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1. 发明申请

WO2013019830A3 MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
标题翻译：微流体药物递送装置
公开(公告)号：WO2013019830A3
公开(公告)日：2013-04-04
申请号：PCT/US2012049100
申请日：2012-08-01
申请人： ALCYONE LIFESCIENCES INC , ANAND PJ , SINGH DEEP ARJUN
发明人： ANAND PJ , SINGH DEEP ARJUN
IPC分类号： A61M37/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M5/16804 , A61B5/036 , A61B5/14503 , A61B5/4839 , A61M5/172 , A61M25/0023 , A61M25/0026 , A61M2025/0042 , A61M2205/50
摘要： The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.
摘要翻译：本文公开的方法，系统和装置通常涉及将药物对流增强递送至患者体内的目标区域。公开了微流体导管装置，其特别适用于经由对流的药物的靶向递送，包括能够进行多向药物递送的装置，使用文丘里效应控制流体压力和速度的装置，以及包括适形球囊的装置。还公开了使用这种装置治疗各种疾病的方法，包括治疗脑和脊柱海绵状血管畸形，海绵状血管瘤和血管瘤的方法，治疗神经疾病的方法，使用多微流体递送装置治疗的方法，治疗听力障碍的方法，使用微流体装置的脊柱药物递送，以及在胎儿手术期间递送干细胞和治疗剂的方法。还公开了制造这种装置的方法。

2. 发明申请

WO2013019830A2 MICROFLUIDIC DRUG DELIVERY DEVICES 审中-公开
标题翻译：微流感药物递送装置
公开(公告)号：WO2013019830A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/049100
申请日：2012-08-01
申请人： ALCYONE LIFESCIENCES, INC. , ANAND, Pj , SINGH, Deep, Arjun
发明人： ANAND, Pj , SINGH, Deep, Arjun
IPC分类号： A61M37/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M5/16804 , A61B5/036 , A61B5/14503 , A61B5/4839 , A61M5/172 , A61M25/0023 , A61M25/0026 , A61M2025/0042 , A61M2205/50
摘要： The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.
摘要翻译：本文公开的方法，系统和装置通常涉及药物对流增强的递送到患者内的目标区域。公开了微流体导管装置，其特别适用于通过对流靶向递送药物，包括能够多方向药物递送的装置，使用文丘里效应控制流体压力和速度的装置，以及包括适形气囊的装置。还公开了使用这种装置治疗各种疾病的方法，包括治疗脑和脊柱海绵体畸形，海绵体瘤和血管瘤的方法，治疗神经疾病的方法，使用多个微流体递送装置的治疗方法，治疗听力障碍的方法，使用微流体装置的脊髓药物递送，以及在胎儿手术期间递送干细胞和治疗剂的方法。还公开了制造这种装置的方法。

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