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1. 发明申请

WO0231478A8 METHODS AND DEVICES FOR ASSAYS USING ANALYTE-BINDING PARTNERS 审中-公开
标题翻译：使用分析仪结合伙伴进行测定的方法和设备
公开(公告)号：WO0231478A8
公开(公告)日：2003-11-20
申请号：PCT/US0128626
申请日：2001-09-12
申请人： QUANTECH LTD , WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
发明人： WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
IPC分类号： G01N21/55 , G01N33/543 , G01N21/77 , G01N33/58
CPC分类号： G01N21/554 , G01N21/7743 , G01N33/54373
摘要： In a device and method for determining a presence of an analyte in a sample, a first analyte-binding partner (120) is disposed on a test portion of a surface (106). The test portion is then contacted with the sample to bind the analyte (122), if present in the sample, to the first analyte-binding partner. The test portion is subsequently contacted with a second analyte-binding partner (124) to bind the second analyte-binding partner. This second analyte-binding partner also includes a catalyst (126). A substrate (128) is then brought into contact with the catalyst. The catalyst converts the substrate into a product material (130) that is then deposited on the test portion of the reflective surface. The presence of the analyte is then determined by observing a characteristic (e.g., a surface plasmon resonance) of the test portion of the surface. In at least some instances, the device can also provide information regarding the amount or concentration of analyte in the sample.
摘要翻译：在用于确定样品中分析物的存在的装置和方法中，第一分析物结合对象（120）设置在表面（106）的测试部分上。然后将测试部分与样品接触，以将分析物（122）（如果存在于样品中）结合到第一分析物结合配偶体。随后将测试部分与第二分析物 - 结合配偶体（124）接触，以结合第二分析物结合配偶体。该第二分析物结合配偶体还包括催化剂（126）。然后使基底（128）与催化剂接触。催化剂将基材转化成产物材料（130），然后将其沉积在反射表面的测试部分上。然后通过观察表面的测试部分的特性（例如，表面等离子体共振）来确定分析物的存在。在至少一些情况下，该装置还可以提供关于样品中分析物的量或浓度的信息。

2. 发明申请

WO0231478A3 METHODS AND DEVICES FOR ASSAYS USING ANALYTE-BINDING PARTNERS 审中-公开
标题翻译：使用分析仪结合伙伴进行测定的方法和设备
公开(公告)号：WO0231478A3
公开(公告)日：2002-09-12
申请号：PCT/US0128626
申请日：2001-09-12
申请人： QUANTECH LTD , WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
发明人： WITTY THOMAS R , GUSTAFSON CAROL D , HAPKE JOEL H
IPC分类号： G01N21/55 , G01N33/543 , G01N21/77 , G01N33/58
CPC分类号： G01N21/554 , G01N21/7743 , G01N33/54373
摘要： In a device and method for determining a presence of an analyte in a sample, a first analyte-binding partner (120) is disposed on a test portion of a surface (106). The test portion is then contacted with the sample to bind the analyte (122), if present in the sample, to the first analyte-binding partner. The test portion is subsequently contacted with a second analyte-binding partner (124) to bind the second analyte-binding partner. This second analyte-binding partner also includes a catalyst (126). A substrate (128) is then brought into contact with the catalyst. The catalyst converts the substrate into a product material (130) that is then deposited on the test portion of the reflective surface. The presence of the analyte is then determined by observing a characteristic (e.g., a surface plasmon resonance) of the test portion of the surface. In at least some instances, the device can also provide information regarding the amount or concentration of analyte in the sample.
摘要翻译：在用于确定样品中分析物的存在的装置和方法中，第一分析物结合对象（120）设置在表面（106）的测试部分上。然后将测试部分与样品接触，以将分析物（122）（如果存在于样品中）结合到第一分析物结合配偶体。随后将测试部分与第二分析物 - 结合配偶体（124）接触，以结合第二分析物结合配偶体。该第二分析物结合配偶体还包括催化剂（126）。然后使基底（128）与催化剂接触。催化剂将基材转化成产物材料（130），然后将其沉积在反射表面的测试部分上。然后通过观察表面的测试部分的特性（例如，表面等离子体共振）来确定分析物的存在。在至少一些情况下，该装置还可以提供关于样品中分析物的量或浓度的信息。

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