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61. 发明申请

WO2006096255A2 THERMOPLASTIC FILM HAVING METALLIC NANOPARTICLE COATING 审中-公开
标题翻译：具有金属纳米涂层的热塑性膜
公开(公告)号：WO2006096255A2
公开(公告)日：2006-09-14
申请号：PCT/US2006/002990
申请日：2006-01-27
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： PEREZ, Mario A., , MCCLURE, Donald J., , KALGUTKAR, Rajdeep S.,
IPC分类号： G01N21/55 , B32B27/00 , G02B1/04 , G01N33/543
CPC分类号： C23C14/20 , B82Y15/00 , G01N21/554 , G01N33/54373 , G01N33/588 , G02B5/008
摘要： The present invention is directed to a metallic nanoparticle coated thermoplastic film and the process for preparing the same.
摘要翻译：本发明涉及金属纳米粒子涂覆的热塑性薄膜及其制备方法。

62. 发明申请

WO2005008222A3 METHOD FOR DETECTING ANALYTES BASED ON EVANESCENT ILLUMINATION AND SCATTER-BASED DETECTION OF NANOPARTICLE PROBE COMPLEXES 审中-公开
标题翻译：基于常规照明和基于散射的纳米颗粒探针复合物检测方法检测分析物
公开(公告)号：WO2005008222A3
公开(公告)日：2005-07-14
申请号：PCT/US2004016656
申请日：2004-05-27
申请人： NANOSPHERE INC , STORHOFF JAMES J , LUCAS ADAM , MUELLER UWE R , BAO YIJIA P
发明人： STORHOFF JAMES J , LUCAS ADAM , MUELLER UWE R , BAO YIJIA P
IPC分类号： G01N21/55 , G01N33/543 , C12Q1/68 , G01N33/553
CPC分类号： G01N21/554
摘要： The invention provides methods of detecting one or more specific binding analytes, such as nucleic acids and proteins, in the presence of a neutral or anionic polysaccharide, through light scattering techniques, where a change in light scattering caused by the formation of nanoparticle label complexes within the penetration depth of the evanescent wave of a wave guide signals the presence of the analyte.
摘要翻译：本发明提供了在中性或阴离子多糖存在下通过光散射技术检测一种或多种特异性结合分析物（例如核酸和蛋白质）的方法，其中由纳米颗粒标记复合物形成引起的光散射变化波导渐逝波的穿透深度表明分析物的存在。

63. 发明申请

WO2005033335A2 MICROSENSORS AND NANOSENSORS FOR CHEMICAL AND BIOLOGICAL SPECIES WITH SURFACE PLASMONS 审中-公开
标题翻译：具有表面等离子体的化学和生物物种的微生物传感器和纳米生物学
公开(公告)号：WO2005033335A2
公开(公告)日：2005-04-14
申请号：PCT/FR2004050494
申请日：2004-10-07
申请人： COMMISSARIAT ENERGIE ATOMIQUE , CHATON PATRICK , BIJEON JEAN-LOUIS , ROYER PASCAL , ADAM PIERRE MICHEL
发明人： CHATON PATRICK , BIJEON JEAN-LOUIS , ROYER PASCAL , ADAM PIERRE MICHEL
IPC分类号： C12Q1/68 , G01N21/55 , G01N21/64 , G01N21/65
CPC分类号： G01N21/658 , B82Y5/00 , C12Q1/6837 , G01N21/554 , G01N21/648 , G01N2021/258
摘要： The invention relates to a microsensor or nanosensor for chemical or biological species with surface plasmons. The inventive sensor comprises studs (2) which are distributed over the surface of a support (1), said studs (2) measuring less than 1 ñm. Moreover, the studs are made from an electrically-conductive material and can immobilise the chemical or biological species.
摘要翻译：本发明涉及具有表面等离子体激元的化学或生物物种的微传感器或纳米传感器。本发明的传感器包括分布在支撑件（1）的表面上的螺柱（2），所述螺柱（2）的尺寸小于1微米。此外，螺柱由导电材料制成并且可以固定化学或生物物种。

64. 发明申请

WO2004113880A2 CHEMICAL SENSOR AND CHEMICALSENSOR APPARATUS 审中-公开
标题翻译：化学传感器和化学传感器装置
公开(公告)号：WO2004113880A2
公开(公告)日：2004-12-29
申请号：PCT/JP2004/009239
申请日：2004-06-23
申请人： CANON KABUSHIKI KAISHA , KURODA, Ryo , YAMADA, Tomohiro,
发明人： KURODA, Ryo , YAMADA, Tomohiro,
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N21/554
摘要： A chemical sensor for detecting a reaction of a sensor material with a specimen on the basis of an intensity of a surface plasmon polariton wave propagated along a surface of a sensor medium including the sensor material is principally constituted by the sensor medium. The sensor medium includes a periodic structure and the sensor material disposed on the periodic structure. The periodic structure has a pitch substantially equal to an integral multiple of a wavelength of the surface plasma polariton wave generated by irradiating an interface between the periodic structure and the sensor material with light.
摘要翻译：基于传感器材料的传感器介质的表面传播的表面等离子体激元波的强度，检测传感器材料与试样的反应的化学传感器主要由传感器介质构成。传感器介质包括周期性结构和设置在周期性结构上的传感器材料。周期性结构具有基本上等于通过用光照射周期性结构和传感器材料之间的界面而产生的表面等离子体极化子波的波长的整数倍的间距。

65. 发明申请

WO2004068405A2 HIGH CONTRAST OPTOACOUSTICAL IMAGING USING NANOPARTICLES 审中-公开
标题翻译：使用纳米颗粒的高对比度光学成像
公开(公告)号：WO2004068405A2
公开(公告)日：2004-08-12
申请号：PCT/US2004/001707
申请日：2004-01-23
申请人： ORAEVSKY, Alexander, A. , HENRICHS, Paul, M.
发明人： ORAEVSKY, Alexander, A. , HENRICHS, Paul, M.
IPC分类号： G06T
CPC分类号： A61K49/225 , A61B5/0059 , A61B5/0095 , A61B5/415 , A61B5/418 , B82Y15/00 , G01N21/1702 , G01N21/4795 , G01N21/554 , G01N2021/1706
摘要： A method of enhancing detection for a specific object in a body. A nanoparticulate is administered to the body for location in an area to be explored for detection of the object, if present. The nanoparticulate is at least partially metallic, has a formed non-spherical shape having a minimal characteristic dimension in the range from about 1 to about 3000 nanometers, and has a formed composition capable of producing thermal pressure either in the nanoparticulate or in the object greater than the object could produce in the absence of the nanoparticulate. Electromagnetic radiation is directed into the body. The electromagnetic radiation has a specific wavelength or spectrum of wavelengths in the range from 300nm to 300mm selected so that the wavelength or wavelength spectrum is longer by a factor of at least 3 than the minimum characteristic dimension of the nanoparticulate. The nanoparticulate absorbs the electromagnetic radiation more than would one or more non-aggregated spherically shaped particles of the same total volume with a composition identical to the nanoparticulate. The nanoparticulate produces an enhanced optoacoustic signal resulting from the absorption that is received and converted into an electronic signal and presented for assessment of the at least one parameter by a human or a machine.
摘要翻译：一种增强体内特定物体检测的方法。将纳米颗粒施用于身体，用于在要被探查的区域中的位置，以检测物体（如果存在）。纳米颗粒至少部分是金属的，具有形成的非球形形状，其具有在约1至约3000纳米范围内的最小特征尺寸，并且具有能够在纳米颗粒或物体中产生热压力的成形组合物更大比物体在不存在纳米颗粒时可以产生。电磁辐射被引导到体内。电磁辐射具有选定的300nm至300mm范围内的特定波长或波长的光谱，使得波长或波长光谱比纳米颗粒的最小特征尺寸至少3倍。纳米颗粒比一种或多种相同总体积的非聚集球形颗粒吸收电磁辐射，其组成与纳米颗粒相同。纳米颗粒产生由接收的吸收产生的增强的光声信号，并将其转换为电子信号，并呈现用于由人或机器评估至少一个参数。

66. 发明申请

WO03016781A3 SURFACE PLASMON ENHANCED ILLUMINATION SYSTEM 审中-公开
标题翻译：表面等离子体增强照明系统
公开(公告)号：WO03016781A3
公开(公告)日：2003-09-18
申请号：PCT/US0226072
申请日：2002-08-14
申请人： HARVARD COLLEGE , STARK PETER RANDOLPH HAZARD , LARSON DALE N
发明人： STARK PETER RANDOLPH HAZARD , LARSON DALE N
IPC分类号： A61K31/428 , G01N21/55 , G01Q10/00 , G01Q30/20 , G01Q60/18 , G02B21/00 , G03F7/20 , G21K1/00 , G21K5/04 , H05H6/00 , C25D11/02 , G01N33/543 , H01L27/12
CPC分类号： A61K31/428 , G01N21/554 , G01N21/648 , G01Q60/22 , G02B21/004 , G02B21/0068 , G02B21/0072 , G02B21/0076 , G03F7/70375 , G03F7/70483 , G21K1/00 , G21K5/04 , H01J2237/3174 , H05H6/00 , Y10T29/49 , Y10T29/49002 , Y10T436/11
摘要： Methods and apparatus for producing small, bright nanometric light sources from apertures that are smaller than the wavelength of the emitted light. Light 437 is directed at a surface layer 435 of metal onto a light barrier structure that includes one or more apertures each of which directs a small spot of light onto a target. The incident light excites surface plasmons 452 "electron density fluctuations" in the top metal surface layer and this energy couples through the apertures to the opposing surface where it is emitted as light from the apertures of from the rims of the apertures. Means are employed to prevent or severely limit the extent to which surface plasmons are induced on the surface at the aperture exit, thereby constraining the resulting emissions to small target areas. The resulting small spot illunination may be used to increase the resolution, photolithographic processes, and storage capacity of microscopes.
摘要翻译：用于从小于发射光的波长的孔产生小的，明亮的纳米光源的方法和装置。光437被引导到金属的表面层435到包括一个或多个孔的光阻挡结构，每个孔将小的光斑引导到靶上。入射光激发顶部金属表面层中的表面等离子体激元452“电子密度波动”，并且该能量通过孔耦合到相对表面，在该相对表面处，其作为光从孔的边缘的光发射。采用手段来防止或严重限制在孔口处的表面上诱导表面等离子体激元的程度，从而将所得到的排放物约束到小目标区域。所产生的小点染色可用于增加显微镜的分辨率，光刻工艺和存储容量。

67. 发明申请

WO2003021853A2 APPARATUS FOR READING SIGNALS GENERATED FROM RESONANCE LIGHT SCATTERED PARTICLE LABELS 审中-公开
标题翻译：用于从共振光散射的粒子标签中读取信号的装置
公开(公告)号：WO2003021853A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/028475
申请日：2002-09-05
申请人： GENICON SCIENCES CORPORATION
发明人： YGUERABIDE, Juan , WARDEN, Laurence , BODZIN, Leon, J. , PETERSON, Todd , TENBROECK, Dirk
IPC分类号： H04L
CPC分类号： G01N21/47 , G01N15/0205 , G01N15/1475 , G01N21/49 , G01N21/554 , G01N33/54346 , G01N33/58 , G01N33/6803 , G01N2015/1472 , G01N2021/4764 , G01N2021/6421 , G01N2021/6441
摘要： Embodiments of the present invention include a control and analysis system, a signal generation and detection apparatus, or reader for capturing, processing and analyzing images of samples having resonance light scattering (RLS) particle labels. An analyzer/reader includes an illumination system having a unique shutter/aperture assembly for delivering precise patterns of light to sample, a computer controlled X-Y stage, and a detection system comprising a CCD camera to allow separation and analysis of detected light that contains information from gold and/or silver RLS labels. Alternative embodiments include linear scanning apparatus and simplified apparatus for low density samples.
摘要翻译：本发明的实施例包括控制和分析系统（20），用于捕获，处理和分析具有共振光散射粒子标签的样本的图像的信号产生和检测装置（100）或读取器。

68. 发明申请

WO2003021231A2 METHOD AND APPARATUS FOR NORMALIZATION AND DECONVOLUTION OF ASSAY DATA 审中-公开
标题翻译：用于分析数据的归一化和去卷积的方法和设备
公开(公告)号：WO2003021231A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/028566
申请日：2002-09-05
申请人： GENICON SCIENCES CORPORATION
发明人： BODZIN, Leon, J. , YGUERABIDE, Juan , WARDEN, Laurence , ANDERSON, Richard, R. , RHODES, Kate
IPC分类号： G01N
CPC分类号： G01N21/47 , G01N15/0205 , G01N15/1475 , G01N21/49 , G01N21/554 , G01N33/54346 , G01N33/58 , G01N33/6803 , G01N2015/1472 , G01N2021/4764 , G01N2021/6421 , G01N2021/6441
摘要： The present invention is directed to deconvolution and normalization of assay data. The present invention includes a control and analysis system, used in conjunction with a signal generation and detection apparatus, for capturing, processing and analyzing images of samples having resonance light scattering (RLS) particle labels. The control and analysis system processes instructions and algorithms for performing multiplexed assays of two or more colors, for example, to allow separation and analysis of detected light that contains information from two or more different types or sizes of RLS particles. The multiplexing analysis software is preferably incorporated within the system of the present invention, and the multiplexing analysis is preferably performed in real-time during a scanning or assay procedure. The invention provides for a computer readable medium containing instructions for carrying out the same.
摘要翻译：本发明涉及化验数据的解卷积和归一化。本发明包括与信号生成和检测装置结合使用的控制和分析系统，用于捕获，处理和分析具有共振光散射（RLS）颗粒标签的样品的图像。控制和分析系统处理用于执行两种或更多种颜色的多路复用测定的指令和算法，例如以允许分离和分析包含来自两种或更多种不同类型或尺寸的RLS粒子的信息的检测光。多路复用分析软件优选地包含在本发明的系统内，并且多路复用分析优选地在扫描或测定过程期间实时地执行。本发明提供了一种包含用于执行该指令的指令的计算机可读介质。

69. 发明申请

WO0231478A3 METHODS AND DEVICES FOR ASSAYS USING ANALYTE-BINDING PARTNERS 审中-公开
标题翻译：使用分析仪结合伙伴进行测定的方法和设备
公开(公告)号：WO0231478A3
公开(公告)日：2002-09-12
申请号：PCT/US0128626
申请日：2001-09-12
申请人： QUANTECH LTD , WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
发明人： WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
IPC分类号： G01N21/55 , G01N33/543 , G01N21/77 , G01N33/58
CPC分类号： G01N21/554 , G01N21/7743 , G01N33/54373
摘要： In a device and method for determining a presence of an analyte in a sample, a first analyte-binding partner (120) is disposed on a test portion of a surface (106). The test portion is then contacted with the sample to bind the analyte (122), if present in the sample, to the first analyte-binding partner. The test portion is subsequently contacted with a second analyte-binding partner (124) to bind the second analyte-binding partner. This second analyte-binding partner also includes a catalyst (126). A substrate (128) is then brought into contact with the catalyst. The catalyst converts the substrate into a product material (130) that is then deposited on the test portion of the reflective surface. The presence of the analyte is then determined by observing a characteristic (e.g., a surface plasmon resonance) of the test portion of the surface. In at least some instances, the device can also provide information regarding the amount or concentration of analyte in the sample.
摘要翻译：在用于确定样品中分析物的存在的装置和方法中，第一分析物结合对象（120）设置在表面（106）的测试部分上。然后将测试部分与样品接触，以将分析物（122）（如果存在于样品中）结合到第一分析物结合配偶体。随后将测试部分与第二分析物 - 结合配偶体（124）接触，以结合第二分析物结合配偶体。该第二分析物结合配偶体还包括催化剂（126）。然后使基底（128）与催化剂接触。催化剂将基材转化成产物材料（130），然后将其沉积在反射表面的测试部分上。然后通过观察表面的测试部分的特性（例如，表面等离子体共振）来确定分析物的存在。在至少一些情况下，该装置还可以提供关于样品中分析物的量或浓度的信息。

70. 发明申请

WO98057148A1 THE OPTICAL DETECTION AND ANALYSIS OF SUB-MICRON PARTICLES 审中-公开
标题翻译：亚微米颗粒的光学检测和分析
公开(公告)号：WO98057148A1
公开(公告)日：1998-12-17
申请号：PCT/GB1998/001591
申请日：1998-06-01
IPC分类号： G01N15/02 , G01N15/14 , G01N21/55
CPC分类号： G01N21/553 , G01N15/14 , G01N15/1463 , G01N21/554 , G01N21/648 , G01N2015/1486 , G01N2015/1497 , Y10S435/808 , Y10S436/805
摘要： Method and apparatus for the single particle detection of submicron structures such as biological molecules and viruses utilises an optically transparent substrate coated with a thin film of metal illuminated with an optical beam incident at or close to critical or SPR angle wherein part of the beam propagates along the metal surface defining a measurement zone from which submicron particles contained in a sample placed in contact with the metal film scatter light which can be detected in the far field by conventional photodetection systems. The apparatus can be configured in a flow cytometric or optical microscope configuration.
摘要翻译：用于单个微粒检测亚微米结构如生物分子和病毒的方法和装置利用涂覆有金属薄膜的光学透明基底，该光学薄膜被入射到或接近临界或SPR角的光束照射，其中光束的一部分沿着所述金属表面限定测量区域，所述测量区域包含在与所述金属膜接触的样品中的亚微米颗粒从所述测量区域散射可以通过常规光电检测系统在远场中检测的光。该装置可以配置在流式细胞术或光学显微镜配置中。

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