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71. 发明申请

WO2007007284A3 COMPOSITE BIOMIMETIC TOTAL INTERVERTEBRAL DISC PROSTHESIS 审中-公开
标题翻译：复合生物美观全椎间盘假体
公开(公告)号：WO2007007284A3
公开(公告)日：2007-10-11
申请号：PCT/IB2006052365
申请日：2006-07-12
申请人： CONSIGLIO NAZIONALE RICERCHE , AMBROSIO LUIGI , CAUSA FILIPPO , DE SANTIS ROBERTO , NICOLAIS LUIGI
发明人： AMBROSIO LUIGI , CAUSA FILIPPO , DE SANTIS ROBERTO , NICOLAIS LUIGI
IPC分类号： A61L27/44 , A61F2/44
CPC分类号： A61L27/48 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2002/30009 , A61F2002/30075 , A61F2002/30563 , A61F2002/30841 , A61F2002/4495 , A61F2210/0061 , A61F2250/0028 , A61F2310/00293 , A61L27/52 , A61L2430/38
摘要： A disc prosthesis, suitable for replacing an intervertebral disc, comprises a pair of endplates (11, 21) , and an intermediate body (31) , interposed or suitable for being interposed between the endplates. The intermediate body- comprises a nucleus (32) made of hydrogel, around which is wound a peripheral structure (35) made of fibre-reinforced hydrogel .
摘要翻译：适用于替换椎间盘的椎间盘假体包括一对端板（11,21）和中间体（31），中间体（31）插入或适合插入在端板之间。中间体包括由水凝胶制成的核（32），其周围缠绕由纤维增强水凝胶制成的外围结构（35）。

72. 发明申请

WO2007023399A8 A NOVEL INTERVERTEBRAL DISC PROSTHESIS 审中-公开
标题翻译：一个新的跨地区的DISC PROSTHISISIS
公开(公告)号：WO2007023399A8
公开(公告)日：2007-05-18
申请号：PCT/IB2006052359
申请日：2006-07-12
申请人： CONSIGLIO NAZIONALE RICERCHE , AMBROSIO LUIGI , TANNER ELIZABETH K
发明人： AMBROSIO LUIGI , TANNER ELIZABETH K
IPC分类号： A61F2/44 , A61L27/46
CPC分类号： A61F2/4425 , A61F2/30965 , A61F2002/30004 , A61F2002/30649 , A61F2002/30685 , A61F2002/30841 , A61F2250/0014 , A61F2310/00293 , A61L27/46 , A61L2430/38 , C08L23/06
摘要： A disc prosthesis, suitable for replacing an intervertebral disc, includes a first (1; 1') and a second (2; 2') articulation component. The components comprise respective endplates (11, 21; 11', 21') suitable for being anchored to respective vertebrae. . The first articulation component further comprises a spacer member (13; 13') suitable for being interposed between the endplates, and which is disposed on the endplate (11; 11') of the first component (1; 1') and has a convex articulation surface (19; 19') suitable for being placed in contact with a corresponding concave articulation surface (29; 29') disposed on the endplate of- the second component. The articulation -components are made at least partially of polyethylene reinforced with calcium phosphate, one of same further having a part (17; 27'), facing towards the other articulation component, which is made of ultra-high molecular weight polyethylene, and on which one of the articulation surfaces is provided.
摘要翻译：适合于更换椎间盘的椎间盘假体包括第一（1; 1'）和第二（2; 2'）铰接部件。这些部件包括适于锚定到相应椎骨的相应端板（11,21; 11'，21'）。。所述第一关节部件还包括适于插入在所述端板之间并且设置在所述第一部件（1; 1'）的所述端板（11; 11'）上并具有凸起的间隔件（13; 13'）铰接表面（19; 19'）适于与设置在第二部件的端板上的对应的凹形铰接表面（29; 29'）放置接触。关节 - 组件至少部分地由磷酸钙增强的聚乙烯制成，其中一个还具有面向另一个铰接部件的部分（17; 27'），该部分由超高分子量聚乙烯制成，并且在提供哪一个关节表面。

73. 发明申请

WO2006051397A3 OLIGONUCLEOTIDE PROBES 审中-公开
公开(公告)号：WO2006051397A3
公开(公告)日：2006-11-16
申请号：PCT/IB2005003369
申请日：2005-11-10
申请人： CONSIGLIO NAZIONALE RICERCHE , BARBARELLA GIOVANNA , CAPOBIANCO MASSIMO LUIGI , SOTGIU GIOVANNA , ZAMBIANCHI MASSIMO , ARUFFO FABIO , BENZI MARIO , NALDI MARINA , NEGRI UMBERTO
发明人： BARBARELLA GIOVANNA , CAPOBIANCO MASSIMO LUIGI , SOTGIU GIOVANNA , ZAMBIANCHI MASSIMO , ARUFFO FABIO , BENZI MARIO , NALDI MARINA , NEGRI UMBERTO
IPC分类号： C07H21/00 , C07D333/38 , C07D409/14 , C07D495/14 , C12Q1/68
CPC分类号： C07D495/14 , C07D333/38 , C07D409/14 , C07H21/00
摘要： Fluorescent oligonucleotide probe having a general formula (I), wherein Onu represents an oligonucleotide residue, Thio n represents a fluorescent oligothiophene containing n thiophenic rings, n being an integer lower than 8, L representing a binder conceived to maintain Thio n mobile in relation to Onu in a manner so that Thio n can perform its fluorescent action correctly, and Onu can perform its hybridization action. (I) = Onu-L-Thio n.
摘要翻译：具有通式（I）的荧光寡核苷酸探针，其中Onu表示寡核苷酸残基，Thio N n表示含有n个噻吩环的荧光寡聚噻吩，n为低于8的整数，L表示构成的粘合剂保持Thio相对于Onu的移动，使得Thio可以正确地执行其荧光作用，并且Onu可以进行其杂交作用。（I）= Onu-L-Thio

74. 发明申请

WO2005120340A2 RADIO FREQUENCY SURFACE COIL DESIGNS FOR MAGNETIC RESONANCE APPARATUS WITH IMPROVED SPATIAL SENSITIVITY AND SELECTIVITY, AND A MAGNETIC RESONANCE APPARATUS INCLUDING SAID COIL 审中-公开
标题翻译：具有改进的空间灵敏度和选择性的磁性共振装置的无线电频率表面线圈设计以及包括固定线圈的磁共振装置
公开(公告)号：WO2005120340A2
公开(公告)日：2005-12-22
申请号：PCT/IB2005051855
申请日：2005-06-07
申请人： CONSIGLIO NAZIONALE RICERCHE , ALFONSETTI MARIA , PLACIDI GIUSEPPE , SOTGIU ANTONELLO , CLEMENTI VALERIA , IOTTI STEFANO , LODI RAFFAELE , BARBIROLI BRUNO , ALECCI MARCELLO
发明人： ALFONSETTI MARIA , PLACIDI GIUSEPPE , SOTGIU ANTONELLO , CLEMENTI VALERIA , IOTTI STEFANO , LODI RAFFAELE , BARBIROLI BRUNO , ALECCI MARCELLO
IPC分类号： G01R33/341 , A61B5/05
CPC分类号： G01R33/341
摘要： Surface coil configurations for a magnetic resonance apparatus are described, said configurations comprising a conductive path (10; 110) which extends substantially in a figure of eight forming a pair of adjacent lobes (10a, 10b; 110a, 110b) and including a plurality of middle linear sections (20a, 20a', 20a'', 20b, 20b', 20b''; 120a, 120a', 120a'', 120b, 20b', 120b'') passed through by current directed in the same direction or in substantially concordant directions and grouped together in a central region of the coil, and sections with an arbitrary `shape (22a, 22b; 122a, 122b) passed through by current in the opposite direction in the peripheral region, so that the magnetic radiofrequency field in the central region of the coil is substantially directed in a direction parallel to the local plane of the coil and is spatially non-homogeneous and able to be modulated depending on the number and the geometrical arrangement of said middle linear sections (20a, 20a', 20a'', 20b, 20b', 20b''; 120a, 120a', 120a'', 120b, 120b' , 120b'').
摘要翻译：描述了用于磁共振装置的表面线圈结构，所述配置包括基本上以图8形成的形成一对相邻凸角（10a，10b; 110a，110b）的导电路径（10; 110），并且包括多个中间线性部分（20a，20a'，20a“，20b，20b”，20b“; 120a，120a'，120a”，120b，20b'，120b“）通过沿相同方向在线圈的中心区域中以大致一致的方向组合在一起，并且具有任意的“形状”（22a，22b; 122a，122b）的区域在周边区域中以相反的方向通过电流，使得磁性射频场在线圈的中心区域基本上指向与线圈的局部平面平行的方向，并且在空间上是非均匀的，并且能够根据所述中间线性部分（20a，20a'）的数量和几何布置进行调制，，20a“，20b，20b'，20b' “; 120a，120a'，120a“，120b，120b'，120b”）。

75. 发明申请

WO2005057676A8 METHOD FOR REDUCING THE SURFACE ROUGHNESS OF A THIN LAYER OF CONDUCTIVE OXIDES 审中-公开
标题翻译：减少导电性氧化物薄层表面粗糙度的方法
公开(公告)号：WO2005057676A8
公开(公告)日：2005-09-29
申请号：PCT/IT0300813
申请日：2003-12-12
申请人： CONSIGLIO NAZIONALE RICERCHE , COCCHI MASSIMO , DI MARCO PIERGIULIO , FATTORI VALERIA , GIRO GABRIELE , VIRGILI DALIA , GARULLI ALBERTO
发明人： COCCHI MASSIMO , DI MARCO PIERGIULIO , FATTORI VALERIA , GIRO GABRIELE , VIRGILI DALIA , GARULLI ALBERTO
IPC分类号： H01L51/00 , H01L51/30 , H01L51/40 , H01L51/52 , H01L51/20
CPC分类号： H01L51/0001 , H01L51/005 , H01L51/0059 , H01L51/5206
摘要： A method for reducing the surface roughness of thin layers of conductive oxides for thin-layer opto-electronic devices envisages polishing with a finishing cloth and an abrasive compound, which has a basic pH and contains silica particles.
摘要翻译：用于降低薄层光电装置的导电氧化物薄层的表面粗糙度的方法设想用具有碱性pH并含有二氧化硅颗粒的精整布和磨料化合物进行抛光。

76. 发明申请

WO2004104211A2 METHOD FOR DETECTING TOXIC AND NON-TOXIC CYANOBACTERIA 审中-公开
标题翻译：检测毒性和非毒性CYANOBACTERIA的方法
公开(公告)号：WO2004104211A2
公开(公告)日：2004-12-02
申请号：PCT/FI2004000310
申请日：2004-05-21
申请人： HELSINGIN YLIOPISTO , UNIV LIEGE , CONSIGLIO NAZIONALE RICERCHE , SIVONEN KAARINA , RANTALA ANNE , ROUHIAINEN LEO , FEWER DAVID , RAJANIEMI PIRJO , WILMOTTE ANNICK , BOUTTE CHRISTOPHE , GRUBISIC STANA , BALTHASART PIERRE , DE BELLIS GIANLUCA , RIZZI ERMANNO , FROSINI ANDREA , CASTIGLIONI BIANCA , VENTURA STEFANO , MUGNAI MARIA ANGELA
发明人： SIVONEN KAARINA , RANTALA ANNE , ROUHIAINEN LEO , FEWER DAVID , RAJANIEMI PIRJO , WILMOTTE ANNICK , BOUTTE CHRISTOPHE , GRUBISIC STANA , BALTHASART PIERRE , DE BELLIS GIANLUCA , RIZZI ERMANNO , FROSINI ANDREA , CASTIGLIONI BIANCA , VENTURA STEFANO , MUGNAI MARIA ANGELA
IPC分类号： C12Q20060101 , C12Q1/68 , C12Q
CPC分类号： C12Q1/6895 , C12Q1/689 , C12Q2600/154 , C12Q2600/156
摘要： This invention is related to a method for detecting toxic and non-toxic cyanobacteria. The method comprises that nucleic acid from a biological sample is brought into contact with an oligonucleotide designed to be specific for the mcy gene, in particular mcyE and/or mcyD, and with an oligonucleotide designed to be specific for 16SrDNA, and the presence or absence of toxic cyanobacteria is detected by a suitable molecular biology method. The invention is related also to oligonucleotides used in the method.
摘要翻译：本发明涉及一种检测有毒和无毒蓝细菌的方法。该方法包括使来自生物样品的核酸与设计为特异于mcy基因，特别是mcyE和/或mcyD的寡核苷酸和设计为对16SrDNA特异性的寡核苷酸进行接触，并且存在或不存在的有毒蓝细菌通过合适的分子生物学方法检测。本发明也涉及该方法中使用的寡核苷酸。

77. 发明申请

WO2004007553A8 ANTIBODIES ANTI-C5 COMPONENT OF THE COMPLEMENT SYSTEM AND THEIR USE 审中-公开
标题翻译：抗体系统的抗体C5组分及其使用
公开(公告)号：WO2004007553A8
公开(公告)日：2004-04-29
申请号：PCT/EP0307487
申请日：2003-07-10
申请人： UNIV DEGLI STUDI TRIESTE , CONSIGLIO NAZIONALE RICERCHE , TEDESCO FRANCESCO , MARZARI ROBERTO
发明人： TEDESCO FRANCESCO , MARZARI ROBERTO
IPC分类号： C07K16/18 , C12N15/13 , A01K67/027 , A61K39/395 , C12N5/10 , C12N15/63
CPC分类号： C12N15/11 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C12N15/62 , C12N15/70 , C12N15/85
摘要： The present invention refers to recombinant antibodies of human origin specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 alpha chain to C5a and C5b. Moreover the present invention refers to the nucleotide sequences coding for such antibodies and to the therapeutic use of both polypeptide and nucleotide sequences, in particular for the therapy of diseases involving tissue damage deriving from uncontrolled activation of the complement system.
摘要翻译：本发明涉及对活化的补体的C5组分特异的人源重组抗体，其特征在于抑制C5α和C5b转化为C5a和C5b的能力。此外，本发明涉及编码这种抗体的核苷酸序列以及多肽和核苷酸序列的治疗用途，特别是用于治疗由补体系统的不受控激活导致的组织损伤的疾病。

78. 发明申请

WO0220790A9 PARIETARIA JUDAICA NS-LTP ANTIGEN VARIANTS, USES THEREOF AND COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译： PARIETARIA JUDAICA NS-LTP抗原变体，其组合物及其组合物
公开(公告)号：WO0220790A9
公开(公告)日：2003-05-30
申请号：PCT/IT0100471
申请日：2001-09-11
申请人： CONSIGLIO NAZIONALE RICERCHE , GERACI DOMENICO , COLOMBO PAOLO , DURO GIOVANNI , IZZO VINCENZO , COSTA MARIA ASSUNTA
发明人： GERACI DOMENICO , COLOMBO PAOLO , DURO GIOVANNI , IZZO VINCENZO , COSTA MARIA ASSUNTA
IPC分类号： A61K38/11 , C07K14/415 , C12N15/28 , A61K39/36 , C12N15/70 , G01N33/68
CPC分类号： C07K14/415 , A61K38/00
摘要： The present invention relates to hypoallergenic variants of ns-LTPs allergens, to pharmaceutical compositions comprising them and to the use of such variants for the preparation of medicaments suitable in the treatment and in the prevention of the allergic forms associated with an ns-LTP allergen, in particular to the allergen corresponding to the variant used.
摘要翻译：本发明涉及ns-LTPs变应原的低变应原变体，包含它们的药物组合物以及这些变体用于制备适合于治疗和预防与ns-LTP变应原相关的过敏形式的药物的用途，特别是对应于所用变体的变应原。

79. 发明申请

WO0191763A9 EXTRACTS FROM SPERMATOPHYTE PLANTS WITH ANTITUMOR ACTIVITY 审中-公开
标题翻译：从具有抗肿瘤活性的植物植物提取物
公开(公告)号：WO0191763A9
公开(公告)日：2003-05-08
申请号：PCT/IB0100981
申请日：2001-05-29
申请人： CONSIGLIO NAZIONALE RICERCHE , ISTITUTO AGRARIO DI S MICHELE , RAVAGNAN GIAMPIETRO , FALCHETTI ROBERTO , LANZILLI GIULIA , FUGGETTA MARIA PIA , TRICARICO MARIA , MATTIVI FULVIO
发明人： RAVAGNAN GIAMPIETRO , FALCHETTI ROBERTO , LANZILLI GIULIA , FUGGETTA MARIA PIA , TRICARICO MARIA , MATTIVI FULVIO
IPC分类号： A61K20060101 , A61K31/05 , A61K35/00 , A61K36/00 , A61K36/10 , A61K36/18 , A61P35/00 , B01D20060101 , A61K35/78
CPC分类号： A61K36/18 , A61K2300/00
摘要： A method is described for the extraction of products having a pharmacological activity, in particular an anti-tumoral activity, from spermatophyte plants. Said products, which are to be used in the pharmaceutical field, consist of complex mixtures of compounds characterized by one or more stilbene groups, variously hydroxylated and/or glucosidated, and of compounds derived from said group by natural enzymatic biosynthetical processes (stilbenoids). The following compounds are preferred: C-Res, glucosidated C-Res, epsilon -viniferine, H-gnetine, r-2-viniferine, r-viniferine, hopeaphenol, Ampelopepsin A and glucosidated T-Res.
摘要翻译：描述了从精子植物提取具有药理活性，特别是抗肿瘤活性的产品的方法。将用于制药领域的所述产品由化合物的复合混合物组成，其特征在于一种或多种不同羟基化和/或糖苷化的芪基，以及通过天然酶促生物合成方法衍生自所述基团的化合物（芪类化合物）。以下化合物是优选的：C-Res，葡萄糖苷化C-Res，ε-雌二醇，H-gnetine，r-2-viniferine，r-viniferine，希夫苯酚，Ampelopepsin A和glucosidated T-Res。

80. 发明申请

WO0135339A3 AUTOMATIC ANALYSIS OF ANATOMICAL IMAGES TIME SEQUENCE 审中-公开
标题翻译：解剖图像时间序列的自动分析
公开(公告)号：WO0135339A3
公开(公告)日：2002-07-25
申请号：PCT/EP0010658
申请日：2000-10-30
申请人： CONSIGLIO NAZIONALE RICERCHE , SANTARELLI MARIA FILOMENA , POSITANO VINCENZO , LANDINI LUIGI , BENASSI ANTONIO , LOMBARDI MASSIMO , L ABBATE ANTONIO
发明人： SANTARELLI MARIA FILOMENA , POSITANO VINCENZO , LANDINI LUIGI , BENASSI ANTONIO , LOMBARDI MASSIMO , L ABBATE ANTONIO
IPC分类号： G06T5/00 , G06T7/60
CPC分类号： G06T7/0012 , G06T7/12 , G06T7/149 , G06T7/62 , G06T2207/20116 , G06T2207/30048
摘要： The method allows prefiltering, segmentation and analysing time sequence of volumetric images in the field of medical diagnosis. In particular the system allows detecting and selecting, from anatomical images, for example cardiac images, an organ or part of it by means instruments of segmentation and carrying out quantitative analysis for anatomical studies, function and perfusion. From the images cardiache is calcola the volume of the cavity and the thickness of the miocardium and as these variano in the tempo; in the images cardiache of perfusion, is calculated automatically the ventricular wall by means of suitable operations of segmentation and, then, is subdivide this wall in a plurality of selected regions obtaining, by means of a graphic window, time/intensity curves relative to each zone, comprised the reference curve corresponding to the ventricular cavity. The method allows di: 1) to filter the curve tempo/intensita' from heat noise and due to the hardware of the machine and by artefacts due to meccanismi fisiologici, such as the heart beat and attivita' vaso-motoria spontanea; 2) estract data relative to the flow in the regions of the myocardium wall selected automatically.
摘要翻译：该方法允许在医学诊断领域对体积图像进行预过滤，分割和分析。特别地，该系统允许从解剖图像检测和选择例如心脏图像，器官或其一部分通过分割仪器进行解剖学研究，功能和灌注的定量分析。从图像心跳是calcola的体积的腔和miocardium的厚度和这些variano在节奏中; 在图像灌注心电图中，通过适当的分割操作自动计算心室壁，然后将该壁细分为多个选定区域，通过图形窗口获得相对于每个区域的时间/强度曲线包括对应于心室的参考曲线。该方法允许di：1）过滤来自热噪声的曲线速度/强度，并且由于机器的硬件以及由于心跳反应而产生的人为因素，例如心脏跳动和自发性血管运动自发; 2）相对于自动选择的心肌壁区域的流量估计数据。

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