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1. 发明申请

WO2009147007A2 MULTIFUNCTIONAL COATINGS 审中-公开
标题翻译：多功能涂料
公开(公告)号：WO2009147007A2
公开(公告)日：2009-12-10
申请号：PCT/EP2009055960
申请日：2009-05-16
申请人： UNIV LIEGE , VAN DE WEERDT CECILE , DETREMBLEUR CHRISTOPHE , CHARLOT AURELIA , JEROME ROBERT , VREULS CHRISTELLE , ZOCCHI GERMAINE
发明人： VAN DE WEERDT CECILE , DETREMBLEUR CHRISTOPHE , CHARLOT AURELIA , JEROME ROBERT , VREULS CHRISTELLE , ZOCCHI GERMAINE
IPC分类号： C08F220/58 , B32B27/30 , C08K3/22 , C09J133/24
CPC分类号： C08F220/58 , C08F220/06 , C08F220/34 , C09D133/14 , C09D133/16 , C09D133/26 , Y10T428/31699 , Y10T428/31935
摘要： New polyelectrolyte copolymer, composite material, multilayer film and substrate carrying such polyelectrolyte copolymer, composite and multilayer film wherein the polyelectrolyte copolymer comprises a) a first type of identical or different units (A) each comprising one or more dihydroxyphenyl groups such that sidechains are present along the backbone of the polyelectrolyte copolymer which contain at least one dihydroxyphenyl group each; and (b1) a second type of identical or different units (B1) each comprising a cationic moiety, or (b2) a second type of identical or different units (B2) each comprising an anionic moiety.
摘要翻译：新型聚电解质共聚物，复合材料，多层膜和承载这种聚电解质共聚物，复合和多层膜的多层膜，其中聚电解质共聚物包含a）第一类相同或不同的单元（A），每个单元包含一个或多个二羟基苯基，使得侧链存在沿着含有至少一个二羟基苯基的聚电解质共聚物的骨架; 和（b1）各自包含阳离子部分的相同或不同单元（B1）的第二类型，或（b2）各自包含阴离子部分的第二类型相同或不同单元（B2）。

2. 发明申请

WO2007107442A3 BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS 审中-公开
标题翻译： BIS1,2,3,4-四氢喹啉衍生物及其作为药物的用途
公开(公告)号：WO2007107442A3
公开(公告)日：2008-06-05
申请号：PCT/EP2007052029
申请日：2007-03-03
申请人： UNIV LIEGE , GRAULICH AMAURY , LIEGEOIS JEAN-FRANCOIS , MOREAU JACQUELINE , SEUTIN VINCENT
发明人： GRAULICH AMAURY , LIEGEOIS JEAN-FRANCOIS , MOREAU JACQUELINE , SEUTIN VINCENT
IPC分类号： A61K31/4725 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： A61K31/4725 , C07D217/04
摘要： Use of Bis 1,2,3,4-tetrahydroisoquinoline derivatives represented by formula (I) as SK channel blockers and for the preparation of a medicament useful for the treatment of disorders of the central nervous system.
摘要翻译：使用由式（I）表示的双1,2,3,4-四氢异喹啉衍生物作为SK通道阻滞剂并用于制备用于治疗中枢神经系统病症的药物。

3. 发明申请

WO2007137995B1 A THERMAL DETECTOR 审中-公开
标题翻译：一个热探测器
公开(公告)号：WO2007137995B1
公开(公告)日：2008-03-20
申请号：PCT/EP2007055068
申请日：2007-05-24
申请人： UNIV LIEGE , FLEURY-FRENETTE KARL , HABRAKEN SERGE , RENOTTE YVON , HASTANIN JURIY
发明人： FLEURY-FRENETTE KARL , HABRAKEN SERGE , RENOTTE YVON , HASTANIN JURIY
IPC分类号： G01J5/58 , G01J5/40
CPC分类号： G01J5/58 , G01J5/40
摘要： A first object of the invention is a radiation detector comprising an energy absorber (203), for absorbing incident radiation (RAD) and thus undergoing a temperature increase; and optical readout means, for detecting said temperature increase; wherein said optical readout means comprises input coupling means (202) for coupling a light beam (2011) to said energy absorber (203) by exciting surface plasmons resonance, a surface plasmons resonance condition being dependent on the energy absorber (203) temperature, and wherein said energy absorber (203) is separated from said input coupling means (202) by a dielectric layer (2032). A second object of the invention is a micromechanical sensor comprising: a micromechanical oscillator and optical readout means (202) for detecting a displacement of said micromechanical oscillator; wherein said optical readout means comprise input coupling means (202) for coupling a light beam (2011) to a conductive surface (2031) by exciting surface plasmons resonance, a surface plasmons resonance condition being dependent on the displacement of said micromechanical oscillator.
摘要翻译：本发明的第一个目的是一种辐射探测器，其包括用于吸收入射辐射（RAD）并因此经历温度增加的能量吸收器（203）和光学读出装置，用于检测所述温度升高; 其中所述光学读出装置包括用于通过激励表面等离子体激元共振（表面等离子体激元共振条件取决于能量吸收器（203）温度）将光束（2011）耦合到所述能量吸收器（203）的输入耦合装置（202）其中所述能量吸收器（203）通过介电层（2032）与所述输入耦合装置（202）分离。本发明的第二个目的是一种微机械传感器，包括：微机械振荡器和光学读出装置（202），用于检测所述微机械振荡器的位移; 其中所述光学读出装置包括用于通过激励表面等离子体激元共振而将光束（2011）耦合到导电表面（2031）的输入耦合装置（202），表面等离子体激元共振条件取决于所述微机械振荡器的位移。

4. 发明申请

WO2005075986A3 METHOD AND KIT FOR THE MEASUREMENT OF NEUTROPHIL CELL ACTIVATION 审中-公开
标题翻译：用于测量中性粒细胞活化的方法和试剂盒
公开(公告)号：WO2005075986A3
公开(公告)日：2006-01-26
申请号：PCT/BE2005000017
申请日：2005-02-07
申请人： UNIV LIEGE , SERTEYN DIDIER , DUPONT GINETTE , FRANCK THIERRY , KOHNEN STEPHANE
发明人： SERTEYN DIDIER , DUPONT GINETTE , FRANCK THIERRY , KOHNEN STEPHANE
IPC分类号： G01N33/50 , G01N33/569 , G01N33/573
CPC分类号： G01N33/5091 , C12Q1/28 , G01N33/56972 , G01N33/573 , G01N2500/04 , Y10T436/25125
摘要： The present invention is related to accurate detection methods for the measurement only of myeloperoxidase (MPO) levels of neutrophils, preferably equine neutrophils, in complex biological samples. The present invention is further related to ELISA and SIEFED assays for such detection. SIEFED detection sensitivity of active peroxidase activity was found to be enhanced by the addition of nitrite. Such MPO measurement finds its use in many applications such as the prediction, diagnosis and/or monitoring of pathologies correlated with neutrophil activation and/or destruction; the evaluation of drugs and/or immunomodulators; the assessment of immune responses, either natural and/or after treatment with immunomodulators and/or drugs; and the study of cells and their ability to fight microorganisms and/or to destroy them.
摘要翻译：本发明涉及在复杂生物样品中仅测量嗜中性粒细胞（优选马中性粒细胞）的髓过氧化物酶（MPO）水平的精确检测方法。本发明还涉及用于这种检测的ELISA和SIEFED测定。发现活性过氧化物酶活性的SIEFED检测灵敏度通过加入亚硝酸盐而增强。这样的MPO测量可以在诸如预测，诊断和/或监测与嗜中性粒细胞活化和/或破坏相关的病理学的许多应用中得到应用。药物和/或免疫调节剂的评估; 用免疫调节剂和/或药物进行天然和/或治疗后免疫应答的评估; 细胞的研究及其对抗微生物和/或破坏细胞的能力。

5. 发明申请

WO2005049840A3 PROCESS AND APPARATUS FOR MEASURING THE THREE-DIMENSIONAL SHAPE OF AN OBJECT 审中-公开
标题翻译：用于测量物体三维形状的过程和装置
公开(公告)号：WO2005049840A3
公开(公告)日：2005-07-21
申请号：PCT/EP2004012773
申请日：2004-11-10
申请人： UNIV LIEGE , TILKENS BERNARD , RENOTTE YVON , MOREAU VINCENT
发明人： TILKENS BERNARD , RENOTTE YVON , MOREAU VINCENT
IPC分类号： G01B11/25
CPC分类号： G01B11/25
摘要： A process for measuring a three dimensional (3D) shape of an object, comprising: 1.providing a light, 2.splitting said light into two spatially separated and orthogonally polarised signals, 3.filtering and projecting said signals on a surface of said object thus forming an interference lines pattern, and 4.viewing an image of said surface, that includes said lines pattern.
摘要翻译：一种用于测量物体的三维（3D）形状的方法，包括：1.提供光，2.将所述光分成两个空间分离和正交极化信号，3.在所述物体的表面上过滤和投影所述信号从而形成干涉线图案，以及4.观察包括所述线图案的所述表面的图像。

6. 发明申请

WO2005024423A3 A METHOD FOR QUALITATIVE AND/OR QUANTITATIVE DETECTION OF POLYETHYLENE GLYCOLS IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：聚乙烯甘油在生物流体中定性和/或定量检测的方法
公开(公告)号：WO2005024423A3
公开(公告)日：2005-06-23
申请号：PCT/EP2004051970
申请日：2004-08-31
申请人： UNIV LIEGE , GRANDFILS CHRISTIAN , DANDRIFOSSE GUY , REMACLE RENE , BARAKAT IBRAHIM , DELOYER PATRICIA
发明人： GRANDFILS CHRISTIAN , DANDRIFOSSE GUY , REMACLE RENE , BARAKAT IBRAHIM , DELOYER PATRICIA
IPC分类号： G01N31/22 , G01N33/52
CPC分类号： G01N33/52 , G01N31/22
摘要： The subject matter of the present invention relates a method for detection of polyethylene glycols (PEG) in an aqueous solution or in a sample of a biological fluid in a qualitative and/or semi-quantitative and/or quantitative manner, the method comprising the addition of a reagent containing iodine, alkali metal iodide and an acid; and a method for assessing the permeability of the intestine wherein two PEGs of different molecular weight, low molecular weight PEG (l.m.w. PEG) and high molecular weight PEG (h.m.w. PEG) are used as markers, wherein the l.m.w. PEG is able to cross the intestinal mucosa under physiological conditions and the h.m.w. PEG is essentially not able to cross the intestinal mucosa under physiological conditions, but is able to cross the intestinal mucosa under non-physiological, irregular conditions; and wherein h.m.w. and l.m.w. PEG concentrations are measured in a sample of urine from an individual after oral administration of h.m.w. PEG and l.m.w. PEG, wherein the differential index of h.m.w. PEG and l.m.w. PEG in the urine is calculated after determining the concentrations of h.m.w. PEG and l.m.w. PEG by using a reagent for quantitative detection of polyethylene glycol (PEG) in biological fluids, the reagent containing iodine, alkali metal iodide and an acid; and a kit for qualitative and/or semi-quantitative and/or quantitative detection of polyethylene glycol in biological fluids, e.g. in urine.
摘要翻译：本发明的主题涉及以定性和/或半定量和/或定量方式在水溶液或生物流体样品中检测聚乙二醇（PEG）的方法，所述方法包括添加含有碘，碱金属碘化物和酸的试剂; 和用于评估肠的渗透性的方法，其中使用不同分子量的低分子量PEG（1m.w.PEG）和高分子量PEG（h.m.w.PEG）的两种PEG作为标记物，其中l.m.w. PEG在生理条件下能够穿过肠粘膜，而h.m.w. PEG在生理条件下基本上不能穿过肠粘膜，但能够在非生理，不规则的条件下穿过肠粘膜; 并且其中h.m.w 和l.m.w. 在口服h.m.w后，来自个体的尿液样品中测量PEG浓度。 PEG和l.m.w. PEG，其中h.m.w的微分指数 PEG和l.m.w. 在确定h.m.w的浓度后计算尿中的PEG。 PEG和l.m.w. PEG通过使用用于在生物体液中定量检测聚乙二醇（PEG）的试剂，含有碘，碱金属碘化物和酸的试剂; 以及用于生物流体中聚乙二醇的定性和/或半定量和/或定量检测的试剂盒，例如。在尿液

7. 发明申请

WO0131056A3 DETECTION METHOD BY PCR 审中-公开
标题翻译： PCR检测方法
公开(公告)号：WO0131056A3
公开(公告)日：2002-06-27
申请号：PCT/BE0000131
申请日：2000-10-27
申请人： UNIV LIEGE , ZORZI WILLY , MELEN LAURENCE , ZORZI DANIELE , EL MOUALIJ BENAISSA , HEINEN ERNST
发明人： ZORZI WILLY , MELEN LAURENCE , ZORZI DANIELE , EL MOUALIJ BENAISSA , HEINEN ERNST
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/543
CPC分类号： C12Q1/686 , C12Q1/6804
摘要： The invention concerns a method using PCR, in particular immuno-PCR, for detecting microbiological entities and in particular elements or target molecules. The detection method comprises a step which consists in fixing an entity A, more particularly an antigen, directly or via a capture agent, for example an antibody, to one or several surface(s) inside the receptacle(s) of a real time PCR measuring apparatus and a step which consists in associating with said element A a coupling system with a nucleic acid, for example a DNA marker, a step which consists in amplifying the marker nucleic acid. The successive measurements are carried out during the phase amplifying the marker nucleic acid, in the presence of a capture agent and other optional intermediate fixing agents. The detection method is quantitative and can be used in particular for prion polypeptide assay.
摘要翻译：本发明涉及使用PCR，特别是免疫PCR的方法来检测微生物实体，特别是元件或靶分子。检测方法包括将实体A，特别是抗原直接或经由捕获剂（例如抗体）固定在实时PCR中的一个或多个容器内的一个或多个表面的步骤测量装置和步骤，其包括与所述元件A结合与核酸（例如DNA标记）的偶联系统，其包含扩增标记核酸的步骤。在捕获剂和其它任选的中间固定剂的存在下，在标记核酸的相扩增期间进行连续的测量。检测方法是定量的，可以特别用于朊病毒多肽测定。

8. 发明申请

WO0223236A3 A MONOMODE OPTICAL FIBRE 审中-公开
标题翻译：单色光纤
公开(公告)号：WO0223236A3
公开(公告)日：2002-06-06
申请号：PCT/EP0110549
申请日：2001-09-12
申请人： UNIV LIEGE
发明人： LEMAIRE PHILIPPE , SCAUFLAIRE VERONIQUE
IPC分类号： G02B6/02 , G02B6/036 , G02B6/24 , G02B6/26 , G02B6/44 , G02B6/22 , G02B6/16
CPC分类号： G02B6/03627 , G02B6/241 , G02B6/262 , G02B6/4402 , G02B6/4478
摘要： A monomode optical fibre provided for transporting light having a wavelength comprised between 480 and 550 nm. The fibre comprises a core made of a first transparent dielectric material having a first refractive index nc and a substantially circular cross-section with a radius dimension a. The fibre further comprises a first cladding coaxially applied on said core and made of a second transparent dielectric material having a second refractive index nm1 inferior to nc. The first transparent dielectric material consists in substantially pure silica, the second transparent dielectric material consists in doped silica, the thickness of the first cladding is comprised in a range of 5 to 15 microns and the values of nc and nm1 are choosen in such a manner that the numerical aperture is less than 0.1 and the radius dimension a is above 2 microns.
摘要翻译：提供用于传输波长在480和550nm之间的光的单模光纤。纤维包括由具有第一折射率nc的第一透明介电材料制成的芯和具有半径尺寸a的基本圆形的横截面。纤维还包括同轴施加在所述芯上并由具有低于nc的第二折射率nm1的第二透明电介质材料制成的第一包层。第一透明介电材料由基本上纯的二氧化硅组成，第二透明介电材料由掺杂的二氧化硅组成，第一包层的厚度在5至15微米的范围内，并且以这种方式选择nc和nm1的值数值孔径小于0.1，半径尺寸a大于2微米。

9. 发明申请

WO0036143A3 SELECTING ANIMALS FOR PARENTALLY IMPRINTED TRAITS 审中-公开
标题翻译：选择用于特定行为的旅游动物
公开(公告)号：WO0036143A3
公开(公告)日：2000-10-26
申请号：PCT/EP9910209
申请日：1999-12-16
申请人： UNIV LIEGE , MELICA HB , SEGHERSGENTEC N V , ANDERSSON LEIF , GEORGES MICHEL , SPINCEMAILLE GEERT , NEZER CARINE DANIELLE ANDREE
发明人： ANDERSSON LEIF , GEORGES MICHEL , SPINCEMAILLE GEERT , NEZER CARINE DANIELLE ANDREE
IPC分类号： A01K67/027 , A01K67/02 , C07K14/65 , C12N5/06 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6876 , A01K2227/108 , A01K2267/02 , C12Q2600/124 , C12Q2600/156 , C12Q2600/172
摘要： The invention relates to methods to select breeding animals or animals destined for slaughter for having desired genotypic or potential phenotypic properties, in particular related to muscle mass and/or fat deposition. The invention provides a method for selecting a pig for having desired genotypic or potential phenotypic properties comprising testing a sample from said pig for the presence of a quantitative trait locus (QTL) located at a Sus scrofa chromosome 2 mapping at position 2p1.7.
摘要翻译：本发明涉及选择用于屠宰的育种动物或动物具有所需基因型或潜在表型性质，特别是与肌肉质量和/或脂肪沉积相关的方法。本发明提供了一种用于选择具有所需基因型或潜在表型性质的猪的方法，包括测试来自所述猪的样品中存在位于位置2p1.7处的Sus scrofa染色体2图谱的数量性状基因座（QTL）。

10. 发明申请

WO2006018418A3 ANTIANGIOGENIC PEPTIDES 审中-公开
标题翻译：抗血管生成肽
公开(公告)号：WO2006018418A3
公开(公告)日：2006-08-10
申请号：PCT/EP2005053952
申请日：2005-08-11
申请人： UNIV LIEGE , GEMBLOUX FACULTE UNIVERSITAIRE , MARTIAL JOSEPH , STRUMAN INGRID , NGUYEN NGOC-QUYNH-NHU , BRASSEUR ROBERT , LINS LAURENCE
发明人： MARTIAL JOSEPH , STRUMAN INGRID , NGUYEN NGOC-QUYNH-NHU , BRASSEUR ROBERT , LINS LAURENCE
IPC分类号： C07K14/61 , A61K38/16 , A61K38/22 , A61K38/39 , A61P43/00 , C07K14/155 , C07K14/47 , C07K14/575 , C07K14/78
CPC分类号： C07K14/005 , A61K38/00 , C07K14/47 , C07K14/4711 , C07K14/57518 , C07K14/57554 , C07K14/61 , C07K14/78 , C12N2740/15022
摘要： The present invention refers to a pharmaceutical composition comprising an isolated antiangiogenic peptide or a recombinant protein comprising the antiangiogenic peptide, wherein the peptide is between 11 and 40 amino acids in length and having antiangiogenic activity, the peptide comprising the amino acid sequence: X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14, wherein X1 is any amino acid residue compatible with forming a helix; X2 is an amino acid residue of: Leu, lle, Val; X3 is an amino acid residue of: Arg, Lys, His, Ser, Thr; X4 is an amino acid residue of: lle, Leu, Val; X5 is any amino acid residue compatible with forming a helix; X6 is an amino acid residue of: Leu, lle, Val; X7 is an amino acid residue of: Leu, lle, Val, Ser, Thr; X8 is any amino acid residue compatible with forming a helix; X9 is any amino acid residue compatible with forming a helix; X10 is an amino acid residue of: Gln, Glu, Asp, Arg, His, Lys, Asn; X11 is an amino acid residue of: Ser, Thr; X12 is an amino acid residue of: Trp, Tyr, Phe; X13 is an amino acid residue of: Leu, lle, Val, Asn, Gln; X14 is an amino acid residue of: Glu, Gln, Asp, Asn.
摘要翻译：本发明涉及包含分离的抗血管生成肽或包含抗血管生成肽的重组蛋白的药物组合物，其中所述肽的长度在11至40个氨基酸之间并且具有抗血管生成活性，所述肽包含氨基酸序列：X1-X2 -X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14，其中X1是与形成螺旋相容的任何氨基酸残基; X2是以下氨基酸残基：Leu，Ile，Val; X3是Arg，Lys，His，Ser，Thr的氨基酸残基; X4是Ile，Leu，Val的氨基酸残基; X5是与形成螺旋相容的任何氨基酸残基; X6是Leu，Ile，Val的氨基酸残基; X7是Leu，Ile，Val，Ser，Thr的氨基酸残基; X8是与形成螺旋相容的任何氨基酸残基; X9是与形成螺旋相容的任何氨基酸残基; X10是Gln，Glu，Asp，Arg，His，Lys，Asn的氨基酸残基; X11是Ser，Thr的氨基酸残基; X12是Trp，Tyr，Phe的氨基酸残基; X13是Leu，Ile，Val，Asn，Gln的氨基酸残基; X14是Glu，Gln，Asp，Asn的氨基酸残基。

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