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1. 发明申请

WO2023075814A1 ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF P-COUMARIC ACID BY FERMENTATION 审中-公开
公开(公告)号：WO2023075814A1
公开(公告)日：2023-05-04
申请号：PCT/US2021/072020
申请日：2021-10-25
申请人： ZYMERGEN INC.
发明人： TRACEWELL, Cara Ann , SHEARER, Alexander Glennon , TYMOSHENKO, Stepan , CHOWDHURY, Anupam , EDGAR, Steven M.
IPC分类号： C12P7/22 , C12N1/14 , C12N1/20 , C12N9/88
摘要： The present disclosure describes the engineering of microbial cells to express a heterologous L-tyrosine ammonia lyase for fermentative production of p-coumaric acid. Additional genetic alterations were introduced to improve p-coumaric acid titer. The disclosure further describes novel engineered microbial cells and cultures, as well as related p-coumaric acid production methods.

2. 发明申请

WO2021222289A1 PSEUDO-COMPLEMENTARY BASES IN GENOTYPING AND NUCLEIC ACID SEQUENCING 审中-公开
公开(公告)号：WO2021222289A1
公开(公告)日：2021-11-04
申请号：PCT/US2021/029448
申请日：2021-04-27
申请人： CEPHEID
发明人： HIGUCHI, Russell , WANG, Nicolas
IPC分类号： C12Q1/6855 , C12Q1/686 , C12Q1/6876 , C12Q1/6883
摘要： Described herein are methods and compositions that make use of pseudo-complementary bases to reduce unwanted hybridization in assays to detect and/or quantify particular nucleotide sequences, as well as in nucleic acid sequencing protocols.

3. 发明申请

WO2020171867A2 ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF 2-OXOADIPATE BY FERMENTATION 审中-公开
公开(公告)号：WO2020171867A2
公开(公告)日：2020-08-27
申请号：PCT/US2019/063107
申请日：2019-11-25
申请人： ZYMERGEN, INC.
发明人： CHOWDHURY, Anupam , EDGAR, Steven M. , SHEARER, Alexander Glennon , TRACEWELL, Cara Ann , TYMOSHENKO, Stepan , WANG, Zhihao
IPC分类号： C12N15/81
摘要： The present disclosure describes the engineering of microbial cells for fermentative production of 2-oxoadipate and provides novel engineered microbial cells and cultures, as well as related 2-oxoadipate production methods.

4. 发明申请

WO2020154320A1 ELASTOMERIC ADHESIVES COMPRISING BIO-DERIVED COMPOUNDS 审中-公开
公开(公告)号：WO2020154320A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/014467
申请日：2020-01-21
申请人： ZYMERGEN INC.
发明人： BHAGWAT, Nandita , DICKENS, John , RITTER, Joachim , VANDEZANDE, Gerald A. , VANDEZANDE, Jonathon E. , MCNAMARA, John
IPC分类号： C09J175/04 , C08K5/18 , C08L75/00 , C07C211/49 , C07C219/06
摘要： The present disclosure addresses elastomeric adhesives and elastomers that include a modified amine. The modified amine can be the reaction product of an amine with a Michael acceptor. The amine can be represented by H 2 N-Ar-R 1 -NH 2 , wherein Ar is an arylene and R1 is selected from an alkylene and alkenylene. The Michael acceptor can be selected from a variety of compounds including maleates, fumarates, acrylates, and others.

5. 发明申请

WO2018203947A3 ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF TYRAMINE BY FERMENTATION 审中-公开
公开(公告)号：WO2018203947A3
公开(公告)日：2018-11-08
申请号：PCT/US2018/017127
申请日：2018-02-06
申请人： ZYMERGEN INC.
发明人： SIDDIQUI, Michael S. , DE KOK, Stefan , SHEARER, Alexander , LU, Franklin , TRACEWELL, Cara , EDGAR, Steven
IPC分类号： C12N9/88 , C12N1/20 , C12N1/16
摘要： The present disclosure describes the engineering of microbial cells for fermentative production of tyramine and provides novel engineered microbial cells and cultures, as well as related tyramine production methods.

6. 发明申请

WO2016100388A1 EXPONENTIAL BASE-GREATER-THAN-2 NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：特异性碱基 - 大于2的核酸放大
公开(公告)号：WO2016100388A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/065890
申请日：2015-12-15
申请人： CEPHEID
发明人： HIGUCHI, Russell
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2525/155 , C12Q2525/161 , C12Q2525/191 , C12Q2531/119
摘要： Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a greater than 2-fold increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR.
摘要翻译：本文描述了提供高效核酸扩增的方法和组合物。在一些实施方案中，这允许每个扩增循环的扩增产物增加大于2倍，因此与常规PCR相比增加灵敏度和速度。

7. 发明申请

WO2016036999A1 TOPICAL PTEROSTILBENE COMPOSITIONS FOR USE IN TREATING UV-INDUCED LOSS OF BARRIER FUNCTION IN SKIN 审中-公开
标题翻译：用于治疗紫外线诱发的皮肤障碍功能障碍的局部皮质类固醇组合物
公开(公告)号：WO2016036999A1
公开(公告)日：2016-03-10
申请号：PCT/US2015/048422
申请日：2015-09-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MEYSKENS, Frank L. , DELLINGER, Ryan W.
IPC分类号： A61Q17/00
CPC分类号： A61K31/09 , A61K9/0014 , A61K9/08 , A61K47/26 , A61P17/00 , A61P35/00
摘要： A chemoprotective method for treating, inhibiting or preventing loss of barrier function in skin caused by ultraviolet (UV) light by using an effective amount of pterostilbene is provided. Pharmaceutical and nutraceutical compositions containing pterostilbene suitable for administration to an individual in order to prevent subsequent UV-mediated loss of barrier function in skin are provided.
摘要翻译：提供了一种用于通过使用有效量的ter il for来治疗，抑制或预防由紫外线（UV）光引起的皮肤屏障功能丧失的化学保护方法。提供了含有适于给予个体的ter芪苯以防止随后的紫外线介导的皮肤屏障功能丧失的药物和营养组合物。

8. 发明申请

WO2015013676A1 METHODS OF DETECTING CHLAMYDIA AND GONORRHEA AND OF SCREENING FOR INFECTION/INFLAMMATION BASED ON GENOMIC COPY NUMBER 审中-公开
标题翻译：根据基因组复制数检测CHLAMYDIA和GONORRHEA和筛选感染/炎症的方法
公开(公告)号：WO2015013676A1
公开(公告)日：2015-01-29
申请号：PCT/US2014/048295
申请日：2014-07-25
申请人： CEPHEID
发明人： PERSING, David , MURRAY, William E.
IPC分类号： C12Q1/68 , A61P31/00
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q1/6886 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： Compositions and methods for detecting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number. Described herein is a method that entails assaying a sample obtained from the urogenital tract of the mammal for an indicator of genomic copy number, wherein a genomic copy number level that is higher than a control genomic copy number level is indicative of the presence of infection or inflammation of the urogenital tract. Also described in a kit of the invention that includes a primer and/or probe for detecting or sequencing an indicator of genomic copy number, wherein the indicator of genomic copy number comprises a nucleic acid sequence that is expected to be present in the genome of the mammal in one or two copies; and a primer and/or probe for detecting or sequencing a nucleic acid sequence that is indicative of a pathogen that infects the urogenital tract or a miRNA correlated with inflammation.
摘要翻译：提供了检测沙眼衣原体（CT）和淋病奈瑟氏球菌（NG）的组合物和方法。本发明还提供了基于基因组拷贝数筛选感染/炎症的方法和组合物。本文描述了一种方法，其需要测定从哺乳动物的泌尿生殖道获得的样品用于基因组拷贝数的指示符，其中高于对照基因组拷贝数水平的基因组拷贝数水平指示感染的存在或泌尿生殖道炎症。还在本发明的试剂盒中描述，其包括用于检测或测序基因组拷贝数指标的引物和/或探针，其中基因组拷贝数的指示符包含预期存在于基因组拷贝数的基因组中的核酸序列哺乳动物一至二份; 以及用于检测或测序指示感染泌尿生殖道的病原体的核酸序列或与炎症相关的miRNA的引物和/或探针。

9. 发明申请

WO2012162555A2 HEPARIN NANOCLUSTERS 审中-公开
公开(公告)号：WO2012162555A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/039459
申请日：2012-05-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SEGURA, Tatiana , ANDERSON, Sean
发明人： SEGURA, Tatiana , ANDERSON, Sean
IPC分类号： A61K31/727 , A61K38/18 , A61K9/16 , A61K47/48 , A61K9/14
CPC分类号： A61K31/727 , A61K38/1866 , A61K47/61 , A61K47/6903 , A61K47/6933 , A61K47/6939
摘要： The present invention provides a composition of nanoparticles that includes heparin in combination with a heparin-binding factor that can be used to promote angiogenesis, regenerate tissue (nerve, heart, bone, adipose, cartilage, tendons, ligaments, muscle, skin, etc.), and deliver extracellular matrix proteins (fibronectin, collagen, laminin, vitronectin, etc.).
摘要翻译：本发明提供纳米颗粒组合物，其包括肝素结合肝素结合因子，其可用于促进血管发生，再生组织（神经，心脏，骨骼，脂肪，软骨，肌腱，韧带，肌肉，皮肤等）），并传递细胞外基质蛋白（纤连蛋白，胶原，层粘连蛋白，玻连蛋白等）。

10. 发明申请

WO2011142836A2 ASSAYS FOR THE DETECTION OF GENOTYPE, MUTATIONS, AND/OR ANEUPLOIDY 审中-公开
标题翻译：用于检测基因组，突变和/或异常的测定
公开(公告)号：WO2011142836A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/000887
申请日：2011-05-16
申请人： FLUIDIGM CORPORATION , JONES, Robert, C. , LIVAK, Kenneth, J. , MAY, Andrew , MIR, Alain , PIEPRZYK, Martin , QIN, Jian , RAMAKRISHNAN, Ramesh , SPURGEON, Sandra , WANG, Jun , ZIMMERMANN, Bernhard, G.
发明人： JONES, Robert, C. , LIVAK, Kenneth, J. , MAY, Andrew , MIR, Alain , PIEPRZYK, Martin , QIN, Jian , RAMAKRISHNAN, Ramesh , SPURGEON, Sandra , WANG, Jun , ZIMMERMANN, Bernhard, G.
IPC分类号： C12Q1/68 , G01N33/52 , G06F19/18
CPC分类号： C12Q1/6851 , C12Q1/6855 , C12Q1/6858 , G01N33/542 , G01N33/582 , G01N33/6893 , G01N2800/368 , C12Q2521/301 , C12Q2521/501 , C12Q2525/155 , C12Q2535/131 , C12Q2537/143 , C12Q2537/16 , C12Q2563/173
摘要： The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.
摘要翻译：本发明提供用于检测基因型，突变和/或非整倍体的基于扩增的方法。这些方法具有广泛的适用性，但是特别适合于检测和定量存在于母体体液样品中的游离胎儿DNA中的靶核酸。

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