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1. 发明申请

WO2021026383A1 STALL DETECTION FOR AUTOLOADER AXES 审中-公开
公开(公告)号：WO2021026383A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/045258
申请日：2020-08-06
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： NEWBERG, Nicholas , DJELOSEVIC, Prentash , STEARRETT, Aaron
IPC分类号： G05B19/4062
摘要： A stall detection system is provided that determines if a glass slide in motion during an automated process is at risk for being damaged and stops motion in the event of an unacceptable risk of damage. The system includes one or more motors configured to move a glass slide (directly or indirectly). The motors are configured to generate a load resistance value. The system includes one or more processors that monitor the load resistance value of a motor during motion and compares the load resistance value to a predetermined threshold resistance value to determine the risk of a glass slide being damaged. The predetermined threshold resistance value may correspond to a risk of slide breakage in response to a force applied to any surface of the slide, or a risk of losing a controlling grip on a slide rack, or a risk of a motor skipping a motor step.

2. 发明申请

WO2020243545A1 COMPUTER SUPPORTED REVIEW OF TUMORS IN HISTOLOGY IMAGES AND POST OPERATIVE TUMOR MARGIN ASSESSMENT 审中-公开
公开(公告)号：WO2020243545A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035286
申请日：2020-05-29
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： GEORGESCU, Walter
IPC分类号： G06T7/00
摘要： A computer apparatus and method for identifying and visualizing tumors in a histological image and measuring a tumor margin are provided. A CNN is used to classify pixels in the image according to whether they are determined to relate to non-tumorous tissue, or one or more classes for tumorous tissue. Segmentation is carried out based on the CNN results to generate a mask that marks areas occupied by individual tumors. Summary statistics for each tumor are computed and supplied to a filter which edits the segmentation mask by filtering out tumors deemed to be insignificant. Optionally, the tumors that pass the filter may be ranked according to the summary statistics, for example in order of clinical relevance or by a sensible order of review for a pathologist. A visualization application can then display the histological image having regard to the segmentation mask, summary statistics and/or ranking. Tumor masses extracted by resection are painted with an ink to highlight its surface region. The CNN is trained to distinguish ink and no-ink tissue as well as tumor and no-tumor tissue. The CNN is applied to the histological image to generate an output image whose pixels are assigned to the tissue classes. Tumor margin status of the tissue section is determined by the presence or absence of tumor-and-ink classified pixels. Tumor margin involvement and tumor margin distance are determined by computing additional parameters based on classification-specified inter-pixel distance parameters.

3. 发明申请

WO2019133538A2 PROCESSING OF HISTOLOGY IMAGES WITH A CONVOLUTIONAL NEURAL NETWORK TO IDENTIFY TUMORS 审中-公开
公开(公告)号：WO2019133538A2
公开(公告)日：2019-07-04
申请号：PCT/US2018/067349
申请日：2018-12-21
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： GEORGESCU, Walter , OLSON, Allen , ANNALDAS, Bharat , LAWLER, Darragh , SHIELDS, Kevin , SALIGRAMA, Kiran , GREGSON, Mark
IPC分类号： G06T7/00
摘要： A convolutional neural network CNN is applied to identifying tumors in a histological image. The CNN has one channel assigned to each of a plurality of tissue classes that are to be identified, there being at least one class for each of non-tumorous and tumorous tissue types. Multi-stage convolution is performed on image patches extracted from the histological image followed by multi-stage transpose convolution to recover a layer matched in size to the input image patch. The output image patch thus has a one-to-one pixel-to-pixel correspondence with the input image patch such that each pixel in the output image patch has assigned to it one of the multiple available classes. The output image patches are then assembled into a probability map that can be co-rendered with the histological image either alongside it or over it as an overlay. The probability map can then be stored linked to the histological image.

4. 发明申请

WO2018132096A1 AIRCRAFT PASSENGER CABIN AIRFLOW METERING 审中-公开
公开(公告)号：WO2018132096A1
公开(公告)日：2018-07-19
申请号：PCT/US2017/013058
申请日：2017-01-11
申请人： PATS AIRCRAFT, LLC
发明人： PAQUETTE, Tobias
IPC分类号： F16K17/16 , B64C1/00 , B64C1/18 , B64C13/00 , B64C13/02 , B64C13/04
CPC分类号： B64C1/18 , B64C1/00 , B64C2001/009 , F16K17/16
摘要： An aircraft passenger cabin airflow metering apparatus and system is provided. The apparatus includes a blowout disc designed to release at a predetermined air pressure differential on opposite sides of the blowout disc. The blowout disc may include a cutout to allow a desired amount of airflow during normal operation. The apparatus is affixed to an existing structure in a frame bay at the perimeter of the passenger cabin floor level of the aircraft. The airflow metering system includes a combination of airflow metering apparatuses placed within discrete rooms of an aircraft passenger cabin to achieve positive pressure in the passenger cabin and the desired amount of airflow exhaust from the passenger cabin during normal operation across all areas of the aircraft and to also achieve the desired amount of airflow during abnormal operation when the air pressure on either side of the airflow metering apparatus exceeds a predetermined threshold.

5. 发明申请

WO2017204874A1 A COMPOSITION AND METHOD OF USING MIR-302 PRECURSORS AS ANTI-CANCER DRUGS FOR TREATING HUMAN LUNG CANCER 审中-公开
标题翻译： MIR-302前体药物作为抗癌药物治疗人肺癌的组成和方法
公开(公告)号：WO2017204874A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/019511
申请日：2017-02-24
申请人： LIN, Shi-Lung , WU, David TS
发明人： LIN, Shi-Lung , WU, David TS , LU, Hsuan-hsuan
IPC分类号： C12N15/11 , C12N15/113 , C12N15/79 , C12Q1/68
摘要： This invention generally relates to a composition and method of using mam-made small RNAs, such as small interfering RNAs (siRNA), microRNAs (miRNA) and their hairpin-like precursors (pre-miRNA), as tumor suppressing anti-cancer drugs for treating human tumors and cancers, in particular, but not limited, for treating skin (melanoma), blood (leukemia), prostate, breast, liver and lung cancers as well as various neoplastic tumors, such as brain tumors and teratocarcinomas that contain a variety of tumorous and cancerous cells derived from all three germ layers of tissues, including ectoderm, mesoderm and endoderm. More specifically, the present invention relates to the use of miR-302-like siRNA (siR-302) and/or miR-302 precursors (pre-miR-302) for developing novel medicines and therapies against a variety of human cancers, in particular lung cancers.
摘要翻译：本发明一般涉及使用哺乳动物小RNA如小干扰RNA（siRNA），微小RNA（miRNA）及其发夹样前体（pre-miRNA）的组合物和方法，作为用于治疗人类肿瘤和癌症的肿瘤抑制性抗癌药物，特别但不限于用于治疗皮肤（黑素瘤），血液（白血病），前列腺癌，乳腺癌，肝癌和肺癌以及各种肿瘤性肿瘤，例如脑肿瘤和畸胎癌，其中含有来源于组织的所有三个胚层的各种肿瘤和癌细胞，包括外胚层，中胚层和内胚层。更具体地，本发明涉及miR-302样siRNA（siR-302）和/或miR-302前体（pre-miR-302）用于开发针对多种人类癌症的新药和疗法的用途，特别是肺癌。

6. 发明申请

WO2017139794A3 BOWEL CARE USING IONTOPHORESIS 审中-公开
公开(公告)号：WO2017139794A3
公开(公告)日：2017-08-17
申请号：PCT/US2017/017717
申请日：2017-02-13
申请人： UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： KORSTEN, Mark A. , BAUMAN, William A.
IPC分类号： A61K31/407 , A61K31/4015 , A61N1/30 , A61M31/00
摘要： The present disclosure provides compositions and methods for on-going bowel care for persons with chronic intestinal pseudo-obstruction. The compositions and methods can be administered in a non-clinical setting. The compositions comprise acetylcholinesterase inhibitors for stimulating motility of the bowel in combination with anti-cholinergic agents to counteract the potentially dangerous cardiac side effects of the acetylcholinesterase inhibitor. In some examples, the acetylcholinesterase inhibitor, neostigmine, and the anti-cholinergic agent, glycopyrrolate, are combined in a pharmaceutical composition. Certain examples also provide the frequency and duration of administration of the disclosed drug combinations.

7. 发明申请

WO2016197020A1 MULTIPLE DEVICE WRIST BAND 审中-公开
标题翻译：多设备手带
公开(公告)号：WO2016197020A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035860
申请日：2016-06-03
申请人： STREBE, Matthew
发明人： STREBE, Matthew
IPC分类号： G04G17/06 , G04B37/14 , A44C5/14 , A44C5/00
CPC分类号： A44C5/0053 , G04G17/083
摘要： A multiple segment wrist band for securing multiple devices to the wrist of a user is provided. The first segment includes a first half of the band clasp on its first end and a first device connector on its second end. The second segment includes a first device connector on its first end and a second device connector on its second end. The third segment includes a second device connector on its first end a second half of the band clasp on its second end. The length of the second segment approximates the curved distance between the top of the user's wrist and the bottom of the user's wrist and thereby securely positions the first device and the second device on opposite sides of the user's wrist when the first and third segments are clasped together.
摘要翻译：提供了用于将多个设备固定到用户手腕的多段腕带。第一段包括其第一端上的带扣的前半部分和其第二端上的第一设备连接器。第二段包括其第一端上的第一设备连接器和其第二端上的第二设备连接器。第三部分包括在其第一端上的第二装置连接器，在其第二端具有带扣的第二半部分。第二段的长度近似于使用者手腕的顶部和使用者的手腕的底部之间的弯曲距离，从而当第一和第三段被扣紧时将第一装置和第二装置牢固地定位在使用者手腕的相对侧上一起。

8. 发明申请

WO2015095802A1 SYSTEM FOR DETERMINING THE POSITION, SPEED, OR TRAJECTORY OF A SPORTS OBJECT 审中-公开
标题翻译：用于确定运动对象的位置，速度或轨迹的系统
公开(公告)号：WO2015095802A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071689
申请日：2014-12-19
申请人： S&R SPORTS, INC.
发明人： ROSEN, Stephen D. , SEUFERT, Norbert R. , SANCHEZ, Jorge , FONTANA, Michael
IPC分类号： A63B71/00 , A63B71/06 , A63B65/00
CPC分类号： A63B71/06 , A63B63/00 , A63B65/00 , A63B71/0605 , A63B2024/0034 , A63B2024/0043
摘要： Systems for determining motion characteristics of a sports object. In an embodiment, the system comprises a light grid structure and a processor. The light grid structure comprises a frame and light-source assemblies and photo-detector assemblies. Each of the light-source assemblies and photo-detector assemblies is mounted on the frame such that each light-source assembly is on an opposite side of the frame than a corresponding photo-detector assembly, and each light-source assembly emits a light beam which is detected by its corresponding photo-detector assembly. The processor receives data that is based on outputs of the photo-detector assemblies. The data indicates light beam(s) which have been interrupted. Based on the data, the processor determines motion characteristic(s) of an object which interrupted the light beam(s).
摘要翻译：用于确定运动物体的运动特性的系统。在一个实施例中，该系统包括光栅结构和处理器。光栅结构包括框架和光源组件和光电检测器组件。每个光源组件和光电检测器组件安装在框架上，使得每个光源组件位于框架的与相应的光电检测器组件相反的一侧，并且每个光源组件发射光束其由其相应的光电检测器组件检测。处理器接收基于光检测器组件的输出的数据。数据表示已被中断的光束。基于该数据，处理器确定中断光束的对象的运动特性。

9. 发明申请

WO2022066666A1 DETECTION OF ALTERED DOCUMENTS 审中-公开
公开(公告)号：WO2022066666A1
公开(公告)日：2022-03-31
申请号：PCT/US2021/051363
申请日：2021-09-21
申请人： MONEYTHUMB LLC
发明人： MAYER, Ralph , GILES, Erik
IPC分类号： G06F7/04
摘要： Analyzing and detecting altered documents is accomplished by accessing a target portable document format (PDF) document and extracting document content information from the target PDF document. The extracted document content information is analyzed to generate an intra document model for the target PDF document and then the extracted document content information is evaluated in accordance with the intra document model. Artifacts in the document content information are identified and an intra document score is determined based on the identified artifacts and their respective weightings. The document content information is evaluated again in accordance with one or more inter document models and artifacts in the document content information are again identified and an inter document score is similarly determined. A total alteration score is also determined based on the intra document score and inter document score.

10. 发明申请

WO2020243583A1 ARTIFICIAL INTELLIGENCE PROCESSING SYSTEM AND AUTOMATED PRE-DIAGNOSTIC WORKFLOW FOR DIGITAL PATHOLOGY 审中-公开
公开(公告)号：WO2020243583A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035342
申请日：2020-05-29
申请人： LEICA BIOSYSTEMS IMAGING, INC.
发明人： GEORGESCU, Walter , SALIGRAMA, Kiran , LUNA, Carlos , LAWLER, Darragh , LACEY, Claude
IPC分类号： G16H30/20 , G16H30/40 , G16H50/20
摘要： A digital pathology system comprising an AI processing module configured to invoke an instance of an AI processing application for processing image data from a histological image and an application module configured to invoke an instance of an application operable to perform an image processing task on a histological image associated with a patient record, wherein the image processing task includes an AI element. The application creates processing jobs to handle the AI elements of its task which are handled by the AI processing module. The AI processing module may be a CNN that processes a histological image to identify tumors by classifying image pixels into one of multiple tissue classes of tumorous or non-tumorous tissue. A test ordering module automatically determines based on identified tissue classes whether additional tests should be performed on the tissue sample. For each additional test, an order is automatically created and submitted. Advantageously, upon first review by a pathologist, the patient record includes the histological image and results from the automatically ordered additional tests.

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