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    • 6. 发明申请
    • A METHOD AND SYSTEM FOR ALIASED K-SPACE DATA RESTORATION
    • 用于老化的K空间数据恢复的方法和系统
    • WO2014006633A4
    • 2014-04-24
    • PCT/IN2013000379
    • 2013-06-19
    • ARUNACHALAM ARJUN
    • ARUNACHALAM ARJUN
    • G01R33/561
    • G01R33/5612
    • This invention relates to a method and system for unfolding k-space data points, acquired during an accelerated MRI scan that overlapped and collected multiple k- space data points simultaneously, in order to generate desired image data, said method comprising the steps of: (a) obtaining tailored signal excitation modules by using RF excitation pulses in combination with one or more magnetic field gradients; (b) acquiring overlapped k-space data by using a pulse sequence that employs said obtained tailored signal excitation modules, which overlap distinct k- space points; (c) unfolding said acquired overlapped k-space data through a data reconstruction process that utilizes coil spatial sensitivity profiles of multiple RF acquisition coils in order to obtain unfolded k-space data; and (d) performing a Fourier transformation along one or more axes of said un-folded k-space data to generate said desired image data.
    • 本发明涉及一种用于展开在加速MRI扫描期间同时重叠和收集多个k空间数据点的k空间数据点的方法和系统,以便产生期望的图像数据,所述方法包括以下步骤:( a)通过使用RF激励脉冲与一个或多个磁场梯度组合来获得定制的信号激励模块; (b)使用采用所述获得的定制信号激励模块的脉冲序列获取重叠的k空间数据,所述量化信号激励模块与不同的k空间点重叠; (c)通过利用多个RF采集线圈的线圈空间灵敏度分布的数据重建处理展开所述获取的重叠k空间数据,以获得未折叠的k空间数据; 和(d)沿着所述未折叠的k空间数据的一个或多个轴执行傅立叶变换以产生所述期望的图像数据。
    • 8. 发明申请
    • MICROFLUIDIC DRUG DELIVERY DEVICES
    • 微流体药物递送装置
    • WO2013019830A3
    • 2013-04-04
    • PCT/US2012049100
    • 2012-08-01
    • ALCYONE LIFESCIENCES INCANAND PJSINGH DEEP ARJUN
    • ANAND PJSINGH DEEP ARJUN
    • A61M37/00A61M25/01A61M25/06A61M31/00
    • A61M5/16804A61B5/036A61B5/14503A61B5/4839A61M5/172A61M25/0023A61M25/0026A61M2025/0042A61M2205/50
    • The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.
    • 本文公开的方法,系统和装置通常涉及将药物对流增强递送至患者体内的目标区域。 公开了微流体导管装置,其特别适用于经由对流的药物的靶向递送,包括能够进行多向药物递送的装置,使用文丘里效应控制流体压力和速度的装置,以及包括适形球囊的装置。 还公开了使用这种装置治疗各种疾病的方法,包括治疗脑和脊柱海绵状血管畸形,海绵状血管瘤和血管瘤的方法,治疗神经疾病的方法,使用多微流体递送装置治疗的方法,治疗听力障碍的方法, 使用微流体装置的脊柱药物递送,以及在胎儿手术期间递送干细胞和治疗剂的方法。 还公开了制造这种装置的方法。