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71. 发明申请

WO2008136736A2 IMMUNOREGULATORY STRUCTURES FROM NORMALLY OCCURRING PROTEINS 审中-公开
标题翻译：来自正常蛋白质的免疫组织结构
公开(公告)号：WO2008136736A2
公开(公告)日：2008-11-13
申请号：PCT/SE2008/000314
申请日：2008-05-08
申请人： CANIMGUIDE THERAPEUTICS AB , HAKANSSON, Leif , CLINCHY, Birgitta
发明人： HAKANSSON, Leif , CLINCHY, Birgitta
IPC分类号： C07K14/765 , C07K16/18 , A61P37/02 , A61P35/00 , A61K39/395
CPC分类号： C07K16/18 , A61K38/00 , A61K2039/505 , C07K14/765 , C07K2317/34 , G01N33/5044 , G01N33/57484 , G01N2333/55 , G01N2333/765 , G01N2500/10
摘要： The present invention relates to isolated protein sequences that correspond to cell binding peptides, fragments, neo-structures and/or neo-epitopes of a normally occurring serum protein present in human tissue, wherein said peptide, fragment, neo-structure and/or neo- epitope has an immunoregulatory activity and is the result of either an enhanced proteolytic activity and/or conformational changes in a tissue, or a malignant tumour. In the present patent application, a common structure of several of these peptides, fragments, neo-structures and/or neo-epitopes, having immunoregulatory activity by binding to receptors on immune cells, has been identified. The present invention further also relates to monoclonal and/or polyclonal antibodies directed to a cell binding fragment of a normally occurring serum protein present in human tissue, as described above.
摘要翻译：本发明涉及对应于存在于人体组织中的正常存在的血清蛋白的细胞结合肽，片段，新结构和/或新表位的分离的蛋白质序列，其中所述肽，片段，新结构和/或新的 - 表位具有免疫调节活性，并且是组织或恶性肿瘤中增强的蛋白水解活性和/或构象变化的结果。在本专利申请中，已经鉴定出通过与免疫细胞上的受体结合而具有免疫调节活性的这些肽，片段，新结构和/或新表位中的几种的共同结构。本发明还涉及针对人组织中存在的正常存在的血清蛋白的细胞结合片段的单克隆和/或多克隆抗体，如上所述。

72. 发明申请

WO2007131778A3 DIAGNOSTIC AND THERAPEUTIC USES OF PEPTIDES FOR PRE-FORMS OF TYPE 2 DIABETES AND CONDITIONS ASSOCIATED THEREWITH 审中-公开
标题翻译： 2型糖尿病及其相关病症的多肽的诊断和治疗用途
公开(公告)号：WO2007131778A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007004321
申请日：2007-05-15
申请人： DIGILAB BIOVISION GMBH , BUDDE PETRA , ZUCHT HANS-DIETER , TAMMEN HARALD , HESS RUEDIGER , MENZEL CHRISTOPH
发明人： BUDDE PETRA , ZUCHT HANS-DIETER , TAMMEN HARALD , HESS RUEDIGER , MENZEL CHRISTOPH
IPC分类号： G01N33/68 , A61P3/10 , C07K14/575 , C07K14/765
CPC分类号： C07K14/765 , G01N33/6893 , G01N2800/042
摘要： The present invention is in the field of diagnostics and therapeutics. Specifically, the present invention provides methods for diagnosis and therapy of diseases and conditions associated with oxidative stress such as Type 2 diabetes, hyperglycaemia, pre-eclampsia, aging, etc. Furthermore the invention provides peptides, binding agents recognizing said peptides, diagnostic assay kits, and compositions suitable for medical purposes. The peptides of the invention are characterized by a C-terminal, non-enzymatic originated amide or by a nitric oxide binding site. The peptides of the invention are suitable as biomarker or as therapeutic substances capable to function as nitric oxide delivery vehicles.
摘要翻译：本发明属于诊断和治疗领域。具体而言，本发明提供了用于诊断和治疗与氧化应激相关的疾病和病症的方法，例如2型糖尿病，高血糖症，先兆子痫，衰老等。此外，本发明提供了肽，识别所述肽的结合剂，诊断测定试剂盒以及适用于医疗目的的组合物。本发明的肽的特征在于C-端非酶促酰胺或一氧化氮结合位点。本发明的肽适合作为生物标志物或作为能够用作一氧化氮递送载体的治疗物质。

73. 发明申请

WO2007112940A3 ALBUMIN-DERIVED AMINO ACID SEQUENCE, USE THEREOF FOR INCREASING THE HALF-LIFE OF THERAPEUTIC PROTEINS AND OF OTHER THERAPEUTIC COMPOUNDS AND ENTITIES, AND CONSTRUCTS COMPRISING THE SAME 审中-公开
标题翻译： ALBUMIN衍生的氨基酸序列，其用于增加治疗性蛋白质和其他治疗性化合物和实体的半衰期，以及包含其的构建体
公开(公告)号：WO2007112940A3
公开(公告)日：2008-01-03
申请号：PCT/EP2007002817
申请日：2007-03-29
申请人： ABLYNX NV , REVETS HILDE ADI PIERRETTE , HOOGENBOOM HENDRICUS RENERUS J , BEIRNAERT ELS
发明人： REVETS HILDE ADI PIERRETTE , HOOGENBOOM HENDRICUS RENERUS J , BEIRNAERT ELS
IPC分类号： C07K14/765 , C12N15/62
CPC分类号： C07K14/765 , A61K38/00 , C07K16/00 , C07K16/18 , C07K2317/22 , C07K2317/569 , C07K2319/00 , C07K2319/31
摘要： The present invention relates to albumin-derived amino acid sequences that can be used to increase the half-life of therapeutic proteins and of other therapeutic compounds and entities.
摘要翻译：本发明涉及可用于增加治疗性蛋白质和其它治疗化合物和实体的半衰期的白蛋白衍生的氨基酸序列。

74. 发明申请

WO2007123689A1 EXPRESSION, SECRETION AND PURIFICATION OF RECOMBINANT BOVINE SERUM ALBUMIN (RBSA) AND USES THEREOF 审中-公开
标题翻译：重组牛血清白蛋白（RBSA）的表达，分泌和纯化及其用途
公开(公告)号：WO2007123689A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/007921
申请日：2007-03-30
申请人： NEW ENGLAND BIOLABS, INC. , COLUSSI, Paul, A. , EVANS, Thomas, C. , TARON, Christopher, H.
发明人： COLUSSI, Paul, A. , EVANS, Thomas, C. , TARON, Christopher, H.
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , C12N9/22 , C12N9/96 , C12N15/815
摘要： A recombinant BSA (rBSA) that (a) substantially lacks deoxyribonuclease activity as determined by incubating rBSA with linear DNA overnight and gel electrophoresis, (b) lacks animal viruses associated with animal-derived cell growth supplements; and (c) is capable of stabilizing DNA proteins is provided. Methods for making the rBSA and using it to stabilize enzymes are also provided.
摘要翻译：重组BSA（rBSA），其（a）通过将rBSA与线性DNA一起孵育过夜和凝胶电泳确定，基本上缺乏脱氧核糖核酸酶活性，（b）缺少与动物来源的细胞生长补充物相关的动物病毒; 和（c）能提供稳定的DNA蛋白质。还提供了制备rBSA并用于稳定酶的方法。

75. 发明申请

WO2007008071A3 METHOD FOR DETECTING PEPTIDES COMPRISING A CROSS-BETA STRUCTURE 审中-公开
标题翻译：检测包含十字架结构的肽的方法
公开(公告)号：WO2007008071A3
公开(公告)日：2007-03-01
申请号：PCT/NL2006000363
申请日：2006-07-13
申请人： CROSSBETA BIOSCIENCES BV , GEBBINK MARTIJN FRANS BEN GERA , BOUMA BAREND
发明人： GEBBINK MARTIJN FRANS BEN GERA , BOUMA BAREND
IPC分类号： G01N33/68 , C07K1/14 , C07K14/765
CPC分类号： G01N33/68 , C07K14/47 , C07K14/705 , C07K14/765 , C07K14/805 , G01N33/6842
摘要： The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-ß structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides comprising a cross-ß structure from an aqueous solution comprising a protein, said method comprising contacting said aqueous solution comprising a protein with at least one cross-ß structure-binding compound resulting in a bound protein or peptide with cross-ß structure. The invention further provides a aqueous solution comprising a protein obtainable by a method of the invention, and a kit for carrying out the methods of the invention.
摘要翻译：本发明涉及包含蛋白质的水溶液领域。更具体地，本发明涉及从包含蛋白质的水溶液中检测和/或去除包含交叉β结构的构象改变的蛋白质和/或肽。本发明提供了从包含蛋白质的水溶液中检测和/或去除包含交叉β结构的蛋白质和/或肽的方法，所述方法包括使包含蛋白质的水溶液与至少一种交叉结构结合化合物导致结合蛋白或具有交叉β结构的肽。本发明还提供了包含可通过本发明的方法获得的蛋白质的水溶液和用于实施本发明方法的试剂盒。

76. 发明申请

WO2007021494A2 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2007021494A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029391
申请日：2006-07-31
申请人： HUMAN GENOME SCIENCES, INC. , ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
发明人： ROSEN, Craig , BELL, Adam , MOORE, Paul , SHI, Yanggu , LAFLEUR, David , LAIRD, Michael , HASELTINE, William , WOODS, Douglas , BOCK, Jason , SUBRAMANIAN, Mani
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , A61K47/643 , C07K2319/00
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，以及含有这些核酸的载体，用这些核酸载体转化的宿主细胞以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括含有白蛋白融合蛋白的药物组合物和使用本发明的白蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

77. 发明申请

WO2007008069A2 A METHOD FOR DETECTING AND/OR REMOVING A PROTEIN COMPRISING A CROSS-ß STRUCTURE FROM A PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：一种用于检测和/或去除包含来自药物组合物的结构的蛋白质的方法
公开(公告)号：WO2007008069A2
公开(公告)日：2007-01-18
申请号：PCT/NL2006/000361
申请日：2006-07-13
申请人： CROSSBETA BIOSCIENCES B.V. , GEBBINK, Martijn Frans Ben Gerard , BOUMA, Barend
发明人： GEBBINK, Martijn Frans Ben Gerard , BOUMA, Barend
IPC分类号： G01N33/68 , C07K1/14 , C07K14/765 , A61K31/195
CPC分类号： G01N33/68 , G01N33/50 , G01N33/6842
摘要： The invention relates to the field of compositions comprising a protein, more specifically to pharmaceutical compositions. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-ß structure from a pharmaceutical composition or any of its constituents comprising a protein. The present invention discloses that unwanted and/or toxic side effects of pharmaceuticals are caused by proteins present in said pharmaceutical and adopting a cross-b structure conformation. The invention further discloses a method for detecting a protein and/or peptide comprising a cross-ß structure in a pharmaceutical composition or any of its constituents comprising a protein, said method comprising, contacting said pharmaceutical composition or any of its constituents comprising a protein with at least one cross-ß structure-binding compound resulting in a bound protein and/or peptide comprising a cross-ß structure and; detecting whether bound protein and/or peptide comprising a cross-ß structure are present in said pharmaceutical composition or any of its constituents comprising a protein. The invention further disclose methods for removing cross-ß structures from a pharmaceutical composition and controlling manufacturing a pharmaceutical composition.
摘要翻译：本发明涉及包含蛋白质的组合物领域，更具体地涉及药物组合物。更具体地，本发明涉及从药物组合物或其任何包含蛋白质的成分中检测和/或去除包含交叉β结构的构象改变的蛋白质和/或分子。本发明公开了药物的不需要的和/或有毒的副作用是由所述药物中存在的蛋白质引起的，并且采用交叉b结构构象。本发明进一步公开了一种用于检测包含药物组合物或包含蛋白质的任何成分中的交叉β结构的蛋白质和/或肽的方法，所述方法包括使所述药物组合物或其包含蛋白质的任何成分与导致结合蛋白和/或肽的至少一种交叉β结构结合化合物包含交叉β结构;和检测所述药物组合物或其包含蛋白质的任何成分中是否存在结合蛋白和/或包含交叉β结构的肽。本发明还公开了从药物组合物中除去交叉β结构并控制制造药物组合物的方法。

78. 发明申请

WO2006066595A3 RECOMBINANT PRODUCTION OF SERUM ALBUMIN 审中-公开
标题翻译：重组生产血清白蛋白
公开(公告)号：WO2006066595A3
公开(公告)日：2006-08-31
申请号：PCT/DK2005000818
申请日：2005-12-22
申请人： NOVOZYMES AS , CHRISTENSEN BJARKE , HJORT CARSTEN , POULSEN THOMAS AGERSTEN
发明人： CHRISTENSEN BJARKE , HJORT CARSTEN , POULSEN THOMAS AGERSTEN
IPC分类号： C12N15/67 , A61K38/38 , C07K14/765 , C12P21/02 , C12R1/645 , C12R1/66 , C12R1/685 , C12R1/69
CPC分类号： C07K14/765 , A61K9/16 , A61K38/38 , C12N15/67
摘要： The present invention relates to modified nucleotide sequences encoding serum albumin, wherein the mRNA sequence has been codon optimized for expression in a filamentous host cell. Furthermore the present invention relates to serum albumin produced in filamentous fungi or loaded by contacting serum albumin with an extract of a filamentous fungi culture. In an-other aspect the present invention relates to the use of said serum albumin in serum free cell culture media and also to a method of drying and agglomerating serum albumin thereby im-proving wettability and dispersability.
摘要翻译：编码血清白蛋白的修饰核苷酸序列本发明涉及编码血清白蛋白的修饰的核苷酸序列，其中所述mRNA序列已被密码子优化用于在丝状宿主细胞中表达。此外，本发明涉及在丝状真菌中产生的或通过使血清白蛋白与丝状真菌培养物的提取物接触而加载的血清白蛋白。另一方面，本发明涉及所述血清白蛋白在无血清细胞培养基中的用途，还涉及干燥和凝聚血清白蛋白从而提高润湿性和可分散性的方法。

79. 发明申请

WO2006016561A1 表面修飾血清アルブミン－金属ポルフィリン複合体、およびそれを含有する酸素輸液审中-公开
标题翻译：表面改性的血清白蛋白/金属磷脂复合物和含有其的氧气输注
公开(公告)号：WO2006016561A1
公开(公告)日：2006-02-16
申请号：PCT/JP2005/014533
申请日：2005-08-08
申请人：土田英俊 , 小松晃之 , 黄宇彬
发明人：土田英俊 , 小松晃之 , 黄宇彬
IPC分类号： C07K14/765
CPC分类号： C07K14/765 , A61K38/00
摘要：　金属ポルフィリンを包接した血清アルブミンを含み、血清アルブミンの分子表面にポリオキシエチレン基が共有結合されている表面修飾血清アルブミン－金属ポルフィリン複合体。
摘要翻译：包含血清白蛋白和金属卟啉的表面改性的血清白蛋白/金属卟啉复合物，其中包含共价结合到血清白蛋白分子表面的聚氧乙烯基团。

80. 发明申请

WO2005058958A3 NOVEL GLP-1 ANALOGUES LINKED TO ALBUMIN-LIKE AGENTS 审中-公开
标题翻译：新型GLP-1类似物与ALBUMIN-LIKE AGENTS连接
公开(公告)号：WO2005058958A3
公开(公告)日：2005-11-24
申请号：PCT/DK2004000887
申请日：2004-12-17
申请人： NOVO NORDISK AS , HANSEN THOMAS KRUSE , ZUNDEL MAGALI , MADSEN KJELD , SVENDSEN ANNE , SCHIOEDT CHRISTINE BRUUN , LAU JESPER
发明人： HANSEN THOMAS KRUSE , ZUNDEL MAGALI , MADSEN KJELD , SVENDSEN ANNE , SCHIOEDT CHRISTINE BRUUN , LAU JESPER
IPC分类号： A61K38/00 , A61K38/26 , A61K38/38 , A61K47/48 , C07K14/46 , C07K14/47 , C07K14/575 , C07K14/605 , C07K14/765 , C07K19/00 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00 , A61K47/643 , C07K14/46 , C07K14/4705 , C07K14/57563 , C07K2319/00
摘要： The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR is the remains of a reactive residue that has formed a covalent bond with an amino acid residue of the protraction protein, and protraction protein is a protein having a molar weight of at least 5 kDa, having a plasma halflife of at least 24 hours in human plasma , and said protraction protein has been synthesised by a non-mammalian organism or synthetically.
摘要翻译：本发明涉及具有式（I）结构的化合物：GLP-1激动剂-L-RR-延伸蛋白（I），其中GLP-1激动剂是作为人GLP-1受体激动剂的多肽 L是将所述GLP-1激动剂的氨基酸侧链与RR连接的接头，RR是与延伸蛋白质的氨基酸残基形成共价键的反应性残基的残基，延伸蛋白是蛋白质具有至少5kDa的摩尔重量，在人血浆中具有至少24小时的血浆半衰期，并且所述延伸蛋白已经由非哺乳动物生物合成或合成地合成。

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