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1. 发明申请

WO2002068049A1 IMPLANTABLE DEVICE 审中-公开
标题翻译：可植入设备
公开(公告)号：WO2002068049A1
公开(公告)日：2002-09-06
申请号：PCT/SE2002/000345
申请日：2002-02-26
申请人： ST. JUDE MEDICAL AB , KROLL, Mark , ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
发明人： KROLL, Mark , ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/056 , A61N1/326 , A61N1/3962
摘要： An apparatus for treating an infection which may occur in the biofilm which surrounds an implanted cardiac stimulation device, e.g., a cardioverter-defibrillator )ICD) or pacemaker. Such inflections are relatively untreatable by conventional antibiotics treatments. Thus, explanting of the implanted devices may be required. Accordingly, the present apparatus provides an electrical treatment that enables a biocide, i.e., an antibiotic, to successfully treat the infection within the biofilm and thus avoid the necessity to explant the device. Furthermore, the present invention provides this electrical treatment in a manner to not interfere with the stimulation pulses of the cardio stimulation device by alternatively delivering current pulses during atrial and ventricular refractory periods or a high frequency square wave at a frequency that exceeds the frequency response of the heart muscle.
摘要翻译：一种用于治疗可能发生在生物膜中的感染的装置，其围绕植入的心脏刺激装置，例如心律转复除颤器）ICD）或起搏器。传统的抗生素治疗相对来说，这种变化是相对不可行的。因此，可能需要外植植入的装置。因此，本发明的装置提供使杀生物剂即抗生素能够成功地治疗生物膜内的感染并因此避免外植体的必要性的电处理。此外，本发明以不超过心脏刺激装置的频率响应的频率交替地输送电流脉冲在心房和心室不适期间或高频方波中以不影响心脏刺激装置的刺激脉冲的方式提供这种电处理心脏肌肉。

2. 发明申请

WO2002068043A1 IMPLANTABLE HEART STIMULATOR 审中-公开
标题翻译：可植入心脏刺激器
公开(公告)号：WO2002068043A1
公开(公告)日：2002-09-06
申请号：PCT/SE2002/000346
申请日：2002-02-26
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
发明人： ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/375
摘要： An implantable heart stimulator, comprises a pulse generator for delivering electric stimulation pulses to a patient's heart (21) through a lead (14) connectable to said pulse generator, possibly through a connector top (12) on a of pulse generator housing (10). The pulse generator housing is electrically conductive. IN an infection control apparatus for such a heart stimulator the exterior surfaces of the possible connector top and of a proximal part (16) of the lead are electrically conductive. The proximal lead part extends to a position, which after implantation of the lead is situated between a location beyond the entry to the venous system and the entry into vena cava superior. The generator housing and the electrically conductive surfaces of the proximal lead part and of the possible connector top are adapted to form a first electrode and at least one second counter electrode (19) is adapted to be loacted outside subcutaneous pulse generator pocket in which the pulse generator is located after implantation. A curent source is provided to supply an electric infection control current between the electrodes.
摘要翻译：可植入心脏刺激器包括脉冲发生器，用于通过可连接到脉冲发生器壳体（10）上的连接器顶部（12）的可连接到所述脉冲发生器的引线（14）将电刺激脉冲传送到患者心脏（21）。脉冲发生器壳体是导电的。在用于这种心脏刺激器的感染控制装置中，可能的连接器顶部和引线的近侧部分（16）的外表面是导电的。近端引导部分延伸到一个位置，植入后引线位于超过静脉系统入口的位置和进入腔静脉上方的位置。发电机壳体和近端引导部分和可能的连接器顶部的导电表面适于形成第一电极，并且至少一个第二对电极（19）适于被吸收在皮下脉冲发生器口袋外部，其中脉冲发生器位于植入后。提供一种治疗源，以在电极之间提供电感染控制电流。

3. 发明申请

WO2002068048A1 IMPLANTABLE HEART STIMULATOR 审中-公开
标题翻译：可植入心脏刺激器
公开(公告)号：WO2002068048A1
公开(公告)日：2002-09-06
申请号：PCT/SE2002/000344
申请日：2002-02-26
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
发明人： ECKERDAL, Johan , OBEL, Martin , MICSKI, Eva
IPC分类号： A61N1/375
CPC分类号： A61N1/056 , A61N1/205 , A61N1/375
摘要： An implantable heart stimulator comprises a pulse generator for delivering electric stimulation pulses to a patient's heart through a lead (14), connectable to said pulse generator, possibly through a connector top (12) on a pulse generator housing (10). The pulse generator housing is electrically conductive. In an infection control apparatus for such a heart stimulator the exterior surfaces of the possible connector top (12) and of a proximal part (16) of the lead (14) are electrically conductive. The proximal part extends to a position, which after implantation of the lead is situated between a location beyond the entry into the venous system and the entry to vena cava superior. The generator housing (10) and the electrical conductive surfaces of the proximal lead part and of the possible connector top are adapted to form at last two separate electrodes and a current source is provided to supply an electric infection control current between these electrodes.
摘要翻译：可植入心脏刺激器包括脉冲发生器，脉冲发生器可通过引线（14）将电刺激脉冲传送到患者的心脏，该引线可连接到所述脉冲发生器，可能通过脉冲发生器壳体（10）上的连接器顶部（12）连接。脉冲发生器壳体是导电的。在用于这种心脏刺激器的感染控制装置中，可能的连接器顶部（12）和引线（14）的近侧部分（16）的外表面是导电的。近端部分延伸到一个位置，该位置在引线的植入位于超过进入静脉系统的位置和进入腔静脉上方的位置之间。发电机壳体（10）和近端引线部分和可能的连接器顶部的导电表面适于形成最后两个单独的电极，并且提供电流源以在这些电极之间提供电感应控制电流。

4. 发明申请

WO2007053065A1 IMPLANTABLE LEAD WITH A STIMULATING ELECTRODE AND A MAPPING ELECTRODE THAT IS ELECTRICALLY DISCONNECTABLE 审中-公开
标题翻译：具有刺激电极的可植入引线和电气不连接的映射电极
公开(公告)号：WO2007053065A1
公开(公告)日：2007-05-10
申请号：PCT/SE2005/001630
申请日：2005-10-31
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan , DAHLBERG, Kenneth
发明人： ECKERDAL, Johan , DAHLBERG, Kenneth
IPC分类号： A61N1/372 , A61N1/05
CPC分类号： A61N1/056 , A61N1/0573
摘要： An implantable lead for delivering electrical stimuli to a human heart. The lead comprises a stimulating electrode for transmitting electrical stimuli to the myocardium after implantation, and a mapping electrode for use during implantation. The mapping electrode is arranged for delivering electrical stimuli to the heart and for sensing intrinsic cardiac activity, for the purpose of finding a suitable fixation position in the myocardium. During the implantation procedure, the mapping electrode is electrically connected to said conductor. The lead is further arranged for electrically disconnecting the mapping electrode from the conductor.
摘要翻译：用于向人类心脏递送电刺激的可植入引线。引线包括用于在植入后将电刺激传输到心肌的刺激电极和用于植入期间的映射电极。映射电极被布置成用于向心脏递送电刺激并且用于感测内在的心脏活动，以便在心肌中找到合适的固定位置。在植入过程中，映射电极电连接到所述导体。引线还被布置成用于电连接映射电极与导体。

5. 发明申请

WO2007100283A1 MEDICAL DEVICE AND METHOD FOR MONITORING HEMATOCRIT AND SVO2 审中-公开
标题翻译：用于监测血液透析和SVO2的医疗装置和方法
公开(公告)号：WO2007100283A1
公开(公告)日：2007-09-07
申请号：PCT/SE2007/000165
申请日：2007-02-22
申请人： ST. JUDE MEDICAL AB , ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
发明人： ÖHLANDER, Malin , NOREN, Kjell , ECKERDAL, Johan , HIETANEN, Mika , NILSSON, Kenth , LÖNN, Urban
IPC分类号： A61B5/02 , A61B5/1455
CPC分类号： A61B5/02055 , A61B5/0086 , A61B5/053 , A61B5/0538 , A61B5/14535 , A61N1/36521 , G06F19/00 , G06Q50/22
摘要： The present invention generally relates to cardiac pacing systems and, in particular, to a method and an implantable medical device (2; 20) for monitoring physiological parameters such as hematocrit and SvO2 levels of a patient to determine a patient status. The implantable medical device (2; 20) comprises a blood constituent determining device (30) adapted to determine a present hematocrit level and a SvO2 level and a patient status determining device (31) adapted to determine a patient status based on an evaluation of a present hematocrit level and a present SvO2 level, wherein a change of a condition of the patient can be derived.
摘要翻译：本发明一般涉及心脏起搏系统，尤其涉及一种用于监测患者的生理参数例如血细胞比容和SvO2水平以确定患者状态的方法和可植入医疗装置（2; 20）。可植入医疗装置（2; 20）包括适于确定当前血细胞比容水平和SvO2水平的血液成分确定装置（30）和适于基于对所述血液成分确定装置的评估来确定患者状态的患者状态确定装置（31）目前的血细胞比容水平和目前的SvO2水平，其中可以导出患者状况的改变。

6. 发明申请

WO2013060372A1 IMPLANTABLE MEDICAL LEAD WITH BLOOD SEAL 审中-公开
标题翻译：可植入医疗领域与血液密封
公开(公告)号：WO2013060372A1
公开(公告)日：2013-05-02
申请号：PCT/EP2011/068857
申请日：2011-10-27
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan
发明人： ECKERDAL, Johan
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： An implantable medical lead (1) comprises an insulating tubing (41) with a channel (42) housing a conductor (72) electrically connected to a shaft (60) present in a lumen (51) of a bearing (50). The shaft (60) is also connected to a fixation helix (22) present in a lumen (23) of a lead header (21). A clot-inducing structure (80, 82, 84, 86) of a thrombogenic material is present in a distal portion (44) of the channel (42) and/or in the lumen (51) of the bearing (50) to trigger formation of a clot when blood enters the implantable medical lead (1) and thereby inhibit blood from entering further into the channel (42).
摘要翻译：可植入医疗引线（1）包括绝缘管（41），其具有通道（42），该通道（42）容纳与轴承（50）的内腔（51）中存在的轴（60）电连接的导体（72）。轴（60）还连接到存在于引线头（21）的内腔（23）中的固定螺旋（22）。血栓形成材料的凝块诱导结构（80,82,84,86）存在于通道（42）的远端部分（44）和/或轴承（50）的内腔（51）中以触发当血液进入可植入医疗引线（1）时，凝块形成，从而抑制血液进一步进入通道（42）。

7. 发明申请

WO2008118044A1 A SUTURE SLEEVE AND A METHOD FOR IMPLANTING ONE OR TWO LEADS INTO A VEIN 审中-公开
标题翻译：一个套管和一个或两个领导植入一个VEIN的方法
公开(公告)号：WO2008118044A1
公开(公告)日：2008-10-02
申请号：PCT/SE2007/000295
申请日：2007-03-26
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan , HILL, Rolf
发明人： ECKERDAL, Johan , HILL, Rolf
IPC分类号： A61N1/05 , A61M25/04
CPC分类号： A61N1/057 , A61N2001/0582
摘要： The invention relates to a suture sleeve for one or two implantable leads (6, 6'), the suture sleeve (1) being adapted to be inserted into a vein (7) to secure and protect the lead from damage when a suture thread (8) is positioned and tied around the vein in the region over the suture sleeve to prevent bleeding from the vein. The suture sleeve comprises two lead receiving through holes (4, 4'), into each of which a medical implantable lead is insertable. The suture sleeve also comprises two elongated sleeve portions (2, 2'), each including a lead receiving through hole (4, 4'), which are positioned in parallel and displaced in relation to each other such that they are connected in a connecting portion (3), wherein at least one sleeve portion is projecting further in one direction. The invention also relates to a method for implanting one or two leads into a vein.
摘要翻译：本发明涉及一种用于一个或两个可植入引线（6,6'）的缝合套筒，缝线套管（1）适于插入静脉（7）中，以固定并保护引线免受缝合线 8）定位并围绕缝合套管上的区域中的静脉绑扎，以防止静脉渗出。缝合套管包括两个引线接收通孔（4,4'），每个可插入医用可植入引线。缝合套筒还包括两个细长的套筒部分（2,2'），每个细长的套筒部分（2,2'）各自包括引线接纳通孔（4,4'），它们彼此平行地位移并且相对于彼此移位，使得它们以连接部分（3），其中至少一个套筒部分在一个方向上进一步突出。本发明还涉及将一根或两根引线植入静脉的方法。

8. 发明申请

WO2008105691A1 DEVICE AND METHOD FOR DETECTING A MYOCARDIAL INFARCTION AND TREATING THE MYOCARDIAL INFARCTION USING THERAPEUTIC LIGHT 审中-公开
标题翻译：用于检测心肌梗塞并使用治疗光治疗心肌梗塞的装置和方法
公开(公告)号：WO2008105691A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000194
申请日：2007-02-28
申请人： ST. JUDE MEDICAL AB , NORLIN, Anna , HENRIQUEZ, Leda , STRANDERBERG, Hans , HARSTROM, Eva , SJOGREN, Mikael , NAESLUND, Anneika , ECKERDAL, Johan
发明人： NORLIN, Anna , HENRIQUEZ, Leda , STRANDERBERG, Hans , HARSTROM, Eva , SJOGREN, Mikael , NAESLUND, Anneika , ECKERDAL, Johan
IPC分类号： A61N1/37 , A61N1/08 , A61N5/06
CPC分类号： A61N1/36521 , A61B5/0422 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61B5/7239 , A61N1/36557 , A61N1/3702 , A61N5/0601 , A61N2005/063 , A61N2005/0652 , A61N2005/0659 , A61N2005/067
摘要： An implantable medical device (10; 20; 30) and a method are disclosed for treating cardiac tissue of a heart (16) of a patient with therapeutic light. A myocardial infarction is detected and a location the myocardial infarction is identified. A therapy session is initiated by selectively activate one or more of a plurality of light emitting means (31, 32a, 32b; 54, 57a, 57b, 57c, 57d) arranged in at least one medical lead (12, 14; 22a, 22b; 50) connectable to the implantable medical device (10; 20;30) to emit therapeutic light towards a detected location of a myocardial infarction at detection of an occurrence of a myocardial infarction.
摘要翻译：公开了一种用于治疗具有治疗光的患者的心脏（16）的心脏组织的可植入医疗装置（10; 20; 30）和方法。检测到心肌梗塞，并确定心肌梗死的位置。通过选择性地激活布置在至少一个医用引线（12,14; 22a，22b）中的多个发光装置（31,32a，32b; 54,57a，57b，57c，57d）中的一个或多个 ; 50），其可连接到所述可植入医疗装置（10; 20; 30），以在检测到心肌梗死的发生时朝向心肌梗塞的检测位置发射治疗光。

9. 发明申请

WO2011069535A1 CARDIAC STIMULATING DEVICE WITH BACKUP PULSE 审中-公开
标题翻译：具有备用脉冲的CARDIAC刺激装置
公开(公告)号：WO2011069535A1
公开(公告)日：2011-06-16
申请号：PCT/EP2009/066594
申请日：2009-12-08
申请人： ST. JUDE MEDICAL AB , ECKERDAL, Johan
发明人： ECKERDAL, Johan
IPC分类号： A61N1/37
CPC分类号： A61N1/37276 , A61N1/3622 , A61N1/3688 , A61N1/371
摘要： An implantable medical device, IMD, (100) comprises atrial and ventricular sensing units (125, 135) for sensing atrial or ventricular electric events. The IMD (100) also comprises atrial and ventricular pulse generators (120, 130) for generating atrial or ventricular pacing pulses. A controller (140) controls the operation of the IMD (100) according to a first mode, in which the ventricular pulse generator (130) is prevented from generating a back-up pulse if an evoked response detector (133) fails to detect evoked response to a delivered ventricular pacing pulse, and a second mode, in which the ventricular pulse generator (130) is controlled to generate a back-up pulse if no evoked response is detected following delivery of a ventricular stimulating pulse. The controller (140) switches operation from the first mode to the second mode based on the evoked response detector (133) failing to detect an evoked response to a delivered ventricular pacing pulse.
摘要翻译：植入式医疗装置IMD（100）包括用于感测心房或心室电气事件的心房和心室感测单元（125,135）。 IMD（100）还包括用于产生心房或心室起搏脉冲的心房和心室脉冲发生器（120,130）。控制器（140）根据第一模式控制IMD（100）的操作，其中如果诱发响应检测器（133）未能检测到诱发的响应检测器（133），则防止心室脉冲发生器（130）产生备用脉冲响应于递送的心室起搏脉冲，以及第二模式，其中如果在递送心室刺激脉冲之后没有检测到诱发反应，则控制心室脉冲发生器（130）以产生备用脉冲。控制器（140）基于诱发响应检测器（133）未能检测对所传送的心室起搏脉冲的诱发响应，将操作从第一模式切换到第二模式。

10. 发明申请

WO2008066423A1 DEVICE AND METHOD FOR TREATING CARDIAC TISSUE OF A HEART OF A PATIENT WITH THERAPEUTIC LIGHT USING PHOTOBIOMODULATION 审中-公开
标题翻译：使用光电转换治疗患者的心脏的心脏组织的装置和方法
公开(公告)号：WO2008066423A1
公开(公告)日：2008-06-05
申请号：PCT/SE2006/001375
申请日：2006-11-30
申请人： ST. JUDE MEDICAL AB , NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , ECKERDAL, Johan
发明人： NORLIN-WEISSENRIEDER, Anna , HENRIQUEZ, Leda , STRANDBERG, Hans , HARSTRÖM, Eva , SJÖGREN, Mikael , NAESLUND, Annika , ECKERDAL, Johan
IPC分类号： A61N1/05 , A61N1/36 , A61N1/362 , A61N1/372 , A61N5/06
CPC分类号： A61N1/056 , A61N1/057 , A61N1/059 , A61N1/362 , A61N5/0603 , A61N2005/0652 , A61N2005/0659
摘要： The present invention is related to treatment of cardiac tissue of a heart (16) of a patient with therapeutic light using an implantable medical device (10; 20; 30) connectable to at least one medical lead (12, 14; 22a, 22b; 40; 70; 80; 90; 100; 106) comprising electrodes (42, 44; 72; 82; 92; 102; 108) and at least one fixation means (42; 71; 81; 91; 101; 107) adapted to fixate said lead (12, 14; 22a, 22b; 40; 70; 80; 90; 100; 106) at a fixation area of the cardiac tissue. Therapeutic light is emitted towards said at least one fixation area of cardiac tissue and/or towards a contact area between the at least one electrode (42, 44; 72; 82; 92; 102; 108) and cardiac tissue using light emitting means (31, 32; 46; 74; 84; 94; 104; 109a, 109b).
摘要翻译：本发明涉及使用可连接到至少一个医用引线（12,14; 22a，22b; 22b）的可植入医疗装置（10; 20; 30）治疗患有治疗用光的患者的心脏（16）的心脏组织。包括电极（42,44; 72; 82; 92; 102; 108）和至少一个固定装置（42; 71; 81; 91; 101; 107）在所述心脏组织的固定区域处固定所述引线（12,14; 22a，22b; 40; 70; 80; 90; 100; 106）。治疗性光利用发光装置向心脏组织的所述至少一个固定区域和/或朝着至少一个电极（42,44; 72; 82; 92; 102; 108）和心脏组织之间的接触区域发射 31,32; 46; 74; 84; 94; 104; 109a，109b）。

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