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1. 发明申请

WO2007101888A2 IMPROVED BREWING PROCESS 审中-公开
标题翻译：改进的酿造过程
公开(公告)号：WO2007101888A2
公开(公告)日：2007-09-13
申请号：PCT/EP2007/056259
申请日：2007-06-22
申请人： DSM IP Assets B.V. , NGUYEN, Minh-Tam , EDENS, Luppo , ROON, VAN, Jeroen, Louis
发明人： NGUYEN, Minh-Tam , EDENS, Luppo , ROON, VAN, Jeroen, Louis
CPC分类号： C12C5/004 , C12C11/003 , C12H1/22
摘要： The present invention relates to the use of a proline-specific protease for accelerating the beer brewing process. In particular, it relates to the use of a proline-specific protease for accelerating the beer brewing process by shortening and simplifying the stabilisation phase of beer production. The stabilisation period as such can be omitted from the beer making process hereby saving significant costs and adding to the flexibility of beer producing plants.
摘要翻译：本发明涉及脯氨酸特异性蛋白酶用于加速啤酒酿造过程的用途。特别涉及通过缩短和简化啤酒生产的稳定化阶段来加速啤酒酿造过程中使用脯氨酸特异性蛋白酶。这样的稳定期可以从啤酒制造过程中省略，从而节省大量成本并增加啤酒生产厂的灵活性。

2. 发明申请

WO2013110673A1 DITERPENE PRODUCTION 审中-公开
标题翻译：地面生产
公开(公告)号：WO2013110673A1
公开(公告)日：2013-08-01
申请号：PCT/EP2013/051262
申请日：2013-01-23
申请人： DSM IP ASSETS B.V.
发明人： LEHMANN, Martin , TRUEHEART, Joshua , ZWARTJENS, Priscilla , WU, Liang , BOER, Viktor , SAGT, Cornelis, Maria, Jacobus , KUMAR, Manoj , MEIJRINK, Bernard
IPC分类号： A23L1/236 , C12N9/02 , C12N9/88 , C12N9/90 , C12P5/00
CPC分类号： C12P19/56 , A23K20/10 , A23K20/121 , A23K20/163 , A23L2/60 , A23L27/36 , A23V2002/00 , C07H15/256 , C12N9/0073 , C12N9/1051 , C12N9/88 , C12N9/90 , C12N15/52 , C12P5/007 , C12Y114/13078 , C12Y204/01035 , C12Y402/03019 , C12Y505/01013
摘要： The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.
摘要翻译：本发明涉及包含一个或多个核苷酸序列的重组微生物，所述核苷酸序列编码：具有入 - copalyl焦磷酸合成酶活性的多肽; 具有ent-Kaurene合酶活性的多肽; 具有ent-Kaurene氧化酶活性的多肽; 和具有山梨酸13-羟化酶活性的多肽，由此所述核苷酸序列的表达赋予所述微生物至少产生甜菊醇的能力。重组微生物还可能能够表达一种或多种UDP-葡糖基转移酶，使得微生物能够产生一种或多种甜菊糖苷。

3. 发明申请

WO2012123429A1 VECTOR-HOST SYSTEM 审中-公开
标题翻译：矢量主机系统
公开(公告)号：WO2012123429A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054302
申请日：2012-03-12
申请人： DSM IP Assets B.V. , BOVENBERG, Roelof Ary Lans , KIEL, Jan Andries Kornelis Willem , WENZEL, Thibaut José , LOS, Alrik Pieter
发明人： BOVENBERG, Roelof Ary Lans , KIEL, Jan Andries Kornelis Willem , WENZEL, Thibaut José , LOS, Alrik Pieter
IPC分类号： C07K14/385 , C12N15/65 , C12N15/80
CPC分类号： C12N15/80 , C07K14/385 , C12N15/65
摘要： The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest.
摘要翻译：本发明涉及必需基因缺陷的宿主细胞，其包含载体，所述载体至少包含所述必需基因和自主复制序列，其中所述宿主细胞是丝状真菌细胞。本发明还涉及缺乏必需基因的宿主细胞，其包含载体，所述载体至少包含所述必需基因和自主复制序列，其中所述宿主细胞包含重组多核苷酸构建体，其包含编码感兴趣的生物化合物的多核苷酸或涉及合成感兴趣的生物化合物的化合物。

4. 发明申请

WO2012116977A1 PROCESS FOR THE PREPARATION OF 3-METHYLENE-γ-BUTYROLACTONE 审中-公开
标题翻译：制备3-甲基-β-丁氧基酮的方法
公开(公告)号：WO2012116977A1
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053345
申请日：2012-02-28
申请人： DSM IP ASSETS B.V. , DE WILDEMAN, Stefaan, Marie, André , DE VRIES, Johannes, Gerardus , BOOGERS, Jeroen, Antonius, Franciscus
发明人： DE WILDEMAN, Stefaan, Marie, André , DE VRIES, Johannes, Gerardus , BOOGERS, Jeroen, Antonius, Franciscus
IPC分类号： C07D307/58
CPC分类号： C07D307/58
摘要： The invention relates to a process for the preparation of 3-methylene-γ-butyrolactone (Z), the process comprising a hydroformylation step wherein 1,4-butene-diol (X) or its ester derivative cis-1,4-diacetoxy butene (Y) is subjected to H 2 gas and CO gas in the presence of a hydroformylation catalyst, thereby forming an intermediate product comprising a mixture of compounds containing an aldehyde group or a hemiacetal, and an oxidation step wherein the intermediate product or hydrolyzed derivative thereof is oxidized by an oxidation agent thereby forming Z.
摘要翻译：本发明涉及一种制备3-亚甲基-α-丁内酯（Z）的方法，该方法包括加氢甲酰化步骤，其中1,4-丁烯二醇（X）或其酯衍生物顺式-1,4-二乙酰氧基丁烯（Y）在加氢甲酰化催化剂存在下经受H 2气和CO气，由此形成包含含有醛基或半缩醛的化合物的混合物的中间产物和氧化步骤，其中中间产物或其水解衍生物为由氧化剂氧化，从而形成Z。

5. 发明申请

WO2013076280A1 NUCLEIC ACID ASSEMBLY SYSTEM 审中-公开
标题翻译：核酸组装系统
公开(公告)号：WO2013076280A1
公开(公告)日：2013-05-30
申请号：PCT/EP2012/073532
申请日：2012-11-23
申请人： DSM IP ASSETS B.V.
发明人： ROUBOS, Johannes, Andries , MEIJRINK, Bernard , KERKMAN, Richard , DULK, DEN, Ben
IPC分类号： C12N15/10 , C12N15/52 , C40B40/06 , C40B40/08
CPC分类号： C12N15/1082 , C12N15/1027 , C12N15/1093 , C12N15/52 , C12N15/80 , C12N15/905
摘要： The present invention relates to a method for the preparation of a library of host cells, a plurality of which comprise an assembled polynucleotide at a target locus, which method comprises: (a) providing a plurality of polynucleotides comprising two or more polynucleotide subgroups, wherein: (i) a plurality of polynucleotides in each polynucleotide subgroup comprises sequence encoding a peptide or polypeptide and/or a regulatory sequence; (ii) a plurality of peptides or polypeptides encoded by, or a plurality of regulatory sequences comprised within, each polynucleotide subgroup share an activity and/or function; (iii) at least one polynucleotide subgroup comprises at least two non-identical polynucleotide species; (iv) a plurality of polynucleotides of each polynucleotide subgroup comprises sequence enabling homologous recombination with a plurality of polynucleotides from one or more other polynucleotide subgroups; and (v) a plurality of polynucleotides in two polynucleotide subgroups comprise a nucleotide sequence enabling homologous recombination with a target locus in host cells; and (b) assembling the plurality of polynucleotides at the target locus by homologous recombination in vivo in host cells, thereby to generate a library of host cells, a plurality of which comprise an assembled polynucleotide at the target locus. The assembled polynucleotides may be recovered, thereby to prepare a library of nucleic acids.
摘要翻译：本发明涉及一种用于制备宿主细胞文库的方法，其多个在靶位点包含组装的多核苷酸，该方法包括：（a）提供多个包含两个或多个多核苷酸亚基的多核苷酸，其中（i）每个多核苷酸亚组中的多个多核苷酸包含编码肽或多肽和/或调节序列的序列; （ii）每个多核苷酸亚组中由多个或多个编码的多肽或多肽调节序列共享活性和/或功能; （iii）至少一个多核苷酸亚组包含至少两个不相同的多核苷酸种类; （iv）每个多核苷酸亚组的多个多核苷酸包括能够与来自一个或多个其它多核苷酸亚组的多个多核苷酸进行同源重组的序列; 和（v）两个多核苷酸亚组中的多个多核苷酸包含能够与宿主细胞中的靶基因座进行同源重组的核苷酸序列; 和（b）通过在宿主细胞中的体内同源重组在靶位点组装多个多核苷酸，从而产生宿主细胞文库，其多个包含靶标位点处的组装的多核苷酸。可以回收组装的多核苷酸，从而制备核酸文库。

6. 发明申请

WO2013004670A1 PROCESS FOR PREPARING DICARBOXYLIC ACIDS EMPLOYING FUNGAL CELLS 审中-公开
标题翻译：制备使用真菌的二羧酸的方法
公开(公告)号：WO2013004670A1
公开(公告)日：2013-01-10
申请号：PCT/EP2012/062860
申请日：2012-07-02
申请人： DSM IP ASSETS B.V. , JANSEN, Mickel Leonardus August , HEIJNEN, Johannes Joseph , VERWAAL, René
发明人： JANSEN, Mickel Leonardus August , HEIJNEN, Johannes Joseph , VERWAAL, René
IPC分类号： C12P7/46
CPC分类号： C12P7/44 , C12N1/18 , C12P7/46
摘要： The present invention relates to a process for producing a dicarboxylic acid comprising fermenting a fungal cell in a vessel comprising a suitable fermentation medium, comprising adding a gas flow which comprises 20 to 35 v/v% of oxygen and less than 0.1v/v% of carbon dioxide to the fermentation medium, and maintaining an average partial carbon dioxide pressure of at least about 0.35 bar in the fermentation medium, and producing the dicarboxylic acid.
摘要翻译：本发明涉及一种生产二羧酸的方法，包括在包含合适的发酵培养基的容器中发酵真菌细胞，包括加入包含20至35v / v％的氧和小于0.1v / v％的二氧化碳，并且在发酵培养基中保持至少约0.35巴的平均部分二氧化碳压力，并产生二羧酸。

7. 发明申请

WO2008099025A2 BODY-WEIGHT MAINTENANCE AND BODY COMPOSITION 审中-公开
标题翻译：身体重量维持和身体组成
公开(公告)号：WO2008099025A2
公开(公告)日：2008-08-21
申请号：PCT/EP2008/055713
申请日：2008-05-08
申请人： DSM IP ASSETS B.V. , HERSLÖF, Bengt , VIBERG, Annika
发明人： HERSLÖF, Bengt , VIBERG, Annika
IPC分类号： A23D7/005 , A23D9/007 , A23L1/29 , A23L1/30 , A61K31/7032 , A61P3/04 , A61P3/06 , A61P9/12 , C11C3/00
CPC分类号： A23D7/001 , A23D7/003 , A23D7/0053 , A23D7/011 , A23D7/013 , A23L33/115 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/7032 , A23V2200/332 , A23V2250/194 , A23V2250/1842 , A23V2200/222
摘要： Use of a mixture comprising a triglyceride oil having a solid fat content at ambient to body temperature and an emulsifier for the preparation of a pharmacologically active composition for increasing body fat mass loss or maintaining blood pressure in an individual. Such use may be carried out subsequent to a period of weight loss.
摘要翻译：使用包含在环境温度下具有固体脂肪含量的甘油三酯油和乳化剂的混合物，用于制备用于增加体内脂肪量损失或维持个体血压的药理学活性组合物。这种使用可以在减肥时间之后进行。

8. 发明申请

WO2008074884A2 NOVEL XYLANASE ENZYMES XYL001 AND XYL002 AND USES THEREOF 审中-公开
标题翻译：新型XYLANASE ENZYMES XYL001和XYL002及其用途
公开(公告)号：WO2008074884A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064475
申请日：2007-12-21
申请人： VALORBEC S.E.C. , TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory , STORMS, Reginald , MOHRMAN, Lisette , MUTSAERS, Johanna, Henrica, Gerdina, Maria
发明人： TSANG, Adrian , POWLOWSKI, Justin , BUTLER, Gregory , STORMS, Reginald , MOHRMAN, Lisette , MUTSAERS, Johanna, Henrica, Gerdina, Maria
IPC分类号： C12N9/24 , A23K1/165
CPC分类号： C12N9/2482 , A21D8/042 , A23K10/14 , A23K20/189 , A23K50/75 , A23L7/107 , A23L29/06 , C11D3/38645 , C12Y302/01004 , C12Y302/01008 , D21C5/005
摘要： The present invention relates tonovel xylanasesXYL001and XYL002, a polynucleotide sequence encoding for the polypeptide according to the invention, a production process for the enzymes according to the invention and the use of the enzymes according to the invention in various industrial processes.
摘要翻译：本发明涉及吨级木聚糖酶XYL001和XYL002，编码本发明多肽的多核苷酸序列，根据本发明的酶的制备方法和根据本发明的酶在各种工业过程中的用途。

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