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1. 发明申请

WO2017152122A3 AUTOMATED NESTED RECOMBINASE POLYMERASE AMPLIFICATION 审中-公开
公开(公告)号：WO2017152122A3
公开(公告)日：2017-09-08
申请号：PCT/US2017/020782
申请日：2017-03-03
申请人： ALERE SAN DIEGO INC.
发明人： WHYTE, Murray John , ARMES, Niall A. , PIEPENBURG, Olaf
IPC分类号： C12Q1/68 , C12P19/34 , C12N9/16
摘要： A flu assay system including a sample module, a microfluidic nucleic acid amplification device, and an analyzer to facilitate fully automated nested recombinase polymerase amplification (RPA) on a sample delivered to the nucleic acid amplification device via the sample module. The assay includes providing a sample to a microfluidic device, and amplifying a target polynucleotide sequence in the sample. Amplifying the target polynucleotide sequence includes performing a first round of amplification on the sample to yield a first amplification product, and performing a second round of amplification on the first amplification product to yield a second amplification product. The second amplification product includes a smaller sequence completely contained within the first amplification product produced during the first round of amplification.

2. 发明申请

WO2013049294A1 2-HYDROXYHIPPURIC ACID ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE 审中-公开
标题翻译： 2-羟基尿酸类似物及其合成和使用方法
公开(公告)号：WO2013049294A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057471
申请日：2012-09-27
申请人： ALERE SAN DIEGO, INC.
发明人： BANASZCZYK, Mariusz
IPC分类号： A61K39/385
CPC分类号： A61K47/48284 , C07C235/50 , C07C323/41 , C07C323/42 , C07D333/32 , C07D333/36 , C07K16/44 , G01N33/5308 , G01N2800/06
摘要： The present invention relates to novel 2-hydroxyhippuric acid analogs, and methods for their synthesis and use. Such analogs are designed to provide a protected or functional moiety such as a free thiol (-SH) group or a protected thiol group, thereby providing a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
摘要翻译：本发明涉及新型2-羟基丙酸类似物及其合成和用途的方法。这样的类似物被设计成提供受保护或功能部分，例如游离巯基（-SH）基团或受保护的硫醇基团，由此提供方便的连接化学物质，用于在温和条件下与目标蛋白质，多肽，固体上的合适基团偶联相或可检测标签。

3. 发明申请

WO2010141940A1 RECOMBINASE POLYMERASE AMPLIFICATION REAGENTS AND KITS 审中-公开
标题翻译：重组聚合酶扩增试剂和试剂盒
公开(公告)号：WO2010141940A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037611
申请日：2010-06-07
申请人： ALERE SAN DIEGO, INC. , PIEPENBURG, Olaf , ARMES, Niall, A.
发明人： PIEPENBURG, Olaf , ARMES, Niall, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6844 , C12Q1/6806 , C12Q1/6848 , C12Q2549/101 , C12Q2527/125 , C12Q2521/507 , C12Q2527/137
摘要： This disclosure describes kits, reagents and methods for Recombinase Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed kits, reagents and methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods.
摘要翻译：本公开描述了利用重组酶和相关蛋白质的特性的靶DNA的重组酶聚合酶扩增（RPA）的试剂盒，试剂和方法，以允许DNA聚合酶反应的序列特异性引发的单链同源DNA侵入双链DNA。所公开的试剂盒，试剂和方法具有不需要热循环或嗜热酶的优点，因此相对于其它扩增方法提供了容易且价格实惠的实施和便携性。

4. 发明申请

WO2017147486A1 REDOX LABELED OLIGONUCLEOTIDE PROBES AND THEIR USE 审中-公开
标题翻译：氧化还原标记的寡核苷酸探针及其用途
公开(公告)号：WO2017147486A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019446
申请日：2017-02-24
申请人： ALERE SAN DIEGO INC.
发明人： BOWLER, Frank Ray , ORLOWSKI, Grzegorz Artur , GREETHAM, Hazel Lucy , ZHOU, Cheng , ARMES, Niall A. , PIEPENBURG, Olaf
IPC分类号： C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/04 , C12P19/34 , C12Q1/6816 , C12Q2525/186 , C12Q2563/113
摘要： This invention relates to sequence specific electrochemically-labeled oligonucleotide probes for the detection of nucleic acids and methods associated therewith.
摘要翻译：本发明涉及用于检测核酸的序列特异性电化学标记寡核苷酸探针及与其相关的方法。

5. 发明申请

WO2013006629A1 METHODS AND COMPOSITIONS FOR ASSIGNING LIKELIHOOD OF ACUTE KIDNEY INJURY PROGRESSION 审中-公开
标题翻译：用于评估急性KIDNEY损伤进展的方法和组成
公开(公告)号：WO2013006629A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045421
申请日：2012-07-03
申请人： ALERE SAN DIEGO INC. , ARNOLD, William, D. , JOST, Christelle , NOLAND, Brian , GARY, Jonathan , BUECHLER, Joseph , WONG, Vance , RONGEY, Scott, Harold , VEERAMALLU, Uday, Kumar , RODEMS, Kelline, Marie
发明人： ARNOLD, William, D. , JOST, Christelle , NOLAND, Brian , GARY, Jonathan , BUECHLER, Joseph , WONG, Vance , RONGEY, Scott, Harold , VEERAMALLU, Uday, Kumar , RODEMS, Kelline, Marie
IPC分类号： A61K48/00
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： The invention encompasses diagnosis and prognosis in the context of heart or renal failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The invention also relates to methods of assigning an increased likelihood that a subject having AKI is susceptible to AKI progression. The invention relates in part to assigning a diagnosis of heart and/or renal failure, and/or an outcome risk (e.g., worsening cardiac and/or renal function or a mortality risk) to a subject based, at least in part, on the result(s) obtained from an assay that detects WAP four-bisulfide core domain protein 2 performed on a body fluid sample obtained from a subject.
摘要翻译：本发明包括在心脏或肾衰竭的情况下的诊断和预后，特别是在表现出利尿钠肽的正常体液水平的受试者中。本发明还涉及分配具有AKI的受试者对AKI进展敏感的增加的可能性的方法。本发明部分地涉及至少部分地基于对受试者的心脏和/或肾衰竭的诊断和/或结局风险（例如，恶化的心脏和/或肾脏功能或死亡风险）的分配。从检测从受试者获得的体液样品上进行的检测WAP四硫化物核心域蛋白2的测定获得的结果。

6. 发明申请

WO2019055780A1 DETECTION OF RECOMBINASE POLYMERASE AMPLIFICATION USING DUAL-HAPTEN PROBE 审中-公开
公开(公告)号：WO2019055780A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/051078
申请日：2018-09-14
申请人： ALERE SAN DIEGO INC.
发明人： POWELL, Michael L. , BOWLER, Frank Ray , GREENWOOD, Catherine Jean , PIEPENBURG, Olaf , ARMES, Niall A.
IPC分类号： C12Q1/6858 , C12Q1/683 , C12Q1/6844 , C12Q1/6853 , C12Q1/6874
摘要： This disclosure relates to methods and compositions for detecting a target nucleic acid sequence using a dual-hapten probe. More specifically, the present disclosure relates to using recombinase polymerase amplification (RPA) and a dual-hapten probe to detect a target nucleic acid sequence. In some cases, the detection is on lateral flow strips.

7. 发明申请

WO2018160574A1 MICROFLUIDIC DEVICES AND RELATED METHODS 审中-公开
公开(公告)号：WO2018160574A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/019975
申请日：2018-02-27
申请人： ALERE SAN DIEGO INC. , ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean , NENTWICH, Oliver
发明人： ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean , NENTWICH, Oliver , ZU SCHWEINSBERG, Alexander Schenk , DERFUS, Austin Matthew , DAVIDSON, Justin , KUMARAVADIVELU, Karthikeyan , PATEL, Maulik Vinod
IPC分类号： B01L3/00 , C12Q1/00 , C12Q1/68 , C12Q1/6806 , G01N33/48
摘要： A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.

8. 发明申请

WO2017201314A1 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE 审中-公开
标题翻译： 2-乙烯-1,5-二甲基-3,3-二苯基吡咯烷类似物及其合成和使用方法
公开(公告)号：WO2017201314A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033373
申请日：2017-05-18
申请人： ALERE SAN DIEGO, INC.
发明人： HUANG, Fei , WU, Dongpei , MEJORADO, Lupe , BANASZCZYK, Mariusz
IPC分类号： C07D207/02 , C07D207/18 , C07D207/36
摘要： The present invention relates to novel 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
摘要翻译：本发明涉及新的2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷类似物，以及它们的合成和使用方法。这种类似物被设计为提供方便的连接化学，用于在温和条件下与目标蛋白质，多肽，固相或可检测标记上的合适基团偶联。

9. 发明申请

WO2017156038A2 IMMUNOASSAY CONTROLS AND THE USE THEREOF 审中-公开
标题翻译：免疫控制及其用途
公开(公告)号：WO2017156038A2
公开(公告)日：2017-09-14
申请号：PCT/US2017/021211
申请日：2017-03-07
申请人： ALERE SAN DIEGO, INC.
发明人： GARY, Jonathan , RONGEY, Scott , POWELL, James
IPC分类号： G01N33/53
摘要： The present invention relates to compositions and methods use in designing immunoassay controls. In various aspects, the invention provides synthetic peptides comprising the sequence CPRRPYIL or an analog thereof; ELAGLGFAELQC or an analog thereof; and CDWRKNIDAL or an analog thereof; specific binding reagents that bind to a CPRRPYIL, ELAGLGFAELQC or CDWRKNIDAL peptide; methods of producing such reagents; and assays utilizing such reagents to provide assay controls signals that are unrelated to the measurement of the analyte or analytes of interest in that no reagents used in the analyte assay(s) contribute to the control signal.
摘要翻译：本发明涉及用于设计免疫测定对照的组合物和方法。在各个方面，本发明提供了包含序列CPRRPYIL或其类似物的合成肽; ELAGLGFAELQC或其类似物; 和CDWRKNIDAL或其类似物; 与CPRRPYIL，ELAGLGFAELQC或CDWRKNIDAL肽结合的特异性结合试剂; 生产这种试剂的方法; 以及利用这些试剂提供测定对照信号的测定，所述信号与所关注分析物或分析物的测量无关，因为分析物测定中使用的试剂不会对对照信号有贡献。

10. 发明申请

WO2013071175A8 DEVICES AND METHODS FOR DETECTION OF PANTON-VALENTINE LEUKOCIDIN (PVL) 审中-公开
标题翻译：用于检测泛黄素白蛋白（PVL）的装置和方法
公开(公告)号：WO2013071175A8
公开(公告)日：2014-05-08
申请号：PCT/US2012064535
申请日：2012-11-09
申请人： ALERE SAN DIEGO INC
发明人： EHRICHT RALF , MONECKE STEFAN , REJMAN JOHN J , BUECHLER JOSEPH
IPC分类号： G01N33/53
CPC分类号： G01N33/56938 , C07K16/1271 , G01N33/53
摘要： The present invention provides methods and devices for detecting the presence of biomolecules in a biological sample, such as PVL, PBP2a and SPA.
摘要翻译：本发明提供用于检测生物样品如PVL，PBP2a和SPA中存在生物分子的方法和装置。

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