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71. 发明申请

WO2003010303A1 METHODS OF INDUCING DIFFERENTIATION OF STEM CELLS 审中-公开
标题翻译：诱导干细胞分化的方法
公开(公告)号：WO2003010303A1
公开(公告)日：2003-02-06
申请号：PCT/AU2002/000978
申请日：2002-07-23
申请人： ES CELL INTERNATIONAL PTE LTD , NETHERLANDS INSTITUUT VOOR ONTWIKKELINGSBIOLOGIE , MUMMERY, Christine, Lindsay
发明人： MUMMERY, Christine, Lindsay
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0603 , C12N5/0657 , C12N5/0658 , C12N5/069 , C12N2501/10 , C12N2501/155 , C12N2502/02 , C12N2502/1329 , C12N2502/28 , C12N2506/02 , C12N2510/00
摘要： The present invention relates to methods of inducing differentiation of stem cells. In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. The invention also includes cells, cell lines, testing models and culture systems used in the methods of the present invention and differentiated cells produced therefrom. The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes.
摘要翻译：本发明涉及诱导干细胞分化的方法。特别地，本发明涉及诱导胚胎干细胞分化成肌肉细胞或血管内皮细胞的方法。本发明还包括在本发明的方法中使用的细胞，细胞系，测试模型和培养系统以及由其产生的分化细胞。本发明还提供了将本发明的分化细胞用于治疗目的的方法。

72. 发明申请

WO02074946A2 METHOD FOR GENERATING INSULIN-SECRETING CELLS SUITABLE FOR TRANSPLANTATION 审中-公开
标题翻译：用于产生适于移植的胰岛素分泌细胞的方法
公开(公告)号：WO02074946A2
公开(公告)日：2002-09-26
申请号：PCT/DK0200130
申请日：2002-02-26
申请人： NOVO NORDISK AS
发明人： SERUP PALLE , HEIMBERG HARRY , GRADWOHL GERARD
IPC分类号： A61K35/12 , C12N5/071 , C12N15/00
CPC分类号： C12N5/0676 , A61K35/12 , C12N2501/60 , C12N2502/02 , C12N2503/02 , C12N2510/02
摘要： The invention relates to methods for generating insulin secreting cells from precursor stem cells or from adult pancreatic exocrine cells. The methods of the invention are useful, for example, for generation of glucose sensitive insulin-secreting ss-cells suitable for transplantation, as well as for in situ development of insulin-secreting cells in a patient in need thereof. Further, the method of the invention relates to methods for preventing premature differentiation of precursor stem cells into insulin-secreting ss-cells. Still further, the invention relates to assay methods for identification of compounds that prevent or activate ss-cell differentiation.
摘要翻译：本发明涉及从前体干细胞或成年胰腺外分泌细胞产生胰岛素分泌细胞的方法。本发明的方法可用于例如用于产生适合于移植的葡萄糖敏感的分泌胰岛素的β细胞，以及用于有需要的患者中胰岛素分泌细胞的原位发育。此外，本发明的方法涉及用于预防前体干细胞过早分化成胰岛素分泌型ss细胞的方法。此外，本发明涉及用于鉴定预防或激活β-细胞分化的化合物的测定方法。

73. 发明申请

WO02009506A1 A METHOD FOR IMPROVING DEVELOPMENT POTENTIAL OF AN EMBRYO AND EMBRYOS DEVELOPED THEREFROM 审中-公开
标题翻译：一种改善其发育的胚胎和胚胎发育潜力的方法
公开(公告)号：WO02009506A1
公开(公告)日：2002-02-07
申请号：PCT/AU2001/000937
申请日：2001-07-31
IPC分类号： C12N15/877 , A01K67/02
CPC分类号： C12N15/8771 , A01K2217/05 , C12N5/0604 , C12N2501/119 , C12N2502/02
摘要： The present invention relates to a method of improving development potential of an embryo, embryos developed therefrom and organisms resulting from embryos developed from the method. In a first aspect of the present invention, there is provided a method of culturing an embryo to improve development potential, said method comprising; obtaining an embryo; and culturing the embryo to enhance trophectoderm development of the embryo. The method relates to improving the chances of an embryo implanting to result in a successful pregnancy. The embryos desirably become implantation competent favouring foetal-maternal interaction and development to term of an embryo. The trophectoderm stimulating agent may be any compound which is proven to stimulate normal trophectoderm development. Preferably the agent is fibroblast growth factor-4 (FGF4) protein.
摘要翻译：本发明涉及一种提高胚胎发育潜力的方法，从其开发的胚胎和从该方法开发的胚胎产生的生物。在本发明的第一方面，提供了培养胚胎以改善发育潜力的方法，所述方法包括：获得胚胎; 并培养胚胎以增强胚胎的滋养外胚层发育。该方法涉及提高胚胎植入以导致成功怀孕的机会。胚胎期望成为植入能力有利于胎儿 - 母亲的相互作用和胚胎发育。滋养外胚层刺激剂可以是被证明刺激正常滋养外胚层发育的任何化合物。优选地，该试剂是成纤维细胞生长因子-4（FGF4）蛋白。

74. 发明申请

WO00023008A3 CARDIOVASCULAR COMPONENTS FOR TRANSPLANTATION AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：心血管移植组件及其制备方法
公开(公告)号：WO00023008A3
公开(公告)日：2000-09-28
申请号：PCT/US1999/024354
申请日：1999-10-19
IPC分类号： A61L27/00 , A61F2/24 , A61K35/12 , C12N5/071
CPC分类号： A61F2/2415 , A61K35/12 , C12N5/0656 , C12N2502/02 , C12N2502/14 , C12N2533/50 , C12N2533/54
摘要： Cardiovascular components such as biocompatible heart valves and annular sewing rings are disclosed, as well as, methods for making the same. The heart valves include biodegradable polymer fiber scaffolds and collagen. Also disclosed are donor aortic heart valves processed without the use of crosslinking chemicals.
摘要翻译：本发明首先涉及心血管组件，例如生物相容性心脏瓣膜和环形缝合环，并且其次涉及它们的制造方法。心脏瓣膜由生物可降解聚合物纤维和胶原蛋白的支架组成。另外，本发明涉及在没有交联化学物质的情况下治疗的供体主动脉心脏瓣膜。

75. 发明申请

WO1998012306A1 HEMATOPOIETIC STEM CELLS AND METHODS FOR GENERATING SUCH CELLS 审中-公开
标题翻译： HEMATOPOIETIC干细胞和用于产生这种细胞的方法
公开(公告)号：WO1998012306A1
公开(公告)日：1998-03-26
申请号：PCT/IB1997001246
申请日：1997-09-23
申请人： ONTOGENY, INC. , CARLSSON, Leif
发明人： ONTOGENY, INC.
IPC分类号： C12N05/08
CPC分类号： C07K14/4702 , A61K38/00 , C12N5/0647 , C12N2501/125 , C12N2501/235 , C12N2501/60 , C12N2502/02 , C12N2502/99 , C12N2506/02 , C12N2510/00
摘要： The present invention offers a developmental hematopoietic system which can be used to reproducibly and efficiently develop hematopoietic cells with a well-defined kinetic pattern. In one aspect, the method of the present invention generally includes the steps of obtaining viable stem cells from an animal donor and transfecting the cells with an expression construct including a hematopoietic gene, such as the LH-2 gene, to produce viable hematopoietic stem cells.
摘要翻译：本发明提供了一种发育造血系统，其可用于以明确的动力学模式可再现和有效地开发造血细胞。一方面，本发明的方法通常包括以下步骤：从动物供体获得活的干细胞，并用包含造血基因（如LH-2基因）的表达构建体转染细胞，以产生活的造血干细胞。

76. 发明申请

WO2016164915A1 STEM CELL COMPOSITIONS FOR COSMETIC AND DERMATOLOGIC USE 审中-公开
标题翻译：用于化妆和皮肤用途的干细胞组合物
公开(公告)号：WO2016164915A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026968
申请日：2016-04-11
申请人： NEOSTEM ONCOLOGY, LLC
发明人： NISTOR, Gabriel , POOLE, Aleksandra, J. , KEIRSTEAD, Hans, S.
IPC分类号： A61P17/00 , C12N5/0735 , C12N5/0789
CPC分类号： A61K8/981 , A61K8/00 , A61K8/068 , A61K8/345 , A61K8/64 , A61K35/545 , A61K38/1741 , A61K45/06 , A61Q19/00 , A61Q19/08 , C12N5/00 , C12N2502/02 , A61K2300/00
摘要： Disclosed herein are cosmetic or dermatologic compositions containing stem cell secreted proteins and fetuin that, in an effective amount, enhance appearance of photo- damaged, or aged, skin.
摘要翻译：本文公开了含有干细胞分泌蛋白质和胎球蛋白的化妆品或皮肤病学组合物，其有效量增强光损伤或老化皮肤的外观。

77. 发明申请

WO2015056982A1 만능 줄기세포의 유도 방법 및 상기 방법에 의해 제조된 만능줄기세포 审中-公开
标题翻译：诱导细胞干细胞的方法和通过方法制备的PLUIPOTENT干细胞
公开(公告)号：WO2015056982A1
公开(公告)日：2015-04-23
申请号：PCT/KR2014/009702
申请日：2014-10-16
申请人： (주)아모레퍼시픽 , 서울대학교산학협력단
发明人： 김아름 , 김수나 , 박원석 , 권유욱 , 박영배 , 김효수 , 백재승
IPC分类号： C12N5/074 , C12N5/02 , C07C62/32 , A61K35/12
CPC分类号： A61K8/365 , A23L2/52 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K8/0204 , A61K8/0216 , A61K8/0225 , A61K8/06 , A61K8/11 , A61K8/368 , A61K8/97 , A61K8/981 , A61K9/0019 , A61K9/0056 , A61K9/0095 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/191 , A61K35/28 , A61K36/14 , A61K2800/74 , A61K2800/78 , A61K2800/91 , A61K2800/92 , A61Q19/00 , A61Q19/08 , C12N5/0696 , C12N2500/14 , C12N2500/76 , C12N2501/115 , C12N2501/603 , C12N2501/73 , C12N2502/02 , C12N2502/13 , C12N2506/02 , C12N2506/1307 , C12N2533/54
摘要： 본 발명은 시킴산, 시킴산을 함유하는 식물추출물 또는 식물 줄기세포 및 식물 역분화 줄기세포 (callus)의 추출물을 사용하여 성체의 분화된 세포를 재프로그램화 시킴으로써 맞춤형 만능줄기세포를 유도하는 방법, 상기 방법에 의해 제조된 만능줄기세포 및 상기 만능줄기세포를 포함하는 조성물에 관한 것이다. 본 발명에 따르면, 배아줄기세포와 같은 능력을 가진 만능줄기세포를 만드는데 난자를 사용하지 않기 때문에 윤리 문제를 해결할 수 있고, 무엇보다도 인체에 해가 없는 것이 검증된 식물 줄기세포 추출물을 사용하므로 안전성이 확보된 만능줄기세포를 제조할 수 있으며, 또한 각 개체에 맞추어진 면역적합성 세포 치료제를 개발하는데 이용될 수 있을 것이다. 이에 더하여, 질병을 가진 개체로부터 만능줄기세포를 유도함으로써 질환의 원인 규명 및 치료방법을 연구하는데 있어 매우 유용하게 이용될 수 있을 것으로 기대된다. 또한 본 발명은 시킴산 또는 시킴산을 함유하는 식물추출물을 함유하는 조성물에 관한 것이다.
摘要翻译：本发明涉及用于诱导定制多能干细胞的方法，通过该方法制备的多能干细胞和包含多能干细胞的组合物，其中通过使用莽草酸重新编程分化的成体细胞诱导定制的多能干细胞，含有莽草酸的植物提取物，或植物干细胞和再分化植物干细胞（愈伤组织）的提取物。根据本发明，由于不使用卵来制备具有与胚胎干细胞相同能力的多能干细胞，所以可以解决伦理问题。最重要的是，通过使用被证明对人体无害的植物干细胞提取物，可以制备具有确保安全性的多能干细胞。此外，本发明可用于开发针对每个受试者定制的免疫兼容性细胞治疗剂。此外，预期本发明可以非常有用于研究治疗方法并通过从具有该疾病的受试者诱导多能干细胞来鉴定疾病的病因。此外，本发明涉及含有莽草酸或含有莽草酸的植物提取物的组合物。

78. 发明申请

WO2014171824A1 BLASTOID, CELL LINE BASED ARTIFICIAL BLASTOCYST 审中-公开
标题翻译： BLASTOID，细胞系的人造芽孢杆菌
公开(公告)号：WO2014171824A1
公开(公告)日：2014-10-23
申请号：PCT/NL2014/050239
申请日：2014-04-16
申请人： UNIVERSITEIT TWENTE , KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN
发明人： RIVRON, Nicolas Clément , VAN BLITTERSWIJK, Clemens Antoni , GEIJSEN, Niels , VRIJ, Erik Jacob
IPC分类号： C12N5/073 , C12N5/0735 , A01K67/027
CPC分类号： C12N5/0603 , A01K67/027 , A01K2227/105 , A01K2267/02 , A61B17/435 , C12N5/0604 , C12N5/0697 , C12N15/873 , C12N2500/44 , C12N2501/01 , C12N2501/105 , C12N2501/119 , C12N2501/15 , C12N2501/16 , C12N2501/235 , C12N2501/392 , C12N2501/415 , C12N2501/727 , C12N2501/91 , C12N2502/02 , C12N2502/025 , C12N2517/00 , C12N2531/00 , C12N2535/00
摘要： The invention relates to a method for making an at least double layered cell aggregate and/or an artificial blastocyst, and/or a further-developed blastoid termed blastoid, by forming a double layered cell aggregate from at least one trophoblast cell and at least one pluripotent and/or totipotent cell, and culturing said aggregate to obtain an artificial blastocyst. This artificial blastocyst has a trophectoderm-like tissue that surrounds a blastocoel and an inner cell mass-like tissue. The cell aggregate can be formed from toti- or pluripotent stem cell types, or induced pluripotent stem cell types, in combination with trophoblast stem cells. Formation of a blastoid can be achieved by culturing the cell aggregate in a medium preferably comprising one or more of a Rho/ROCK inhibitor, a Wnt pathway modulator, a PKA pathway modulator, a PKC pathway modulator, a MAPK pathway modulator, a STAT pathway modulator, an Akt pathway modulator, a Tgf pathway modulator and a Hippo pathway modulator. The invention further relates to a method for growing an at least double layered cell aggregate into an artificial blastocyst, and into a further-developed blastoid, a fetus or a live animal. The invention further pertains to an in vitro cell culture comprising the mentioned compounds and/or cell aggregates.
摘要翻译：本发明涉及一种通过从至少一个滋养层细胞和至少一个滋养层细胞形成双层细胞聚集体来制备至少双层细胞聚集体和/或人造囊胚和/或进一步开发的称为“ 多能和/或全能细胞，并培养所述骨料以获得人造囊胚。这种人造囊胚具有围绕胚泡和内细胞块状组织的滋养外胚层样组织。细胞聚集体可以由干细胞或多能干细胞类型或诱导多能干细胞类型与滋养层干细胞组合形成。可以通过在优选包含Rho / ROCK抑制剂，Wnt途径调节剂，PKA途径调节剂，PKC途径调节剂，MAPK途径调节剂，STAT途径中的一种或多种的培养基中培养细胞聚集体来实现blastoid的形成调节剂，Akt途径调节剂，Tgf途径调节剂和河马途径调节剂。本发明还涉及一种将至少双层细胞聚集体生长成人造囊胚并进一步发育的胚轴，胎儿或活动物的方法。本发明还涉及包含所述化合物和/或细胞聚集体的体外细胞培养物。

79. 发明申请

WO2012148130A1 배아줄기세포유래 마이크로베시클을 이용한 유도만능줄기세포의 제조방법 审中-公开
标题翻译：使用从胚胎干细胞衍生的微血管制备诱导的大脑干细胞的方法
公开(公告)号：WO2012148130A1
公开(公告)日：2012-11-01
申请号：PCT/KR2012/003019
申请日：2012-04-19
申请人： 포항공과대학교 산학협력단 , 박재성 , 고용송 , 김윤근 , 김준호 , 장수철 , 이남우 , 정다영 , 최은정
发明人： 박재성 , 고용송 , 김윤근 , 김준호 , 장수철 , 이남우 , 정다영 , 최은정
IPC分类号： C12N5/0735 , C12N5/10 , A61K35/54
CPC分类号： C12N5/0696 , A61K35/545 , C12N2502/02 , C12N2506/13
摘要： 본 발명은 배아줄기세포유래 마이크로베시클을 이용하여 체세포를 역분화시키는 방법에 관한 것이다. 구체적으로 본 발명은 배아줄기세포로부터 유래된 마이크로베시클을 포함하는 조성물을 체세포에 처리하여 유도만능줄기세포를 제조하는 방법을 제공한다. 본 발명에 따른 유도만능줄기세포의 제조방법은 배아줄기세포유래 마이크로베시클을 이용하여 부작용 없이 체세포의 역분화를 효율적으로 진행할 수 있으며, 나아가 각 개체 별로 면역적합성이 확보된 세포치료제를 개발하는데 매우 유용하게 이용될 수 있을 것으로 기대된다.
摘要翻译：本发明涉及使用源于胚胎干细胞的微泡去分化体细胞的方法。更具体地说，本发明涉及通过用具有源于胚胎干细胞的微泡的组合物处理体细胞来制备多能干细胞的方法。根据本发明的多能干细胞的制备方法有效地促进体细胞的去分化，而不使用微泡的副作用，并且进一步预期在开发具有适合特异性的免疫相容性的细胞治疗产品方面显着有用个人。

80. 发明申请

WO2011064669A3 ADHERENT CELLS FROM PLACENTA AND USE OF SAME IN DISEASE TREATMENT 审中-公开
标题翻译：来自斑AD的粘附细胞及其在疾病治疗中的应用
公开(公告)号：WO2011064669A3
公开(公告)日：2011-12-15
申请号：PCT/IB2010003219
申请日：2010-11-29
申请人： PLURISTEM LTD , ABERMAN ZAMI
发明人： ABERMAN ZAMI
IPC分类号： C12N5/073 , A61K35/50
CPC分类号： A61K35/50 , A61K2035/122 , C12N5/0605 , C12N2502/02
摘要： Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic pain, and myocardial infarction. Also provided are methods wherein the adherent stromal cells administered are cultured under 2 dimensional or 3 dimensional growth conditions. Also provided are methods in which the cells administered are at least 70 % adherent cells from a maternal or fetal portion of the placenta.
摘要翻译：提供了通过将胎盘衍生的贴壁基质细胞给予其中的受试者来治疗病症的方法。这种情况包括骨骼肌缺陷，神经性疼痛和心肌梗塞。还提供了其中所施用的贴壁基质细胞在2维或3维生长条件下培养的方法。还提供了其中施用的细胞是来自胎盘的母体或胎儿部分的至少70％贴壁细胞的方法。

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