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1. 发明申请

WO2017152122A3 AUTOMATED NESTED RECOMBINASE POLYMERASE AMPLIFICATION 审中-公开
公开(公告)号：WO2017152122A3
公开(公告)日：2017-09-08
申请号：PCT/US2017/020782
申请日：2017-03-03
申请人： ALERE SAN DIEGO INC.
发明人： WHYTE, Murray John , ARMES, Niall A. , PIEPENBURG, Olaf
IPC分类号： C12Q1/68 , C12P19/34 , C12N9/16
摘要： A flu assay system including a sample module, a microfluidic nucleic acid amplification device, and an analyzer to facilitate fully automated nested recombinase polymerase amplification (RPA) on a sample delivered to the nucleic acid amplification device via the sample module. The assay includes providing a sample to a microfluidic device, and amplifying a target polynucleotide sequence in the sample. Amplifying the target polynucleotide sequence includes performing a first round of amplification on the sample to yield a first amplification product, and performing a second round of amplification on the first amplification product to yield a second amplification product. The second amplification product includes a smaller sequence completely contained within the first amplification product produced during the first round of amplification.

2. 发明申请

WO2017147486A1 REDOX LABELED OLIGONUCLEOTIDE PROBES AND THEIR USE 审中-公开
标题翻译：氧化还原标记的寡核苷酸探针及其用途
公开(公告)号：WO2017147486A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019446
申请日：2017-02-24
申请人： ALERE SAN DIEGO INC.
发明人： BOWLER, Frank Ray , ORLOWSKI, Grzegorz Artur , GREETHAM, Hazel Lucy , ZHOU, Cheng , ARMES, Niall A. , PIEPENBURG, Olaf
IPC分类号： C07H21/04 , C12P19/34 , C12Q1/68
CPC分类号： C07H21/04 , C12P19/34 , C12Q1/6816 , C12Q2525/186 , C12Q2563/113
摘要： This invention relates to sequence specific electrochemically-labeled oligonucleotide probes for the detection of nucleic acids and methods associated therewith.
摘要翻译：本发明涉及用于检测核酸的序列特异性电化学标记寡核苷酸探针及与其相关的方法。

3. 发明申请

WO2019055780A1 DETECTION OF RECOMBINASE POLYMERASE AMPLIFICATION USING DUAL-HAPTEN PROBE 审中-公开
公开(公告)号：WO2019055780A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/051078
申请日：2018-09-14
申请人： ALERE SAN DIEGO INC.
发明人： POWELL, Michael L. , BOWLER, Frank Ray , GREENWOOD, Catherine Jean , PIEPENBURG, Olaf , ARMES, Niall A.
IPC分类号： C12Q1/6858 , C12Q1/683 , C12Q1/6844 , C12Q1/6853 , C12Q1/6874
摘要： This disclosure relates to methods and compositions for detecting a target nucleic acid sequence using a dual-hapten probe. More specifically, the present disclosure relates to using recombinase polymerase amplification (RPA) and a dual-hapten probe to detect a target nucleic acid sequence. In some cases, the detection is on lateral flow strips.

4. 发明申请

WO2018160574A1 MICROFLUIDIC DEVICES AND RELATED METHODS 审中-公开
公开(公告)号：WO2018160574A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/019975
申请日：2018-02-27
申请人： ALERE SAN DIEGO INC. , ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean , NENTWICH, Oliver
发明人： ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean , NENTWICH, Oliver , ZU SCHWEINSBERG, Alexander Schenk , DERFUS, Austin Matthew , DAVIDSON, Justin , KUMARAVADIVELU, Karthikeyan , PATEL, Maulik Vinod
IPC分类号： B01L3/00 , C12Q1/00 , C12Q1/68 , C12Q1/6806 , G01N33/48
摘要： A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.

5. 发明申请

WO2017152122A2 AUTOMATED NESTED RECOMBINASE POLYMERASE AMPLIFICATION 审中-公开
标题翻译：自动嵌套重组酶聚合酶扩增
公开(公告)号：WO2017152122A2
公开(公告)日：2017-09-08
申请号：PCT/US2017/020782
申请日：2017-03-03
申请人： ALERE SAN DIEGO INC.
发明人： WHYTE, Murray John , ARMES, Niall A. , PIEPENBURG, Olaf
IPC分类号： C12Q1/70 , C12Q1/68
摘要： A flu assay system including a sample module, a microfluidic nucleic acid amplification device, and an analyzer to facilitate fully automated nested recombinase polymerase amplification (RPA) on a sample delivered to the nucleic acid amplification device via the sample module. The assay includes providing a sample to a microfluidic device, and amplifying a target polynucleotide sequence in the sample. Amplifying the target polynucleotide sequence includes performing a first round of amplification on the sample to yield a first amplification product, and performing a second round of amplification on the first amplification product to yield a second amplification product. The second amplification product includes a smaller sequence completely contained within the first amplification product produced during the first round of amplification.
摘要翻译：流感测定系统包括样品模块，微流体核酸扩增装置和分析仪，以促进对通过所述核酸扩增装置递送到所述核酸扩增装置的样品的全自动嵌套重组酶聚合酶扩增（RPA）样本模块。该测定包括将样品提供给微流体装置，并扩增样品中的靶多核苷酸序列。扩增靶多核苷酸序列包括对样品进行第一轮扩增以产生第一扩增产物，并对第一扩增产物进行第二轮扩增以产生第二扩增产物。第二扩增产物包含完全包含在第一轮扩增期间产生的第一扩增产物内的较小序列。

6. 发明申请

WO2012138989A1 MONITORING RECOMBINASE POLYMERASE AMPLIFICATION MIXTURES 审中-公开
标题翻译：监测重组蛋白聚合酶扩增混合物
公开(公告)号：WO2012138989A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032508
申请日：2012-04-06
申请人： ALERE SAN DIEGO INC. , ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean
发明人： ARMES, Niall A. , PIEPENBURG, Olaf , GREENWOOD, Catherine Jean
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6844 , C12Q1/689 , C12Q2600/158 , G01N21/6428 , G01N21/6456 , G01N2021/6432 , Y02A50/53 , C12Q2521/507 , C12Q2522/101 , C12Q2527/137 , C12Q2565/629 , C12Q2563/155 , C12Q2563/159
摘要： A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.
摘要翻译：一种方法包括提供包含重组酶，单链结合蛋白和一种或多种寡核苷酸的混合物; 并检测反应混合物中的颗粒。

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