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2. 发明申请

WO2015153679A1 MICRORNA ASSAY FOR DETECTION AND MANAGEMENT OF PANCREATIC CANCER PRECURSORS 审中-公开
标题翻译： MICRORNA测定胰腺癌前列腺癌的检测和治疗
公开(公告)号：WO2015153679A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/023702
申请日：2015-03-31
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
发明人： MALAFA, Mokenge, P. , PERMUTH-WEY, Jennifer , CHEN, Dung-tsa
IPC分类号： C12Q1/68 , C12N15/113 , C04B40/06
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
摘要： The current invention pertains to miRNAs that are differentially expressed in samples of an individual having pancreatic cancer, or having a high risk of developing pancreatic cancer, as compared to the corresponding sample of an individual not having pancreatic cancer, or having low risk of developing pancreatic cancer, respectively. In certain embodiments, the miRNAs are differentially expressed in a tissue sample or blood plasma sample of an individual having a pancreatic lesion and having a high risk of developing pancreatic cancer as compared to the corresponding tissue sample or blood sample of an individual having the pancreatic lesion and having no risk or low risk of developing pancreatic cancer. These differentially expressed miRNAs can be used as biomarkers for diagnosis, treatment, and/or prevention of pancreatic cancer, particularly, in a subject having a pancreatic lesion. Microarray containing miRNAs indicative of the presence of pancreatic cancer, or having a high risk of pancreatic cancer development, particularly, in a subject having a pancreatic lesion, and methods of use of the microarrays are also provided.
摘要翻译：本发明涉及与没有胰腺癌的个体或具有低胰腺发展风险的相应样品相比，具有胰腺癌个体或具有发展胰腺癌的高风险的样品差异表达的miRNA 癌症。在某些实施方案中，与具有胰腺病变的个体的相应组织样品或血液样品相比，miRNA在具有胰腺损伤并且具有发展胰腺癌的高风险的个体的组织样品或血浆样品中差异表达并且没有发生胰腺癌的风险或低风险。这些差异表达的miRNA可用作胰腺癌的诊断，治疗和/或预防的生物标志物，特别是在具有胰腺病变的受试者中。还提供了含有指示胰腺癌存在或具有胰腺癌发展风险高的miRNA的微阵列，特别是在具有胰腺病变的受试者中，以及微阵列的使用方法。

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