专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008039644A2 COMPOSITIONS AND METHODS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2008039644A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/078228
申请日：2007-09-12
申请人： FERNANDO AND ANNA FOUNDATION , FERRETTI, Fernando , FERRETTI, Anna
发明人： FERRETTI, Fernando , FERRETTI, Anna
IPC分类号： A61K38/46 , A61K36/886
CPC分类号： A61K36/886 , A61K35/58 , A61K38/1703 , G01N33/57407 , G01N33/57484
摘要： An improved more comprehensive understanding of tumors is disclosed including a precise molecular etiology leading to tumor cell growth. The disclosed molecular etiology explains the lack of control of tumor cell growth as well as the activation of a variety of phenotypic and pathological molecular mechanisms that are the natural result of the disclosed tumor etiology. A comprehensive approach to the detection and treatment of neoplasia is also disclosed.
摘要翻译：公开了对肿瘤的更全面的了解，包括导致肿瘤细胞生长的精确分子病因。所公开的分子病因解释了对肿瘤细胞生长的控制以及作为所公开的肿瘤病因的天然结果的多种表型和病理分子机制的激活。还公开了检测和治疗肿瘤的综合方法。

2. 发明申请

WO2007103763A3 METHODS FOR GENERATING AND USING STEM CELL PROFILES 审中-公开
公开(公告)号：WO2007103763A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/063123
申请日：2007-03-02
申请人： BIO REGENERATE, INC. , TREVES, Ami
发明人： TREVES, Ami
IPC分类号： C12N5/08
摘要： A method for phenotypical and functional characterization of various populations of stem and progenitor cells from cell samples, such as tissue samples is disclosed. In one aspect, the method can be used to identify the status of these cells and their functions in individuals. The method, when applied to blood tissue, can include a step of enriching stem cell lineages that are commonly found in both the bone marrow and peripheral blood: the hematopoietic, endothelial and mesenchymal stem/progenitor cells. The variety and population of stem cells can be identified by analysis of cell markers for several defined stem cell and lineage committed markers and by analysis of characteristic ex vivo self renewal potential. Such techniques can be used to obtain a functional profile of stem/progenitor populations for each cell sample, and for various clinical conditions. The profile can also be associated with and add value to the storage and banking business of stem cells. Profiles and consecutive profiles for individuals can be included in a database along with health characteristics of the individuals. The database can be used for patient follow-up or scientific reference. Database profiles for certain populations may serve for statistical, epidemiological and health evaluations.

3. 发明申请

WO2007101191A2 COMPOSITIONS AND METHODS FOR REDUCING CELLULAR FAT AND FOR PREDICTING CARDIAC TOXICITY AND UPON TREATMENT WITH TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：用酪蛋白激酶抑制剂减少细胞脂肪和预测心脏毒性并治疗的组合物和方法
公开(公告)号：WO2007101191A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/062871
申请日：2007-02-27
申请人： TARGETED MOLECULAR DIAGNOSTICS, LLC , BACUS, Sarah, S.
发明人： BACUS, Sarah, S.
CPC分类号： G01N33/5061 , G01N33/5091 , G01N2333/4706 , G01N2333/81 , G01N2800/52
摘要： Methods are disclosed for determining whether organ toxicity, particularly cardiotoxicity, will occur in a patient selected for treatment with various kinase inhibitors, such as tyrosine kinase inhibitors, more particularly erbB inhibitors such as Herceptin. In addition, methods are disclosed for determining whether a potential drug is likely to produce a cardiotoxic effect. The methods involve analyzing lipid levels or the expression fatty acid oxidation enzymes, pAMP activated protein kinase, glucose uptake, to determine whether a fatty acid oxidation disorder is present. The identification of a fatty acid oxidation disorder can be used as a predictor of toxicity, especially cardiac toxicity, and as an indication that organ function should be carefully monitored if a drug such as a tyrosine kinase inhibitor is administered. Methods are also disclosed for protecting organs from metabolic stress and for the treatment of cells, such as adipocytes, to reduce their lipid content.
摘要翻译：公开了用于确定选择用各种激酶抑制剂治疗的患者（例如酪氨酸激酶抑制剂，更特别是erbB抑制剂如赫赛汀）是否会发生器官毒性，特别是心脏毒性的方法。另外，公开了用于确定潜在药物是否可能产生心脏毒性效应的方法。该方法涉及分析脂质水平或表达脂肪酸氧化酶，pAMP活化蛋白激酶，葡萄糖摄取，以确定是否存在脂肪酸氧化障碍。脂肪酸氧化障碍的鉴定可以用作毒性的预测指标，尤其是心脏毒性，并且指出如果施用诸如酪氨酸激酶抑制剂的药物，应仔细监测器官功能。还公开了用于保护器官免受代谢应激和用于治疗细胞（例如脂肪细胞）以降低其脂质含量的方法。

4. 发明申请

WO2007073560A2 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS 审中-公开
标题翻译：药物组合物及使用高亲液性硫酸化合物的方法
公开(公告)号：WO2007073560A2
公开(公告)日：2007-06-28
申请号：PCT/US2006/062418
申请日：2006-12-20
申请人： RND PHARMACEUTICALS, INC. , GATELY, Stephen , WEST, Robert
发明人： GATELY, Stephen , WEST, Robert
CPC分类号： C07F7/0818 , C07D213/60 , C07D213/75 , C07F7/0814
摘要： Novel compositions of silicon-containing sulfhydryl compounds, their preparation and use in methods for treating disease are described. Silicon confers lipophilicity that can enhance the penetration of the silicon derivative sulfhydryl compounds across the gut wall, cell membranes and blood brain barrier, thus improving therapeutic properties including bioavailability, metabolism, and/or pharmacokinetics. The organosilyl group provides compounds having improved pharmacokinetics. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：描述了含硅巯基化合物的新型组合物，其制备方法和用于治疗疾病的方法中的用途。硅赋予亲脂性，其可以增强硅衍生物巯基化合物穿过肠壁，细胞膜和血脑屏障的渗透，从而改善治疗特性，包括生物利用度，代谢和/或药代动力学。有机甲硅烷基提供具有改善的药代动力学的化合物。本发明包括新型化合物，类似物，前药和药学上可接受的盐，用于治疗疾病和其它疾病或病症等的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

5. 发明申请

WO2007048020A1 EXERCISE DEVICE 审中-公开
标题翻译：锻炼装置
公开(公告)号：WO2007048020A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/041210
申请日：2006-10-20
申请人： SHARPER IMAGE CORPORATION , TAYLOR, Charles, E. , SNYDER, Gregory, S. , CHRISTIANSON, Tristan, M. , BRENNER, Patricia, I.
发明人： TAYLOR, Charles, E. , SNYDER, Gregory, S. , CHRISTIANSON, Tristan, M. , BRENNER, Patricia, I.
IPC分类号： A63B21/00 , A63B22/00
CPC分类号： A63B23/03575 , A63B21/015 , A63B23/0222 , A63B2023/003 , A63B2208/0214 , A63B2220/17 , A63B2225/09
摘要： An exercise machine is provided that can be used to more effectively strengthen and increase the flexibility of the middle section of the body and also can be used to strengthen most muscle groups in the body. The exercise device contains a frame which supports a handle and a pivoting mechanism joined to a leg support. The handle can also be joined to a pivoting mechanism in some embodiments. Typically, the leg support and the handle are joined to their pivoting mechanisms through support arms. Where both the leg support and the handle support are joined to a pivoting mechanism, the pivoting mechanisms can have the same central pivot axis, different pivot axis that are parallel to each other or altogether distinct pivot axis. The handle and leg supports of the device can be conveniently adjusted so that the device can accommodate individuals of various sizes.
摘要翻译：提供了一种可用于更有效地增强和增加身体中段的柔韧性的锻炼机，还可用于加强身体中的大多数肌肉群。锻炼装置包括支撑手柄的框架和连接到腿支撑件的枢转机构。在一些实施例中，手柄也可以连接到枢转机构。通常，腿支撑件和手柄通过支撑臂连接到它们的枢转机构。在腿部支撑件和手柄支撑件都连接到枢转机构的情况下，枢转机构可以具有相同的中心枢转轴线，不同的枢转轴线彼此平行或完全不同的枢转轴线。可以方便地调节装置的手柄和腿部支撑，使得装置可以容纳各种尺寸的个体。

6. 发明申请

WO2006105161A2 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：WO2006105161A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011410
申请日：2006-03-29
申请人： CARTILIX, INC. , HUERTA, Frank , ELISSEEFF, Jennifer , MARCUS, Norman
发明人： HUERTA, Frank , ELISSEEFF, Jennifer , MARCUS, Norman
IPC分类号： A61F2/02
CPC分类号： A61F2/30767 , A61F2/28 , A61F2/30756 , A61F2/30771 , A61F2310/00011 , A61F2310/00179 , A61F2310/00389 , A61F2310/00976 , A61L27/34 , Y10T428/31536 , Y10T428/31703 , Y10T428/31971
摘要： Biologic coatings on a surface of a prosthesis or implantable device.
摘要翻译：假体或可植入装置表面上的生物涂层。

7. 发明申请

WO2006039562A2 AIR CONDITIONER SYSTEM INCLUDING PIN-RING ELECTRODE CONFIGURATION WITH A PIN-RING ELECTRODE CLEANING MECHANISM 审中-公开
标题翻译：空调系统，包括带环形电极清洁机构的PIN环电极配置
公开(公告)号：WO2006039562A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/035316
申请日：2005-09-30
申请人： SHARPER IMAGE CORPORATION , TAYLOR, Charles E. , PARKER, Andrew J. , BOTVINNIK, Igor Y. , LAU, Shek Fai , SNYDER, Gregory S. , REEVES, John Paul
发明人： TAYLOR, Charles E. , PARKER, Andrew J. , BOTVINNIK, Igor Y. , LAU, Shek Fai , SNYDER, Gregory S. , REEVES, John Paul
CPC分类号： H01T23/00 , B03C3/49 , B03C3/60 , B03C3/64 , B03C3/743 , B03C2201/06 , B03C2201/08 , B03C2201/10 , B03C2201/14
摘要： The present invention is related to electro-kinetic air conditioner systems having at least one emitter electrode and at least one collector electrode. The emitter electrode can have a plurality of pins axially arranged about a center axis and can include a cleaning mechanism which removes debris and particulates from the pins when the emitter electrode and/or cleaning mechanism is moved. Preferably, a driver electrode is located within the interior of the collector electrode. A high voltage source provides a voltage potential to at least one of the emitter electrode and the collector electrode to thereby provide a potential difference therebetween.
摘要翻译：本发明涉及具有至少一个发射电极和至少一个集电极的电动空调系统。发射电极可以具有围绕中心轴线轴向布置的多个销，并且可以包括清洁机构，当发射电极和/或清洁机构移动时，该清洁机构从销中除去碎屑和微粒。优选地，驱动电极位于集电极的内部。高电压源向发射电极和集电极中的至少一个提供电压电位，从而在它们之间提供电位差。

8. 发明申请

WO2006026436A3 ROBOT CLEANER WITH IMPROVED VACUUM UNIT 审中-公开
公开(公告)号：WO2006026436A3
公开(公告)日：2006-03-09
申请号：PCT/US2005/030422
申请日：2005-08-26
申请人： SHARPER IMAGE CORPORATION , TAYLOR, Charles E. , PARKER, Andrew J. , LAU, Shek Fai , BLAIR, Eric C. , HENINGER, Andrew , NG, Eric
发明人： TAYLOR, Charles E. , PARKER, Andrew J. , LAU, Shek Fai , BLAIR, Eric C. , HENINGER, Andrew , NG, Eric
IPC分类号： B25J5/00
摘要： A robot cleaner includes a vacuum air path including an inlet, a particulate collection dustbin, a fan, and an air exit.

9. 发明申请

WO2008073574A1 METHODS FOR DIAGNOSIS AND TREATMENT OF PROCESSING DIFFICULTIES, INTEGRATION PROBLEMS, IMBALANCES AND ABNORMAL POSTURES 审中-公开
标题翻译：处理困难的诊断和处理方法，整合问题，难题和异常情况
公开(公告)号：WO2008073574A1
公开(公告)日：2008-06-19
申请号：PCT/US2007/081928
申请日：2007-10-19
申请人： ZELINSKY, Deborah
发明人： ZELINSKY, Deborah
IPC分类号： A61B19/00
CPC分类号： A61B17/12022 , A61B5/1116 , A61B5/16 , A61B5/4023 , A61B5/411 , A61B17/12036 , A61B17/12099 , A61B17/12159 , A61F9/00772 , A61N5/0618
摘要： Methods for diagnosis and treatment are provided for a patient having processing difficulties, integration problems, imbalances or abnormal postures. In one embodiment, a patient is identified having retinal signal problems creating at least one negative medical condition. Then the amount of a natural hormone in the eye is increased such that, as a result of the diagnosis and treatment, the patient achieves improved retinal signal processing and at least one of the patient's negative medical conditions is improved. Other embodiments include using the treatment in combination with the Z-Bell Test and/or light blocking or altering devices for diagnosis and treatment.
摘要翻译：为具有加工困难，整合问题，不平衡或异常姿势的患者提供诊断和治疗方法。在一个实施方案中，鉴定出患有视网膜信号问题的患者产生至少一种阴性的医疗状况。然后增加眼睛中天然激素的量，使得作为诊断和治疗的结果，患者实现了改善的视网膜信号处理，并且改善了患者的负面医疗条件中的至少一个。其他实施方案包括将该治疗与Z-Bell试验和/或遮光或改变装置结合用于诊断和治疗。

10. 发明申请

WO2007118159A2 USE OF STORAGE-STABLE AQUEOUS SOLUTIONS OF CHLORINE DIOXIDE TO GENERATE PURE CHLORINE DIOXIDE GAS FOR DECONTAMINATION 审中-公开
标题翻译：使用二氧化氯储存稳定的水溶液生成纯二氧化氯气体，用于去除
公开(公告)号：WO2007118159A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/066081
申请日：2007-04-05
申请人： CDG RESEARCH CORPORATION , MCWHORTER, Thomas Ellsworth , ROSENBLATT, Aaron A. , ANAND, Madhu , HOBBS, John Peter
发明人： MCWHORTER, Thomas Ellsworth , ROSENBLATT, Aaron A. , ANAND, Madhu , HOBBS, John Peter
IPC分类号： C01B11/02
CPC分类号： C01B11/022 , A61L2/20 , A61L2/22
摘要： New compositions and methods are disclosed for decontaminating surfaces and enclosures that avoid problems such as salt deposits, corrosion and condensation that accompany the use of known methods. The process involves the use of chlorine dioxide solutions prepared by passing dilute chlorine gas over solid granular sodium chlorite to produce chlorine dioxide gas which is then collected in solution. The chlorine dioxide gas can be introduced into an enclosure and used to disinfect a portion of the contents of the enclosure.
摘要翻译：公开了用于净化表面和外壳的新组合物和方法，其避免了使用已知方法的问题，例如盐沉积，腐蚀和冷凝。该方法包括使用通过将稀氯气通过固体颗粒状亚氯酸钠制备的二氧化氯溶液以产生二氧化氯气体，然后将其收集在溶液中。可以将二氧化氯气体引入外壳中，并用于消毒外壳内容物的一部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式