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1. 发明申请

WO2009014563A2 CONTINUOUS MONITOR FOR CYANIDE AND CYANOGEN BLOOD AGENT DETECTION IN WATER 审中-公开
公开(公告)号：WO2009014563A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/005082
申请日：2008-04-21
申请人： AGENTASE, LLC , WALKER, Jeremy, P. , WASHBURN, Jon, M., Jr. , ERBELDINGER, Markus
发明人： WALKER, Jeremy, P. , WASHBURN, Jon, M., Jr. , ERBELDINGER, Markus
IPC分类号： G01N21/01 , G01N21/75
CPC分类号： G01N21/78 , Y10T436/172307
摘要： A device for continuous detection of the presence of a cyanide analyte and/or cyanogen analyte in an aqueous sample which relies upon continuous sampling and controlled delivery of reagents for a chemical reaction which forms a colored dye in the presence of the analyte(s). The device employs a single chemical detection pathway which detects both cyanide and cyanogen and demonstrates continuous user- free operational stability over at least a one month period of time. The continuous monitoring device optionally may include a command post computer interface for enabling the remote monitoring of one or more devices, a wireless communication module for providing real-time data monitoring of the devices to a central monitoring facility, and a global positioning system module to enable the determination of an exact location of the analyte contamination in a water network. A method for detecting these analytes is also provided.

2. 发明申请

WO2002090577A2 POSITIVE RESPONSE BIOSENSORS AND OTHER SENSORS 审中-公开
标题翻译：积极响应生物传感器和其他传感器
公开(公告)号：WO2002090577A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/013692
申请日：2002-05-02
申请人： AGENTASE, LLC
发明人： LEJEUNE, Keith, E. , ERBELDINGER, Markus
IPC分类号： C12Q1/34
CPC分类号： C12Q1/001 , G01N33/5438 , G01N33/94 , Y10S435/963
摘要： A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the substrate catalyzed by the first enzyme. The sensor further includes at least a second reaction system that reacts to produce a first detectable state when the first enzyme is inhibited. In some embodiments, the reaction of the first reaction system can produce a second detectible state, different from the first detectible state. Another sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme or a first substrate for the first enzyme. In this embodiment, the analyte is either a substrate for the first enzyme or the first enzyme if the first reaction system includes the first substrate. Figure (1) illustrates reaction schematics of one embodiment of a sensor of the present invention for detecting nerve agents.
摘要翻译：用于检测环境中的分析物的传感器包括包含第一酶和第一酶底物的第一反应体系。分析物抑制由第一种酶催化的底物的反应。所述传感器还包括至少第二反应体系，当第一酶被抑制时，所述第二反应系统反应以产生第一可检测状态。在一些实施方案中，第一反应体系的反应可产生与第一可检测状态不同的第二可检测状态。用于检测环境中的分析物的另一传感器包括包含第一酶或第一酶的第一底物的第一反应系统。在该实施方案中，如果第一反应体系包括第一底物，则分析物是第一酶的底物或第一酶。图（1）示出了用于检测神经毒素的本发明的传感器的一个实施例的反应示意图。

3. 发明申请

WO2004014974A8 BUFFER POLYMERS, CO-IMMOBILE BUFFER AND ENZYME POLYMERS AND METHODS OF SYNTHESIS THEREOF 审中-公开
标题翻译：缓冲聚合物，混合缓冲剂和酶聚合物及其合成方法
公开(公告)号：WO2004014974A8
公开(公告)日：2005-03-24
申请号：PCT/US0324537
申请日：2003-08-06
申请人： AGENTASE LLC
发明人： LEJEUNE KEITH E , ALLINSON BRYAN
IPC分类号： C08G18/10 , C08G18/64 , C12N11/08 , C08G18/00
CPC分类号： C12N11/08 , C08G18/10 , C08G18/6446 , C08G18/64 , C08G18/302
摘要： A polyurethane polymer includes at least one buffer selected to adjust pH to a pH within a desired range. The buffer compound is immobilized within the polymer, and the polymer has a buffer capacity in excess of 3 micromoles of acid or base per gram polymer. A polymer includes at least one enzyme that is selected to catalyze a reaction of a substance. The enzyme is immobilized within the polymer. The polymer also includes at least one buffer selected to adjust the pH in the vicinity of the enzyme to a pH within a desired range. The buffer compound is also immobilized within the polymer. The polymer preferably has enzyme activity and a buffer capacity in excess of 3 micromoles acids or base per gram polymer. In one embodiment, each of the enzymes(s) and the buffer(s) are covalently bonded to the polymer.
摘要翻译：聚氨酯聚合物包括至少一种选择用于将pH调节至pH在所需范围内的缓冲液。缓冲剂化合物固定在聚合物内，聚合物的缓冲能力超过3微摩尔酸或碱/克聚合物。聚合物包括至少一种选择用于催化物质反应的酶。酶固定在聚合物内。聚合物还包括至少一种选择用于将酶附近的pH调节到所需范围内的pH的缓冲液。缓冲剂化合物也固定在聚合物内。聚合物优选具有超过3微摩尔酸或碱/克聚合物的酶活性和缓冲能力。在一个实施方案中，每种酶和缓冲液共价键合到聚合物上。

4. 发明申请

WO2003031563A1 SENSORS FOR THE DETECTION OF AN ANALYTE 审中-公开
标题翻译：用于检测分析仪的传感器
公开(公告)号：WO2003031563A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/032519
申请日：2002-10-11
申请人： AGENTASE LLC
发明人： LEJEUNE, Keith, E. , ERBELDINGER, Markus
IPC分类号： C12M1/34
CPC分类号： C12Q1/34 , C12Q1/001 , C12Q1/005 , C12Q1/46 , G01N33/94
摘要： A sensor (10) for the detection of an analyte includes a first reagent in one section (4) of the housing and at least a second reagent in another section (6) of the housing. The sensor also includes a reservoir (1) of a carrier fluid (that is, a liquid or a gas) within the housing. A release mechanism (3) of the sensor is in operable connection with the reservoir so that when the release mechanism is activated, the carrier fluid is released from the reservoir. The carrier fluid mobilizes the second reagent to contact the first reagent with the second reagent. The interaction of the first reagent and the second reagent is affected by the presence or absence of the analyte to cause a measurable change of state within the sensor.
摘要翻译：用于检测分析物的传感器（10）包括壳体的一个部分（4）中的第一试剂和壳体的另一部分（6）中的至少第二试剂。传感器还包括壳体内的载体流体（即，液体或气体）的储存器（1）。传感器的释放机构（3）与储存器可操作地连接，使得当释放机构被启动时，载体流体从贮存器释放。载液流动地移动第二试剂以使第一试剂与第二试剂接触。第一试剂和第二试剂的相互作用受分析物的存在或不存在而影响传感器内状态的可测量的改变。

5. 发明申请

WO2008076153A3 ENZYME CONTAINING LIQUID AND DELIVERY SYSTEM FOR DETECTION OF ANALYTES ON SURFACES 审中-公开
公开(公告)号：WO2008076153A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/017563
申请日：2007-08-07
申请人： AGENTASE, LLC , LEJEUNE, Keith, E. , BACIOR, Jennifer, A. , BERBERICH, Jason, A. , ERBELDINGER, Markus , LELE, Bhalchandra, Shripad
发明人： LEJEUNE, Keith, E. , BACIOR, Jennifer, A. , BERBERICH, Jason, A. , ERBELDINGER, Markus , LELE, Bhalchandra, Shripad
IPC分类号： C12Q1/34 , C12Q1/68 , C12M3/00
摘要： An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided.

6. 发明申请

WO2008076153A2 ENZYME CONTAINING LIQUID AND DELIVERY SYSTEM FOR DETECTION OF ANALYTES ON SURFACES 审中-公开
标题翻译：用于检测表面分析物的含酶液体和输送系统
公开(公告)号：WO2008076153A2
公开(公告)日：2008-06-26
申请号：PCT/US2007017563
申请日：2007-08-07
申请人： AGENTASE LLC , LEJEUNE KEITH E , BACIOR JENNIFER A , BERBERICH JASON A , ERBELDINGER MARKUS , LELE BHALCHANDRA SHRIPAD
发明人： LEJEUNE KEITH E , BACIOR JENNIFER A , BERBERICH JASON A , ERBELDINGER MARKUS , LELE BHALCHANDRA SHRIPAD
IPC分类号： C12M3/00
CPC分类号： C12Q1/28 , C12Q1/34 , C12Q1/37 , C12Q1/46
摘要： An aqueous enzyme based sensor comprising one or more enzymes and at least one indicator compound capable of indicating a reaction of at least one of the enzymes with at least one target analyte, wherein the enzyme and the indicator are capable of being delivered, preferably by being sprayed, to a surface having the target analyte without sampling the surface. An aqueous enzyme based sensor is provided that is capable of detecting an enzyme specific substrate as the analyte. This aqueous enzyme based sensor further comprises of one or more enzyme specific substrates in which the sensor detects enzyme inhibition. The aqueous enzyme based sensor optionally comprises one or more of a light scattering additive(s), an adhesive polymer(s), a protein stabilizer(s), a protein stabilizing sugar(s), a surfactant(s), and a solvent(s), and combinations thereof. A dispensing system and a method of detecting a target chemical on a surface without sampling the surface is provided.
摘要翻译：一种含水酶的传感器，其包含一种或多种酶和至少一种能够指示至少一种酶与至少一种目标分析物的反应的指示剂化合物，其中酶和指示剂能够被递送，优选通过喷射到具有目标分析物的表面，而不对表面进行取样。提供了一种基于水性酶的传感器，其能够检测作为分析物的酶特异性底物。该基于水性酶的传感器还包含一种或多种酶特异性底物，其中传感器检测酶抑制。基于水性酶的传感器任选地包含一种或多种光散射添加剂，粘合剂聚合物，蛋白稳定剂，蛋白质稳定糖，表面活性剂和溶剂（s）及其组合。提供了一种分配系统和一种在不对表面进行取样的情况下在表面上检测目标化学物质的方法。

7. 发明申请

WO2008036061A2 ENZYMES AND FORMULATIONS FOR BROAD-SPECIFICITY DECONTAMINATION OF CHEMICAL AND BIOLOGICAL WARFARE AGENTS 审中-公开
标题翻译：化学和生物保护剂广泛消除的酶和制剂
公开(公告)号：WO2008036061A2
公开(公告)日：2008-03-27
申请号：PCT/US2006013031
申请日：2006-04-06
申请人： VERENIUM CORP , AGENTASE LLC , LIFE SCIENCE RES ISRAEL LTD , ROBERTSON DAN E , RICHARDSON TOBY , KUSTEDJO KAREN , AMITAI GABRIEL , LEJEUNE KEITH , BERBERICH JASON , CHAPLIN JENNIFER ANN , SINCLAIR JESSICA
发明人： ROBERTSON DAN E , RICHARDSON TOBY , KUSTEDJO KAREN , AMITAI GABRIEL , LEJEUNE KEITH , BERBERICH JASON , CHAPLIN JENNIFER ANN , SINCLAIR JESSICA
IPC分类号： A62D3/02 , A62D101/04
CPC分类号： A62D3/02 , A62D2101/02 , C12N9/00 , C12N9/16
摘要： The invention provides novel enzymes and methods for enzyme-based active decontamination, e.g., nerve agent detoxification. In one aspect, the invention provides enzymes having non-heme chloroperoxidase (nhCPOs) activity, and methods for bleaching and degradation of lignin. The invention provides polypeptides, nucleic acids, infective vehicles, transduced or infected cells or plants and/or transgenic plants to, and methods of using them, e.g., provide self-protecting, pesticide-resistant and/or herbicide-resistant cells or plants, where in one aspect the polypeptides of the invention act to hydrolyzing P-S or P-F bonds and detoxify acetylcholinesterases or butyrylcholinesterases. In one aspect, the invention provides an enzyme mixture or composition that provides broad-spectrum, agent-specific oxidation and hydrolysis activities as well as hypohalite generation for oxidation or hydrolysis of V-agents, G-agents and H-agents and which generates oxidants such as chlorine dioxide and reactive radicals for killing of biological agents, including anthrax spores.
摘要翻译：本发明提供用于酶的活性去污的新型酶和方法，例如神经毒素解毒。一方面，本发明提供了具有非血红素氯过氧化物酶（nhCPOs）活性的酶以及木质素的漂白和降解方法。本发明提供多肽，核酸，感染性载体，转导或感染的细胞或植物和/或转基因植物及其使用方法，例如提供自我保护，抗农药和/或除草剂抗性细胞或植物，其中在一个方面，本发明的多肽起到水解PS或PF键并使乙酰胆碱酯酶或丁酰胆碱酯酶解毒的作用。一方面，本发明提供了提供广谱，试剂特异性氧化和水解活性的酶混合物或组合物，以及用于氧化或水解V-剂，G-剂和H-剂并产生氧化剂的次卤酸盐例如用于杀死生物制剂（包括炭疽孢子）的二氧化氯和反应性基团。

8. 发明申请

WO2006041472A3 ENZYME-BASED DEVICE FOR ENVIRONMENTAL MONITORING 审中-公开
公开(公告)号：WO2006041472A3
公开(公告)日：2006-04-20
申请号：PCT/US2004/032832
申请日：2004-10-06
申请人： AGENTASE, LLC , LEJEUNE, Keith, E. , MYSLIWCZYK, Richard, J. , HOLZAPFEL, Paul, L. , ERBELDINGER, Markus
发明人： LEJEUNE, Keith, E. , MYSLIWCZYK, Richard, J. , HOLZAPFEL, Paul, L. , ERBELDINGER, Markus
IPC分类号： C12M1/34 , C12Q1/34 , C12Q1/46
摘要： A sensor for the intermittent or continuous detection of the presence of at least one analyte in an environmental sample includes at least one enzyme that is selected to either (i) catalyze a reaction of the analyte to chemically convert the analyte to a product compound or (ii) be inhibited by the analyte in the presence of a substrate compound. The sensor also includes at least one sensor for monitoring or at least one indicator compound selected to produce a measurable change of state as a result of the interaction of the analyte and the enzyme. Optionally, each of the enzyme and the indicator compound are incorporated within a single polymer.

9. 发明申请

WO2013188497A3 A SMART, SELF-DECONTAMINATING POLYMER AND METHOD FOR INHIBITING THE GROWTH OF A BACTERIA AND FUNGUS 审中-公开
标题翻译：一种智能，自我去除的聚合物和抑制细菌和真菌生长的方法
公开(公告)号：WO2013188497A3
公开(公告)日：2014-03-20
申请号：PCT/US2013045331
申请日：2013-06-12
申请人： AGENTASE LLC A SUBSIDIARY OF FLIR SYSTEMS INC
发明人： LEECH ANNA M , WALKER JEREMY P , DONAHUE SCOTT , JOHNSON JERMAINE D , SINCLAIR JESSICA J
IPC分类号： A61L15/38 , A61L15/60 , C12Q1/26
CPC分类号： A61L15/38 , A61F13/00059 , A61F13/00063 , A61K9/06 , A61K9/7007 , A61K38/443 , A61L15/26 , A61L15/425 , A61L15/44 , A61L15/46 , A61L2300/404 , A61L2300/434 , A61L2420/06 , C08L75/04
摘要： A smart antimicrobial material and dressing to inhibit microbial growth is provided. Endogenous chemicals, such as metabolites produced from bacteria are utilized as chemical substrates and converted by enzymes to produce a disinfecting compound that will in turn inhibit the targeted microorganism. The material shall remain passive until such time as it encounters a microbe which expresses and/or secretes specific metabolites or markers. The enzyme or enzymes embedded in the smart material converts the metabolite into a disinfecting compound, which in turn either kills the microorganism or prevents it from multiplying on the surface of the material.
摘要翻译：提供了一种智能抗菌材料和敷料以抑制微生物生长。内源性化学物质如细菌产生的代谢物被用作化学底物并由酶转化以产生消毒化合物，这又将抑制靶向的微生物。材料应保持被动，直到遇到表达和/或分泌特定代谢物或标记物的微生物。嵌入在智能材料中的酶或酶将代谢物转化为消毒化合物，其又杀死微生物或阻止其在材料的表面上繁殖。

10. 发明申请

WO2013074168A1 METHOD AND DEVICE FOR DETECTING, CLASSIFYING, AND IDENTIFYING PARTICLES, AEROSOLS OR VAPORS 审中-公开
标题翻译：用于检测，分类和鉴定颗粒，气溶胶或蒸气的方法和装置
公开(公告)号：WO2013074168A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/052481
申请日：2012-08-27
申请人： AGENTASE, LLC, A SUBSIDIARY OF FLIR SYSTEMS, INC. , ERBELDINGER, Markus , SILCOTT, David B. , BERBERICH, Jason Aaron , LEJEUNE, Keith E.
发明人： ERBELDINGER, Markus , SILCOTT, David B. , BERBERICH, Jason Aaron , LEJEUNE, Keith E.
IPC分类号： C12Q1/00 , G01N21/00 , B01J10/00
CPC分类号： C12Q1/25 , G01N1/2273 , G01N15/0606 , G01N21/6428 , G01N21/766 , G01N33/0013
摘要： A method and device are disclosed for continuously detecting, classifying and identifying toxic particles, aerosols and/ or vapor in an air sample, in near real time by directing an air sample containing an optional target analyte, in the form of particles, aerosols and/or vapors, enzyme(s), and enzyme substrate(s), to a surface of a collection matrix for forming a biocatalytic reaction product of a plurality of freely mobile optical reporters, and by using a light source with optical reader to interpret the signal from the optical reporter, enabling the detection, classification and identification of toxic particles, aerosols and/ or vapor in the air sample.
摘要翻译：公开了一种方法和装置，用于通过将含有任选的目标分析物的空气样品以颗粒，气溶胶和/或气体的形式连续地检测，分类和鉴定空气样品中的有毒颗粒，气溶胶和/或蒸气，或蒸气，酶和酶底物转移到用于形成多个自由移动光学记录器的生物催化反应产物的收集基质的表面，并且通过使用具有光学读取器的光源来解释信号从光学报告员，能够检测，分类和鉴定空气样品中的有毒颗粒，气溶胶和/或蒸气。

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