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1. 发明申请

WO2017037108A1 SYNTHETIC NICHE MATRICES FOR STEM CELL CULTURE 审中-公开
标题翻译：用于干细胞培养的合成NICHE MATRICES
公开(公告)号：WO2017037108A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070500
申请日：2016-08-31
申请人： POLITECNICO DI MILANO , CONSIGLIO NAZIONALE DELLE RICERCHE , FONDAZIONE CASSA DI RISPARMIO DELLE PROVINCE LOMBARDE
发明人： RAIMONDI, Manuela Teresa , CERULLO, Giulio , OSELLAME, Roberto , REMUZZI, Andrea
IPC分类号： A61L27/56 , C12N5/00
CPC分类号： A61L27/3834 , A61L27/50 , A61L27/56 , A61L2400/18 , C12N5/0068 , C12N5/0606 , C12N5/0663 , C12N2533/30 , C12N2535/00
摘要： The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n x m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
摘要翻译：本发明涉及包含至少两个龛的基质的合成龛的超基质，其中每个基质包含nxm龛，并且其中基质与另一个之间的距离（d）大于零，并且其中在每个基质中，每个合成龛具有一个或更多的墙壁与其他基体的合成壁龛共同。支持细胞培养，其包括至少一种超基质，以及使用所述超基质或支持物进行体外培养细胞，特别是干细胞，或用于体内植入物，以促进组织或器官通过细胞再生的再生也在本发明的范围内。

2. 发明申请

WO2017037081A1 COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY 审中-公开
标题翻译：具有抗炎和抗氧化活性的化合物
公开(公告)号：WO2017037081A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/070453
申请日：2016-08-31
申请人： UNIVERSITÀ DEGLI STUDI DI FERRARA
发明人： PEDRINI, Paola , FERRO, Sergio
IPC分类号： C07J5/00 , A61K31/573 , A61P5/44 , A61P25/16 , A61P25/28
CPC分类号： C07J5/0053
摘要： The present invention relates to new compounds of formula (1) wherein R is -C(=O)CH 2 OH or -CH(OH)CH 2 OH; R 1 , is =O or OH; R 2 is H or OH; R 3 is H or C 1 -C 4 alkyl; R 4 is H or C 1 C 4 alkyl. These compounds are obtained by a process using at least one bacterium belonging to the Actinobacteria class, preferably belonging to the Rhodococcus genus. Thanks to their antiinflammatory and anti-oxidant properties, the compounds of the invention can be advantageously used in the treatment of inflammatory diseases, autoimmune diseases and of diseases in need of a joined anti-inflammatory and anti-oxidant activity.
摘要翻译：本发明涉及新的式（1）化合物，其中R是-C（= O）CH 2 OH或-CH（OH）CH 2 OH; R1，is = O或OH; R2是H或OH; R3是H或C1-C4烷基; R 4是H或C 1 -C 4烷基。这些化合物通过使用至少一种属于放线菌属类的细菌的方法获得，优选属于红球菌属。由于其抗炎和抗氧化性质，本发明的化合物可有利地用于治疗炎性疾病，自身免疫性疾病和需要联合抗炎和抗氧化活性的疾病。

3. 发明申请

WO2016128921A1 A METHOD FOR MANUFACTURING PAPER DISAGGREGATABLE IN AQUEOUS LIQUIDS AND A CONTINUOUS MACHINE FOR ITS MANUFACTURING 审中-公开
标题翻译：水性液体制造方法及其连续制造方法
公开(公告)号：WO2016128921A1
公开(公告)日：2016-08-18
申请号：PCT/IB2016/050721
申请日：2016-02-11
申请人： RONCO, Danilo
发明人： RONCO, Danilo , AVOLTINI, Roberto , BOZZI, Claudio , CRIPPA, Gianfranco
IPC分类号： D21F11/14
CPC分类号： D21F11/14
摘要： One object of the present invention is a method for producing disaggregatable paper, comprising the following steps: a) forming the paper web; b) drying the paper web, the drying being carried out by drainage, mechanical dewatering and/or evaporation to a dry content of about 30%, and the subsequent drying being carried out by evaporation; if required, a step b') of surface treatment, for example impregnation with detergents; and c) winding the web into a reel, wherein the web being formed must not be subjected to an open draw until it has reached a consistency of more than about 30% dry. Another object of the present invention is a continuous machine for producing disaggregatable paper, comprising: a) a forming section; b) a section for drying by drainage and/or mechanical dewatering and/or evaporation until the web has reached a dry percentage of about 30%; c) a controlled air blowing system, if required; d) a further evaporation drying section; and e) a winding section, wherein the first open draw is provided when the web has reached a consistency of more than about 30% dry.
摘要翻译：本发明的一个目的是一种生产可分解纸的方法，包括以下步骤：a）形成纸幅; b）干燥纸幅，通过排水进行干燥，机械脱水和/或蒸发至约30％的干燥含量，随后通过蒸发进行干燥; 如果需要，进行表面处理的步骤b'），例如用洗涤剂浸渍; 以及c）将卷材卷绕到卷轴中，其中所形成的卷材不得经受开放拉伸，直到达到大于约30％干燥度的稠度。本发明的另一个目的是一种用于生产可分解纸的连续机器，包括：a）成形部分; b）通过排水和/或机械脱水和/或蒸发进行干燥的部分，直到幅材达到约30％的干燥百分比; c）如果需要，可以控制吹气系统; d）另外的蒸发干燥段; 以及e）卷绕部分，其中当幅材已经达到大于约30％干燥度的稠度时，提供第一开放拉伸。

4. 发明申请

WO2016046721A1 LOADING AND FEEDING DEVICE OF A BOOKBINDING STITCHING MACHINE 审中-公开
标题翻译： BOOKBINDING缝纫机的装载和送料装置
公开(公告)号：WO2016046721A1
公开(公告)日：2016-03-31
申请号：PCT/IB2015/057251
申请日：2015-09-21
申请人： MEGRAF S.R.L. SOCIETA UNIPERSONALE
发明人： LICCIONE, Mauro
IPC分类号： B42C1/12 , B42C5/04 , B42C7/00 , B42C19/02 , B42C19/08 , B65H3/08 , B65H45/26 , B65H45/30
CPC分类号： B42C19/08 , B42C1/125 , B42C5/04 , B42C7/008 , B42C19/02 , B65H1/22 , B65H1/30 , B65H3/10 , B65H45/26 , B65H45/30 , B65H2701/1932 , B65H2801/48
摘要： A device (100) for the loading and feeding of a bookbinding stitching machine is described which allows the stitching machine to be fed without interruption and comprises a. means (101) for advancing sheets of paper (111), where said sheets are arranged in scaled manner and said means (101) are operated by a first motor (102); b. downwardly with respect to said means for advancing (101), is provided a housing 105 for said sheets of paper; c. a suction drum (103), operated by a second motor (104), is located below said housing (105), said drum (103) being capable of picking up said sheets from below; d. a counting system (106) of said sheets is located in said housing (105); e. one or more advancing drums (109) is or are downwardly located with respect to said housing (105); f. one or more creasing drums (107) is or are downwardly arranged with respect to said one ore more advancing drums 8109); g. one or more folding belts (108) is or are downwardly arranged with respect to said creasing drums (107).
摘要翻译：描述了用于装订和输送装订缝纫机的装置（100），其允许缝合机器不间断地进给，并且包括a。用于推进纸张（111）的装置（101），其中所述纸张按比例排列，并且所述装置（101）由第一电动机（102）操作; 湾相对于前进装置（101）向下方设置有用于所述纸张的壳体105; C。由第二马达（104）操作的吸盘（103）位于所述壳体（105）的下方，所述滚筒（103）能够从下方拾取所述片材; 天。所述纸张的计数系统（106）位于所述壳体（105）中; 即一个或多个前进滚筒（109）相对于所述壳体（105）向下定位; F。一个或多个折痕鼓（107）相对于所述一个或多个前进滚筒8109或向下布置; G。一个或多个折叠带（108）相对于所述折痕鼓（107）向下布置。

5. 发明申请

WO2015150171A1 POLYMORPHIC MIXTURE OF RIFAXIMIN AND ITS USE FOR THE PREPARATION OF SOLID FORMULATIONS 审中-公开
标题翻译：利福霉素的多晶混合物及其制备固体制剂的用途
公开(公告)号：WO2015150171A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/056304
申请日：2015-03-24
申请人： EUTICALS SPA
发明人： GRISENTI, Paride , ARGESE, Maria , PENGO, Daniele , GRILLI, Maria Donata , FUMAGALLI, Emanuela , MOTTA, Giuseppe
IPC分类号： C07D498/22 , A61K31/395 , A61P31/04
CPC分类号： C07D498/22 , A61K9/2095 , A61K9/28 , A61K9/2893 , A61K31/437
摘要： A Rifaximin polymorphic mixture of α/β form in a relative ratio of 85/15 ± 3 and a process for its preparation are herein disclosed. Said polymorphic mixture of Rifaximin is also disclosed for use as a medicament, in particular in the treatment of traveler's diarrhea and hepatic encephalopathy. A pharmaceutical composition comprising said polymorphic mixture of Rifaximin as active ingredient, in particular a solid formulation, more in particular a film coated tablet are disclosed. A polymorphic form of crude wet rifaximin and of purified wet rifaximin and their use as intermediates in a process for the preparation of Rifaximin polymorphic mixture of α/β form in a relative ratio of 85/15 ± 3 are also disclosed.
摘要翻译：本文公开了相对比例为85/15±3的α/β形式的利福昔明多晶型混合物及其制备方法。还公开了利福昔明的多晶型混合物用作药物，特别是用于治疗旅行者腹泻和肝性脑病。公开了包含作为活性成分的所述多晶型混合物，特别是固体制剂，更特别是薄膜包衣片剂的药物组合物。还公开了粗制湿利福昔明和纯化的湿利福昔明的多晶型物及其在制备相对比率为85/15±3的α/β型的利福昔明多晶型混合物的方法中作为中间体的用途。

6. 发明申请

WO2015063127A1 SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT 审中-公开
标题翻译：系统提供自适应膈肌和/或子系统电动脊髓刺激，以便在神经元损伤后进行修复和恢复机械
公开(公告)号：WO2015063127A1
公开(公告)日：2015-05-07
申请号：PCT/EP2014/073183
申请日：2014-10-29
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： COURTINE, Grégoire , WENGER, Nikolaus , MARTIN MORAUD, Eduardo , MICERA, Silvestro , BONIZZATO, Marco
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/112 , A61B5/1121 , A61B5/1127 , A61B5/4836 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , A61N1/0551 , A61N1/36003 , A61N1/36103 , A61N1/36135 , A61N1/36139
摘要： The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: a) means for applying to a subject neuromodulation with adjustable stimulation parameters, said means a) being operatively connected with b) a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system b) being operatively connected with c) a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means a) and providing said means a) with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
摘要翻译：本发明提供了一种用于硬膜外和/或硬膜下电刺激的实时控制的闭环系统，包括：a）用可调节刺激参数施加到受试者神经调节的装置，所述装置a）与b）实际连接时间监测部件，包括传感器连续获取来自所述对象的反馈信号，所述信号是提供所述对象的运动特征的神经信号和/或信号，所述系统b）可操作地连接c）信号处理装置，其接收所述反馈信号和操作实时自动控制算法，所述信号处理装置与所述装置a）可操作地连接，并以最小的延迟提供所述装置a）新的刺激参数。本发明的系统提高了在具有神经运动障碍的受试者中行走的一致性。使用实时自动控制算法，其包括采用单输入单输出模型（SISO）或多输入单输出（MISO）模型的前馈分量。

7. 发明申请

WO2015018700A1 PORPHYRINOID COMPOUNDS, METHOD AND APPARATUS FOR WATER PHOTODISINFECTION 审中-公开
标题翻译：吡啶类化合物，水分光电效应的方法和装置
公开(公告)号：WO2015018700A1
公开(公告)日：2015-02-12
申请号：PCT/EP2014/066348
申请日：2014-07-30
申请人： NIMARTECH LIMITED
发明人： GUIDOLIN, Laura , COPPELLOTTI, Olimpia
IPC分类号： A01N43/90 , A61L2/18 , C02F1/50 , A01P1/00 , A01N25/10
CPC分类号： C09B47/00 , A01N43/90 , A61L2/084 , A61L2202/11 , C02F1/30 , C02F1/50 , C02F1/68 , C02F1/72 , C02F2201/002 , C02F2303/04 , C02F2305/023 , C09B68/4253 , Y02W10/37 , A01N25/10 , A01N25/34
摘要： The present invention relates to disinfection of water polluted by microbial pathogens through the use of photosensitizers. The photosensitizer is a porphyrinoid which is part of an adduct comprising a resin, a spacer and said porphyrinoid. An apparatus wherein said adduct is excited by light sources and water is disinfected while flowing inside the apparatus is also provided. A system for the disinfection of water comprising said apparatus and further elements is also within the scope of the invention.
摘要翻译：本发明涉及通过使用光敏剂消毒微生物病原体污染的水。光敏剂是卟啉类，其是包含树脂，间隔子和所述卟啉类的加合物的一部分。还提供了一种装置，其中所述加合物由光源和水激发，同时在装置内流动时对其进行消毒。包括所述装置和其它元件的用于消毒水的系统也在本发明的范围内。

8. 发明申请

WO2012013704A1 PARTICLE COMPRISING CYTOKINES, ANTIBODIES AND POLYMERS AND USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：包含细胞因子，抗体和聚合物的颗粒以及作为治疗癌症的药物使用
公开(公告)号：WO2012013704A1
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062907
申请日：2011-07-27
申请人： CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCRL , KROL, Silke
发明人： KROL, Silke
IPC分类号： A61K9/16 , A61K9/51 , A61K38/20 , A61K38/21 , A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/146 , A61K38/2013 , A61K38/2026 , A61K38/217 , A61K39/395 , A61K2300/00
摘要： The present invention refers to a particle comprising cytokines with an antibody, connected to a polymer, which release the cytokines and the antibody in the extracellular environment of the tumor site, providing a guided and enhanced immune response. It also refers to said particle for use a medicament, in particular for use as drug delivery system and as an anticancer agent, to pharmaceutical composition and a process for the preparation thereof.
摘要翻译：本发明涉及包含与聚合物连接的具有抗体的细胞因子的颗粒，所述抗体在肿瘤部位的细胞外环境中释放细胞因子和抗体，提供引导和增强的免疫应答。它还涉及用于使用药物，特别是用作药物递送系统和作为抗癌剂的药物组合物的所述颗粒及其制备方法。

9. 发明申请

WO2010095082A1 HIGH SAFETY LITHIUM-ION BATTERY 审中-公开
标题翻译：高安全性锂离子电池
公开(公告)号：WO2010095082A1
公开(公告)日：2010-08-26
申请号：PCT/IB2010/050655
申请日：2010-02-12
申请人： UNIVERSITA' DEGLI STUDI DI ROMA LA SAPIENZA , ZENTRUM FUR SONNENENERGIE-UND WASSERSTOFF-FORSCHUNG BADEN WURTTEMBERG , SCROSATI, Bruno , REALE, Priscilla , FERNICOLA, Alessandra , TILLMETZ, Werner , WOHLFAHRT-MEHRENS, Margret , KUBIAK, Pierre
发明人： SCROSATI, Bruno , REALE, Priscilla , FERNICOLA, Alessandra , TILLMETZ, Werner , WOHLFAHRT-MEHRENS, Margret , KUBIAK, Pierre
IPC分类号： H01B1/00 , C07D207/00 , H01M10/0525 , H01M10/0569
CPC分类号： H01M10/0569 , H01B1/122 , H01M4/36 , H01M4/485 , H01M4/5825 , H01M10/052 , H01M10/0525 , Y02E60/122
摘要： A Lithium-Ion battery characterised in that it comprises: a. an ionic liquid consisting of a cationic portion of quaternary ammonium of formula R 1 N+R 2 R 3 R 4 where: R 1 is a linear or branched alkyl with from 2 to 5 carbon atoms, optionally substituted with an ethyl alkoxy group with from 1 to 3 carbon atoms; R 2 , R 3 e R 4 , being the same or different, are a linear or branched alkyl with from 2 to 5 carbon atoms, or R 3 and R 4 , together with the nitrous atom to which they are bound form a pyrrolidinium or piperidinium; b. an anionic part, wherein the anion is selected form the group consisting of: bis(methantrifluoridesulphonyl)imide, tetrafluorideborate, esafluoridephosphate; c. a lithium salt selected form the group consisting of lithium N,N- (bis(methantrifluoridesulphonyl)imide, lithium tetrafluorideborate, lithium esafluoridephosphate and lithium bisoxalateborate; is disclosed. The battery is safe thanks to the high thermal stability of the ionic liquid as used in the present invention, without additives, as flame retardant or other additives, being suitable for the use in the field of mobile electronic, sustainable transportation and Renewable energy.
摘要翻译：一种锂离子电池，其特征在于它包括：a。由式R1N + R2 R3 R4的季铵的阳离子部分组成的离子液体，其中：R1是具有2至5个碳原子的直链或支链烷基，任选被具有1至3个碳原子的乙基烷氧基取代; R2，R3e R4相同或不同，是具有2至5个碳原子的直链或支链烷基，或者R3和R4与它们所连接的亚硝基一起形成吡咯烷鎓或哌啶鎓; 湾阴离子部分，其中所述阴离子选自：双（三氟甲磺酰基）酰亚胺，四氟硼酸盐，五氟磷酸盐; C。选自由N，N-（双（甲基三氟化磺酰基）酰亚胺锂，四氟硼酸锂，五氟磷酸锂和双草酸硼酸锂组成的组中的锂盐;由于离子液体的高热稳定性，如本发明无添加剂作为阻燃剂或其它添加剂，适用于移动电子，可持续运输和可再生能源领域。

10. 发明申请

WO2010052665A2 GOLD NANOPARTICLES COATED WITH POLYELECTROLYTES AND USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CAUSED BY PROTEIN AGGREGATES 审中-公开
标题翻译：用聚电解质涂覆的金纳米颗粒，并用作治疗由蛋白质聚集体引起的神经损伤性疾病的药物
公开(公告)号：WO2010052665A2
公开(公告)日：2010-05-14
申请号：PCT/IB2009/054922
申请日：2009-11-05
申请人： CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCRL , SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI - S.I.S.S.A. , LEGNAME, Giuseppe Antonio , KROL, Silke , COSTA DE SOUSA, Maria Fernanda
发明人： LEGNAME, Giuseppe Antonio , KROL, Silke , COSTA DE SOUSA, Maria Fernanda
IPC分类号： A61K9/51
CPC分类号： A61K9/5169
摘要： It is described a gold nanoparticle coated with from two to five layers of a combination of a polyelectrolyte having amino functionality and a polyelectrolyte having sulfonic functionality, or with one single layer of said polyelectrolyte having amino functionality, preferably polyallylamine, or sulfonic functionality, preferably polystyrenesulfonic, characterized in that said nanoparticle comprises an outer layer of albumin. It is also described the process for its preparation, its use as carriers intended to cross blood-brain barrier and its use as medicament, in particular for treatment of neurodegenerative diseases, more in particular of diseases caused by protein aggregates, such as prion diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis. Also described are pharmaceutical compositions comprising said nanoparticle.
摘要翻译：描述了由二至五层涂覆有具有氨基官能团的聚电解质和具有磺酸官能团的聚电解质的组合的金纳米颗粒，或者与具有氨基官能团的所述聚电解质的一个单层，优选聚烯丙胺或磺酸官能团，优选聚苯乙烯磺酸其特征在于，所述纳米颗粒包含白蛋白的外层。还描述了其制备方法，其用作用于跨血脑屏障的载体及其作为药物的用途，特别是用于治疗神经变性疾病，特别是由蛋白质聚集体引起的疾病如朊病毒疾病，阿尔茨海默氏病，帕金森病，亨廷顿病和肌萎缩性侧索硬化。还描述了包含所述纳米颗粒的药物组合物。

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