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81. 发明申请

WO2003002197A1 A STYLET UNIT 审中-公开
标题翻译：一个STYLET单位
公开(公告)号：WO2003002197A1
公开(公告)日：2003-01-09
申请号：PCT/SE2002/000707
申请日：2002-04-09
申请人： ST. JUDE MEDICAL AB , JARL, Per , HILL, Rolf , NORÉN, Bengt-Åke
发明人： JARL, Per , HILL, Rolf , NORÉN, Bengt-Åke
IPC分类号： A61N1/372
CPC分类号： A61M25/0102 , A61M25/0136 , A61M2025/09116 , A61M2025/09125 , A61N1/056 , A61N2001/0578
摘要： A stylet unit, comprising a flexible, tubular stylet sleeve (1), a flexible innet stylet wire (2), inserted into the stylet sleeve (1), at least one portion of said stylet wire (2) and at least one portion of a channel defined by the stylet sleeve (1) having a non-circular cross-section for preventing rotation of the wire (2) inside the sleeve (1), a handle (3), by means of which the sleeve (1) and the stylet wire (2) are movable in relation to each other in a longitudinal direction, the sleeve (1) and the wire (2) being connected at one end thereof to the handle (3). The sleeve (1) is rotationally arranged within the handle (3).
摘要翻译：一个探针单元，包括柔性的管状探针套管（1），插入到探针套管（1）中的柔性innet探针线（2），所述探针线（2）的至少一部分和至少一部分由探针套筒（1）限定的通道具有非圆形横截面，用于防止套管（1）内部的线（2）旋转，手柄（3）通过套筒（1）和探针线（2）能够在纵向方向上相对于彼此移动，套筒（1）和线（2）在其一端连接到手柄（3）。套筒（1）旋转地布置在手柄（3）内。

82. 发明申请

WO2002068048A1 IMPLANTABLE HEART STIMULATOR 审中-公开
标题翻译：可植入心脏刺激器
公开(公告)号：WO2002068048A1
公开(公告)日：2002-09-06
申请号：PCT/SE2002/000344
申请日：2002-02-26
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
发明人： ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
IPC分类号： A61N1/375
CPC分类号： A61N1/056 , A61N1/205 , A61N1/375
摘要： An implantable heart stimulator comprises a pulse generator for delivering electric stimulation pulses to a patient's heart through a lead (14), connectable to said pulse generator, possibly through a connector top (12) on a pulse generator housing (10). The pulse generator housing is electrically conductive. In an infection control apparatus for such a heart stimulator the exterior surfaces of the possible connector top (12) and of a proximal part (16) of the lead (14) are electrically conductive. The proximal part extends to a position, which after implantation of the lead is situated between a location beyond the entry into the venous system and the entry to vena cava superior. The generator housing (10) and the electrical conductive surfaces of the proximal lead part and of the possible connector top are adapted to form at last two separate electrodes and a current source is provided to supply an electric infection control current between these electrodes.
摘要翻译：可植入心脏刺激器包括脉冲发生器，脉冲发生器可通过引线（14）将电刺激脉冲传送到患者的心脏，该引线可连接到所述脉冲发生器，可能通过脉冲发生器壳体（10）上的连接器顶部（12）连接。脉冲发生器壳体是导电的。在用于这种心脏刺激器的感染控制装置中，可能的连接器顶部（12）和引线（14）的近侧部分（16）的外表面是导电的。近端部分延伸到一个位置，该位置在引线的植入位于超过进入静脉系统的位置和进入腔静脉上方的位置之间。发电机壳体（10）和近端引线部分和可能的连接器顶部的导电表面适于形成最后两个单独的电极，并且提供电流源以在这些电极之间提供电感应控制电流。

83. 发明申请

WO2013060372A1 IMPLANTABLE MEDICAL LEAD WITH BLOOD SEAL 审中-公开
标题翻译：可植入医疗领域与血液密封
公开(公告)号：WO2013060372A1
公开(公告)日：2013-05-02
申请号：PCT/EP2011/068857
申请日：2011-10-27
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan
发明人： ECKERDAL, Johan
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： An implantable medical lead (1) comprises an insulating tubing (41) with a channel (42) housing a conductor (72) electrically connected to a shaft (60) present in a lumen (51) of a bearing (50). The shaft (60) is also connected to a fixation helix (22) present in a lumen (23) of a lead header (21). A clot-inducing structure (80, 82, 84, 86) of a thrombogenic material is present in a distal portion (44) of the channel (42) and/or in the lumen (51) of the bearing (50) to trigger formation of a clot when blood enters the implantable medical lead (1) and thereby inhibit blood from entering further into the channel (42).
摘要翻译：可植入医疗引线（1）包括绝缘管（41），其具有通道（42），该通道（42）容纳与轴承（50）的内腔（51）中存在的轴（60）电连接的导体（72）。轴（60）还连接到存在于引线头（21）的内腔（23）中的固定螺旋（22）。血栓形成材料的凝块诱导结构（80,82,84,86）存在于通道（42）的远端部分（44）和/或轴承（50）的内腔（51）中以触发当血液进入可植入医疗引线（1）时，凝块形成，从而抑制血液进一步进入通道（42）。

84. 发明申请

WO2012175105A1 SYSTEM AND METHOD FOR DETERMINING CARDIAC EVENTS USING LAP SIGNALS 审中-公开
标题翻译：使用LAP信号确定心脏事件的系统和方法
公开(公告)号：WO2012175105A1
公开(公告)日：2012-12-27
申请号：PCT/EP2011/060200
申请日：2011-06-20
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , NORÈN, Kjell
发明人： BLOMQVIST, Andreas , NORÈN, Kjell
IPC分类号： A61N1/365 , A61B5/0215
CPC分类号： A61B5/02028 , A61B5/0215 , A61B5/04012 , A61B5/0422 , A61B5/0472 , A61B5/7239 , A61N1/36514 , A61N1/36564
摘要： Cardiac valve events are monitored by recording a left atrial pressure (LAP) representing signal using an implantable pressure sensor (50). The LAP signal is processed in order to generate a derivative LAP signal representative of the first time derivative of the LAP signal. The opening of the aortic valve of the heart is then identified to coincide in time with a minimum in the derivative LAP signal following ventricular depolarization in a cardiac cycle.
摘要翻译：通过使用可植入压力传感器（50）记录表示信号的左心房压力（LAP）来监测心脏瓣膜事件。处理LAP信号以产生代表LAP信号的第一时间导数的导数LAP信号。然后心脏的主动脉瓣的开口被确定为在心脏周期中心室去极化后的衍生LAP信号中的时间上的最小值。

85. 发明申请

WO2012126503A1 HEMODYNAMIC STATUS ASSESSMENT 审中-公开
标题翻译：动态状态评估
公开(公告)号：WO2012126503A1
公开(公告)日：2012-09-27
申请号：PCT/EP2011/054164
申请日：2011-03-18
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin , BJÖRLING, Anders , HOLLMARK, Malin , NORÈN, Kjell , SVENSSON, Tomas , HJELM, Stefan
发明人： JÄRVERUD, Karin , BJÖRLING, Anders , HOLLMARK, Malin , NORÈN, Kjell , SVENSSON, Tomas , HJELM, Stefan
IPC分类号： A61B5/053 , A61N1/365 , A61B5/0464
CPC分类号： G06F19/34 , A61B5/0464 , A61B5/0538 , A61N1/36521 , A61N1/36535 , G06F19/00 , G06F19/12 , G06F19/24 , G16H50/50
摘要： A patient-specific hemodyanmic status model is determined from impedance data collected during periods of normal and abnormal hemodynamic status by deriving parameter values of a set of multiple impedance-derivable parameters from impedance signals collected during periods of normal hemodynamic status and in connection with periods of abnormal hemodynamic status. The parameter values are employed to estimate coefficients of a linear parametric status model. These coefficients can then be used together with parameter values determined from impedance signals determined during status assessment periods in order to determine a current hemdoynamic status of the patient (10).
摘要翻译：通过从正常血液动力学状态期间收集的阻抗信号中导出一组多个阻抗可导出参数的参数值，并与正常血液动力学状态期间相关联的时期，从正常和异常血液动力学状态期间收集的阻抗数据确定患者特异性血液动力学状态模型异常血液动力学状态。参数值用于估计线性参数状态模型的系数。然后可以将这些系数与在状态评估期间确定的阻抗信号确定的参数值一起使用，以便确定患者（10）的当前血液动力学状态。

86. 发明申请

WO2012097891A1 IMPLANTABLE DEVICE WITH IMPROVED SURFACE CHARACTERISTICS 审中-公开
标题翻译：具有改进表面特性的可植入装置
公开(公告)号：WO2012097891A1
公开(公告)日：2012-07-26
申请号：PCT/EP2011/069653
申请日：2011-11-08
申请人： ST. JUDE MEDICAL AB , CARLSSON, Louise , SAVAGE, Steven , WIGENIUS, Jens , ERIKSSON, Jessica , DOWLING, Kenneth
发明人： CARLSSON, Louise , SAVAGE, Steven , WIGENIUS, Jens , ERIKSSON, Jessica , DOWLING, Kenneth
IPC分类号： A61B5/00 , A61L29/06 , A61L29/14 , A61M25/00 , A61N1/04 , A61N1/36
CPC分类号： A61N1/05 , A61B5/00 , A61B5/042 , A61B2560/0406 , A61B2562/12 , A61F2/0077 , A61L27/18 , A61L27/50 , A61L2400/12 , A61L2400/18 , A61N1/056 , A61N1/375 , C08L75/04 , C08L83/04
摘要： An implantable device (1) comprises a polymer structure (40) having an outer surface facing a surrounding tissue when the implantable device (1) is implanted in a subject body. At least a portion of the surface of the structure (40) has a semi-random pattern of extending micropillars (50). The semi-random pattern of micropillars (50) on the surface contributes to advantageous surface characteristicsof the implantable device (1) in terms of reducing adhesion viable cells to the implantable device (1) as compared to regular patterns of micropillars (50).
摘要翻译：可植入装置（1）包括聚合物结构（40），当将可植入装置（1）植入到被检体时，其具有面向周围组织的外表面。结构（40）的表面的至少一部分具有延伸微柱（50）的半随机图案。与微量柱（50）的规则图案相比，表面上的微柱（50）的半随机图案有助于可植入装置（1）的有利的表面特性，从而将可活细胞粘附到可植入装置（1）。

87. 发明申请

WO2012072104A1 METHODS AND SYSTEMS FOR STIMULATING A HEART 审中-公开
标题翻译：用于刺激心脏的方法和系统
公开(公告)号：WO2012072104A1
公开(公告)日：2012-06-07
申请号：PCT/EP2010/068472
申请日：2010-11-30
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , PERSSON, Torbjörn , HILL, Rolf
发明人： BLOMQVIST, Andreas , PERSSON, Torbjörn , HILL, Rolf
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/365 , A61N1/3627 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to methods for implantable medical devices and more particularly to methods for optimizing stimulation of a heart of a patient. The method comprises: determining recommended pacing settings including recommended AV delays and/or recommended W delays based on IEGM data. Further, at least one hemodynamical parameter is determined based on measured at least one hemodynamical signal. Reference pacing settings are determined including reference AV delays and/or reference W delays based on said hemodynamical parameters. An AV delay correction value and a W delay correction value are calculated as a difference between recommended AV and/or VV delays and reference AV and/or W delays, respectively. The correction values are used for updating recommended AV and/or VV delays, respectively.
摘要翻译：本发明一般涉及可植入医疗装置的方法，更具体地涉及用于优化患者心脏的刺激的方法。该方法包括：基于IEGM数据确定推荐的起搏设置，包括推荐的AV延迟和/或推荐的W延迟。此外，基于测量的至少一个血液动力学信号来确定至少一个血液动力学参数。基于所述血流动力学参数确定参考起搏设置，包括参考AV延迟和/或参考W延迟。 AV延迟校正值和W延迟校正值分别被计算为推荐的AV和/或VV延迟与参考AV和/或W延迟之间的差。校正值分别用于更新推荐的AV和/或VV延迟。

88. 发明申请

WO2012039654A1 MRI-COMPATIBLE IMPLANTABLE MEDICAL LEAD 审中-公开
标题翻译： MRI兼容可植入医疗领域
公开(公告)号：WO2012039654A1
公开(公告)日：2012-03-29
申请号：PCT/SE2010/051002
申请日：2010-09-20
申请人： ST. JUDE MEDICAL AB , FORSLUND, Mikael , ÖRNBERG, Andreas
发明人： FORSLUND, Mikael , ÖRNBERG, Andreas
IPC分类号： A61N1/16 , A61N1/05 , A61N1/08
CPC分类号： A61B5/055 , A61B5/04 , A61N1/05 , A61N1/056 , A61N1/086 , H01F41/066 , Y10T29/49071
摘要： An implantable medical lead (1) comprises multiple electrodes (22, 24, 26, 28) arranged at a distal end (2), multiple electrode terminals (32, 34, 36, 38) at a proximal end (3) and a lead body (4) with an insulating tubing (40). A conductor coil (10) comprises a coiled tubular insulator (19) having multiple separate lumens (12, 14, 16, 18). Each lumen (12, 14, 16, 18) houses a respective conductor (11, 13, 15, 17). The conductor coil (10) is arranged in a bore (42) of the insulating tubing (40) and each conductor (11, 13, 15, 17) is electrically connected to one of the electrodes (22, 24, 26, 28) and one of the electrode terminals (32, 34, 36, 38).
摘要翻译：植入式医疗引线（1）包括布置在远端（2）处的多个电极（22,24,26,28），在近端（3）处的多个电极端子（32,34,38）和引线主体（4）具有绝缘管（40）。导体线圈（10）包括具有多个分离的管腔（12,14,16,18）的螺旋管状绝缘体（19）。每个管腔（12,14,16,18）容纳相应的导体（11,13,15,17）。导体线圈（10）布置在绝缘管（40）的孔（42）中，并且每个导体（11,13,15,17）电连接到电极（22,24,26,28）之一，和电极端子（32,34,36,38）中的一个。

89. 发明申请

WO2011076264A1 METHOD AND DEVICE FOR DETECTING INCIPIENT A-V NODE MALFUNCTION 审中-公开
标题翻译：用于检测致命的A-V节点故障的方法和装置
公开(公告)号：WO2011076264A1
公开(公告)日：2011-06-30
申请号：PCT/EP2009/067787
申请日：2009-12-22
申请人： ST. JUDE MEDICAL AB , LINDGREN, Anders
发明人： LINDGREN, Anders
IPC分类号： A61B5/0456 , A61N1/368
CPC分类号： A61N1/3702 , A61B5/02438 , A61B5/0402 , A61B5/686 , A61B5/6869 , A61N1/365 , A61N1/3682 , A61N1/37258
摘要： The present invention generally relates to implantable stimulation devices, such as pacemakers, defibrillators, and cardioverters, and, in particular, to implantable medical devices using atrial based pacing such as an AAI pacing mode and methods for such implantable medical devices for detecting early stages of incipient A-V node malfunction as well as presence of A-V node malfunction. An AV conduction capacity is detected, wherein a sensed ventricular event following an intrinsic or paced atrial event during a predetermined period of time indicates good AV conduction capacity and wherein absence of a ventricular event within the predetermined period of time indicates poor AV conduction capacity. At least one A- V node function parameter indicating a function of the A-V node is determined, wherein the A-V node function parameter includes whether a status of the AV conduction capacity is good or poor. Incipient A-V node malfunction is detected where poor AV conduction capacity indicates incipient A-V node malfunction.
摘要翻译：本发明一般涉及可植入的刺激装置，例如起搏器，除颤器和心律转换器，特别是涉及使用基于心房的起搏（例如AAI起搏模式）的可植入医疗装置以及用于这种可植入医疗装置的方法来检测早期阶段初始AV节点故障以及AV节点故障的存在。检测到AV传导容量，其中在预定时间段内的本征或起搏心房事件之后的感测到的心室事件表示良好的AV传导能力，并且其中在预定时间段内不存在心室事件表示差的AV传导能力。确定表示A-V节点的功能的至少一个A- V节点功能参数，其中，所述A-V节点功能参数包括AV传导容量的状态是好还是差。检测到初始的A-V节点故障，其中差的AV传导容量指示初始的A-V节点故障。

90. 发明申请

WO2010074611A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING SYNCHRONICITY OF THE VENTRICLES OF A HEART 审中-公开
标题翻译：用于监测心脏通气道的同步性的可植入医疗装置和方法
公开(公告)号：WO2010074611A1
公开(公告)日：2010-07-01
申请号：PCT/SE2008/000742
申请日：2008-12-22
申请人： ST. JUDE MEDICAL AB , JÄRVERUD, Karin
发明人： JÄRVERUD, Karin
IPC分类号： A61N1/365 , A61B5/053
CPC分类号： A61N1/3622 , A61B5/053 , A61B5/7239 , A61N1/36521 , A61N1/36585
摘要： The present invention generally relates to the field of implantable heart stimulation devices, such as pacemakers, and similar cardiac stimulation devices that also are capable of monitoring and detecting electrical activities and events within the heart. More specifically, the present invention relates to an implantable medical device and a method for monitoring ventricular synchronicity of a heart. In particular, impedance signals are measured and an occurrence of a notch is detected in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle. The notch is indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle. A degree of synchronicity is determined based on the notch feature, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles.
摘要翻译：本发明一般涉及可植入的心脏刺激装置领域，例如起搏器和类似的心脏刺激装置，其也能够监测和检测心脏内的电活动和事件。更具体地，本发明涉及可植入医疗装置和用于监测心脏的心室同步性的方法。特别地，测量阻抗信号，并且在阻抗信号中检测到陷波的发生，该阻抗信号与包括从心室的快速到慢速填充的变化的周期一致。在心脏周期的舒张期期间，在预定时间窗中的负斜率的第一正斜率变化来表示凹口。基于凹口特征确定同步度，其中减小的切口特征表示在心室的填充阶段中增加的同步度。

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