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1. 发明申请

WO2018204725A1 THERANOSTIC TOOLS FOR MANAGEMENT OF PANCREATIC CANCER AND ITS PRECURSORS 审中-公开
公开(公告)号：WO2018204725A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/030994
申请日：2018-05-03
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
发明人： PERMUTH, Jennifer , JEONG, Daniel , CHOI, Jung , BALAGURUNATHAN, Yoganand , CHEN, Dung-tsa , MALAFA, Mokenge
IPC分类号： C12Q1/68
摘要： The present invention concerns materials and methods for identifying and classifying pancreatic ductal adenocarcinoma (PDAC) precursors or intraductal papillary mucinous neoplasm (IPMN) using messenger RNAs, microRNAs, long non-coding RNAs, radiomic features, radiologic measures of abdominal/visceral obesity, and combinations thereof, as diagnostic markers for integration with clinical management and interventions for personalized care.

2. 发明申请

WO2016191323A1 LITHIUM CO-CRYSTALS FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于治疗神经功能障碍的锂复合物
公开(公告)号：WO2016191323A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/033673
申请日：2016-05-21
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： TAN, Jun , SMITH, Adam, John , SHYTLE, Roland, Douglas
IPC分类号： A61K33/14 , A61K31/198 , A61K31/401 , A61K45/06
CPC分类号： A61K33/00 , A61K31/401 , A61K38/00 , A61K45/06 , A61K2300/00
摘要： The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in need thereof, wherein the co-crystal comprises lithium, or a pharmaceutically acceptable salt thereof, and an amino acid.
摘要翻译：本发明涉及用于治疗神经精神障碍的方法和组合物，其中所述方法包括向有需要的受试者施用有效量的锂共共晶体，其中所述共晶体包含锂或其药学上可接受的盐，以及氨基酸。

3. 发明申请

WO2015035265A1 INDUCED EXPRESSION OF PROTEINS IN INSECT CELLS 审中-公开
标题翻译：诱导昆虫细胞在昆虫细胞中的表达
公开(公告)号：WO2015035265A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/054433
申请日：2014-09-06
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDAION, INC.
发明人： BLOOMQUIST, Jeffrey, Richard , TONG, Fan , JENSON, Lacey, Jo
IPC分类号： C12Q1/24 , G01N33/50
CPC分类号： G01N33/5023 , C12N5/0601 , C12P21/00 , G01N33/5044 , G01N2333/43552 , G01N2333/43591
摘要： The present invention concerns insect cells that have been induced to express one or more proteins by contact with one or more insect hormones or one or more modulators of the G protein-coupled receptor signaling pathway, compositions comprising such insect cells, a method for inducing protein expression in insect cells, and a screening method using such insect cells.
摘要翻译：本发明涉及通过与一种或多种昆虫激素或G蛋白偶联受体信号传导途径的一种或多种调节剂接触而诱导表达一种或多种蛋白质的昆虫细胞，包含这种昆虫细胞，诱导昆虫细胞中蛋白质表达的方法，以及使用这种昆虫细胞的筛选方法。

4. 发明申请

WO2014172456A1 TREATMENT AND PROGNOSTIC MONITORING OF PROLIFERATION DISORDERS USING HEDGEHOG PATHWAY INHIBITORS 审中-公开
标题翻译：使用HEDGEHOG PATHWAY抑制剂治疗和预防性增生性疾病的监测
公开(公告)号：WO2014172456A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034359
申请日：2014-04-16
申请人： HEDGEPATH, LLC
发明人： VIRCA, Nicholas, J. , O'DONNELL, Francis, E., Jr
IPC分类号： A61K31/497 , A61K31/496 , A61P35/00 , A61P3/00
CPC分类号： A61K31/496 , A61K9/0053 , A61K9/4866 , A61K31/519 , A61K31/58 , A61K33/24 , A61K45/06 , G01N33/57484 , G01N2333/96455 , A61K2300/00
摘要： The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the Hedgehog pathway (HhP); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.
摘要翻译：本发明涉及使用Hedgehog途径抑制剂（HhP）治疗增殖病症如前列腺癌，基底细胞癌，肺癌和其它癌症的方法; 以及基于生物标志物监测受试者进行这种治疗的方法以及预测功效的其他标准。

5. 发明申请

WO2014036488A1 METHODS FOR PRODUCING HIGH-FIDELITY AUTOLOGOUS IDIOTYPE VACCINES 审中-公开
标题翻译：用于生产高保鲜性自身疫苗的方法
公开(公告)号：WO2014036488A1
公开(公告)日：2014-03-06
申请号：PCT/US2013/057667
申请日：2013-08-30
申请人： BIOVEST INTERNATIONAL, INC.
发明人： SANTOS, Carlos, F. , MCCORD, Amy, M. , HIRSCHEL, Mark
IPC分类号： C12Q1/68 , A61K48/00
CPC分类号： C12Q1/6886 , A61K2039/505 , C07K16/00 , C07K16/30 , C12Q1/6858 , C12Q2600/156 , G01N33/686 , G06F19/22
摘要： The present invention concerns methods for selecting and producing idiotype vaccines, and in particular methods for selecting and producing an idiotype vaccine for treatment of a B-cell derived malignancy in a subject based on the clonal profile (clonotype) of the malignancy; a method for producing an updated idiotype vaccine matched to a B-cell derived malignancy exhibiting a shifting clonal profile; and the high- fidelity idiotype vaccines produced using the methods. The invention also includes idiotype vaccines produced using the described methods and methods of treating B-cell derived malignancies using the produced vaccines.
摘要翻译：本发明涉及用于选择和产生独特型疫苗的方法，特别是基于恶性肿瘤的克隆谱（克隆型）选择和产生用于治疗受试者中B细胞衍生恶性肿瘤的独特型疫苗的方法; 用于产生与表现出移位克隆谱的B细胞衍生恶性肿瘤相匹配的更新型个体型疫苗的方法; 和使用该方法生产的高保真独特型疫苗。本发明还包括使用所述方法和使用所产生的疫苗治疗B细胞衍生的恶性肿瘤的方法产生的独特型疫苗。

6. 发明申请

WO2014003844A1 BIOCOMPATIBLE POLYACRYLATE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：生物聚合聚丙烯酸酯组合物和使用方法
公开(公告)号：WO2014003844A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/030848
申请日：2013-03-13
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： GREENHALGH, Kerriann, Robyn , TUROS, Edward , ESPINOSA, Julio
IPC分类号： C08L33/04 , C08J3/03 , C08F20/10 , A61L31/10 , A61P9/10
CPC分类号： A61L31/10 , A61L15/24 , A61L15/44 , A61L15/46 , A61L24/0015 , A61L24/06 , A61L26/0014 , A61L26/0019 , A61L26/0066 , A61L27/34 , A61L27/54 , A61L31/16 , A61L2300/624 , A61L2400/04 , A61L2400/08 , A61L2400/12 , C08F220/14 , C08F220/18 , C08L33/08
摘要： A biocompatible polymer material is described that exhibits mechanical and physical properties that are fundamental to many medical devices and treatment of many medical diseases and disorders. The material is composed of a combination of acrylate monomers polymerized via a microemulsion polymerization. Multiple applications of the polymer material are presented.
摘要翻译：描述了生物相容性聚合物材料，其表现出许多医疗装置的基础和许多医学疾病和障碍的治疗的机械和物理性质。该材料由通过微乳液聚合聚合的丙烯酸酯单体的组合组成。介绍了聚合物材料的多种应用。

7. 发明申请

WO2013056211A2 TELOMERASE REVERSE TRANSCRIPTASE DEFICIENCE AS DIAGNOSTIC MARKER OF MYELODYSPLASTIC SYNDROME 审中-公开
标题翻译： TELOMERASE逆转录病毒作为诊断标记的缺陷症状
公开(公告)号：WO2013056211A2
公开(公告)日：2013-04-18
申请号：PCT/US2012/060201
申请日：2012-10-15
申请人： H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.
发明人： ROLLISON, Dana, E. , BURNETTE, Pearlie, K.
IPC分类号： G01N33/68 , C12Q1/25
CPC分类号： C12Q1/6883 , A61K31/454 , A61K31/706 , C12Q1/48 , C12Q2600/158 , G01N33/573 , G01N2333/9128 , G01N2800/22
摘要： The subject invention pertains to methods and compositions for the detection and treatment of myelodysplastic syndromes based on impaired telomerase function.
摘要翻译：本发明涉及用于基于端粒酶功能受损的骨髓增生异常综合征的检测和治疗的方法和组合物。

8. 发明申请

WO2011115688A3 INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2011115688A3
公开(公告)日：2011-09-22
申请号：PCT/US2011/000512
申请日：2011-03-21
申请人： H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE , UNIVERSITY OF SOUTH FLORIDA , HAZLEHURST, Lori , MCLAUGHLIN, Mark , JAIN, Priyesh , DALTON, William, S.
发明人： HAZLEHURST, Lori , MCLAUGHLIN, Mark , JAIN, Priyesh , DALTON, William, S.
IPC分类号： C07K7/64 , A61K38/12 , A61P35/00
摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interacts with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etopside.

9. 发明申请

WO2008005577A2 COMPOSITIONS OF POLYPHENOLS AND METHODS OF USE 审中-公开
标题翻译：多酚的组合物和使用方法
公开(公告)号：WO2008005577A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015684
申请日：2007-07-05
申请人： UNIVERSITY OF SOUTH FLORIDA , SHYTLE, R., Douglas , TAN, Jun
发明人： SHYTLE, R., Douglas , TAN, Jun
CPC分类号： A61K31/353 , A61K31/05
摘要： The subject invention concerns materials and methods for treating or preventing any condition or disease that is treatable by a green tea polyphenol, or an analog, isomer, metabolite, or prodrug thereof, wherein the polyphenol is administered as an intranasal formulation to a person or animal in need of treatment. In one embodiment, the intranasal polyphenol formulation comprises (-)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. The subject invention also concerns materials and methods for treating or preventing dementia, such as AIDS-dementia in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof. In one embodiment, a composition of the invention increases expression or activity of a protein that exhibits α-secretase activity.
摘要翻译：本发明涉及用于治疗或预防可被绿茶多酚或其类似物，异构体，代谢物或前药治疗的任何病症或疾病的材料和方法，其中所述多酚以鼻内制剂施用于人或动物需要治疗。在一个实施方案中，鼻内多酚制剂包含（ - ） - 表没食子儿茶酚-3-没食子酸酯（EGCG）和表儿茶素（EC），两种来自绿茶和其他植物的多酚，可以合成制备。本发明还涉及通过施用治疗有效量的多酚或其类似物，代谢物或前药来治疗或预防痴呆的物质和方法，例如人或动物的AIDS-痴呆。在一个实施方案中，本发明的组合物增加了表现出分泌酶活性的蛋白质的表达或活性。

10. 发明申请

WO2006045042A1 DEVICES AND METHODS FOR VAGINAL RECONSTRUCTION 审中-公开
标题翻译：用于血管重建的装置和方法
公开(公告)号：WO2006045042A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/037888
申请日：2005-10-20
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , GOLDWASSER, Steve, Eric
发明人： GOLDWASSER, Steve, Eric
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2250/0097
摘要： The present invention concerns grafts and methods of vaginal reconstruction for treatment of pelvic organ prolapse. The method of the present invention is a minimally invasive procedure using a vaginal approach and fixed, (reproducible) anatomical landmarks in the pelvis as points of fixation for tension free graft attachment providing anatomical support for the vaginal apex, anterior and/or posterior vaginal walls.
摘要翻译：本发明涉及用于治疗盆腔器官脱垂的阴道重建的移植物和方法。本发明的方法是使用阴道方法和在骨盆中固定的（可重复的）解剖标志作为无张力移植物连接的固定点的微创手术，为阴道顶点，阴道前壁和/或后阴道壁提供解剖支撑。

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