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61. 发明申请

WO2014194435A2 METHOD OF APPLYING A COMPOSITION AND PHARMACEUTICAL COMPOSITION WITH A REGIMEN OF ADMINISTERING IT 审中-公开
标题翻译：应用组合物和药物组合物与施用方案的方法
公开(公告)号：WO2014194435A2
公开(公告)日：2014-12-11
申请号：PCT/CH2014/000075
申请日：2014-06-04
申请人： HAFEZI, Farhad , RICHOZ, Olivier
发明人： HAFEZI, Farhad , RICHOZ, Olivier
IPC分类号： A61K41/00 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/5383 , A61K31/65 , A61K31/704 , A61K31/7048 , A61P35/00 , A61P31/04 , A61P31/00 , A61N1/00 , A61N5/06 , A61F9/00
CPC分类号： A61K41/0057 , A61B2017/00084 , A61B2090/373 , A61F9/0026 , A61F9/00825 , A61F2009/00842 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/5383 , A61K31/65 , A61K31/704 , A61K31/7048 , A61L2/088 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61N2005/005 , A61N2005/0626 , A61N2005/0628 , A61N2005/063 , A61N2005/0651 , A61N2005/0661 , A61N2005/0663 , A61K2300/00
摘要： The invention addresses in particular the problem resistant pathogens and cancer cells. A method is provided of applying a composition to a human or non-human individual or to an object or a surface area and a pharmaceutical composition with a regimen of administering it to a human or non-human individual is provided. The composition comprises an active chemical component for killing of or retarding proliferation of target cells including pathogens, infected cells and cancer cells. The application of the composition and the regimen of administration of the composition are accompanied by at least one exposure to electromagnetic radiation in a range of wavelength, in which the active chemical component absorbs and which has a lower limit of 190 nm thereby photo-activating the active component.
摘要翻译：本发明特别涉及耐病病原体和癌细胞。提供了将组合物施用于人或非人个体或物体或表面区域的方法，并且提供了将其施用于人或非人个体的方案的药物组合物。该组合物包含用于杀死或延缓包括病原体，感染细胞和癌细胞在内的靶细胞增殖的活性化学成分。组合物的施用和组合物施用方案伴随着至少一种暴露于波长范围内的电磁辐射，其中活性化学组分吸收并具有190nm的下限，从而光激活活性组分。

62. 发明申请

WO2014172621A3 CORNEAL TOPOGRAPHY MEASUREMENT AND ALIGNMENT OF CORNEAL SURGICAL PROCEDURES 审中-公开
标题翻译：脊柱外科手术的角膜测量和对位
公开(公告)号：WO2014172621A3
公开(公告)日：2014-12-11
申请号：PCT/US2014034628
申请日：2014-04-18
申请人： OPTIMEDICA CORP , SCOTT DAVID D , GONZALEZ JAVIER , DEWEY DAVID , BAREKET NOAH , SCHUELE GEORG
发明人： SCOTT DAVID D , GONZALEZ JAVIER , DEWEY DAVID , BAREKET NOAH , SCHUELE GEORG
IPC分类号： A61F9/009 , A61B3/107
CPC分类号： A61F9/00825 , A61B3/10 , A61B3/107 , A61B5/0073 , A61F9/00827 , A61F9/00829 , A61F2009/00846 , A61F2009/00853 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889
摘要： Methods and apparatus are configures to measure an eye without contacting the eye with a patient interface, and these measurements are used to determine alignment and placement of the incisions when the patient interface contacts the eye. The pre-contact locations of one or more structures of the eye can be used to determine corresponding post-contact locations of the one or more optical structures of the eye when the patient interface has contacted the eye, such that the laser incisions are placed at locations that promote normal vision of the eye. The incisions are positioned in relation to the pre-contact optical structures of the eye, such as an astigmatic treatment axis, nodal points of the eye, and visual axis of the eye.
摘要翻译：方法和装置是用于测量眼睛而不将眼睛与患者界面接触的配置，并且当患者界面接触眼睛时，这些测量用于确定切口的对准和放置。当患者接口已经接触眼睛时，眼睛的一个或多个结构的预接触位置可以用于确定眼睛的一个或多个光学结构的对应的接触后位置，使得激光切口被放置在促进眼睛正常视力的位置。切口相对于眼睛的预接触光学结构定位，例如散光治疗轴，眼睛的节点和眼睛的视轴。

63. 发明申请

WO2014149541A1 HYBRID FIBER-BULK LASER ISOLATOR 审中-公开
标题翻译：混合纤维激光分离器
公开(公告)号：WO2014149541A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/019416
申请日：2014-02-28
申请人： AMO DEVELOPMENT, LLC. , IMESHEV, Gennady
发明人： IMESHEV, Gennady
IPC分类号： A61F9/008
CPC分类号： A61F9/0084 , A61F9/00814 , A61F9/00823 , A61F9/00825 , A61F2009/00842
摘要： An apparatus and method for performing ophthalmic laser surgery is provided. The apparatus includes a laser engine configured to deliver a laser pulse to a patient's eye, including a three-port isolator and a collimator attached to the three-port isolator. The collimator includes a collimating lens positioned adjacent to the three-port isolator and a fiber configured to receive laser light energy and provide laser light energy to the collimating lens and three-port isolator in a desired orientation.
摘要翻译：提供了一种用于进行眼科激光手术的装置和方法。该装置包括：激光引擎，被配置为向患者的眼睛传递激光脉冲，包括连接到三端口隔离器的三端口隔离器和准直器。准直器包括邻近三端口隔离器定位的准直透镜和被配置为接收激光光能并且以期望的方向向准直透镜和三端口隔离器提供激光能量的光纤。

64. 发明申请

WO2014087250A2 FEMTO SECOND MULTI SHOOTING FOR EYE SURGERY 审中-公开
标题翻译：有限公司第二次多用于眼科手术
公开(公告)号：WO2014087250A2
公开(公告)日：2014-06-12
申请号：PCT/IB2013/003190
申请日：2013-12-06
申请人： TELANDRO, Alain
发明人： TELANDRO, Alain
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00825 , A61F9/00827 , A61F9/00829 , A61F9/00838 , A61F2009/0087 , A61F2009/00872 , A61F2009/00893 , A61F2009/00895
摘要： Provided herein are methods for non-invasive ophthalmic surgery based on femto second multi shooting (FSMS) laser techniques. In one embodiment the FSMS laser technique is directed to corneal stroma. In another embodiment the FSMS laser technique is directed to crystalline lens.
摘要翻译：本文提供了基于毫微微秒多拍（FSMS）激光技术的非侵入性眼科手术的方法。在一个实施例中，FSMS激光技术涉及角膜基质。在另一个实施例中，FSMS激光技术针对晶状体。

65. 发明申请

WO2014074623A1 APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR 审中-公开
标题翻译：实时大型舵机范围顺序波形传感器的设备和方法
公开(公告)号：WO2014074623A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068786
申请日：2013-11-06
申请人： CLARITY MEDICAL SYSTEMS, INC.
发明人： ZHOU, Yan , CHEW, Bradford , SHEA, William
IPC分类号： A61B3/10 , A61B3/103 , A61B3/113 , A61F9/008
CPC分类号： A61B3/1015 , A61F9/008 , A61F9/00825 , A61F2009/00846 , A61F2009/00848 , A61F2009/00851 , A61F2009/00853 , A61F2009/0087 , A61F2009/00872 , F04C2270/041
摘要： An apparatus including a wavefront sensor including a light source (172) configured to illuminate a subject eye, a detector (122), an image sensor (162) configured to output an image of the subject eye, a first beam deflecting element (112) configured to intercept a wavefront beam returned from a subject eye when the subject eye is illuminated by the light source (172) and configured to direct a portion of the wavefront from the subject eye through an aperture (118) toward the detector (122), and a controller coupled to the light source (172), the image sensor (162) and the beam deflecting element (112), configured to process the image to determine transverse movement of the subject eye and to control the beam deflecting element (112) to deflect and project through the aperture (118) portions of an annular ring portion of the wavefront and further configured to pulse the light source (172) at a firing rate to sample selected portions of the annular ring at the detector (122), to process the image of the subject eye to calculate transverse movement of the subject eye and to orient the beam deflecting element (112) at a DC offset angle to compensate transverse movement of the subject eye.
摘要翻译：一种包括波形传感器的装置，包括被配置为照亮被摄体眼睛的光源（172），检测器（122），被配置为输出被检眼的图像的图像传感器（162），第一光束偏转元件（112）被配置为当所述对象眼被所述光源（172）照射并且被配置为将来自所述对象眼睛的所述波前的一部分经由孔（118）朝向所述检测器（122）引导时拦截从被检眼返回的波前束，以及耦合到所述光源（172）的控制器，所述图像传感器（162）和所述光束偏转元件（112）被配置为处理所述图像以确定所述被检眼的横向移动并且控制所述光束偏转元件（112）偏转并突出通过波前的环形环部分的孔（118）部分，并进一步配置成以点火速率对光源（172）进行脉冲以对检测器（122）处的环形环的选定部分进行采样，以便理线是目标眼睛的图像，以计算被检眼的横向运动，并将束偏转元件（112）定向在直流偏移角以补偿被检眼的横向移动。

66. 发明申请

WO2014074595A1 APPARATUS AND METHOD FOR OPERATING A REAL TIME LARGE DIOPTER RANGE SEQUENTIAL WAVEFRONT SENSOR 审中-公开
标题翻译：实时大型舵机范围顺序波形传感器的设备和方法
公开(公告)号：WO2014074595A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068737
申请日：2013-11-06
申请人： CLARITY MEDICAL SYSTEMS, INC.
发明人： ZHOU, Yan , CHEW, Bradford , SHEA, William
IPC分类号： A61B3/103 , A61B3/113 , A61B3/10 , A61F9/008
CPC分类号： A61B3/1015 , A61F9/008 , A61F9/00825 , A61F2009/00846 , A61F2009/00848 , A61F2009/00851 , A61F2009/00853 , A61F2009/0087 , A61F2009/00872 , F04C2270/041
摘要： A wavefront sensor including a light source (172) for providing a light beam to illuminate a subject eye and a first beam deflecting element (180) to deflect the light beam to compensate transverse movement of the subject eye. A second beam deflecting element (182) scans the beam around a small portion of the retina to dissipate energy.
摘要翻译：一种波前传感器，包括用于提供光束以照亮被摄体眼睛的光源（172）和第一光束偏转元件（180），以偏转光束以补偿被摄体的横向移动。第二光束偏转元件（182）围绕视网膜的一小部分扫描光束以消散能量。

67. 发明申请

WO2014071221A2 OPTICAL SURFACE IDENTIFICATION FOR LASER SURGERY 审中-公开
标题翻译：激光手术的光学表面鉴定
公开(公告)号：WO2014071221A2
公开(公告)日：2014-05-08
申请号：PCT/US2013068120
申请日：2013-11-01
申请人： OPTIMEDICA CORP , GONZALEZ JAVIER , WOODLEY BRUCE
发明人： GONZALEZ JAVIER , WOODLEY BRUCE
IPC分类号： A61F9/008 , A61B3/10
CPC分类号： A61F9/00825 , A61B3/102 , A61B3/107 , A61B3/117 , A61F9/008 , A61F9/009 , A61F2009/00851 , A61F2009/00887
摘要： Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.
摘要翻译：系统和方法自动定位眼睛的光学表面，并自动生成光学表面的表面模型。一种方法包括眼睛的OCT扫描。对样品光束的返回部分进行处理，以在点的第一径向距离内定位光学表面上的点和光学表面上的第一位置。基于点的位置和第一位置产生光学表面的第一表面模型。对样品光束的返回部分进行处理，以便检测超过第一径向距离的光学表面上的第二位置，并且距该点的第二径向距离内。基于光学表面上的点的位置和光学表面上的第一和第二位置来产生光学表面的第二表面模型。

68. 发明申请

WO2012135579A3 LASER GENERATED CORNEAL AND CRYSTALLINE LENS INCISIONS 审中-公开
标题翻译：激光生成的角膜和晶状体镜片
公开(公告)号：WO2012135579A3
公开(公告)日：2014-05-01
申请号：PCT/US2012031377
申请日：2012-03-30
申请人： LENSAR INC , CURATU GEORGE CHRISTIAN , FREY RUDOLPH W , MCWHIRTER JOHN EARL , BOTT STEVEN E
发明人： CURATU GEORGE CHRISTIAN , FREY RUDOLPH W , MCWHIRTER JOHN EARL , BOTT STEVEN E
IPC分类号： A61B18/18
CPC分类号： G02B13/0005 , A61F9/00825 , A61F9/009 , A61F2009/0087 , A61F2009/00872 , A61F2009/00897 , G02B15/177 , G02B26/101 , G02B27/0031
摘要： A laser system including a laser source that generates a laser beam and an optical switch that receives the laser beam and selectively sends the laser beam to either a fast path or a slow path, wherein in the fast path the laser beam has a first F/# and in the slow path the laser beam has a second F/# that is higher than that of the first F/#. The laser system also includes an afocal optical system that is in the slow path and an x-y scanner that receives either a first laser beam from the slow path or a second laser beam from the fast path. The laser system further includes a scan lens system that receives a scanning laser beam from the x-y scanner and performs a z-scan for the scanning laser beam from the laser beam in the fast path.
摘要翻译：一种激光系统，包括产生激光束的激光源和接收激光束的光开关，并选择性地将激光束发送到快速路径或慢路径，其中在快速路径中激光束具有第一F / ＃，而在慢路径上，激光束具有比第一F /＃高的第二F /＃。激光系统还包括处于慢路径的无焦光学系统以及从慢路径接收第一激光束或从快速路径接收第二激光束的x-y扫描器。激光系统还包括扫描透镜系统，其接收来自x-y扫描仪的扫描激光束，并对来自快速通路中的激光束的扫描激光束执行z扫描。

69. 发明申请

WO2014032678A1 SCANNING METHODS AND SYSTEMS TO REDUCE OPAQUE BUBBLE LAYERS 审中-公开
标题翻译：扫描方法和系统，以减少OPAQUE泡沫层
公开(公告)号：WO2014032678A1
公开(公告)日：2014-03-06
申请号：PCT/EP2012/003615
申请日：2012-08-28
申请人： WAVELIGHT GMBH , SCHUMACHER, Silvia , MROCHEN, Michael , WUELLNER, Christian , DONITZKY, Christof , VOGLER, Klaus
发明人： SCHUMACHER, Silvia , MROCHEN, Michael , WUELLNER, Christian , DONITZKY, Christof , VOGLER, Klaus
IPC分类号： A61F9/008
CPC分类号： A61F9/00825 , A61F9/0084 , A61F2009/00851 , A61F2009/00872 , A61F2009/00878 , A61F2009/00897
摘要： In certain embodiments, reducing opaque bubble layers (OBLs) comprises receiving information describing a tissue region of a tissue where laser pulses are applied to yield laser-induced optical breakdowns (LIOBs) in the tissue region. The LIOBs yield bubbles of gas. A concentration of the gas in the tissue region is estimated from the information. One or more laser parameters are adjusted in response to the concentration of the gas to satisfy a critical concentration rule.
摘要翻译：在某些实施方案中，减少不透明气泡层（OBL）包括接收描述组织的组织区域的信息，其中施加激光脉冲以在组织区域中产生激光诱导的光学破坏（LIOB）。 LIOB产生气体气泡。从信息估计组织区域中的气体浓度。响应于气体的浓度来调节一个或多个激光参数以满足临界浓度规则。

70. 发明申请

WO2013134650A1 SPATIO-TEMPORAL BEAM MODULATOR FOR SURGICAL LASER SYSTEMS 审中-公开
标题翻译：用于外科激光系统的SPATIO-TEMPORAL BEAM调制器
公开(公告)号：WO2013134650A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029896
申请日：2013-03-08
申请人： ALCON LENSX, INC.
发明人： RAKSI, Ferenc
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00825 , A61F9/0084 , A61F2009/0087 , A61F2009/00887 , A61F2009/00897
摘要： A surgical laser system can include a laser engine to generate a laser beam of laser pulses; a scanning delivery system to direct the laser beam to a target region and to scan the laser beam along a scan-pattern in the target region: and a spatio-temporal modulator to perform a space- and time dependent modulation of the laser beam. The spatio-temporal modulation of the phases or amplitudes of the beam components can reduce or even eliminate uncut regions in the target region, caused by the destructive interference of the beam components brought about by a wrinkling of a portion of the target or by other beam distorting factors.
摘要翻译：外科激光系统可以包括激光引擎以产生激光脉冲的激光束; 扫描传送系统，用于将激光束引导到目标区域并沿着目标区域中的扫描图案扫描激光束;以及空间 - 时间调制器，以执行激光束的空间和时间相关的调制。波束分量的相位或振幅的时空调制可以减少或甚至消除目标区域中的未切割区域，这是由于由目标的一部分起皱引起的波束分量或其他波束的相消干涉引起的扭曲因素。

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