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1. 发明申请

WO2008005577A3 COMPOSITIONS OF POLYPHENOLS AND METHODS OF USE 审中-公开
标题翻译：多酚的组成和使用方法
公开(公告)号：WO2008005577A3
公开(公告)日：2008-02-21
申请号：PCT/US2007015684
申请日：2007-07-05
申请人： UNIV SOUTH FLORIDA , SHYTLE R DOUGLAS , TAN JUN
发明人： SHYTLE R DOUGLAS , TAN JUN
IPC分类号： A61K31/353 , A61K31/05 , A61P25/28
CPC分类号： A61K31/353 , A61K31/05
摘要： The subject invention concerns materials and methods for treating or preventing any condition or disease that is treatable by a green tea polyphenol, or an analog, isomer, metabolite, or prodrug thereof, wherein the polyphenol is administered as an intranasal formulation to a person or animal in need of treatment. In one embodiment, the intranasal polyphenol formulation comprises (-)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. The subject invention also concerns materials and methods for treating or preventing dementia, such as AIDS-dementia in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof. In one embodiment, a composition of the invention increases expression or activity of a protein that exhibits a-secretase activity.
摘要翻译：本发明涉及用于治疗或预防可通过绿茶多酚或其类似物，异构体，代谢物或前药治疗的任何病症或疾病的材料和方法，其中所述多酚作为鼻内制剂给予人或动物需要治疗。在一个实施方案中，鼻内多酚制剂包含（ - ） - 表没食子儿茶素-3-没食子酸酯（EGCG）和表儿茶素（EC），两种衍生自绿茶和其他植物的多酚，并且可以合成制备。本发明还涉及通过施用治疗有效量的多酚或其类似物，异构体，代谢物或前药来治疗或预防人或动物中的痴呆（例如AIDS-痴呆）的材料和方法。在一个实施方案中，本发明的组合物增加表现α-分泌酶活性的蛋白质的表达或活性。

2. 发明申请

WO2008005577A2 COMPOSITIONS OF POLYPHENOLS AND METHODS OF USE 审中-公开
标题翻译：多酚的组合物和使用方法
公开(公告)号：WO2008005577A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015684
申请日：2007-07-05
申请人： UNIVERSITY OF SOUTH FLORIDA , SHYTLE, R., Douglas , TAN, Jun
发明人： SHYTLE, R., Douglas , TAN, Jun
CPC分类号： A61K31/353 , A61K31/05
摘要： The subject invention concerns materials and methods for treating or preventing any condition or disease that is treatable by a green tea polyphenol, or an analog, isomer, metabolite, or prodrug thereof, wherein the polyphenol is administered as an intranasal formulation to a person or animal in need of treatment. In one embodiment, the intranasal polyphenol formulation comprises (-)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. The subject invention also concerns materials and methods for treating or preventing dementia, such as AIDS-dementia in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof. In one embodiment, a composition of the invention increases expression or activity of a protein that exhibits α-secretase activity.
摘要翻译：本发明涉及用于治疗或预防可被绿茶多酚或其类似物，异构体，代谢物或前药治疗的任何病症或疾病的材料和方法，其中所述多酚以鼻内制剂施用于人或动物需要治疗。在一个实施方案中，鼻内多酚制剂包含（ - ） - 表没食子儿茶酚-3-没食子酸酯（EGCG）和表儿茶素（EC），两种来自绿茶和其他植物的多酚，可以合成制备。本发明还涉及通过施用治疗有效量的多酚或其类似物，代谢物或前药来治疗或预防痴呆的物质和方法，例如人或动物的AIDS-痴呆。在一个实施方案中，本发明的组合物增加了表现出分泌酶活性的蛋白质的表达或活性。

3. 发明申请

WO2011047341A3 TREATMENT OF SUICIDAL IDEATION OR BEHAVIOR USING INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
标题翻译：用尼古丁乙酰胆碱受体抑制剂治疗自杀意念或行为
公开(公告)号：WO2011047341A3
公开(公告)日：2011-08-18
申请号：PCT/US2010052949
申请日：2010-10-15
申请人： UNIV SOUTH FLORIDA , SHEEHAN DAVID V , SHYTLE R DOUGLAS
发明人： SHEEHAN DAVID V , SHYTLE R DOUGLAS
IPC分类号： A61K31/407 , A61K31/55 , A61K33/14 , A61P25/18 , A61P25/24
CPC分类号： A61K45/06 , A61K31/407 , A61K31/55 , A61K31/5513 , A61K33/14 , A61K2300/00
摘要： The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the subject; therapeutic packages for treating suicidal ideation or behavior; and methods for determining the efficacy of a treatment for suicidal ideation or behavior. In some embodiments, the treatment methods comprise administering to the subject an effective amount of an inhibitor of a nAChR, such as a lithium compound, mecamylamine, clozapine, or asenapine.
摘要翻译：本发明涉及治疗有需要的受试者的自杀意念或行为的方法，其包括降低受试者中的内源性烟碱乙酰胆碱受体（nAChR）活性; 用于治疗自杀意念或行为的治疗包; 以及确定治疗对自杀意念或行为的功效的方法。在一些实施方案中，治疗方法包括向受试者施用有效量的nAChR抑制剂，例如锂化合物，美加明胺，氯氮平或阿塞那平。

4. 发明申请

WO2011047341A2 TREATMENT OF SUICIDAL IDEATION OR BEHAVIOR USING INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTORS 审中-公开
标题翻译：使用NICOTINIC乙酰胆碱受体的抑制剂治疗消化性疾病或行为
公开(公告)号：WO2011047341A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052949
申请日：2010-10-15
申请人： UNIVERSITY OF SOUTH FLORIDA , SHEEHAN, David, V. , SHYTLE, R., Douglas
发明人： SHEEHAN, David, V. , SHYTLE, R., Douglas
IPC分类号： A61K31/407 , A61K31/55 , A61K33/14 , A61P25/18 , A61P25/24
CPC分类号： A61K45/06 , A61K31/407 , A61K31/55 , A61K31/5513 , A61K33/14 , A61K2300/00
摘要： The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the subject; therapeutic packages for treating suicidal ideation or behavior; and methods for determining the efficacy of a treatment for suicidal ideation or behavior. In some embodiments, the treatment methods comprise administering to the subject an effective amount of an inhibitor of a nAChR, such as a lithium compound, mecamylamine, clozapine, or asenapine.
摘要翻译：本发明涉及在有需要的受试者中治疗自杀意念或行为的方法，包括降低受试者内源性烟碱乙酰胆碱受体（nAChR）活性; 用于治疗自杀意念或行为的治疗包; 以及用于确定治疗自杀意念或行为的功效的方法。在一些实施方案中，治疗方法包括向受试者施用有效量的nAChR抑制剂，例如锂化合物，美加明，氯氮平或阿替那非。

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