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1. 发明申请

WO2010048199A2 CRANIAL ELECTROSTIMULATION DEVICE FOR TREATMENT OF POLYSUBSTANCE ADDICTION AND METHOD OF USE 审中-公开
标题翻译：用于治疗多汗症的临时电泳装置及使用方法
公开(公告)号：WO2010048199A2
公开(公告)日：2010-04-29
申请号：PCT/US2009/061346
申请日：2009-10-20
申请人： SEABOARD ASSETS CORP. , MOYER, Eric P. , WINSTON, Joseph R.
发明人： MOYER, Eric P. , WINSTON, Joseph R.
IPC分类号： A61N1/36 , A61N1/18
CPC分类号： A61N1/36089 , A61N1/36014 , A61N1/36025 , A61N1/36192
摘要： The cranial electrostimulation devices described herein are suitable for use in detoxification from and amelioration of the symptoms of acute and chronic withdrawal from simultaneous multiple addictive substances by transcutaneous electric nerve stimulation. A plurality of time-division multiplexed analog waveforms is applied to the mastoid process of a person in need thereof, thereby treating symptoms of withdrawal from addictive substances. The invention also provides a protocol for encoding a plurality of different waveforms combined sequentially or simultaneously, as well as an improved cranial electrostimulation apparatus having a stable output waveform signal over the useful service life of the power supply, e.g., the battery.
摘要翻译：本文所述颅脑电刺激装置适用于通过经皮电神经刺激来解毒并改善急性和慢性同时多种成瘾物质戒断的症状。多个时分多路复用模拟波形被应用于有需要的人的乳突过程，由此治疗从成瘾物质中撤出的症状。本发明还提供了用于对顺序地或同时地组合的多个不同波形进行编码的协议，以及在电源（例如电池）的有效使用寿命期间具有稳定的输出波形信号的改进的颅脑电刺激设备。

2. 发明申请

WO2009026375A2 SPERMICIDAL AND MICROBICIDAL COMPOSITIONS 审中-公开
标题翻译：杀精子和微生物组合物
公开(公告)号：WO2009026375A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/073730
申请日：2008-08-20
申请人： LEHIGH UNIVERSITY , BEAN, Barry , FLOWERS, Robert A. , VENDITTI, Jennifer J. , SINGH, Rajni
发明人： BEAN, Barry , FLOWERS, Robert A. , VENDITTI, Jennifer J. , SINGH, Rajni
IPC分类号： G01N33/48 , C07C43/00 , A61K31/11 , A61F6/04
CPC分类号： A61K31/80 , Y02A50/473
摘要： Provided herein are new spermicidal compositions that include one or more fluorous surfactants, e.g., non-ionic fluorous surfactants, anionic fluorous surfactants, cationic fluorous surfactants, and combinations thereof. Also provided are methods of preventing fertilization of an ovum, which include a step of contacting at least one spermatozoon with one or more fluorous surfactants. Additionally described herein are methods of preventing infection, which include a step of contacting at least one infectious pathogenic microorganism with one or more fluorous surfactants. Numerous fluorine-containing surfactants are demonstrated to be efficacious as human spermicides.
摘要翻译：本文提供了新的杀精子组合物，其包含一种或多种氟表面活性剂，例如非离子氟表面活性剂，阴离子氟表面活性剂，阳离子氟表面活性剂及其组合。还提供了防止卵子受精的方法，其包括使至少一个精子与一种或多种氟表面活性剂接触的步骤。本文另外描述了预防感染的方法，其包括使至少一种感染性病原微生物与一种或多种氟表面活性剂接触的步骤。许多含氟表面活性剂被证明是有效的杀精子剂。

3. 发明申请

WO2007092475A2 SITE-SPECIFIC INCORPORATION OF FLUORINATED AMINO ACIDS INTO PROTEINS 审中-公开
标题翻译：荧光氨基酸进入蛋白质的特定地点
公开(公告)号：WO2007092475A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/003217
申请日：2007-02-05
申请人： FRANKLIN AND MARSHALL COLLEGE , MEHL, Ryan A.
发明人： MEHL, Ryan A.
CPC分类号： C12P21/02 , C07C229/36 , C07K1/006 , C12N9/93
摘要： This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; and uses of the polynucleotides, polypeptides, variants and derivatives. The invention also relates to compositions of orthogonal aminoacyl-tRNA synthetases, and pairs of orthogonal aminoacyl-tRNA synthetases, and orthogonal tRNAs that incorporate fluorinated amino acids into proteins in response to selector codons. The present invention also includes translation biochemistry methods for site-specific incorporation of fluorinated amino acids, for example, 18 F- or 19 F-labelled amino acids, into proteins or peptides. Such amino acids may be used as an NMR probe for characterizing protein structure, dynamics, and reactivity or for radionuclide imaging ( e.g ., PET). Fluorinated amino acids may also be used to stabilize proteins or peptides.
摘要翻译：本发明部分涉及新鉴定的多核苷酸，多肽，变体和衍生物; 制备多核苷酸和多肽的方法及其变体和衍生物; 以及多核苷酸，多肽，变体和衍生物的用途。本发明还涉及正交氨酰-tRNA合成酶的组合物，以及正交氨酰-tRNA合成物对，以及响应选择密码子将氟化氨基酸掺入蛋白质的正交tRNA。本发明还包括用于将氟化氨基酸（例如，18 F-或19 F-标记的氨基酸）的位点特异性并入蛋白质或肽的翻译生物化学方法。这些氨基酸可以用作用于表征蛋白质结构，动力学和反应性或用于放射性核素成像（例如PET）的NMR探针。氟化氨基酸也可用于稳定蛋白质或肽。

4. 发明申请

WO2007095634A2 PRION PROTEIN DETECTION 审中-公开
标题翻译： PRION蛋白检测
公开(公告)号：WO2007095634A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/062337
申请日：2007-02-16
申请人： HANSON TECHNOLOGIES, INC. , DYER, Maureen, Angela , HANSON, William, Paynter , MEEKER, Thrygve, Richard
发明人： DYER, Maureen, Angela , HANSON, William, Paynter , MEEKER, Thrygve, Richard
CPC分类号： G01N33/54373
摘要： An example embodiment of the invention includes a method of performing an assay comprising the steps of (1) providing a multimode waveguide; (2) fixing one or more fluidic cells to the multimode waveguide, wherein each of the one or more fluidic cells including a surface having a portion thereof sealed to the coated region, the surface including a depression therein defining a fluidic channel bounded at least in part by the optically exposed region, and a sample introduction port for the introduction of a fluid sample into the fluidic channel; (3) introducing a fluid sample into the fluidic channel via the sample introduction port so that the fluid sample physically contacts the optically exposed region; (4) launching light into the waveguide so as to produce a wave at the optically exposed region; and (5) detecting an optical signal generated at the optically exposed region in response to the wave, wherein the optical signal is correlated with the presence of a prion protein in the fluid sample. An example waveguide device comprises a multimode waveguide having a surface-bearing patterned reflective coating defining a reflectively coated region and an optically exposed region on the surface, wherein one or more first antibodies are covalently bonded to or non-covalently immobilized on the optically exposed region, and wherein the one or more first antibodies selectively binds a prion protein.
摘要翻译：本发明的示例性实施例包括执行测定的方法，包括以下步骤：（1）提供多模波导; （2）将一个或多个流体单元固定到多模波导，其中，所述一个或多个流体单元中的每一个包括其一部分密封到所述涂覆区域的表面，所述表面包括凹陷，所述凹陷限定了至少在通过光学曝光区域的一部分，以及用于将流体样品引入流体通道的样品引入口; （3）通过样品引入口将流体样品引入流体通道，使得流体样品物理地接触光学曝光区域; （4）将光发射到波导中以在光学曝光区域产生波; 以及（5）响应于所述波检测在所述光学曝光区域产生的光信号，其中所述光信号与所述流体样品中存在朊病毒蛋白相关。示例性的波导器件包括多模波导，其具有限定反射涂覆区域和表面上的光学曝光区域的表面承载图案化反射涂层，其中一个或多个第一抗体共价键合或非共价固定在光学曝光区域上并且其中所述一种或多种第一抗体选择性地结合朊病毒蛋白。

5. 发明申请

WO2010016832A1 MEDICAL DEVICES FOR USE IN THE SURGICAL TREATMENT OF HYPERPROLIFERATIVE DISEASES AFFECTING THE SPINAL CORD 审中-公开
标题翻译：用于影响脊髓的高增殖性疾病的手术治疗的医疗装置
公开(公告)号：WO2010016832A1
公开(公告)日：2010-02-11
申请号：PCT/US2008/072226
申请日：2008-08-05
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LANGER, Robert S. , SAIGAL, Rajiv , TENG, Yang , WOODARD, Eric
发明人： LANGER, Robert S. , SAIGAL, Rajiv , TENG, Yang , WOODARD, Eric
IPC分类号： A61N1/00 , A61K9/22
CPC分类号： A61L27/14 , A61L27/58 , A61L2430/38 , A61N1/326
摘要： Provided herein are new methods for the treatment of hyperproliferative diseases affecting the spinal cord, including the use of biodegradable polymers to treat spinal cord tumor recessing, i.e., to patch open zones left by spinal tumor removal. Biocompatible polymeric materials are tailored to fill areas previously occupied by tumors, e.g., materials in the form of tubular articles configured for insertion into the spinal column after surgical removal of a tumor. These protective articles may also include medicinal agents that stimulate spinal column neural regeneration, such as medicines or donor neuronal cells such as human neural stem cells, thus assisting patients to recover motorsensory function after spinal tumor surgery.
摘要翻译：本文提供了用于治疗影响脊髓的过度增生性疾病的新方法，包括使用可生物降解的聚合物来治疗脊髓肿瘤凹陷，即通过脊髓肿瘤去除留下的开放区域。生物相容的聚合物材料被调整以填补先前由肿瘤占据的区域，例如被构造成在手术切除肿瘤后插入到脊柱中的管状制品形式的材料。这些保护制品还可以包括刺激脊柱神经再生的药剂，例如药物或供体神经元细胞例如人神经干细胞，从而帮助患者恢复脊髓肿瘤手术后的感觉功能。

6. 发明申请

WO2009108921A3 OPTO-FLUIDIC NANOPARTICLE DETECTION APPARATUS 审中-公开
公开(公告)号：WO2009108921A3
公开(公告)日：2009-09-03
申请号：PCT/US2009/035683
申请日：2009-03-02
申请人： LEHIGH UNIVERSITY , OU-YANG, H., Daniel , CHENG, Xuanhong
发明人： OU-YANG, H., Daniel , CHENG, Xuanhong
IPC分类号： G01N21/25 , G01N21/64 , G01N33/48 , C12Q1/68
摘要： Provided herein are new methods and apparatus for quantitative measurement and analysis of particles, including new apparatus systems to process and detect nanoparticles in suspension. By focusing a laser beam at the center of a reservoir, nanoparticles are concentrated by optical energy, and fluorescent intensity at the focal point of the laser is measured to quantify particle concentration in the reservoir. The techniques may be applied to the analysis of suspensions of nanoparticles, including natural particles (e.g., microorganisms including whole viruses, bacteria, animal cells, and proteins) and synthetic particles (e.g., colloidal latexes, paints, pigments, and metallic or semiconductor nanoparticles) for medical and industrial applications, among others.

7. 发明申请

WO2008151208A1 RAPID SENSING OF TOXIC METALS WITH HYBRID INORGANIC MATERIALS 审中-公开
标题翻译：用混合无机材料快速感测有毒金属
公开(公告)号：WO2008151208A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/065706
申请日：2008-06-04
申请人： LEHIGH UNIVERSITY , SENGUPTA, Arup K. , CHATTERJEE, Prasun K.
发明人： SENGUPTA, Arup K. , CHATTERJEE, Prasun K.
IPC分类号： G01N27/26 , G01N27/06
CPC分类号： G01N33/1813
摘要： Methods for rapid sensing of dissolved toxic heavy metals use a hybrid inorganic material ("HIM"), which is synthesized from hydrated iron oxide ("HFO") and calcium magnesium silicate. HIM thus synthesized is used in sensing dissolved toxic heavy metals. Water containing toxic heavy metals ( e.g ., lead, copper, zinc, nickel, etc.) is passed through a sorbent bed of HIM, whereupon it shows a sharp drop in pH after a certain length of time. The presence of HFO and calcium magnesium silicates in HIM synergistically provide a precipitous drop in pH, which is characteristic of the concentration and type of toxic heavy metal. Therefore, observing a change in pH indicates the presence and identity of heavy metal ions in a test water sample.
摘要翻译：用于快速检测溶解的有毒重金属的方法使用由水合氧化铁（“HFO”）和硅酸钙镁合成的杂化无机材料（“HIM”）。因此合成的HIM用于检测溶解的有毒重金属。含有有毒重金属（例如铅，铜，锌，镍等）的水通过HIM的吸附剂床，于是在一段时间后，pH值显着下降。在HIM中HFO和硅酸镁镁的存在协同地提供了pH的急剧下降，这是有毒重金属的浓度和类型的特征。因此，观察pH值的变化表明测试水样品中重金属离子的存在和一致性。

8. 发明申请

WO2008028036A1 NANO/MACROPOROUS BONE TISSUE SCAFFOLDS FOR REGENERATIVE MEDICINE 审中-公开
标题翻译： NANO / MACROPOROUS骨组织用于再生医学
公开(公告)号：WO2008028036A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/077238
申请日：2007-08-30
申请人： LEHIGH UNIVERSITY , JAIN, Himanshu , MARQUES, Ana C. , ALMEIDA, Rui M.
发明人： JAIN, Himanshu , MARQUES, Ana C. , ALMEIDA, Rui M.
IPC分类号： A61L27/56 , A61L27/52
CPC分类号： A61L27/56 , A61L27/52
摘要： A biocompatible inorganic porous material having a three-dimensional coexistent network of interconnected macropores and nanopores produced by the steps of mixing an organic water-soluble polymer (e.g., polyethylene oxide or a block copolymer of ethylene oxide and propylene oxide), an alkoxysilane, and an inorganic water-soluble calcium salt in an aqueous acid solution, such that a sol-gel process of hydrolysis and polycondensation is initiated and thereby producing a gel; drying the gel to remove solvent by evaporation; and heating the gel to remove the polymer by thermal decomposition, thereby forming an inorganic porous material, which may be suitable for use as a bone tissue scaffold.
摘要翻译：具有互连的大孔和纳米孔的三维共存网络的生物相容性无机多孔材料，其通过将有机水溶性聚合物（例如聚环氧乙烷或环氧乙烷和环氧丙烷的嵌段共聚物），烷氧基硅烷和在酸性水溶液中的无机水溶性钙盐，开始水解和缩聚的溶胶 - 凝胶法，从而产生凝胶; 干燥凝胶以通过蒸发除去溶剂; 并加热凝胶以通过热分解除去聚合物，从而形成可适合用作骨组织支架的无机多孔材料。

9. 发明申请

WO2007120844A2 SYSTEM AND METHOD FOR SCREENING FOR FRAUD IN COMMERCIAL TRANSACTIONS 审中-公开
标题翻译：在商业交易中筛选欺诈的系统和方法
公开(公告)号：WO2007120844A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/009167
申请日：2007-04-12
申请人： CHIMENTO, Marc A.
发明人： CHIMENTO, Marc A.
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q20/00 , G06Q20/042 , G06Q20/4016 , G07D7/0047
摘要： A method for screening for potential fraud in commercial paper is provided. For example, a method of the invention comprises steps of presenting a check for cashing to a check cashing agent (e.g., a bank teller); scanning or inspecting the check for data; selecting data for analysis; analyzing selected data with a commercial paper fraud detection system ("CPFDS"); and reporting results of the fraud detection system analysis to the check cashing agent. The commercial paper fraud detection system provides a means for predicting if commercial paper is potentially fraudulent. For example, the commercial paper fraud detection system may detect stolen checks, altered checks, and fabricated or counterfeit checks, among other types of fraud. Also provided is a computer program product for detecting fraud in commercial paper.
摘要翻译：提供了一种在商业票据中筛选潜在欺诈的方法。例如，本发明的方法包括以下步骤：向支票兑现代理（例如银行柜员）提供兑现支票; 扫描或检查数据的检查; 选择数据进行分析; 用商业纸欺诈检测系统（“CPFDS”）分析所选数据; 并向支票兑现代理机构报告欺诈检测系统分析结果。商业票据欺诈检测系统提供了一种预测商业票据是否具有欺诈性的手段。例如，商业票据欺诈检测系统可以检测被盗检查，改变的检查，以及制造或伪造检查以及其他类型的欺诈。还提供了用于检测商业纸张中的欺诈的计算机程序产品。

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