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1. 发明申请

WO2007095634A2 PRION PROTEIN DETECTION 审中-公开
标题翻译： PRION蛋白检测
公开(公告)号：WO2007095634A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/062337
申请日：2007-02-16
申请人： HANSON TECHNOLOGIES, INC. , DYER, Maureen, Angela , HANSON, William, Paynter , MEEKER, Thrygve, Richard
发明人： DYER, Maureen, Angela , HANSON, William, Paynter , MEEKER, Thrygve, Richard
CPC分类号： G01N33/54373
摘要： An example embodiment of the invention includes a method of performing an assay comprising the steps of (1) providing a multimode waveguide; (2) fixing one or more fluidic cells to the multimode waveguide, wherein each of the one or more fluidic cells including a surface having a portion thereof sealed to the coated region, the surface including a depression therein defining a fluidic channel bounded at least in part by the optically exposed region, and a sample introduction port for the introduction of a fluid sample into the fluidic channel; (3) introducing a fluid sample into the fluidic channel via the sample introduction port so that the fluid sample physically contacts the optically exposed region; (4) launching light into the waveguide so as to produce a wave at the optically exposed region; and (5) detecting an optical signal generated at the optically exposed region in response to the wave, wherein the optical signal is correlated with the presence of a prion protein in the fluid sample. An example waveguide device comprises a multimode waveguide having a surface-bearing patterned reflective coating defining a reflectively coated region and an optically exposed region on the surface, wherein one or more first antibodies are covalently bonded to or non-covalently immobilized on the optically exposed region, and wherein the one or more first antibodies selectively binds a prion protein.
摘要翻译：本发明的示例性实施例包括执行测定的方法，包括以下步骤：（1）提供多模波导; （2）将一个或多个流体单元固定到多模波导，其中，所述一个或多个流体单元中的每一个包括其一部分密封到所述涂覆区域的表面，所述表面包括凹陷，所述凹陷限定了至少在通过光学曝光区域的一部分，以及用于将流体样品引入流体通道的样品引入口; （3）通过样品引入口将流体样品引入流体通道，使得流体样品物理地接触光学曝光区域; （4）将光发射到波导中以在光学曝光区域产生波; 以及（5）响应于所述波检测在所述光学曝光区域产生的光信号，其中所述光信号与所述流体样品中存在朊病毒蛋白相关。示例性的波导器件包括多模波导，其具有限定反射涂覆区域和表面上的光学曝光区域的表面承载图案化反射涂层，其中一个或多个第一抗体共价键合或非共价固定在光学曝光区域上并且其中所述一种或多种第一抗体选择性地结合朊病毒蛋白。

2. 发明申请

WO2007095634A8 PRION PROTEIN DETECTION 审中-公开
标题翻译： PRION蛋白检测
公开(公告)号：WO2007095634A8
公开(公告)日：2009-07-30
申请号：PCT/US2007062337
申请日：2007-02-16
申请人： HANSON TECHNOLOGIES INC , DYER MAUREEN ANGELA , HANSON WILLIAM PAYNTER , MEEKER THRYGVE RICHARD
发明人： DYER MAUREEN ANGELA , HANSON WILLIAM PAYNTER , MEEKER THRYGVE RICHARD
IPC分类号： G01N33/543
CPC分类号： G01N33/54373
摘要： A waveguide device comprises a multimode waveguide having a surface-bearing patterned reflective coating defining a reflectively coated region and an optically exposed region on the surface, wherein one or more first antibodies are covalently bonded to or non-covalently immobilized on the optically exposed region, and wherein the one or more first antibodies selectively binds a prion protein. Use of said device to detect prions.
摘要翻译：波导装置包括具有表面承载图案化反射涂层的多模波导，其限定了表面上的反射涂覆区域和光学曝光区域，其中一个或多个第一抗体共价键合或非共价固定在光学曝光区域上，并且其中所述一种或多种第一抗体选择性结合朊病毒蛋白。使用所述装置检测朊病毒。

3. 发明申请

WO2007095634A3 PRION PROTEIN DETECTION 审中-公开
标题翻译： PRION蛋白检测
公开(公告)号：WO2007095634A3
公开(公告)日：2008-04-03
申请号：PCT/US2007062337
申请日：2007-02-16
申请人： HANSON TECHNOLOGIES INC , DYER MAUREEN ANGELA , HANSON WILLIAM PAYNTER , MEEKER THRYGVE RICHARD
发明人： DYER MAUREEN ANGELA , HANSON WILLIAM PAYNTER , MEEKER THRYGVE RICHARD
IPC分类号： G01N33/543
CPC分类号： G01N33/54373
摘要： A waveguide device comprises a multimode waveguide having a surface-bearing patterned reflective coating defining a reflectively coated region and an optically exposed region on the surface, wherein one or more first antibodies are covalently bonded to or non-covalently immobilized on the optically exposed region, and wherein the one or more first antibodies selectively binds a prion protein. Use of said device to detect prions.
摘要翻译：波导装置包括具有表面承载图案化反射涂层的多模波导，其限定了表面上的反射涂覆区域和光学曝光区域，其中一个或多个第一抗体共价键合或非共价固定在光学曝光区域上，并且其中所述一种或多种第一抗体选择性结合朊病毒蛋白。使用所述装置检测朊病毒。

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