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1. 发明申请

WO2013066629A1 METHYLENE BETA-KETOESTER MONOMERS, METHODS FOR MAKING METHYLENE BETA-KETOESTER MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFROM 审中-公开
标题翻译：甲基β-卡通单体，制备甲基β-卡通单体的方法，可聚合组合物和形成的产物
公开(公告)号：WO2013066629A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/060837
申请日：2012-10-18
申请人： BIOFORMIX, LLC
发明人： MALOFSKY, Bernard Miles , MALOFSKY, Adam Gregg , DEY, Tanmoy , SULLIVAN, Jeffrey M.
IPC分类号： C08F16/36
CPC分类号： C08F20/28 , C07C45/75 , C07C49/794 , C07C49/796 , C07C49/798 , C07C49/80 , C07C67/03 , C07C67/30 , C07C69/604 , C07C69/738 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C08F20/14 , C08F20/30 , C08F20/38 , C08F20/68 , C08F22/20 , C08F24/00 , C08F28/06 , C08F116/36 , C08F128/06 , C08F222/1006 , C08F222/14 , C08K3/013 , C08K5/0008 , C08L21/00 , C08L33/14 , C08L33/16 , C08L35/02 , C09D4/00 , C09D129/12 , C09D133/14 , C09D133/16 , C09D135/02 , C09D141/00 , C09J133/06 , C09J133/14 , C09J133/16 , C09J135/02 , Y02P20/127
摘要： The present invention provides methylene beta-ketoester monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-ketoesters of the invention, a beta-ketoester is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-ketoester monomer. The present invention further compositions and products formed from methylene beta-ketoester monomers of the invention, including monomer-based products ( e.g ., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products ( e.g ., fibers, films, sheets, medical polymers, composite polymers and surfactants).
摘要翻译：本发明提供亚甲基β-酮酯单体，其制备方法，以及由其形成的组合物和产品。在制备本发明的亚甲基β-酮酯的方法中，β-酮酯与改性的Knoevenagel反应中的甲醛源反应，任选地在酸性或碱性催化剂存在下，任选地在酸性或碱性非酸性溶剂，形成反应络合物。反应络合物可以是低聚物。将反应复合物进行进一步处理，其可以通过与能量转移装置接触而蒸发，以分离β-酮酯单体。本发明还包括由本发明的亚甲基β-酮酯单体形成的组合物和产品，包括基于单体的产品（例如油墨，粘合剂，涂料，密封剂或反应性模塑）和基于聚合物的产品（例如纤维，薄膜，片材，医用聚合物，复合聚合物和表面活性剂）。

2. 发明申请

WO2013059479A2 METHYLENE BETA-DIKETONE MONOMERS, METHODS FOR MAKING METHYLENE BETA-DIKETONE MONOMERS, POLYMERIZABLE COMPOSITIONS AND PRODUCTS FORMED THEREFROM 审中-公开
标题翻译：甲基β-二酮单体，制备甲基β-二酮单体的方法，可聚合组合物和形成的产物
公开(公告)号：WO2013059479A2
公开(公告)日：2013-04-25
申请号：PCT/US2012/060840
申请日：2012-10-18
申请人： BIOFORMIX INC.
发明人： MALOFSKY, Bernard Miles , MALOFSKY, Adam Gregg , DEY, Tanmoy , SULLIVAN, Jeffrey M.
IPC分类号： C08F16/36
CPC分类号： C08F20/28 , C07C45/75 , C07C49/794 , C07C49/796 , C07C49/798 , C07C49/80 , C07C67/03 , C07C67/30 , C07C69/604 , C07C69/738 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C08F20/14 , C08F20/30 , C08F20/38 , C08F20/68 , C08F22/20 , C08F24/00 , C08F28/06 , C08F116/36 , C08F128/06 , C08F222/1006 , C08F222/14 , C08K3/013 , C08K5/0008 , C08L21/00 , C08L33/14 , C08L33/16 , C08L35/02 , C09D4/00 , C09D129/12 , C09D133/14 , C09D133/16 , C09D135/02 , C09D141/00 , C09J133/06 , C09J133/14 , C09J133/16 , C09J135/02 , Y02P20/127
摘要： The present invention provides methylene beta-diketone monomers, methods for producing the same, and compositions and products formed therefrom. In the method for producing the methylene beta-diketones of the invention, a beta-diketone is reacted with a source of formaldehyde in a modified Knoevenagel reaction optionally in the presence of an acidic or basic catalyst, and optionally in the presence of an acidic or non-acidic solvent, to form reaction complex. The reaction complex may be an oligomeric complex. The reaction complex is subjected to further processing, which may be vaporization by contact with an energy transfer means in order to isolate the beta-diketone monomer. The present invention further compositions and products formed from methylene beta-diketone monomers of the invention, including monomer-based products (e.g., inks, adhesives, coatings, sealants or reactive molding) and polymer-based products (e.g., fibers, films, sheets, medical polymers, composite polymers and surfactants).
摘要翻译：本发明提供亚甲基β-二酮单体，其制备方法，以及由其形成的组合物和产品。在制备本发明的亚甲基β-二酮的方法中，β-二酮与改性的Knoevenagel反应中的甲醛源反应，任选地在酸性或碱性催化剂存在下，任选地在酸性或碱性非酸性溶剂，形成反应络合物。反应络合物可以是低聚物。将反应复合物进行进一步处理，其可以通过与能量转移装置接触而汽化，以分离β-二酮单体。本发明还包括由本发明的亚甲基β-二酮单体形成的组合物和产品，包括基于单体的产品（例如油墨，粘合剂，涂料，密封剂或反应性模塑）和基于聚合物的产品（例如纤维，薄膜，片材，医用聚合物，复合聚合物和表面活性剂）。

3. 发明申请

WO2014110388A1 METHOD TO OBTAIN METHYLENE MALONATE VIA BIS(HYDROXYMETHYL) MALONATE PATHWAY 审中-公开
标题翻译：通过双（羟甲基）马来酸酐途径获得亚甲基马来酸盐的方法
公开(公告)号：WO2014110388A1
公开(公告)日：2014-07-17
申请号：PCT/US2014/011068
申请日：2014-01-10
申请人： BIOFORMIX INC.
发明人： MALOFSKY, Bernard, Miles , MALOFSKY, Adam, Gregg , SULLIVAN, Jeffrey, M. , KISANGA, Philip, B. , ANDERSON, John, Joseph , COCKREM, Michael Charles, Milner , CARLBERG, Philip, Jay
IPC分类号： C07C69/07 , C07C61/00
CPC分类号： B01J19/245 , B01J8/067 , B01J29/40 , B01J2208/00168 , B01J2208/065 , B01J2219/00033 , B01J2219/0004 , B01J2219/00087 , B01J2219/00177 , B01J2219/24 , C07C67/31 , C07C67/327 , C07C67/333 , C07C67/56 , C07C69/593 , C08F222/14 , C09D4/00 , C09J4/00
摘要： Method to obtain methylene malonate and related monomers following a bis(hydroxymethyl) malonate pathway. A bis(hydroxymethyl) malonate intermediary is subsequently reacted (i.e., subjected to thermolysis) to provide a methylene malonate monomer species. A source of formaldehyde (e.g., formalin) is provided in the presence of a basic catalyst (e.g., calcium hydroxide), to which a malonate (e.g., diethyl malonate) is added under suitable reaction conditions to obtain the desired intermediary (e.g., dialkyl bis(hydroxymethyl) malonate). The intermediary is reacted (i.e., subjected to thermolysis) under suitable conditions in the presence of a suitable catalyst (e.g., a zeolite) to obtain a methylene malonate monomer. In an exemplary embodiment, the thermolysis reaction includes the addition of the bis(hydroxymethyl) malonate intermediary onto a heated catalyst. The reaction product is collected and purified. The disclosed methods may be performed in a continuous operation. Discrete steps may be performed by using modular units within a plant.
摘要翻译：获得二（羟甲基）丙二酸酯途径后亚甲基丙二酸酯和相关单体的方法。随后将双（羟甲基）丙二酸酯中间体反应（即进行热解）以提供亚甲基丙二酸酯单体种类。在碱性催化剂（如氢氧化钙）的存在下提供甲醛源（如福尔马林），在合适的反应条件下加入丙二酸酯（如丙二酸二乙酯）以获得所需的中间体（如二烷基双（羟甲基）丙二酸酯）。中间体在合适的条件下，在合适的催化剂（如沸石）存在下反应（即进行热解），得到亚甲基丙二酸单体。在一个示例性实施方案中，热解反应包括在加热的催化剂上加入双（羟甲基）丙二酸酯中间体。收集并纯化反应产物。所公开的方法可以在连续操作中执行。离散步骤可以通过使用工厂内的模块化单元来执行。

4. 发明申请

WO2013149165A1 METHODS FOR ACTIVATING POLYMERIZABLE COMPOSITIONS, POLYMERIZABLE SYSTEMS, AND PRODUCTS FORMED THEREBY 审中-公开
标题翻译：活化可聚合组合物的方法，可聚合体系和形成的产物
公开(公告)号：WO2013149165A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034636
申请日：2013-03-29
申请人： BIOFORMIX INC.
发明人： MALOFSKY, Bernard, Miles , MALOFSKY, Adam, Gregg , ELLISON, Matthew, McBrayer , WOJCIAK, Stanley, C.
IPC分类号： C08F2/38
CPC分类号： C08F22/14 , C08F2/38
摘要： The exemplary embodiments disclosed herein relate to activating methods for initiation polymerization of methylene malonates and other polymerizable compositions. The polymerization may be activated by anionic or free radical mechanisms. Because the polymerization may occur very quickly upon contact between the activating agent and the polymerizable composition, methods are provide herein for separating or otherwise rendering the activating agent ineffective to initiate polymerization, until such a reaction is desired. The separation may be physical (separate packaging, separate application steps, encapsulation) or it may be based on latent- activation methods (activation precursors, UV activation). Products formed from the methods disclosed herein may include inks, adhesives, coatings, sealants, reactive moldings, fibers, films, sheets, medical polymers, composites, laminates and the like. Exemplary polymerizable compositions and products formed therefrom are environmentally sustainable, environmentally benign and/or biologically benign.
摘要翻译：本文公开的示例性实施方案涉及丙烯酸亚甲酯和其它可聚合组合物的起始聚合的活化方法。聚合可以通过阴离子或自由基机制来活化。因为在活化剂和可聚合组合物接触之后聚合可能非常快地发生，因此本文提供了分离或以其它方式使活化剂无效引发聚合的方法，直到需要这种反应。分离可以是物理的（单独的包装，单独的施加步骤，包封），或者它可以基于潜在活化方法（活化前体，UV活化）。由本文公开的方法形成的产品可以包括油墨，粘合剂，涂料，密封剂，反应性模塑品，纤维，薄膜，片材，医用聚合物，复合材料，层压材料等。示例性的可聚合组合物和由其形成的产品是环境可持续的，环境友好的和/或生物学良性的。

5. 发明申请

WO2013149173A1 INK AND COATING FORMULATIONS AND POLYMERIZABLE SYSTEMS FOR PRODUCING THE SAME 审中-公开
标题翻译：油墨和涂料配方和用于生产它的聚合体系
公开(公告)号：WO2013149173A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034649
申请日：2013-03-29
申请人： BIOFORMIX INC.
发明人： MALOFSKY, Bernard, Miles , MALOFSKY, Adam, Gregg , ELLISON, Matthew, Mcbrayer
IPC分类号： C09D11/02
CPC分类号： C09D4/00 , C08F222/14 , C08K3/04 , C08K3/22 , C08K5/23 , C08K5/3437 , C08K5/3467 , C08K2003/2241 , C09D11/02 , C09D11/037 , C09D11/101 , C09D11/106 , C09D11/107 , C09D11/322 , Y10T428/31935
摘要： Ink and coating compositions, printing and coating processes, and printed and coated substrates utilizing a polymerizable composition comprising one or more di-activated vinyl compounds, with the proviso that said a di-activated vinyl compound is not a cyanoacrylate. Exemplary compositions include methylene malonates, methylene β-ketoesters, methylene β-diketones, dialkyl disubstituted vinyls, and dihaloalkyl disubstituted vinyls. Exemplary compositions are polymerizable at ambient temperatures.
摘要翻译：使用包含一种或多种二活化乙烯基化合物的可聚合组合物的油墨和涂料组合物，印刷和涂布方法以及印刷和涂布的基材，条件是所述二活化乙烯基化合物不是氰基丙烯酸酯。示例性组合物包括丙二酸亚甲基酯，亚甲基β-酮酯，亚甲基β-二酮，二烷基二取代的乙烯基和二卤烷基二取代的乙烯基。示例性组合物在环境温度下是可聚合的。

6. 发明申请

WO2013149168A1 COMPOSITE AND LAMINATE ARTICLES AND POLYMERIZABLE SYSTEMS FOR PRODUCING THE SAME 审中-公开
标题翻译：复合材料和层压制品及其生产方法的可聚合体系
公开(公告)号：WO2013149168A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/034641
申请日：2013-03-29
申请人： BIOFORMIX, INC.
发明人： MALOFSKY, Bernard, Miles , MALOFSKY, Adam, Gregg , ELLISON, Matthew, McBrayer
IPC分类号： C08F2/38
CPC分类号： C09J4/00 , B32B5/24 , B32B7/12 , B32B15/04 , B32B15/18 , B32B15/20 , B32B21/04 , B32B27/283 , B32B27/285 , B32B27/32 , B32B27/36 , B32B27/365 , B32B29/002 , B32B2255/00 , B32B2255/26 , B32B2262/101 , B32B2307/516 , B32B2307/518 , B32B2419/00 , B32B2479/00 , B32B2605/00 , C08F20/28 , C08F20/36 , C08F122/14 , C08F216/36 , C08F216/38 , C08F222/14 , C08F2222/1013 , C08F2222/145 , C08J3/242 , C08J5/24 , C08J2335/02 , C08K3/22 , C08K3/36 , C08K7/06 , C08K7/14 , C08K2003/2227 , C09J5/00 , C09J11/04 , C09J11/08 , C09J135/02 , Y10T428/31938 , Y10T442/2738
摘要： A composite material comprises a reinforcing material carried in a polymer matrix material which is the polymerization product of a polymerizable composition comprising a di-activated vinyl compound, with the proviso that the di-activated vinyl compound is not a cyanoacrylate. The reinforcing materials may be a wide variety of substrates including thermally sensitive materials. Exemplary composites can be molded and cured at ambient temperatures. Also disclosed are laminate materials having layered materials adhered by curing a di-activated vinyl polymerizable composition.
摘要翻译：复合材料包括承载在聚合物基质材料中的增强材料，其是包含二活化乙烯基化合物的可聚合组合物的聚合产物，条件是二活化乙烯基化合物不是氰基丙烯酸酯。增强材料可以是各种各样的基材，包括热敏材料。典型的复合材料可以在环境温度下模制和固化。还公开了具有通过固化二活化的乙烯基聚合性组合物而附着的层状材料的层压材料。

7. 发明申请

WO2009064843A1 METHOD TO MEASURE AMINO ACID CONCENTRATIONS 审中-公开
标题翻译：测量氨基酸浓度的方法
公开(公告)号：WO2009064843A1
公开(公告)日：2009-05-22
申请号：PCT/US2008/083340
申请日：2008-11-13
申请人： BAYER HEALTHCARE LLC , LANDRO, James, A. , FORBES, Chris , SZEWCZAK, Alex
发明人： LANDRO, James, A. , FORBES, Chris , SZEWCZAK, Alex
IPC分类号： C12Q1/00
CPC分类号： G01N33/6812 , G01N33/60 , G01N2333/9015
摘要： The instant invention provides a method of determining amino acid concentration in a sample, by performing an aminoacyl-tRNA synthetase charging reaction at equilibrium which comprises a cognate aminoacyl-tRNA synthetase, a cognate tRNA, a fixed quantity of radiolabeled target amino acid, and the sample comprising the target amino acid. The method further quantifies the signal emitted from the resultant aminoacylated cognate tRNA by a scintillation proximity assay, and compares the signal against a calibration curve to reveal the concentration of the target amino acid in the sample.
摘要翻译：本发明提供了一种通过在平衡下进行氨酰-tRNA合成酶装料反应来测定样品中氨基酸浓度的方法，其包括同源氨酰-tRNA合成酶，同源tRNA，固定量的放射性标记的靶氨基酸，以及样品包含靶氨基酸。该方法通过闪烁亲和测定进一步量化由所得氨基酰化同源tRNA发射的信号，并将该信号与校准曲线进行比较，以揭示样品中目标氨基酸的浓度。

8. 发明申请

WO2009042543A1 PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 审中-公开
标题翻译：用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物
公开(公告)号：WO2009042543A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077211
申请日：2008-09-22
申请人： BAYER HEALTHCARE LLC , MAGNUSON, Steven , WICKENS, Philip , ZHANG, Zhonghua , QI, Ning , MA, Xin
发明人： MAGNUSON, Steven , WICKENS, Philip , ZHANG, Zhonghua , QI, Ning , MA, Xin
IPC分类号： A01N43/64 , A61K31/53
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
摘要翻译：本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。

9. 发明申请

WO2006052960A2 METHODS AND COMPOSITIONS FOR INCREASING STEM CELL HOMING USING Gαs ACTIVATORS 审中-公开
标题翻译：使用气体活化剂增加干细胞的方法和组合物
公开(公告)号：WO2006052960A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040416
申请日：2005-11-07
申请人： THE GENERAL HOSPITAL CORPORATION , SCADDEN, David, T. , KRONENBERG, Henry , ADAMS, Gregor
发明人： SCADDEN, David, T. , KRONENBERG, Henry , ADAMS, Gregor
IPC分类号： C12N5/08 , A61K48/00
CPC分类号： G01N33/5073 , A61K48/00 , A61K2035/124 , C12N5/0647 , C12N2501/01 , G01N2333/4719
摘要： The present invention provides methods for increasing engraftment of stem cells in a subject by treating the cells with a Gαs activator. The invention further provides methods for identifying Gαs activators for use in increasing engraftment of stem cells in a subject.
摘要翻译：本发明提供了通过用气体活化剂处理细胞来增加受试者中干细胞植入的方法。本发明还提供了用于鉴定用于增加受试者中干细胞移植物的气体活化剂的方法。

10. 发明申请

WO2014085570A1 COMPOSITE COMPOSITIONS FOR ELECTRONICS APPLICATIONS 审中-公开
标题翻译：电子应用的复合组合物
公开(公告)号：WO2014085570A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072203
申请日：2013-11-27
申请人： BIOFORMIX, INC.
发明人： MALOFSKY, Bernard, Miles , MALOFSKY, Adam, Gregg , ELLISON, Matthew, Mcbrayer
IPC分类号： H01L21/56
CPC分类号： H01L23/295 , H01L21/563 , H01L23/49811 , H01L24/09 , H01L2224/0401 , H01L2224/16225 , H01L2224/32225 , H01L2224/73204 , H01L2924/1461 , H01L2924/15192 , H01L2924/15311 , H01L2924/00
摘要： An electronics composition includes a curable matrix material and, optionally, a filler material disposed within the matrix material. The cured matrix material includes an oligomer or polymer material derived from a compound selected from a methylene malonate monomer, a multifunctional methylene monomer, a methylene beta ketoester monomer, a methylene beta diketone monomer, or a mixture thereof.
摘要翻译：电子组合物包括可固化的基质材料和任选的布置在基体材料内的填充材料。固化的基质材料包括衍生自选自亚甲基丙二酸酯单体，多官能亚甲基单体，亚甲基β-酮酯单体，亚甲基二酮单体或其混合物的化合物的低聚物或聚合物材料。

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