专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2019143893A1 METAL CLEANING COMPOSITIONS COMPRISING FUROATE ESTERS AND USES THEREFOR 审中-公开
公开(公告)号：WO2019143893A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/014130
申请日：2019-01-18
申请人： Q-MAXX PRODUCTS GROUP, INC.
发明人： FATIGATI, Michael , FARONE, William , RIVERA, Rocio , HAUPT, Dawnell , MCCREERY, David , WHIPPLE, Devin
IPC分类号： F01P11/06 , C10M129/02 , C11D7/26 , C10M129/68
摘要： Disclosed are metal cleaning formulations and methods of use. A formulation of the present teachings comprises one or more furoate esters such as ethyl 5-methyl-2-furoate and methyl 5-methyl-2-furoate. The formulations further comprise a base oil, which can be, for example, a naphthenic oil, a synthetic oil or a combination thereof. In some embodiments, a formulation can further comprise a metal protection additive and a lubrication additive. A variety of base oils, metal protection additives, and lubrication additives are suitable for use in the present teachings. Formulations of the present teachings are especially useful for the cleaning of metal products such as firearms. The cleaning power of a formulation of the instant teachings can exceed that required for US Military Specifications.

2. 发明申请

WO2019108615A1 THREE PHASE PARTITIONING (TPP) METHOD FOR VIRUS PURIFICATION 审中-公开
公开(公告)号：WO2019108615A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062795
申请日：2018-11-28
申请人： VIROVEK, INC.
发明人： CHEN, Haifeng
IPC分类号： C12N7/00
摘要： Methods of purifying a virus from a virus-infected cell lysate using three-phase partitioning (TPP) are disclosed. The methods comprise a first round of TPP, including mixing a cell lysate comprising a virus with ammonium sulfate and t-butanol, and separating the mixture, thereby forming a first aqueous phase, a first organic phase, and a first interphase. The first aqueous phase can comprise the virus, which can be subjected to a second round of TPP, resulting in a second aqueous phase, a second organic phase, and a second interphase. The second interphase can comprise highly purified virus. The methods can comprise subjecting a first aqueous phase to further purification by column chromatography or density gradient centrifugation. Purification of AAV, including AAV2, AAV5 and AAV6, from lysates of infected insect cell cultures is demonstrated. TPP-purified AAV particles infect at least as well as those prepared by standard methods.

3. 发明申请

WO2015161314A1 ADENOVIRAL TARGETING, COMPOSITIONS AND METHODS THEREFOR 审中-公开
标题翻译： ADENOVIRAL目标，其组成和方法
公开(公告)号：WO2015161314A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/026627
申请日：2015-04-20
申请人： WASHINGTON UNIVERSITY
发明人： CURIEL, David , KALIBEROV, Sergey
IPC分类号： C12N15/62 , C12N15/861 , A61P35/00 , C07K19/00
CPC分类号： C07K16/3007 , C07K14/005 , C07K2317/22 , C07K2317/24 , C07K2317/622 , C07K2319/00 , C07K2319/33 , C07K2319/73 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10345 , C12N2810/859 , C12N2830/008 , C12N2830/85
摘要： Polypeptides are disclosed comprising, in N-terminal-to-C-terminal order: an N-terminal segment of Ad5 fiber tail sequence; at least 2 pseudorepeats of an Ad5 fiber shaft domain sequence; a portion of a third Ad5 fiber shaft domain sequence; a carboxy-terminal segment of a T4 fibritin bacteriophage trimerization domain sequence; a linker sequence; and a camelid single chain antibody sequence. A camelid single chain antibody sequence can be against a human carcinoembryonic antigen. Also disclosed are nucleic acids encoding these polypeptides, and adenovirus vectors comprising the polypeptides. Methods are disclosed for treating a neoplastic disease. These methods can comprise administering an adenovirus vector comprising a disclosed polypeptide. Also disclosed are methods of targeting a vector to CEA-expressing cells. These methods comprise administering an adenovirus vector comprising a disclosed polypeptide. Methods can further comprise subjecting a subject to ionizing radiation in an amount effective for inducing CEA overexpression.
摘要翻译：公开了多肽，其包含N末端至C末端顺序：Ad5纤维尾序列的N末端片段; 至少2个伪距的Ad5纤维轴结构域序列; 第三个Ad5纤维轴域序列的一部分; T4纤维蛋白噬菌体三聚体结构域序列的羧基末端片段; 接头序列; 和骆驼单链抗体序列。骆驼单链抗体序列可以针对人癌胚抗原。还公开了编码这些多肽的核酸和包含多肽的腺病毒载体。公开了治疗肿瘤性疾病的方法。这些方法可以包括施用包含公开的多肽的腺病毒载体。还公开了将载体靶向表达CEA的细胞的方法。这些方法包括施用包含公开的多肽的腺病毒载体。方法可以进一步包括使受试者以有效诱导CEA过表达的量进行电离辐射。

4. 发明申请

WO2015153814A1 SIGMA-2 RECEPTOR LIGAND DRUG CONJUGATES AS ANTITUMOR COMPOUNDS, METHODS OF SYNTHESIS AND USES THEREOF 审中-公开
标题翻译： SIGMA-2受体配体药物作为抗微生物化合物，其合成方法及用途
公开(公告)号：WO2015153814A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/023954
申请日：2015-04-01
申请人： WASHINGTON UNIVERSITY
发明人： HAWKINS, William , MACH, Robert , SPITZER, Dirk , VANGVERAVONG, Suwanna
IPC分类号： C07D403/14 , A61P35/00
CPC分类号： C07D451/14 , A61K31/496 , A61K31/517 , A61K45/06 , C07D471/08
摘要： Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC 50 value below 5 μΜ against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.
摘要翻译：公开了治疗癌症如胰腺癌和滑膜肉瘤的方法和组合物。描述了包含σ-2受体结合部分和诱导铁诱发部分的化合物。至少一种所述的分子物质在体外显示低于5μM的IC 50值对人胰腺癌细胞。这种物种的管理促进了体内鼠模型系统中胰腺癌肿瘤的收缩，并且导致实验动物的100％存活时间过程，其中对照治疗仅提供30％或40％的存活率。还公开了合成分子种类的方法。

5. 发明申请

WO2015103526A1 RADIOLABELED TRACERS FOR POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1), METHODS AND USES THEREFOR 审中-公开
标题翻译：聚（ADP-RIBOSE）聚合酶-1（PARP-1）的放射性跟踪器，其方法和用途
公开(公告)号：WO2015103526A1
公开(公告)日：2015-07-09
申请号：PCT/US2015/010129
申请日：2015-01-05
申请人： WASHINGTON UNIVERSITY
发明人： MACH, Robert , CHU, Wenhua , ZHOU, Dong , MICHEL, Loren , CHEN, Delphine
IPC分类号： C07D243/24 , C07D235/26 , A61K36/55 , C07D263/62 , C07D277/62 , C07D411/04 , A01N43/52 , A01N43/76 , A01N43/78
CPC分类号： A61K51/0468 , A61B6/037 , C07D235/18 , C07D403/12 , C07D487/04
摘要： Disclosed are PARP-1 inhibitors, which can be 18 F-labeled for use as tracers in positron emission tomographic (PET) imaging. Further disclosed are methods of synthesis. Of the compounds synthesized, 2-[p-(2-Fluoroethoxy)phenyl]-1.3.10-triazatricyclo[6.4.1.0 4,13 ]trideca-2,4(13),5,7-tetraen-9-one (12) had the highest inhibition potency for PARP-1 (IC 50 = 6.3 nM). Synthesis of [ 18 F]-12 is disclosed under conventional conditions in high specific activity with 40-50% decay-corrected yield. MicroPET imaging using [ 18 F]-12 in MDA-MB-436 tumor-bearing mice demonstrated accumulation of [ 18 F]-12 in a tumor. Binding can be blocked by olaparib. The compounds have utility for tumor imaging.
摘要翻译：公开了PARP-1抑制剂，其可以被18F标记用于正电子发射断层摄影（PET）成像中的示踪剂。进一步公开的是合成方法。在合成的化合物中，将2- [对 - （2-氟乙氧基）苯基] -1.3.10-三氮杂三环[6.4.1.04,13]十三烷-2,4（13），5,7-四烯-9-酮（12 ）对PARP-1具有最高的抑制效能（IC50 = 6.3nM）。在具有40-50％衰变校正产率的高比活性的常规条件下公开了[18 F] -12的合成。使用[18F] -12在MDA-MB-436肿瘤小鼠中的MicroPET成像显示[18F] -12在肿瘤中的积累。结合可以被olaparib阻断。该化合物可用于肿瘤成像。

6. 发明申请

WO2012109611A2 PET/SPECT AGENTS FOR APPLICATIONS IN BIOMEDICAL IMAGING 审中-公开
标题翻译： PET / SPECT代理应用于生物医学成像
公开(公告)号：WO2012109611A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024752
申请日：2012-02-10
申请人： WASHINGTON UNIVERSITY , SHARMA, Vijay , SIVAPACKIAM, Jothilingam , PIWNICA-WORMS, David
发明人： SHARMA, Vijay , SIVAPACKIAM, Jothilingam , PIWNICA-WORMS, David
IPC分类号： C07C211/49 , C07F5/00 , C05D9/00
CPC分类号： A61K51/0478 , C05D9/02 , C07B59/001 , C07B59/002 , C07C251/24 , C07F5/003
摘要： Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67 Ga or 68 Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as heart or tumor tissue. In various embodiments, disclosed tracers can exhibit, a) enhanced first pass extraction into heart tissue compared to presently available probes, b) linearity with true blood flow, c) enhanced detection of myocardial viability compared to presently available probes, d) reduced liver retention compared to presently available probes, and e) more efficient clearance from non cardiac and adjoining tissues compared to presently available probes.
摘要翻译：可以用于Pgp分布的PET或SPECT成像的示踪剂被公开。示踪剂是金属探针，其可以包含放射性金属离子如67 Ga或68 Ga。还公开了合成示踪物的方法以及使心脏和其他组织成像的方法。示踪剂可用于获得用于体内成像组织（例如心脏或肿瘤组织）的高信号背景比。在各种实施方案中，公开的示踪剂可以表现出a）与当前可用的探针相比提高到心脏组织中的首过提取，b）与真实血流的线性，c）与目前可用的探针相比，增强的心肌活力检测，d）与目前可用的探针相比，e）与目前可用的探针相比，非心脏和邻近组织更有效的清除。

7. 发明申请

WO2010129572A2 PET RADIOTRACERS FOR IMAGING FATTY ACID METABLOLISM AND STORAGE 审中-公开
标题翻译：用于成像脂肪酸代谢和存储的PET放射剂
公开(公告)号：WO2010129572A2
公开(公告)日：2010-11-11
申请号：PCT/US2010/033579
申请日：2010-05-04
申请人： WASHINGTON UNIVERSITY , MACH, Robert, H. , GROPLER, Robert, John , TU, Zhude , HERRERO, Pilar
发明人： MACH, Robert, H. , GROPLER, Robert, John , TU, Zhude , HERRERO, Pilar
IPC分类号： A61K51/04 , C07D249/04
CPC分类号： A61K51/0402 , C07B59/00 , C07C51/09 , C07C59/64 , C07D249/04 , C07C59/68
摘要： Fatty acid analogue ( FAA) molecules comprising positron-emitting radionuclides, salts thereof, and FAA-triglycerides are disclosed Also disclosed are methods of synthesis, and methods of imaging distribution and metabolism of fatty acids and fatty acid triglycerides.
摘要翻译：公开了包含正电子发射放射性核素，其盐和FAA-甘油三酸酯的脂肪酸类似物（FAA）分子。还公开了合成方法以及成像脂肪酸和脂肪酸甘油三酯分布和代谢成像的方法。

8. 发明申请

WO2009134811A1 METHOD AND APPARATUS FOR FACILITATING HVAC DESIGN FOR A BUILDING 审中-公开
标题翻译：促进建筑暖气设计的方法和装置
公开(公告)号：WO2009134811A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/041989
申请日：2009-04-28
申请人： COAD ENGINEERING ENTERPRISES, INC. , COAD, William, J. , POLLACK, David, A. , BLACK, Albert, W.
发明人： COAD, William, J. , POLLACK, David, A. , BLACK, Albert, W.
IPC分类号： G06F17/50
CPC分类号： G06F17/5004 , F24F11/30 , F24F11/58 , G06F2217/04 , G06F2217/16 , G06F2217/34 , G06F2217/80
摘要： A system which facilitates HVAC design for buildings or portions thereof is disclosed. The system comprises a server and one or more remotely situated terminals. The server, which can be a secure server, comprises software that facilitates calculation of HVAC design. A user can access one or more calculation modules in a session of use of a project. The user can provide alphanumeric information items in one or more data input fields. A calculation module can determine a variety of HVAC design output information items using the data added by the user. Both input and output information items can be securely recorded by the server in a record of a session for a project. Furthermore, multiple users can collaborate by accessing the system and contributing to the record of a project in separate sessions. A record of a session or project can be provided in a printable text file.
摘要翻译：公开了一种促进建筑物或其部分的HVAC设计的系统。该系统包括服务器和一个或多个远程位置的终端。可以是安全服务器的服务器包括有助于HVAC设计计算的软件。用户可以在项目的使用会话中访问一个或多个计算模块。用户可以在一个或多个数据输入字段中提供字母数字信息项。计算模块可以使用用户添加的数据来确定各种HVAC设计输出信息项。输入和输出信息项都可以由服务器安全记录在项目的会话记录中。此外，多个用户可以通过访问系统进行协作，并在单独的会话中对项目的记录作出贡献。可以在可打印的文本文件中提供会话或项目的记录。

9. 发明申请

WO2006121612A1 TREATMENT OF JOINT DISEASE, METHODS AND APPARATUSES THEREFOR 审中-公开
标题翻译：联合疾病的治疗方法及其设备
公开(公告)号：WO2006121612A1
公开(公告)日：2006-11-16
申请号：PCT/US2006/015743
申请日：2006-04-26
申请人： ISTO TECHNOLOGIES, INC. , ADKISSON, H., Davis, IV , SEYEDIN, Mitchell, S.
发明人： ADKISSON, H., Davis, IV , SEYEDIN, Mitchell, S.
IPC分类号： C12N5/00 , C12N5/08 , A61K9/00 , C12M3/00
CPC分类号： A61K35/32 , A61F2/30756 , A61F2/4618 , A61F2310/00365 , A61K9/0019 , A61K35/12 , A61L27/3817 , A61L27/3852 , A61L2400/06 , A61L2430/24 , C12N5/0655 , C12N2501/998
摘要： The present application discloses compositions, methods and devices for treatment of degenerative cartilaginous structures of an arthritic joint, including articular cartilage and the meniscus. A composition can comprise chondrocytes expressing type II collagen and a biological macromolecule such as hyaluronic acid or a collagen. The chondrocytes can be obtained from hyaline cartilage of human cadavers up to about two weeks following death, and can be grown in vitro. A composition can be delivered to a recipient by intra-articular injection. Examples of joints into which a composition can be injected include a knee joint, a hip joint, a shoulder joint, an ankle joint, a wrist joint, a digit joint and an elbow joint.
摘要翻译：本申请公开了用于治疗关节炎关节的退行性软骨结构的组合物，方法和装置，包括关节软骨和半月板。组合物可以包含表达II型胶原的软骨细胞和生物大分子如透明质酸或胶原蛋白。软骨细胞可以从死亡后约两周的人体尸体的透明软骨获得，并且可以在体外生长。可通过关节内注射将组合物递送至受体。可以注射组合物的关节的实例包括膝关节，髋关节，肩关节，踝关节，腕关节，数字关节和肘关节。

10. 发明申请

WO2017205423A1 PULMONARY TARGETED CAS9/CRISPR FOR IN VIVO EDITING OF DISEASE GENES 审中-公开
标题翻译：肺部疾病靶向CAS9 / CRISPR
公开(公告)号：WO2017205423A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034070
申请日：2017-05-23
申请人： WASHINGTON UNIVERSITY
发明人： CURIEL, David
IPC分类号： C12N15/861 , C12N15/66 , A61K48/00 , C12N15/10 , C12N15/63
CPC分类号： A61K48/0058 , A61K48/00 , A61K48/0008 , A61K48/0066 , A61P7/04 , C07K14/755 , C12N9/22 , C12N9/644 , C12N15/10 , C12N15/102 , C12N15/63 , C12N15/66 , C12N15/86 , C12N2310/20 , C12N2710/10343 , C12N2710/10345 , C12N2710/10371
摘要： An adenovirus vector comprising: a pulmonary targeting coding sequence, CRISPR components such as a Cas9 coding sequence, and a guideRNA coding sequence which can be used for gene therapy. The adenovirus can be a gorilla adenovirus, and can include a pulmonary cell targeting sequence such as an MBP targeting ligand coding sequence. The adenovirus can be targeted to pulmonary epithelium with a vascular specific promoter and integrin targeting peptides incorporated into a viral knob. The adenovirus can be used to introduce serum proteins via the pulmonary epithelium. Hemophilia can be treated by adenoviral introduction of factor VIII or factor IX.
摘要翻译：包含：肺靶向编码序列，CRISPR组分如Cas9编码序列和可用于基因治疗的指导RNA编码序列的腺病毒载体。腺病毒可以是大猩猩腺病毒，并且可以包括肺细胞靶向序列，例如MBP靶向配体编码序列。腺病毒可以用血管特异性启动子靶向肺上皮细胞，并将整合素靶向肽掺入病毒瘤中。腺病毒可用于通过肺上皮细胞引入血清蛋白。血友病可以通过腺病毒引入因子VIII或因子IX来治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式