专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

WO2008114003A1 IMPROVEMENTS IN OR RELATING TO DETECTION AND/OR CHARACTERISATION OF OLIGOMERS 审中-公开
标题翻译：对低聚物的检测和/或表征的改进或相关
公开(公告)号：WO2008114003A1
公开(公告)日：2008-09-25
申请号：PCT/GB2008/000947
申请日：2008-03-17
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , COOPER, Matthew
发明人： COOPER, Matthew
IPC分类号： G01N33/543 , G01N29/036
CPC分类号： G01N29/022 , G01N29/036 , G01N29/4418 , G01N29/4454 , G01N33/54373 , G01N2291/012 , G01N2291/015 , G01N2291/018 , G01N2291/0255 , G01N2291/0256 , G01N2291/02809 , G01N2333/4709 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835
摘要： Disclosed is a method of detecting the presence of an oligomer analyte in a liquid sample, the method comprising the steps of: (a) contacting a sample comprising the oligomer or aggregate with an oscillating sensor surface, which surface may optionally be coated with a receptor that binds directly or indirectly to at least one component of the oligomer or aggregate, so as to cause direct or indirect binding of the oligomer or aggregate to the surface; (b) using a detection circuit to measure or calculate at least two of the following parameters: series resonance frequency (f 0 ), and hence the series resonance frequency shift (ΔF); motional resistance (R M ), and hence the motional resistance shift ΔR; motional inductance (L M ); motional capacitance (C M ); parallel capacitance (C 0 ); frequency half-band half- width (Γ); Q-factor (= f/(2Γ); dissipative factor (1/Q); impedance or admittance phase (φ) and hence phase shift (Δφ); and impedance or admittance amplitude (Z, or Y) and hence amplitude change (ΔZ, or ΔY); (c) and analysing the calculated values to derive data which vary according to the presence and/or amount of oligomer in the sample; (d) and, optionally, repeating the measurements continuously or intermittently to derive data which vary according to the presence and/or amount of oligomer or aggregate in the sample to be calculated as a function of elapsed time.
摘要翻译：公开了一种检测液体样品中低聚物分析物的存在的方法，所述方法包括以下步骤：（a）使包含低聚物或聚集体的样品与振荡传感器表面接触，该表面可任选地涂覆有受体其直接或间接地结合至低聚物或聚集体的至少一种组分，以便使低聚物或聚集体与表面直接或间接结合; （b）使用检测电路来测量或计算以下参数中的至少两个：串联谐振频率（f <0> 0），因此串联共振频移（ΔF）; 运动阻力（R M M），因此运动阻力位移ΔR; 运动电感（L M M）; 运动电容（C M M）; 并联电容（C 0）; 频率半带半宽（G）; Q因子（= f /（2G）;耗散因子（1 / Q）;阻抗或导纳相（f），因此相移（Δf）;阻抗或导纳幅度（Z或Y）（ΔZ或ΔY）;（c）并分析所计算的值以导出根据样品中低聚物的存在和/或量的变化的数据;（d）和任选地连续或间歇地将测量重复到导出根据待计算的样品中的寡聚物或聚集体的存在和/或量的数量而变化的数据，作为经过时间的函数。

82. 发明申请

WO2008075044A3 DEVICE 审中-公开
标题翻译：设备
公开(公告)号：WO2008075044A3
公开(公告)日：2008-08-07
申请号：PCT/GB2007004885
申请日：2007-12-19
申请人： INVERNESS MEDICAL SWITZERLAND , RUTTER PAUL , JONES CHRIS , LEDGEWAY ANDREW , GANI JAMES , TISSINGTON BRYAN
发明人： RUTTER PAUL , JONES CHRIS , LEDGEWAY ANDREW , GANI JAMES , TISSINGTON BRYAN
IPC分类号： B01L3/00 , G01N33/53
CPC分类号： B01L3/5023 , B01L3/5029 , B01L2200/027 , B01L2300/044 , B01L2300/0672 , B01L2300/0816 , B01L2400/0406 , B01L2400/0683
摘要： The present invention relates to an assay device for determining the presence and/or amount of an analyte of interest in a sample, the assay device comprising a sample receiving liquid container for containing a liquid and adapted to receive the sample into said liquid, the liquid container comprising a first openable liquid seal and a second openable liquid seal, an opening means capable of opening a first liquid seal, and an assay means for determining the presence and/or amount of an analyte of interest in the sample. The invention also relates to a method of determining the presence and/or amount of an analyte of interest in a sample using the assay device of the invention, and to components of the assay device.
摘要翻译：本发明涉及用于确定样品中感兴趣分析物的存在和/或量的测定装置，该测定装置包括用于容纳液体并适于将样品接收到所述液体中的样品接收液体容器，液体容器，其包括第一可打开液封和第二可打开液封，能够打开第一液封的打开装置以及用于确定样本中感兴趣分析物的存在和/或量的测定装置。本发明还涉及使用本发明的测定装置以及测定装置的组件确定样品中感兴趣分析物的存在和/或量的方法。

83. 发明申请

WO2008075194A2 ASSAY DEVICE AND METHOD 审中-公开
标题翻译：测定装置和方法
公开(公告)号：WO2008075194A2
公开(公告)日：2008-06-26
申请号：PCT/IB2007/004022
申请日：2007-12-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DILLEEN, John William , LOWE, Philip , GILL, Andrew
发明人： DILLEEN, John William , LOWE, Philip , GILL, Andrew
CPC分类号： G01N33/54326 , G01N33/54366 , G01N33/84 , G01N2333/765 , G01N2800/2871 , G01N2800/32
摘要： A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separating a portion of analyte-bound second reagent from excess second reagent. After the magnetic separation, the interaction of the analyte and the second reagent can be disrupted to produce a detectable form of the second reagent, which can be detected. A device and system suited to performing the method are also described.
摘要翻译：用于检测分析物的方法可包括使分析物与与磁性颗粒缔合的第一试剂结合，使分析物与过量的能够与分析物相互作用的第二试剂相互作用，并从过量的第二试剂中磁性分离一部分分析物结合的第二试剂。磁性分离后，分析物与第二试剂的相互作用可被破坏以产生可检测的可检测形式的第二试剂。还描述了适合于执行该方法的设备和系统。

84. 发明申请

WO2007093902A8 ASSAYS 审中-公开
公开(公告)号：WO2007093902A8
公开(公告)日：2007-12-13
申请号：PCT/IB2007000369
申请日：2007-02-15
申请人： INVERNESS MEDICAL SWITZERLAND , BOLBOT JOHN ANTHONY , DILLEEN JOHN WILLIAM , SLEVIN CHRISTOPHER JOHN
发明人： BOLBOT JOHN ANTHONY , DILLEEN JOHN WILLIAM , SLEVIN CHRISTOPHER JOHN
IPC分类号： G01N33/84 , G01N33/68
CPC分类号： G01N33/6803 , G01N33/02 , G01N33/18 , G01N33/48707 , G01N33/49 , G01N33/54386 , G01N33/683 , G01N2333/765 , G01N2800/325
摘要： A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the first detection zone and second electrodes are in communication with the second detection zone. The device is configured to receive a blood derived sample introduced to the inlet, partition the blood sample into first and second blood sample portions, form a first mixture including at least some of the first blood sample portion and at least some of the cobalt reagent, and form a second mixture including at least some of the second blood sample portion, at least some of the cobalt reagent and at least some of the nickel reagent.
摘要翻译：一种装置包括至少部分地限定微流体网络的基底，该微流体网络包括与第一检测区域和第二检测区域连通的入口。钴试剂和镍试剂置于微流体网络内。第一电极与第一检测区域连通，第二电极与第二检测区域连通。该装置被配置为接收引入入口的血液衍生的样品，将血液样品分隔成第一和第二血液样本部分，形成包括第一血液样本部分和至少一些钴试剂中的至少一些的第一混合物，并形成第二混合物，其包括至少一些第二血液样品部分，至少一些钴试剂和至少一些镍试剂。

85. 发明申请

WO2007093902A1 ESSAYS FOR ISCHEMIA 审中-公开
公开(公告)号：WO2007093902A1
公开(公告)日：2007-08-23
申请号：PCT/IB2007/000369
申请日：2007-02-15
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BOLBOT, John, Anthony , DILLEEN, John, William , SLEVIN, Christopher, John
发明人： BOLBOT, John, Anthony , DILLEEN, John, William , SLEVIN, Christopher, John
IPC分类号： G01N33/84 , G01N33/68
CPC分类号： G01N33/6803 , G01N33/02 , G01N33/18 , G01N33/48707 , G01N33/49 , G01N33/54386 , G01N33/683 , G01N2333/765 , G01N2800/325
摘要： A device includes a substrate that defines, at least in part, a microfluidic network including an inlet in communication with a first detection zone and with a second detection zone. A cobalt reagent and a nickel reagent are disposed within the microfluidic network. First electrodes are in communication with the first detection zone and second electrodes are in communication with the second detection zone. The device is configured to receive a blood derived sample introduced to the inlet, partition the blood sample into first and second blood sample portions, form a first mixture including at least some of the first blood sample portion and at least some of the cobalt reagent, and form a second mixture including at least some of the second blood sample portion, at least some of the cobalt reagent and at least some of the nickel reagent.
摘要翻译：一种装置包括至少部分地限定微流体网络的基底，该微流体网络包括与第一检测区域和第二检测区域连通的入口。钴试剂和镍试剂置于微流体网络内。第一电极与第一检测区域连通，第二电极与第二检测区域连通。该装置被配置为接收引入入口的血液衍生的样品，将血液样品分隔成第一和第二血液样本部分，形成包括第一血液样本部分和至少一些钴试剂中的至少一些的第一混合物，并形成第二混合物，其包括至少一些第二血液样品部分，至少一些钴试剂和至少一些镍试剂。

86. 发明申请

WO2007057744A8 FLUID RESERVOIR 审中-公开
标题翻译：流体储层
公开(公告)号：WO2007057744A8
公开(公告)日：2007-08-16
申请号：PCT/IB2006003206
申请日：2006-11-14
申请人： INVERNESS MEDICAL SWITZERLAND , PANESAR SATWINDER SINGH , HANNA COLIN , LANG DAVID KINNIBURGH , GILL ANDREW , MARQUORDT CLAUS
发明人： PANESAR SATWINDER SINGH , HANNA COLIN , LANG DAVID KINNIBURGH , GILL ANDREW , MARQUORDT CLAUS
IPC分类号： G01N33/68 , B01L3/00
CPC分类号： B01L3/502715 , B01L2200/16 , B01L2300/0672 , B01L2300/0816 , B01L2400/0478 , B01L2400/0481 , B01L2400/0683
摘要： Devices can include fluid reservoirs for storage of small amounts of liquid. Methods of removal of the liquid stored in a fluid reservoirs can include fluid activators such as an indentor, a slider, or a piston.
摘要翻译：装置可以包括用于存储少量液体的液体储存器。除去储存在流体储存器中的液体的方法可以包括流体活化剂，例如压头，滑块或活塞。

87. 发明申请

WO2007063326A2 ASSAY DEVICE AND METHOD 审中-公开
标题翻译：测定装置和方法
公开(公告)号：WO2007063326A2
公开(公告)日：2007-06-07
申请号：PCT/GB2006004500
申请日：2006-12-04
申请人： INVERNESS MEDICAL SWITZERLAND , RAJ BALBIR , CHANG SAMANTHA
发明人： RAJ BALBIR , CHANG SAMANTHA
IPC分类号： G01N33/558 , G01N33/58
CPC分类号： G01N33/585 , G01N33/558 , G01N33/58 , G01N33/583
摘要： Disclosed is an assay device for determining the presence or absence of an analyte of interest in a liquid sample, the device comprising: a first, mobilisable labelled, moiety and a second moiety; a capture zone comprising a first immobilised capture agent for the first mobilisable labelled moiety; and at least a liquid transport means to transport the first mobilisable labelled moiety to the capture zone; wherein the first mobilisable labelled moiety is capable of generating a first signal at the capture zone and the second moiety is capable of generating a second signal at the capture zone; and wherein the second signal generated at the capture zone is essentially independent of the presence or absence of analyte of interest in the sample and wherein the strength or intensity of the first signal generated at the capture zone is dependent on the amount of analyte in the sample; and further wherein the first mobilisable labelled moiety is of a first colour and the second moiety is of a second colour, and wherein the first signal generated by the capture of the first labelled moiety in the capture zone is capable of obscuring the second signal generated by the second moiety at the capture zone.
摘要翻译：公开了一种用于确定液体样品中目标分析物的存在或不存在的测定装置，该装置包括：第一可运动标记的部分和第二部分; 包含第一可移动标记部分的第一固定化捕获剂的捕获区; 以及至少一种液体输送装置，用于将第一可移动标记部分运送到捕获区; 其中所述第一可运动标记部分能够在所述捕获区产生第一信号，并且所述第二部分能够在所述捕获区产生第二信号; 并且其中在捕获区产生的第二信号基本上独立于样品中有关分析物的存在或不存在，并且其中在捕获区产生的第一信号的强度或强度取决于样品中分析物的量 ; 并且其中所述第一可移动标记部分是第一颜色，并且所述第二部分是第二颜色，并且其中通过捕获所述捕获区中的所述第一标记部分捕获而产生的所述第一信号能够遮蔽由捕获区的第二个部分。

88. 发明申请

WO2007049010A1 DEVICE FOR DETECTING ANALYTES IN FLUID SAMPLES 审中-公开
标题翻译：用于检测流体样品中分析物的装置
公开(公告)号：WO2007049010A1
公开(公告)日：2007-05-03
申请号：PCT/GB2006/003910
申请日：2006-10-20
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , LEE, Nicholas, John , WU, Yuzhang , HU, Haipeng , DAI, Jielin , GOU, Lijian
发明人： WU, Yuzhang , HU, Haipeng , DAI, Jielin , GOU, Lijian
IPC分类号： G01N33/543 , A61B10/00 , B01L3/00
CPC分类号： G01N33/54366 , A61B10/007 , B01L3/502 , B01L2300/0663 , B01L2300/087 , B01L2400/0478 , Y10T436/2575
摘要： The present invention provides a device (100) for detecting the presence of an analyte in a liquid sample. The device (100) has an opening (115) for introducing the liquid sample into a first chamber (301) for collecting the liquid sample, and a second chamber (601) connected to the first chamber (301) by a passageway (205) and containing a test element. The device also has a third chamber (701) connected to the second chamber (601) by a channel and containing a movable member (311) having first and second positions. The third chamber (701) is divided by the movable member (311) into first (901) and second (902) zones, and the first zone (901) has a vent hole (165). The movable member (311) is in contact with at least one wall of the third chamber (701) to prevent gas communication between the first and second zones (901, 902).
摘要翻译：本发明提供一种用于检测液体样品中分析物的存在的装置（100）。装置（100）具有用于将液体样品引入用于收集液体样品的第一室（301）的开口（115）和通过通道（205）连接到第一室（301）的第二室（601）并包含测试元素。该装置还具有通过通道连接到第二室（601）的第三室（701）并且容纳具有第一和第二位置的可动构件（311）。第三室（701）由可移动部件（311）分成第一（901）和第二（902）区域，第一区域（901）具有通气孔（165）。可移动构件（311）与第三腔室（701）的至少一个壁接触，以防止第一和第二区域（901,902）之间的气体连通。

89. 发明申请

WO2007012975A1 HYBRID DEVICE 审中-公开
标题翻译：混合装置
公开(公告)号：WO2007012975A1
公开(公告)日：2007-02-01
申请号：PCT/IB2006/002770
申请日：2006-03-28
申请人： INVERNESS MEDICAL SWITZERLAND GmbH , KHAN, Aman
发明人： KHAN, Aman
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/502746 , B01L2200/16 , B01L2300/0663 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , B01L2400/086 , Y10T29/49826
摘要： A hybrid device (10) that combines a microfluidic component and a porous components (15) is provided. The microfluidic component includes a sample addition zone (1), a resuspension chamber (13), a mixing chamber (17), and a transfer structure (16), which facilitates fluid flow by capillary action.
摘要翻译：提供了组合微流体组分和多孔组分（15）的混合装置（10）。微流体组分包括样品添加区（1），再悬浮室（13），混合室（17）和转移结构（16），其通过毛细管作用促进流体流动。

90. 发明申请

WO2007010368A1 ASSAY DEVICE AND METHOD 审中-公开
标题翻译：测定装置和方法
公开(公告)号：WO2007010368A1
公开(公告)日：2007-01-25
申请号：PCT/IB2006/001985
申请日：2006-07-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DAVIES, Oliver, William, Hardwicke , LANG, David, Kinniburgh , DILLEEN, John, William , LOWE, Phillip , HOWELL, Steven , SLEVIN, Christopher, John
发明人： DAVIES, Oliver, William, Hardwicke , LANG, David, Kinniburgh , DILLEEN, John, William , LOWE, Phillip , HOWELL, Steven , SLEVIN, Christopher, John
IPC分类号： G01N33/543
CPC分类号： G01N33/54326
摘要： An assay device includes a first reagent including a magnetic particle and a second reagent including detectable component. The first and second reagent can each independently bind to an analyte in a sample . Applying a magnetic field can selectively concentrate the detectable component in a detection zone, where a detectable change ca be measured and related to the amount of analyte in the sample .
摘要翻译：测定装置包括包含磁性颗粒的第一试剂和包含可检测组分的第二试剂。第一和第二试剂可以各自独立地结合样品中的分析物。施加磁场可以选择性地将可检测组分浓缩在检测区域，其中可测量可检测的变化并与样品中分析物的量相关。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式