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1. 发明申请

WO2008055916A3 NEW ANTIGENS FOR PARATUBERCULOSIS DIAGNOSIS AND VACCINATION 审中-公开
公开(公告)号：WO2008055916A3
公开(公告)日：2008-05-15
申请号：PCT/EP2007/061954
申请日：2007-11-06
申请人： UNIVERSITE DE MONS HAINAUT , CERVA-CODA , INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE , LEROY, Baptiste , WATTIEZ, Ruddy , HUYGEN, Christiane A. J. , ROUPIE, Virginie , GOVAERT, Marc , GEORIS, Isabelle
发明人： LEROY, Baptiste , WATTIEZ, Ruddy , HUYGEN, Christiane A. J. , ROUPIE, Virginie , GOVAERT, Marc , GEORIS, Isabelle
IPC分类号： C07K14/35 , C12Q1/68 , A61K39/04
摘要： The present invention discloses new antigens of Mycobacterium avium subsp. paratuberculosis, antigenic compositions comprising at least two of said antigens, as well as epitopes, antibodies or hypervariable fragments thereof and nucleotide sequences coding for them. The present invention also concerns their use in diagnosis and/or vaccination against Mycobacterium avium subsp. paratuberculosis, in mammals, and in particular in cattle, but also in sheep and caprines. The invention also concerns their potential application in diagnosis and/or vaccination against Crohn's disease in human.

2. 发明申请

WO2007112518A1 LIVE ATTENUATED SALMONELLA VACCINE 审中-公开
标题翻译：活泼的SALMONELLA VACCINE
公开(公告)号：WO2007112518A1
公开(公告)日：2007-10-11
申请号：PCT/BE2006/000020
申请日：2006-03-30
申请人： VRIJE UNIVERSITEIT BRUSSEL , DE GREVE, Henri Marcel Jozef , ADRIAENSEN, Connie Theresia , HERNALSTEENS, Jean-Pierre Ernest Clément
发明人： DE GREVE, Henri Marcel Jozef , ADRIAENSEN, Connie Theresia , HERNALSTEENS, Jean-Pierre Ernest Clément
IPC分类号： C12N1/20 , G01N33/53 , A61K39/108 , A61K39/112 , A61P31/04
CPC分类号： A61K39/0275 , A61K39/0258 , A61K2039/522 , A61K2039/552 , G01N33/56916 , Y02A50/474 , Y02A50/482
摘要： The present invention is related to double and triple attenuated mutant strains of a bacterium infecting veterinary species such as Salmonella enterica and/or (a pathogenic) Escherichia coli. The mutants of the invention contain at least one first genetic modification and at least one second genetic modification, said first modification in one or more motility genes, and said second modification in one or more genes involved in the survival or the proliferation of the pathogen in the host. The present invention further relates to live attenuated vaccines based on such mutants for preventing amongst others Salmonellosis and/or an infection by an E. coli pathogen in a veterinary species.
摘要翻译：本发明涉及感染兽医物种如沙门氏菌和/或（致病性）大肠杆菌的细菌的双重或三重减毒突变菌株。本发明的突变体含有至少一种第一种遗传修饰和至少一种第二种遗传修饰，一种或多种运动性基因中的所述第一修饰，以及涉及病原体存活或增殖的一个或多个基因中的所述第二修饰主人。本发明还涉及基于这样的突变体的减毒疫苗，用于预防兽医物种中的沙门氏菌病和/或大肠杆菌病原体的感染。

3. 发明申请

WO2007041813A1 APPARATUS COMPRISING A BODY OF A HELICOID SHAPE ROLLING ON A BODY HAVING A HYPERBOLOID SHAPE 审中-公开
标题翻译：包含有一个具有高胆固醇形状的身体的HELICOID形状的身体的装置
公开(公告)号：WO2007041813A1
公开(公告)日：2007-04-19
申请号：PCT/BE2006/000110
申请日：2006-10-05
申请人： VRIJE UNIVERSITEIT BRUSSEL , KOOL, Patrick
发明人： KOOL, Patrick
IPC分类号： F16H37/12 , F16H25/22
CPC分类号： F16H25/186
摘要： The present invention is related to an apparatus, comprising a first body with a ruled surface being a helicoid, and a second body with a ruled surface being a hyperboloid, characterized in that the hyperboloid is arranged to roll over the helicoid essentially without longitudinal nor lateral slip. The invention is related in particular to apparatuses of this kind, arranged for transforming a linear into a rotational movement or vice versa.
摘要翻译：本发明涉及一种装置，其包括具有螺旋形的格状表面的第一主体和具有划线表面的双曲面的第二主体，其特征在于，所述双曲面被布置成基本上不旋转地纵向或横向地滚动螺旋体滑。本发明特别涉及这样的装置，其被布置为将线性变换成旋转运动，反之亦然。

4. 发明申请

WO2006130935A3 TITANIUM, TITANIUM ALLOY AND NiTi FOAMS WITH HIGH DUCTILITY 审中-公开
公开(公告)号：WO2006130935A3
公开(公告)日：2006-12-14
申请号：PCT/BE2006/000066
申请日：2006-06-07
申请人： VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK (VITO) , MULLENS, Steven , THIJS, Ivo , COOYMANS, Jozef , LUYTEN, Jan
发明人： MULLENS, Steven , THIJS, Ivo , COOYMANS, Jozef , LUYTEN, Jan
IPC分类号： B22F3/11 , B22F3/10
摘要： The present invention is related to a method for manufacturing a high ductility Ti-, Ti-alloy or NiTi-foam, meaning a compression strain higher than 10%, comprising the steps of: Preparing a powder suspension of a Ti-, NiTi- or Ti-alloy powder, Bring said powder suspension into a desired form by gelcasting to form a green artefact, A calcination step wherein said green artefact is calcined, and Sintering said artefact, characterised in that said calcination step comprises a slow heating step wherein said green artefact is heated at a rate lower or equal to 20°C/hour to a temperature between 400°C and 600°C and that the Ti-, NiTi- or Ti-alloy powder has a particle size less than 100 µm. A high ductility Ti-, Ti-alloy or NiTi-foam, with a compression higher than 10%, with a theoretical density less than 30%, pore size (cell size) between 50 to 1000µm can be obtained with such a method.

5. 发明申请

WO2006060886A1 PATIENT POSITIONING IMAGING DEVICE AND METHOD 审中-公开
标题翻译：患者定位成像装置及方法
公开(公告)号：WO2006060886A1
公开(公告)日：2006-06-15
申请号：PCT/BE2005/000183
申请日：2005-12-12
申请人： ION BEAM APPLICATIONS SA , AMELIA, Jean-claude , GENIN, Frédéric
发明人： AMELIA, Jean-claude , GENIN, Frédéric
IPC分类号： A61N5/10
CPC分类号： A61N5/1081 , A61N5/1049 , A61N5/1069 , A61N2005/1061 , A61N2005/1087
摘要： The present invention is related to a patient positioning imaging device for positioning a patient in a hadron therapy device provided with a rotatable gantry (20). The patient positioning imaging device comprises a rotatable structure (10) provided with an extensible arm or foldable pivoting arm (12) arranged for connecting an imaging beam source (121) and an extensible structure or foldable pivoting structure (14) arranged for carrying an imaging beam receiver (141). The rotatable structure (10) is arranged for taking CBCT shots of the patient while the patient is located in an offset position with respect to an isocentre of the hadron therapy device, said offset position being in the direction of a rotational axis of the rotatable gantry (20). The rotatable structure (10) is arranged for being rotated while the rotatable gantry (20) remains fixed, and while the extensible or pivoting arm (12) and the extensible or pivoting structure (14) are in extended or unfolded position.
摘要翻译：本发明涉及一种用于将患者定位在设置有可旋转机架（20）的强子治疗装置中的患者定位成像装置。患者定位成像装置包括设置有可伸缩臂或可折叠枢转臂（12）的可旋转结构（10），所述可伸缩臂或可折叠枢转臂（12）被布置用于连接成像束源（121）和可延展结构或可折叠枢转结构（14）光束接收器（141）。可旋转结构（10）布置成用于在患者位于相对于强子治疗装置的等中心的偏移位置中的患者的CBCT拍摄时，所述偏移位置在可旋转机架的旋转轴线的方向上（20）。可旋转结构（10）被布置成在可旋转机架（20）保持固定的同时旋转，并且当可伸展或枢转臂（12）和可伸展或枢转结构（14）处于伸展或展开位置时。

6. 发明申请

WO2006053406A1 REINFORCED CAPILLARY MEMBRANES AND PROCESS FOR MANUFACTURING THEREOF 审中-公开
标题翻译：增强毛细管膜及其制造方法
公开(公告)号：WO2006053406A1
公开(公告)日：2006-05-26
申请号：PCT/BE2005/000167
申请日：2005-11-18
申请人： VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK (VITO) , BECKERS, Herman , DOYEN, Willy
发明人： BECKERS, Herman , DOYEN, Willy
IPC分类号： B01D69/08 , B01D69/10
CPC分类号： B01D69/08 , B01D67/0011 , B01D67/0016 , B01D69/02 , B01D69/10 , B01D2325/40 , Y10T428/2935
摘要： A process for manufacturing asymmetric braid reinforced capillary ultra- or micro-filtration membranes (1), comprising the subsequent steps of pulling a tubular braid (5) through a spinneret (7) and coating the braid with a dope, characterised in that prior to said coating step, the braid is impregnated with a non-coagulation liquid, being a liquid which does not cause coagulation of said dope, when brought in contact with said dope. The result is a membrane with an outer skin, i.e. smaller pores near the outside diameter than near the inside diameter, and a coating which is closely arranged around the outside diameter of the braid, without any substantial penetration of the coating into the braid.
摘要翻译：一种用于制造不对称编织增强毛细管超微过滤膜（1）的方法，包括以下步骤：通过喷丝头（7）拉动管状编织物（5）并用涂料涂覆编织物，其特征在于，在所述涂布步骤，当与所述涂料接触时，所述编织物用非凝固液体浸渍，所述液体不会引起所述涂料的凝结。结果是具有外皮的膜，即靠近外径的外径较小的孔，以及围绕编织物的外径紧密布置的涂层，而涂层没有任何实质的穿透到编织物中。

7. 发明申请

WO2006026839A2 DEVICE FOR ATTACHING A PRINTING MEDIA ROLL TO A SHAFT 审中-公开
标题翻译：将印刷媒体连接到轴上的装置
公开(公告)号：WO2006026839A2
公开(公告)日：2006-03-16
申请号：PCT/BE2005/000136
申请日：2005-09-08
申请人： MUTOH EUROPE NV , SAMPSON, Rudy , SCHUDDINCK, Jo , VANDENBERGHE, Jef
发明人： SAMPSON, Rudy , SCHUDDINCK, Jo , VANDENBERGHE, Jef
IPC分类号： B41J15/04
CPC分类号： B41J15/04 , B41J3/4078 , B41J11/08
摘要： The present invention is related to a holder for attaching the core of a printing media roll to a shaft, said holder comprising one or more compressible discs which are arranged to be compressed and thereby expand radially, so that they clamp the holder to both the shaft and the core. The invention is equally related to a removable gutter which can be mounted on the printing area of a printing device.
摘要翻译：本发明涉及一种用于将打印介质辊的芯连接到轴的保持器，所述保持器包括一个或多个可压缩盘，其被布置成被压缩并由此径向扩张，使得它们将保持器夹紧到两个轴和核心。本发明同样涉及一种能够安装在打印装置的打印区域上的可移动沟槽。

8. 发明申请

WO2006000066A2 NUCLEOTIDE PYROPHOSPHATASE INHIBITOR AND COENZYME REGENERATING SYSTEMS 审中-公开
标题翻译：核苷酸磷酸酯酶抑制剂和重组体系统
公开(公告)号：WO2006000066A2
公开(公告)日：2006-01-05
申请号：PCT/BE2005/000104
申请日：2005-06-29
申请人： PURATOS Naamloze Vennootschap , PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
发明人： PARMENTIER, Sofie , VANDAMME, Eric , BEAUPREZ, Joeri , ARNAUT, Filip
IPC分类号： A21D2/02 , A21D8/04
CPC分类号： A21D2/02 , A21D8/042 , C12N9/14
摘要： The present invention is related to a method for inhibiting nicotinamide coenzyme degradation in a cereal flour or wheat based product, comprising the addition of an effective amount of nucleotide pyrophosphatase inhibitor to said cereal flour based product, product such as a wheat based product. A further aspect of the present invention is a nucleotide pyrophosphatase having an amino acid N-terminal sequence being (G)IDDRHEVDLPPRP. In another aspect of the present invention, a dough comprising a nucleotide pyrophosphatase inhibitor such as pyrophosphate, and optionally a coenzyme regeneration system comprising at least one NAD(P) or NAD(P)H dependent hydrogenase or dehydrogenase is disclosed. Preferably the coenzyme regeneration system comprises (consists of) mannitol dehydrogenase and D-fructose.
摘要翻译：本发明涉及一种抑制谷类粉或小麦基产品中烟酰胺辅酶降解的方法，包括向所述谷类粉基产品，例如小麦基产品等产品中加入有效量的核苷酸焦磷酸酶抑制剂。本发明的另一方面是具有氨基酸N-末端序列为（G）IDDRHEVDLPPRP的核苷酸焦磷酸酶。在本发明的另一方面，公开了一种包含核苷酸焦磷酸酶抑制剂如焦磷酸盐的面团，以及任选地包含至少一种NAD（P）或NAD（P）H依赖性氢化酶或脱氢酶的辅酶再生系统。优选地，辅酶再生系统包含（由甘露糖醇脱氢酶和D-果糖组成）。

9. 发明申请

WO2005117705A1 MEDICAL DEVICE ADAPTED TO THE MONITORING OF LIMB MUSCLE BEHAVIOUR IN PATIENTS 审中-公开
标题翻译：适用于LIMB肌肉行为监测患者的医疗器械
公开(公告)号：WO2005117705A1
公开(公告)日：2005-12-15
申请号：PCT/BE2005/000090
申请日：2005-06-03
申请人： UNIVERSITE LIBRE DE BRUXELLES , FCS CONTROL SYSTEMS , MANTO, Mario , VAN DER LINDE, Richard , LAMMERTSE, Piet
发明人： MANTO, Mario , VAN DER LINDE, Richard , LAMMERTSE, Piet
IPC分类号： A61B5/22
CPC分类号： A61B5/224 , A61B5/0488 , A61B5/1121 , A61B5/1126 , A61B5/6824 , A61B5/6825 , A61B5/6828
摘要： The present invention is related to a medical device for monitoring limb muscle behaviour in a patient, said limb corresponding to a leg, an arm, or the neck, said medical device comprising: - a moving unit (1) adapted to receive a first part of a limb, said moving unit (1) presenting at least one degree of freedom (11) according to which the moving unit (1) may move; - a haptic device (6) adapted to receive a second part of the limb and to measure in the form of an analogical signal the mechanical response of said second part to a movement of the moving unit (1); - a set of electromyographic electrodes (4) able to measure in the form of an analogical signal the electrical activities in the muscle(s) of the limb; - an analogical signal acquisition unit (9) able to acquire the analogical signals from the electromyographic electrodes and the haptic device (6) and converting said analogical signals into digital signals; - a controller (8) able to process said digital signals and to control the moving unit (1).
摘要翻译：本发明涉及一种用于监测患者的肢体肌肉行为的医疗装置，所述肢体对应于腿部，手臂或颈部，所述医疗装置包括： - 移动单元（1），适于接纳第一部分所述移动单元（1）具有至少一个自由度（11），所述移动单元（1）可移动; - 适于接收所述肢体的第二部分并且以模拟信号的形式测量所述第二部分对所述移动单元（1）的运动的机械响应的触觉装置（6）。 - 一组肌电图电极（4），能够以类似信号的形式测量肢体肌肉的电活动; - 能够从肌电图电极和触觉装置（6）获取模拟信号并将所述模拟信号转换为数字信号的模拟信号获取单元（9） - 能够处理所述数字信号并控制移动单元（1）的控制器（8）。

10. 发明申请

WO2005111180A1 ASSEMBLY OF MUTUALLY CO-OPERATING MACHINE PARTS, LUBRICATED WITH BIOLOGICALLY DECOMPOSABLE LUBRICANT 审中-公开
标题翻译：装配有生物分解润滑剂的混合动力机械部件
公开(公告)号：WO2005111180A1
公开(公告)日：2005-11-24
申请号：PCT/BE2005/000082
申请日：2005-05-19
申请人： CENTER ZA TRIBOLOGIJO IN TEHNICNO DIAGNOSTIKO FAKULTETA ZA STROJNISTVO , VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.(VITO) , VOLVO TECHNOLOGY AB , KALIN, Mitjan , VIZINTIN, Jozef , VERCAMMEN, Karen , MENEVE, Jan , NILSSON, Per, Henrik
发明人： KALIN, Mitjan , VIZINTIN, Jozef , VERCAMMEN, Karen , MENEVE, Jan , NILSSON, Per, Henrik
IPC分类号： C10M169/04
CPC分类号： C10M105/32 , C10M169/04 , C10M2207/2805 , C10M2207/401 , C10N2220/10 , C10N2230/06 , C10N2230/10
摘要： The present invention is related to the modification of mutually co-operating machine parts, in particular those surfaces of such parts, which are exposed to friction and wear, that even in such loading conditions, in which previously for the purposes of decreasing of friction coefficient and preventing of wear various mineral or synthetic lubricants had to be used, a sufficiently efficient lubrication could also be achieved by means of biologically decomposable lubricants, especially oils of plant sources and/or saturated and/or non-saturated esters, without reduction of efficiency and reliability of the lubrication as such. According to the invention, at least one of the said parts is equipped with the DLC-coating (diamond-like carbon), which leads to essential reduction of friction at least in the so-called boundary-friction conditions, and consequently also to decreasing of temperature, which normally has negative impact to durability of the lubricants, so that a biologically decomposable lubricant can then be applied either with or without included additives on the basis of biologically acceptable substances.
摘要翻译：本发明涉及相互协调的机器部件，特别是暴露于摩擦和磨损的这些部件的那些表面的修改，即使在以前为了降低摩擦系数的这种装载条件下必须使用各种矿物或合成润滑剂，防止磨损，还可以通过生物可分解的润滑剂，尤其是植物来源的油和/或饱和和/或非饱和酯来实现充分有效的润滑，而不降低效率以及润滑的可靠性。根据本发明，所述部件中的至少一个配备有DLC涂层（类金刚石碳），其至少在所谓的边界摩擦条件下导致摩擦力的重要降低，因此也降低的温度，其通常对润滑剂的耐久性具有负面影响，使得生物可分解的润滑剂随后可以基于生物学上可接受的物质施用或不包含添加剂。

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