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1. 发明申请

WO2008082444A3 ARTICLES AND METHODS FOR TISSUE REPAIR 审中-公开
标题翻译：组织修复的文章和方法
公开(公告)号：WO2008082444A3
公开(公告)日：2009-04-16
申请号：PCT/US2007021217
申请日：2007-10-03
申请人： ARSENAL MEDICAL INC , CARBECK JEFFREY , ANAND PJ , MCNALLY-HEINTZELMAN KAREN M , MRKSICH MILAN , CHEN CHRISTOPHER , HODNELAND CHRISTIAN , ROBERTS CARMICHAEL , BLOOM JEFFREY N , DUFFY MARK T
发明人： CARBECK JEFFREY , ANAND PJ , MCNALLY-HEINTZELMAN KAREN M , MRKSICH MILAN , CHEN CHRISTOPHER , HODNELAND CHRISTIAN , ROBERTS CARMICHAEL , BLOOM JEFFREY N , DUFFY MARK T
IPC分类号： A61B17/00 , A61B10/02 , A61F13/02 , A61L15/58
CPC分类号： A61L24/001 , A61B10/02 , A61B17/00491 , A61F9/0017 , A61F13/00063 , A61F13/023 , A61F13/025 , A61F13/0253 , A61F13/0256 , A61F13/0276 , A61F13/15252 , A61F2013/00357 , A61F2013/00412 , A61F2013/00429 , A61F2013/00451 , A61F2013/00497 , A61F2013/00642 , A61F2013/00655 , A61F2013/0077 , A61F2013/0091 , A61L24/0047
摘要： Articles and methods for tissue repair are provided. A support may include a patterned adhesive that provides regions of discrete adhesion points. An adhesive isolating material may cover all or a portion of the adhesive and may delay adhesion between the support and the tissue until the isolating material is removed from the support (e.g., by biodegradation), thereby exposing the adhesive. Adhesion between the support and the tissue surface may be varied after repositioning, for example, by controlling the amount of adhesive exposed to the tissue and/or the composition of the adhesive. Methods of applying a support to a tissue using a transfer device are also provided. A support may be transferred to a tissue surface and/or a material may be removed from a tissue surface by contact adhesion, e.g., where the adhesion strength between the support and the tissue (or material and removal instrument) is greater than the adhesion strength between the support and the transfer device (or material and tissue surface).
摘要翻译：提供了组织修复的制品和方法。载体可以包括提供离散粘合点的区域的图案化粘合剂。粘合剂隔离材料可以覆盖粘合剂的全部或部分并且可以延迟载体和组织之间的粘合，直到隔离材料从载体上移除（例如通过生物降解），从而暴露粘合剂。载体和组织表面之间的粘附可以在重新定位之后变化，例如通过控制暴露于组织的粘合剂的量和/或粘合剂的组成。还提供了使用转移装置将支撑物施加到组织的方法。支撑体可以转移到组织表面，和/或可以通过接触粘合从组织表面去除材料，例如，其中支撑体和组织（或材料和去除器械）之间的粘合强度大于粘合强度在支撑和转移装置（或材料和组织表面）之间。

2. 发明申请

WO2013019830A2 MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
标题翻译：微流感药物递送装置
公开(公告)号：WO2013019830A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/049100
申请日：2012-08-01
申请人： ALCYONE LIFESCIENCES, INC. , ANAND, Pj , SINGH, Deep, Arjun
发明人： ANAND, Pj , SINGH, Deep, Arjun
IPC分类号： A61M37/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M5/16804 , A61B5/036 , A61B5/14503 , A61B5/4839 , A61M5/172 , A61M25/0023 , A61M25/0026 , A61M2025/0042 , A61M2205/50
摘要： The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.
摘要翻译：本文公开的方法，系统和装置通常涉及药物对流增强的递送到患者内的目标区域。公开了微流体导管装置，其特别适用于通过对流靶向递送药物，包括能够多方向药物递送的装置，使用文丘里效应控制流体压力和速度的装置，以及包括适形气囊的装置。还公开了使用这种装置治疗各种疾病的方法，包括治疗脑和脊柱海绵体畸形，海绵体瘤和血管瘤的方法，治疗神经疾病的方法，使用多个微流体递送装置的治疗方法，治疗听力障碍的方法，使用微流体装置的脊髓药物递送，以及在胎儿手术期间递送干细胞和治疗剂的方法。还公开了制造这种装置的方法。

3. 发明申请

WO2013019830A3 MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
标题翻译：微流体药物递送装置
公开(公告)号：WO2013019830A3
公开(公告)日：2013-04-04
申请号：PCT/US2012049100
申请日：2012-08-01
申请人： ALCYONE LIFESCIENCES INC , ANAND PJ , SINGH DEEP ARJUN
发明人： ANAND PJ , SINGH DEEP ARJUN
IPC分类号： A61M37/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M5/16804 , A61B5/036 , A61B5/14503 , A61B5/4839 , A61M5/172 , A61M25/0023 , A61M25/0026 , A61M2025/0042 , A61M2205/50
摘要： The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.
摘要翻译：本文公开的方法，系统和装置通常涉及将药物对流增强递送至患者体内的目标区域。公开了微流体导管装置，其特别适用于经由对流的药物的靶向递送，包括能够进行多向药物递送的装置，使用文丘里效应控制流体压力和速度的装置，以及包括适形球囊的装置。还公开了使用这种装置治疗各种疾病的方法，包括治疗脑和脊柱海绵状血管畸形，海绵状血管瘤和血管瘤的方法，治疗神经疾病的方法，使用多微流体递送装置治疗的方法，治疗听力障碍的方法，使用微流体装置的脊柱药物递送，以及在胎儿手术期间递送干细胞和治疗剂的方法。还公开了制造这种装置的方法。

4. 发明申请

WO2004105599A1 APPARATUS FOR INSERTING MULTI-LUMEN SPLIT-TIP CATHETERS INTO A BLOOD VESSEL 审中-公开
标题翻译：用于将多片分离针导管插入血液容器的装置
公开(公告)号：WO2004105599A1
公开(公告)日：2004-12-09
申请号：PCT/US2004/016300
申请日：2004-05-24
申请人： SPIRE CORPORATION , NIMKAR, Shekhar , ALBRECHT, Stephen, E. , ANAND, Pj. , TOBIN, Eric
发明人： NIMKAR, Shekhar , ALBRECHT, Stephen, E. , ANAND, Pj. , TOBIN, Eric
IPC分类号： A61B5/00
CPC分类号： A61M25/0102 , A61B17/3415 , A61M1/16 , A61M25/0026 , A61M25/0194 , A61M25/09 , A61M29/00
摘要： Apparatus for inserting flexible, multi-lumen catheters into blood vessels, and in particular, for inserting flexible, split-tip catheters into blood vessels. The invention accomplishes these objects by temporarily stiffening each catheter lumen and tip independently through use of intra-catheter stiffener elements (24) disposed within the catheter lumens. This provides means for advancing the catheter/stiffeners assembly through a subcutaneous tunnel, and over a plurality of guidewires (26) until a distal tip of the catheter is at a desired position within the vessel. The intra-catheter stiffener elements are sufficiently stiffening to allow advancing the catheter over guidewires, but sufficiently flexible to allow bending and looping of the catheter for proper placement within the vessel.
摘要翻译：用于将柔性多管腔导管插入血管的装置，特别是用于将柔性的分流导管插入血管中。本发明通过使用布置在导管内腔内的导管内加强元件（24）来临时硬化每个导管内腔和尖端来实现这些目的。这提供了用于使导管/加强件组件通过皮下隧道以及在多根导线（26）上行进直到导管的远侧末端处于血管内所需位置的装置。导管内加强元件足够坚固以允许导管穿过导丝线前进，但是足够柔性以允许导管的弯曲和环绕以适当地放置在容器内。

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