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    • 81. 发明申请
    • METHOD FOR ADHESION OF POLYMERS TO METAL-COATED SUBSTRATES
    • 将聚合物粘合到金属涂层基材上的方法
    • WO02025282A2
    • 2002-03-28
    • PCT/US2001/029796
    • 2001-09-24
    • B05D1/18B05D7/00C03C17/38G01N33/553G01N33/543
    • B82Y30/00B05D1/185B05D7/00B05D2202/00B05D2350/65B82Y5/00B82Y15/00B82Y40/00C03C17/38G01N33/553G01N2610/00
    • The present invention provides methods for improving the adhesion of gels to metalcoated substrates. In particular, the present invention provides a method comprising the steps of forming a thiol or disulfide self-assembled monolayer on the metal-coated substrate prior to deposition of the gel structures. The invention further provides devices fabricated according to the methods of the invention, comprising a substrate having a surface, a noble metal layer deposited on the substrate surface, a self-assembled monolayer comprised of bifunctional molecules having a thiol or disulfide end and a polymerizable end formed on the noble metal layer, and a plurality of gel pads a & Bred to the self-assembled monolayer. The devices of the invention are advantageously used for performing assays using optical and/or electrochemical detection methods.
    • 本发明提供了改善凝胶对金属涂层基材的粘合性的方法。 特别地,本发明提供了一种方法,其包括以下步骤:在沉积凝胶结构之前在金属涂覆的基底上形成硫醇或二硫键自组装单层。 本发明还提供了根据本发明的方法制造的器件,其包括具有表面的衬底,沉积在衬底表面上的贵金属层,由具有硫醇或二硫键的双功能分子和可聚合端部组成的自组装单层 形成在贵金属层上,以及多个凝胶垫和自组装单层。 本发明的装置有利地用于使用光学和/或电化学检测方法进行测定。
    • 83. 发明申请
    • METHOD FOR IMPREGNATING A SUPPORT MATRIX WITH SOLID AND/OR LIQUID COMPOUNDS USING COMPRESSED GASES, AND MATERIALS IMPREGNATED IN THIS MANNER
    • METHOD FOR含浸在使用压缩气体,固体和/或液体连线等浸渍的物质的载体基质
    • WO02020177A1
    • 2002-03-14
    • PCT/EP2001/009669
    • 2001-08-21
    • B05D1/18A01C1/00A23K40/00A23L5/00A23L5/30B01J3/00B01J20/32B05D1/00B05D1/40B05D7/00C04B41/45C08J7/00A23L1/00
    • C08J9/122A01C1/06A01N25/00A23K40/00A23L5/00A23L5/30A23V2002/00C08J2201/032C08J2203/06C08J2203/08Y02P20/544A23V2300/44
    • The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using compressed gases, which is substantially characterized in that the solid and/or liquid compound(s) (impregnating substance) and the insoluble support matrix are contacted with a compressed gas or a compressed gas mixture at gas densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations) in such a manner that the respective interval until the pressure maximum is reached is longer per individual pulsation of a duration of between 5 s and 60 min than the interval until the pressure is reduced to its minimum. The absolute pressure minimum is determined by the minimum dissolving capacity of the compressed gas or compressed gas mixture for the impregnating substances. The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, and support matrices of biological origin as well as organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access. The inventive method is preferably carried out using compressed carbon dioxide, propane, butane, ethane or ammonia and can be used to treat untreated support material or already precoated materials. The impregnated materials obtained are characterized by inner surfaces that are fairly homogeneously coated with the impregnating substances and that are mainly suitable for use in the pharmaceutical, agrochemical, cosmetic and technical industry.
    • 至少两个延伸不对称变压序列(脉动)下,使用在气体密度压缩气体(混合物)从0.15至1.3千克/升含浸固体和/或液体化合物的载体基质中的方法。 该方法的特征在于,既可以使用浸渍材料,例如生物活性化合物,技术织物或有机金属化合物,以及生物来源以及有机或无机物质的支持矩阵的Veilzahl,所有的广泛和/或难以到达的 有内表面。
    • 86. 发明申请
    • SELF-ASSEMBLED THIN FILM COATING TO ENHANCE THE BIOCOMPATIBILITY OF MATERIALS
    • 自组装薄膜涂层,增强材料的生物活性
    • WO01078906A1
    • 2001-10-25
    • PCT/US2001/012042
    • 2001-04-13
    • A61N1/36A61F2/84A61L15/00A61L27/00A61L27/34A61L29/00A61L31/10A61M1/14A61M5/14A61M25/00B05B5/08B05C3/09B05D1/04B05D1/18
    • B05D1/185A61L27/34A61L31/10B82Y5/00B82Y30/00B82Y40/00Y10T428/139Y10T428/1393
    • We make a subtrate biocompatible by contacting it with a starting material and initiating alternating charge layer electrostatic self-assembly to form a thin film. Starting materials may be poly(vinylpyrrolidone), poly{bis-(carboxylatophenoxy)phosphazene}, poly(methacrylic acid), poly( l)-lysine , poly(ethylene glycol), poly(D-glucosamine), poly( l -glutamic acid), poly(diallyldimethylamine), poly(ethylenimine), hydroxy fullerene, long-sidechain fullerene, or other polymers that participate in electrostatic self-assembly. The thin film fabrication advantageously may be at room temperature. A biocompatible thin film that is uniform and homogeneous can be provided. Optionally, ZrO2, Al2O3 or TiO2 nanoclusters also may be used in the film assembly. The film may be used in a drug delivery device or a medical device. The film may be used for tissue engineering. We also provide a biocompatible composition in which are present a plurality of layers electrostatically self-assembled from at least a polymer or fullerene asmentioned. The substrate is not particulary limited, and may be quartz, glass, plastic, metal or ceramic, a material for a bone implant, bioactive glass, polyester or other polymers, plastic or rubber tubing, bandaging material, composite material, insulator material, semi-conductor material, an artificial hip, a pacemaker, a catheter, a stent or other substrates.
    • 我们通过使其与起始材料接触并产生交替的电荷层静电自组装以形成薄膜,使其生物相容。 原料可以是聚(乙烯基吡咯烷酮),聚{双((羧基苯氧基)磷腈},聚(甲基丙烯酸),聚(l) - 赖氨酸,聚(乙二醇),聚(D-葡糖胺 ),聚(1'-谷氨酸),聚(二烯丙基二甲基胺),聚(亚乙基亚胺),羟基富勒烯,长侧链富勒烯或参与静电自组装的其它聚合物。 有利地,薄膜制造可以在室温下。 可以提供均匀且均匀的生物相容性薄膜。 任选地,也可以在膜组件中使用ZrO 2,Al 2 O 3或TiO 2纳米团簇。 该膜可以用于药物输送装置或医疗装置。 该膜可用于组织工程。 我们还提供一种生物相容性组合物,其中存在从至少一种聚合物或富勒烯静电自组装的多个层,如上所述。 基材不受特别限制,可以是石英,玻璃,塑料,金属或陶瓷,用于骨植入物的材料,生物活性玻璃,聚酯或其它聚合物,塑料或橡胶管,绷带材料,复合材料,绝缘体材料,半 导体材料,人造髋,起搏器,导管,支架或其他基底。