(公告)日：2010-09-10
申请号：PCT/IB2010/050538
申请日：2010-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , SETHURAMAN, Shriram , EHNHOLM, Gosta , RAJU, Balasundara, I.
发明人： SETHURAMAN, Shriram , EHNHOLM, Gosta , RAJU, Balasundara, I.
IPC分类号： A61N7/02 , A61B19/00
CPC分类号： A61N7/022 , A61B2017/00911 , A61B2018/00023 , A61B2090/0472 , A61B2090/374
摘要： A probe (40) includes a shaft (52) on which an ultrasound element (42) is mounted. An outer sheath (64) and an acoustic membrane (66) surround the shaft and the ultrasound element such that the shaft and ultrasound element are rotatable therein. Passages (56) supply a cooling and acoustic coupling fluid to an inlet and outlet (48) adjacent the acoustic element to cool the acoustic element and fill a volume between the acoustic element and the acoustic sheath with the fluid. A balloon (90) mounted on the probe is selectively inflated in order to fix a position of the probe. A drain (94, 98) drains urine and other bodily fluids through the probe.
摘要翻译：探针（40）包括其上安装有超声波元件（42）的轴（52）。围绕轴和超声波元件的外护套（64）和声膜（66）使得轴和超声元件能够在其中旋转。通道（56）将冷却和声耦合流体提供给邻近声学元件的入口和出口（48），以冷却声学元件并用流体填充声学元件和声学护套之间的体积。安装在探针上的球囊（90）选择性地膨胀以固定探针的位置。排水口（94,98）通过探头排出尿液和其他体液。

3. 发明申请

WO2013021310A1 DISPLACEMENT FEEDBACK DEVICE AND METHOD FOR SENSING OR THERAPY DELIVERY PROBES 审中-公开
标题翻译：位移反馈装置和用于感测或治疗传送探针的方法
公开(公告)号：WO2013021310A1
公开(公告)日：2013-02-14
申请号：PCT/IB2012/053876
申请日：2012-07-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DALAL, Sandeep M. , KUNG, Cynthia Ming-fu , SETHURAMAN, Shriram , KRUECKER, Jochen
发明人： DALAL, Sandeep M. , KUNG, Cynthia Ming-fu , SETHURAMAN, Shriram , KRUECKER, Jochen
IPC分类号： A61B17/34 , A61B5/06
CPC分类号： A61B5/065 , A61B17/3403 , A61B2090/061 , A61B2090/062 , F04C2270/041
摘要： A device, system and method for accessing internal tissue include a probe (108) disposed on a distal end portion of a medical device and configured to be inserted into a body along a trajectory path. A sensor(102)is mounted on a displacement tracker portion(104)of the medical device which is disposed on a proximal end portion of the device. The sensor is configured to measure a distance parallel to the probe between the displacement tracker portion and a tissue surface such that a position of the probe is determinable relative to the tissue surface upon advance or retraction of the probe along the trajectory path.
摘要翻译：用于访问内部组织的装置，系统和方法包括设置在医疗装置的远端部分上并且被配置为沿着轨迹路径插入到身体中的探针（108）。传感器（102）安装在设置在装置的近端部分上的医疗装置的移动跟踪器部分（104）上。传感器被配置成测量平行于位移跟踪器部分和组织表面之间的探头的距离，使得当探针沿着轨迹路径前进或缩回时探针的位置相对于组织表面是可确定的。

4. 发明申请

WO2012001551A1 SYSTEM AND METHOD FOR GUIDED ADAPTIVE BRACHYTHERAPY 审中-公开
标题翻译：用于自适应BRACHYTHERAPY的系统和方法
公开(公告)号：WO2012001551A1
公开(公告)日：2012-01-05
申请号：PCT/IB2011/052341
申请日：2011-05-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BINNEKAMP, Dirk , GUTIERREZ, Luis Felipe , GLOSSOP, Neil David , KRUECKER, Jochen , SETHURAMAN, Shriram
发明人： BINNEKAMP, Dirk , GUTIERREZ, Luis Felipe , GLOSSOP, Neil David , KRUECKER, Jochen , SETHURAMAN, Shriram
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61B5/062 , A61B5/065 , A61B6/02 , A61B8/12 , A61B2034/2061 , A61N5/1007 , A61N5/1027 , A61N5/103 , A61N5/1038 , A61N5/1048 , A61N5/107 , A61N5/1071 , A61N2005/1058
摘要： A system and methods for adaptive placement of a treatment element include a placement device (134), and a localization system (120) configured to track progress of the placement device such that a position of a treatment element (146, 132) placed by or to be placed by the placement device is stored in memory. A computer system (142) includes a program (104) implemented in computer readable storage media and configured to compute an effect of the treatment element at the position and determine whether a dosage amount has been achieved by the treatment element for treatment of an organ.
摘要翻译：用于治疗元件的自适应放置的系统和方法包括放置装置（134）和配置成跟踪放置装置的进度的定位系统（120），使得治疗元件（146,132）的位置由由放置设备放置存储在存储器中。计算机系统（142）包括在计算机可读存储介质中实现的程序（104），并且被配置为计算处置元件在该位置的影响，并且确定用于治疗器官的治疗元件是否已经实现了剂量。

5. 发明申请

WO2008100386A3 INTRAVASCULAR PHOTOACOUSTIC AND ULTRASOUND ECHO IMAGING 审中-公开
公开(公告)号：WO2008100386A3
公开(公告)日：2008-08-21
申请号：PCT/US2008/001379
申请日：2008-02-01
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SETHURAMAN, Shriram , EMELIANOV, Stanislav, Y. , SMALLING, Richard, W. , AGLYAMOV, Salavat, R.
发明人： SETHURAMAN, Shriram , EMELIANOV, Stanislav, Y. , SMALLING, Richard, W. , AGLYAMOV, Salavat, R.
IPC分类号： A61B8/00
摘要： The invention relates to photoacoustic imaging and ultrasound echo imaging In combination, and applies in particular to the field of imaging a lumen of an organ or vessel of a subject, wherein the Images are acquired from within a lumen of the organ or vessel, especially a lumen of a blood vessel to diagnose and treat vascular disease An exemplary embodiment of the invention is a catheter having an ultrasound transducer, the transducer comprising a probe suitable for generating and detecting photoacoustic signals and ultrasound echo signals, wherein the photoacoustic signals and the ultrasound echo signals are convertible to images which are integrated into an enriched image. The photoacoustic signals are generated by a multiplicity of energy sources suitable for inducing th walls of the blood vessel to generate acoustic waves, wherein the energy sources are arrayed in an annulus around the flexible tubular member.

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