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1. 发明申请

WO2015161314A1 ADENOVIRAL TARGETING, COMPOSITIONS AND METHODS THEREFOR 审中-公开
标题翻译： ADENOVIRAL目标，其组成和方法
公开(公告)号：WO2015161314A1
公开(公告)日：2015-10-22
申请号：PCT/US2015/026627
申请日：2015-04-20
申请人： WASHINGTON UNIVERSITY
发明人： CURIEL, David , KALIBEROV, Sergey
IPC分类号： C12N15/62 , C12N15/861 , A61P35/00 , C07K19/00
CPC分类号： C07K16/3007 , C07K14/005 , C07K2317/22 , C07K2317/24 , C07K2317/622 , C07K2319/00 , C07K2319/33 , C07K2319/73 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10345 , C12N2810/859 , C12N2830/008 , C12N2830/85
摘要： Polypeptides are disclosed comprising, in N-terminal-to-C-terminal order: an N-terminal segment of Ad5 fiber tail sequence; at least 2 pseudorepeats of an Ad5 fiber shaft domain sequence; a portion of a third Ad5 fiber shaft domain sequence; a carboxy-terminal segment of a T4 fibritin bacteriophage trimerization domain sequence; a linker sequence; and a camelid single chain antibody sequence. A camelid single chain antibody sequence can be against a human carcinoembryonic antigen. Also disclosed are nucleic acids encoding these polypeptides, and adenovirus vectors comprising the polypeptides. Methods are disclosed for treating a neoplastic disease. These methods can comprise administering an adenovirus vector comprising a disclosed polypeptide. Also disclosed are methods of targeting a vector to CEA-expressing cells. These methods comprise administering an adenovirus vector comprising a disclosed polypeptide. Methods can further comprise subjecting a subject to ionizing radiation in an amount effective for inducing CEA overexpression.
摘要翻译：公开了多肽，其包含N末端至C末端顺序：Ad5纤维尾序列的N末端片段; 至少2个伪距的Ad5纤维轴结构域序列; 第三个Ad5纤维轴域序列的一部分; T4纤维蛋白噬菌体三聚体结构域序列的羧基末端片段; 接头序列; 和骆驼单链抗体序列。骆驼单链抗体序列可以针对人癌胚抗原。还公开了编码这些多肽的核酸和包含多肽的腺病毒载体。公开了治疗肿瘤性疾病的方法。这些方法可以包括施用包含公开的多肽的腺病毒载体。还公开了将载体靶向表达CEA的细胞的方法。这些方法包括施用包含公开的多肽的腺病毒载体。方法可以进一步包括使受试者以有效诱导CEA过表达的量进行电离辐射。

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