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1. 发明申请

WO2017119499A1 A combination therapy using REIC/Dkk-3 gene and a checkpoint inhibitor 审中-公开
标题翻译：使用REIC / Dkk-3基因和检查点抑制剂的联合疗法
公开(公告)号：WO2017119499A1
公开(公告)日：2017-07-13
申请号：PCT/JP2017/000318
申请日：2017-01-06
申请人： MOMOTARO-GENE INC.
发明人： KUMON Hiromi , LOWENTHAL Richard
IPC分类号： A61K48/00 , A61K39/395 , A61K45/00
CPC分类号： A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K16/2818 , C07K16/2827 , C07K2317/76 , C12N2710/10343 , A61K2300/00
摘要： An object of the present invention is to provide a method of treating cancer using a checkpoint inhibitor in combination with REIC/Dkk-3 gene. The present invention is a combination pharmaceutical kit for treating cancer comprising REIC/Dkk-3 in combination with a check point inhibitor and a method for treating cancer by administering REIC/Dkk-3 gene and a check point inhibitor to a cancer patient.
摘要翻译：本发明的目的是提供使用检查点抑制剂与REIC / Dkk-3基因组合治疗癌症的方法。本发明是一种用于治疗癌症的组合药物试剂盒，其包含通过向癌症患者施用REIC / Dkk-3基因和检查点抑制剂来与检验点抑制剂组合的REIC / Dkk-3和癌症治疗方法。 p>

2. 发明申请

WO2016092862A1 EXHAUST GAS PURIFYING CATALYST 审中-公开
标题翻译：排气净化催化剂
公开(公告)号：WO2016092862A1
公开(公告)日：2016-06-16
申请号：PCT/JP2015/006203
申请日：2015-12-11
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , CATALER CORPORATION , SUZUKI, Hiromasa , YOSHIDA, Takeru , MIURA, Masahide , AOKI, Yuki , CHINZEI, Isao , SAITO, Yoshinori , OCHIAI, Daisuke , OKADA, Mitsuyoshi , TANABE, Toshitaka , SUDA, Akihiko , SATO, Masanao , CHIBA, Akiya , MORIKAWA, Akira , ORI, Hirotaka
发明人： SUZUKI, Hiromasa , YOSHIDA, Takeru , MIURA, Masahide , AOKI, Yuki , CHINZEI, Isao , SAITO, Yoshinori , OCHIAI, Daisuke , OKADA, Mitsuyoshi , TANABE, Toshitaka , SUDA, Akihiko , SATO, Masanao , CHIBA, Akiya , MORIKAWA, Akira , ORI, Hirotaka
IPC分类号： B01J37/02 , B01J37/03 , B01J35/00 , B01J23/00 , B01J23/10 , B01J23/63 , B01D53/94 , B01J35/02 , C01G25/00 , C04B35/626
CPC分类号： B01J23/63 , B01D53/945 , B01D2255/1021 , B01D2255/1023 , B01D2255/1025 , B01D2255/2061 , B01D2255/2063 , B01D2255/2066 , B01D2255/407 , B01D2255/9022 , B01D2255/908 , B01D2258/014 , B01J23/002 , B01J23/10 , B01J27/053 , B01J35/0006 , B01J35/002 , B01J35/04 , B01J35/1009 , B01J37/0236 , B01J37/0244 , B01J37/0248 , B01J37/03 , B01J37/031 , B01J37/08 , B01J2523/00 , C01F17/0043 , C01G25/006 , C01G25/02 , C01P2002/36 , C01P2002/50 , C01P2004/61 , F01N3/10 , F01N3/101 , F01N2510/06 , F01N2570/24 , Y02T10/22 , B01J2523/3712 , B01J2523/3718 , B01J2523/48 , B01J2523/25 , B01J2523/31 , B01J2523/828 , B01J2523/822
摘要： The object of the present invention is to provide an exhaust gas purifying catalyst that can achieve high purification performance while suppressing H 2 S emissions.　The object is solved by an exhaust gas purifying catalyst in which the top layer of a catalyst coating layer comprises a ceria-zirconia composite oxide having a pyrochlore-type ordered array structure, in which the ceria-zirconia composite oxide contains at least one additional element selected from the group consisting of praseodymium, lanthanum, and yttrium at 0.5 to 5.0 mol% in relation to the total cation amount, and the molar ratio of (cerium + additional element) : (zirconium) is within the range from 43 : 57 to 48 : 52.
摘要翻译：本发明的目的是提供一种能够在抑制H 2 S排放的同时实现高净化性能的排气净化催化剂。该目的通过一种废气净化催化剂来解决，其中催化剂涂层的顶层包含具有烧绿石型有序阵列结构的二氧化铈 - 氧化锆复合氧化物，其中二氧化铈 - 氧化锆复合氧化物含有至少一种另外的元素选自相对于总阳离子量为0.5〜5.0摩尔％的镨，镧和钇组成的组，（铈+附加元素）:(锆）的摩尔比为43:57〜 48：52。

3. 发明申请

WO2014104403A1 Method for Inducing Exocrine Pancreatic Cells 审中-公开
标题翻译：诱导外分泌胰腺细胞的方法
公开(公告)号：WO2014104403A1
公开(公告)日：2014-07-03
申请号：PCT/JP2013/085334
申请日：2013-12-26
申请人： KYOTO UNIVERSITY
发明人： OSAFUNE, Kenji , FUNATO, Michinori , NISHINO, Norikazu
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , C12N5/0606 , C12N2500/38 , C12N2501/119 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2501/42 , C12N2501/727 , C12N2501/73 , C12N2501/999 , C12N2506/02
摘要： An object of the present invention is to provide a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells. The above object is achieved by providing a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells using a culture solution containing a histone deacetylase inhibitor and/or a ligand protein for a Notch signal, and a protein kinase C activator.
摘要翻译：本发明的目的是提供一种诱导胰前体细胞分化成外分泌胰腺细胞的方法。上述目的通过提供一种使用含有组蛋白脱乙酰酶抑制剂和/或Notch信号的配体蛋白和蛋白激酶C激活剂的培养液诱导胰腺前体细胞分化成外分泌胰腺细胞的方法来实现。

4. 发明申请

WO2013014929A1 METHOD FOR SCREENING INDUCED PLURIPOTENT STEM CELLS 审中-公开
标题翻译：筛选诱导型脑干细胞的方法
公开(公告)号：WO2013014929A1
公开(公告)日：2013-01-31
申请号：PCT/JP2012/004747
申请日：2012-07-25
申请人： KYOTO UNIVERSITY , YAMANAKA, Shinya , TAKAHASHI, Kazutoshi , KOYANAGI, Michiyo , OHNUKI, Mari
发明人： YAMANAKA, Shinya , TAKAHASHI, Kazutoshi , KOYANAGI, Michiyo , OHNUKI, Mari
IPC分类号： C12N15/09 , C12N5/10 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/6888 , C12Q1/6881 , C12Q2600/158 , G01N33/5023 , G01N33/5073
摘要： The present invention provides a method for screening for iPS cells exhibiting differentiation resistance using a marker identified as lincRNA or mRNA that is specifically expressed in an iPS cell line exhibiting differentiation resistance, and such markers.
摘要翻译：本发明提供了使用在鉴定为表现出耐分化性的iPS细胞系中特异表达的鉴定为lincRNA或mRNA的标记物以及这些标记物来筛选显示分化抗性的iPS细胞的方法。

5. 发明申请

WO2012147119A1 MANAGEMENT SYSTEM AND CONTROL METHOD FOR PROVISIONING STORAGE SPACE TO WRITABLE SNAPSHOTS SATISFYING PERFORMANCE REQUIREMENTS 审中-公开
标题翻译：将储存空间提供给满足性能要求的可写入点的管理系统和控制方法
公开(公告)号：WO2012147119A1
公开(公告)日：2012-11-01
申请号：PCT/JP2011/002400
申请日：2011-04-25
申请人： HITACHI, LTD. , OKADA, Wataru , MAKI, Nobuhiro
发明人： OKADA, Wataru , MAKI, Nobuhiro
IPC分类号： G06F3/06
CPC分类号： G06F3/065 , G06F3/0605 , G06F3/067 , G06F3/0689
摘要： To provide a storage management technique for creating and managing, with single operation by a user, a large quantity of writable snapshots, which satisfy a requirement desired by the user, while controlling a use form of a storage apparatus not to exceed limits of the performance and the capacity of the storage apparatus. Therefore, a management computer manages configuration information and performance information of plural storage apparatuses and an operation state of a writable snapshot. When a writable snapshot is created, the management computer controls, concerning an original snapshot, a use form of the storage apparatuses not to exceed a disk performance limit and a controller performance limit and a capacity limit of a storage on the basis of the number of writable snapshots to be created and a performance requirement (IOPS) and a capacity requirement of the writable snapshot.
摘要翻译：为了提供用于创建和管理存储管理技术，在用户单次操作的情况下，满足用户期望的要求的大量可写入快照，同时控制存储设备的使用形式不超过性能的限制和存储装置的容量。因此，管理计算机管理多个存储装置的配置信息和性能信息以及可写快照的操作状态。当创建可写快照时，管理计算机根据原始快照的数量控制存储设备的使用形式，不超过磁盘性能限制，控制器性能限制和存储容量限制要创建的可写快照和性能要求（IOPS）以及可写快照的容量要求。

6. 发明申请

WO2012090499A1 MATURE LEAF - SPECIFIC PROMOTER 审中-公开
标题翻译：成熟叶 - 特殊促销
公开(公告)号：WO2012090499A1
公开(公告)日：2012-07-05
申请号：PCT/JP2011/007337
申请日：2011-12-28
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , HATTORI, Etsuko , NISHIMURA, Satoru , ITO, Kazuyo
发明人： HATTORI, Etsuko , NISHIMURA, Satoru , ITO, Kazuyo
IPC分类号： C07K14/415 , C12N15/82 , A01H5/12
CPC分类号： C12N15/8225 , C07K14/415
摘要： The present invention provides gene expression regulatory DNA having activity of promoting gene expression in a mature-leaf-specific manner. The following is provided: gene expression regulatory DNA having activity of promoting gene expression in a mature-leaf-specific manner, which comprises any one of the following (a) to (d): (a) DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 4; (b) DNA consisting of a nucleotide sequence that has a deletion, a substitution, an addition, or an insertion of one or a plurality of nucleotides in the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 4 and having activity of promoting gene expression in a mature-leaf-specific manner; (c) DNA consisting of a nucleotide sequence having 90% or more sequence identity to the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 4 and having activity of promoting gene expression in a mature-leaf-specific manner; and (d) DNA hybridizing under stringent conditions to DNA consisting of a sequence complementary to a part or the entirety of the nucleotide sequence shown in SEQ ID NO: 1 or SEQ ID NO: 4 and having activity of promoting gene expression in a mature-leaf-specific manner.
摘要翻译：本发明提供具有以成熟叶特异性方式促进基因表达的活性的基因表达调控DNA。提供以下具有以成熟叶特异性方式促进基因表达的活性的基因表达调控DNA，其包含以下（a）至（d）中的任一项：（a）由以下（a）至（d）所示的核苷酸序列组成的DNA： SEQ ID NO：1或SEQ ID NO：4; （b）由SEQ ID NO：1或SEQ ID NO：4所示核苷酸序列中具有一个或多个核苷酸的缺失，取代，添加或插入的核苷酸序列组成的并具有活性的DNA 以成熟叶特异性方式促进基因表达; （c）由与SEQ ID NO：1或SEQ ID NO：4所示核苷酸序列具有90％以上序列同一性且具有以成熟叶特异性方式促进基因表达的活性的核苷酸序列组成的DNA; 和（d）在严格条件下与由与SEQ ID NO：1或SEQ ID NO：4所示的核苷酸序列的一部分或全部互补的序列组成的DNA杂交的DNA，并且具有促进成熟 - 叶特异性的方式。

7. 发明申请

WO2012090247A1 STORAGE SYSTEM, MANAGEMENT METHOD OF THE STORAGE SYSTEM, AND PROGRAM 审中-公开
标题翻译：存储系统，存储系统的管理方法和程序
公开(公告)号：WO2012090247A1
公开(公告)日：2012-07-05
申请号：PCT/JP2010/007583
申请日：2010-12-28
申请人： HITACHI, LTD. , SATOYAMA, Ai , EGUCHI, Yoshiaki
发明人： SATOYAMA, Ai , EGUCHI, Yoshiaki
IPC分类号： G06F3/06
CPC分类号： G06F3/0631 , G06F3/0608 , G06F3/061 , G06F3/0685
摘要： Provided is a technique for realizing allocation of pool areas to virtual volumes in accordance with the use environment of the user with proper cost, while improving the capacity efficiency of media. For this purpose, in the present invention, a pool is constituted by selecting or limiting combinations of tiers of media in the pool to be used (range of tiers that can be used in each pool) for each virtual volume set in a storage system (see Fig. 5).
摘要翻译：提供了一种根据用户的使用环境以适当的成本实现对虚拟卷的池区域的分配的技术，同时提高了媒体的容量效率。为此，在本发明中，通过在存储系统中为每个虚拟卷设置选择或限制要使用的池中的媒体层（可以在每个池中使用的层级的范围）的组合来构成池（参见图5）。

8. 发明申请

WO2012077162A1 STORAGE APPARATUS 审中-公开
标题翻译：存储设备
公开(公告)号：WO2012077162A1
公开(公告)日：2012-06-14
申请号：PCT/JP2010/007135
申请日：2010-12-08
申请人： HITACHI, LTD. , MORI, Hajime , KAWAKAMI, Norihiko , HIRAYAMA, Hiroshi , OUCHI, Katsumi
发明人： MORI, Hajime , KAWAKAMI, Norihiko , HIRAYAMA, Hiroshi , OUCHI, Katsumi
IPC分类号： G06F3/06
CPC分类号： G06F3/0641 , G06F3/061
摘要： It is an object of the present invention to provide a storage apparatus that can suppress access performance degradation owing to processing of data deduplication. The storage apparatus according to the present invention acquires a sum of the access frequencies to each of redundantly allocated pieces of data, and performs the deduplication on the pieces of data having the sum of access frequencies less than a prescribed threshold
摘要翻译：本发明的目的是提供一种可以抑制由于重复数据删除处理而导致的访问性能下降的存储装置。根据本发明的存储装置获取对每个冗余分配的数据片段的访问频率之和，并且对具有小于规定阈值的访问频率之和的数据片段执行重复数据消除

9. 发明申请

WO2012039006A1 DATA STORAGE SYSTEM AND METHOD FOR MANAGING A DATA STORAGE SYSTEM 审中-公开
标题翻译：用于管理数据存储系统的数据存储系统和方法
公开(公告)号：WO2012039006A1
公开(公告)日：2012-03-29
申请号：PCT/JP2010/005737
申请日：2010-09-22
申请人： HITACHI, LTD. , MORI, Mioko , NAKAGAWA, Hirotaka
发明人： MORI, Mioko , NAKAGAWA, Hirotaka
IPC分类号： G06F3/06 , G06F11/10
CPC分类号： G06F3/0647 , G06F3/0604 , G06F3/0619 , G06F3/0629 , G06F3/067 , G06F11/1092
摘要： The present invention provides a technique capable of preventing data loss due to relocation of physical storage devices. When a request to relocate a logical storage area is issued, it is determined if the logical storage area to be relocated, which is composed of the physical storage devices in the source storage apparatus, can be configured in the destination storage apparatus, and if it is, the physical storage devices that constitute the logical storage area to be relocated are switched into a write-inhibit state in the source storage apparatus, and the write-inhibit state of the physical storage devices is maintained until the physical storage devices are set up and the logical storage area to be relocated is configured in the destination storage apparatus.
摘要翻译：本发明提供一种能够防止由于物理存储装置的重定位而引起的数据丢失的技术。当发出重新定位逻辑存储区域的请求时，确定是否可以在目的地存储装置中配置由源存储装置中的物理存储装置构成的要重新定位的逻辑存储区域，如果构成要重新定位的逻辑存储区域的物理存储装置在源存储装置中被切换为禁止写入状态，并且保持物理存储装置的禁止写入状态直到物理存储装置被建立并且将要重新定位的逻辑存储区域配置在目的地存储装置中。

10. 发明申请

WO2011013352A1 RECOMBINANT MICROORGANISM AND METHOD FOR PRODUCING ALIPHATIC POLYESTER WITH THE USE OF THE SAME 审中-公开
标题翻译：重组微生物及其使用生产聚氨酯的方法
公开(公告)号：WO2011013352A1
公开(公告)日：2011-02-03
申请号：PCT/JP2010/004762
申请日：2010-07-27
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , OBATA, Shusei , MURAMATSU, Masayoshi , KANBE, Hiromi , ITO, Masakazu , SHIMAMURA, Takashi , KOHDA, Katsunori
发明人： OBATA, Shusei , MURAMATSU, Masayoshi , KANBE, Hiromi , ITO, Masakazu , SHIMAMURA, Takashi , KOHDA, Katsunori
IPC分类号： C12N9/10 , C12P7/62
CPC分类号： C12N9/13 , C12N9/1029 , C12P7/62
摘要： This invention provides a recombinant microorganism exhibiting excellent aliphatic polyester productivity and a method for producing an aliphatic polyester with the use of the recombinant microorganism. In this invention, the Megasphaera elsdenii-derived pct gene (and/or the Staphylococcus aureus-derived pct gene) and the Pseudomonas sp. 61-3 strain-derived PHA synthase gene (phaC2 gene) (and/or the Alcanivorax borkumensis SK2 strain-derived PHA synthase gene) are introduced into a host microorganism.
摘要翻译：本发明提供使用重组微生物显示优异脂肪族聚酯生产率的重组微生物和生产脂肪族聚酯的方法。在本发明中，来自大疱疹病毒的巨噬细胞源基因（和/或金黄色葡萄球菌来源的pct基因）和假单胞菌属（Pseudomonas sp。 61-3菌株衍生的PHA合酶基因（phaC2基因）（和/或阿尔卡氏菌属Bclumum SK2株衍生的PHA合酶基因）引入宿主微生物中。

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