会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • ADENOVIRAL TARGETING, COMPOSITIONS AND METHODS THEREFOR
    • ADENOVIRAL目标,其组成和方法
    • WO2015161314A1
    • 2015-10-22
    • PCT/US2015/026627
    • 2015-04-20
    • WASHINGTON UNIVERSITY
    • CURIEL, DavidKALIBEROV, Sergey
    • C12N15/62C12N15/861A61P35/00C07K19/00
    • C07K16/3007C07K14/005C07K2317/22C07K2317/24C07K2317/622C07K2319/00C07K2319/33C07K2319/73C12N15/86C12N2710/10322C12N2710/10332C12N2710/10345C12N2810/859C12N2830/008C12N2830/85
    • Polypeptides are disclosed comprising, in N-terminal-to-C-terminal order: an N-terminal segment of Ad5 fiber tail sequence; at least 2 pseudorepeats of an Ad5 fiber shaft domain sequence; a portion of a third Ad5 fiber shaft domain sequence; a carboxy-terminal segment of a T4 fibritin bacteriophage trimerization domain sequence; a linker sequence; and a camelid single chain antibody sequence. A camelid single chain antibody sequence can be against a human carcinoembryonic antigen. Also disclosed are nucleic acids encoding these polypeptides, and adenovirus vectors comprising the polypeptides. Methods are disclosed for treating a neoplastic disease. These methods can comprise administering an adenovirus vector comprising a disclosed polypeptide. Also disclosed are methods of targeting a vector to CEA-expressing cells. These methods comprise administering an adenovirus vector comprising a disclosed polypeptide. Methods can further comprise subjecting a subject to ionizing radiation in an amount effective for inducing CEA overexpression.
    • 公开了多肽,其包含N末端至C末端顺序:Ad5纤维尾序列的N末端片段; 至少2个伪距的Ad5纤维轴结构域序列; 第三个Ad5纤维轴域序列的一部分; T4纤维蛋白噬菌体三聚体结构域序列的羧基末端片段; 接头序列; 和骆驼单链抗体序列。 骆驼单链抗体序列可以针对人癌胚抗原。 还公开了编码这些多肽的核酸和包含多肽的腺病毒载体。 公开了治疗肿瘤性疾病的方法。 这些方法可以包括施用包含公开的多肽的腺病毒载体。 还公开了将载体靶向表达CEA的细胞的方法。 这些方法包括施用包含公开的多肽的腺病毒载体。 方法可以进一步包括使受试者以有效诱导CEA过表达的量进行电离辐射。