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61. 发明申请

WO2013078440A2 ENHANCED TREATMENT REGIMENS USING MTOR INHIBITORS 审中-公开
标题翻译：使用MTOR抑制剂的增强治疗方案
公开(公告)号：WO2013078440A2
公开(公告)日：2013-05-30
申请号：PCT/US2012/066431
申请日：2012-11-21
申请人： INTELLIKINE, LLC , LIU, Yi , BUI, Lynne , MARTIN, Michael , WILSON, Troy, Edward , ROMMEL, Christian
发明人： LIU, Yi , BUI, Lynne , MARTIN, Michael , WILSON, Troy, Edward , ROMMEL, Christian
IPC分类号： A61K31/519
CPC分类号： A61K31/519 , A61K31/437 , A61K31/496 , A61K31/4965 , A61K31/535 , A61K31/5377 , C07D487/04 , C07D519/00
摘要： The present invention provides for methods and pharmaceutical compositions comprising inhibitors of mTorC1 and/or mTorC2. In some aspects, the invention provides for treatment regimens resulting in enhanced treatment efficacy and better tolerability.
摘要翻译：本发明提供包含mTorC1和/或mTorC2抑制剂的方法和药物组合物。在一些方面，本发明提供了治疗方案，从而提高治疗效果和更好的耐受性。

62. 发明申请

WO2013028259A1 BRACKET 审中-公开
标题翻译：托架
公开(公告)号：WO2013028259A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/044145
申请日：2012-06-26
申请人： VICTAULIC COMPANY , LIU, Yi , PENG, Shou
发明人： LIU, Yi , PENG, Shou
IPC分类号： F16L3/08
CPC分类号： A62C35/68 , F16B2/10 , F16L3/24
摘要： A bracket positioned on one side of a membrane or surface is adjustable from the other side of the surface to permit the position of an item supported by the bracket to be readily adjusted relatively to the surface. The bracket has a base to which an arm is movably attached. The arm moves between an open and a closed position to permit the item to be received by the bracket. In the closed position the item is clamped between the base and the arm. A finger is mounted on the base and is movable into and out of engagement with a contact surface on the arm. When the finger engages the contact surface it secures the arm in the closed position and effects the clamping action which holds the item in position. The finger and arm are readily accessible to permit adjustment.
摘要翻译：定位在膜或表面一侧的支架可从表面的另一侧调节，以允许由支架支撑的物品的位置相对于表面容易地调节。支架具有可移动地连接臂的基座。手臂在打开和关闭位置之间移动，以允许物品被支架接收。在关闭位置，物品夹在基座和手臂之间。手指安装在基座上并可移动进入和离开与臂上的接触表面接合。当手指接合接触表面时，它将臂固定在关闭位置，并实现将物品保持在适当位置的夹紧动作。手指和手臂易于接近以允许调节。

63. 发明申请

WO2013012915A9 HETEROCYCLIC COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：WO2013012915A9
公开(公告)日：2013-01-24
申请号：PCT/US2012/047186
申请日：2012-07-18
申请人： INFINITY PHARMACEUTICALS INC. , INTELLIKINE, LLC , CASTRO, Alfredo, C. , EVANS, Catherine, A. , JANARDANANNAIR, Somarajannair , LESCARBEAU, Andre , LIU, Tao , SNYDER, Daniel, A. , TREMBLAY, Martin, R. , REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina
发明人： CASTRO, Alfredo, C. , EVANS, Catherine, A. , JANARDANANNAIR, Somarajannair , LESCARBEAU, Andre , LIU, Tao , SNYDER, Daniel, A. , TREMBLAY, Martin, R. , REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4725 , A61P37/00
摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

64. 发明申请

WO2013012629A1 APPARATUS AND METHOD FOR DETERMINING FORMATION DENSITY FROM NUCLEAR DENSITY MEASUREMENTS MADE USING SENSORS AT MORE THAN ONE LOCATION 审中-公开
标题翻译：用于确定使用传感器超过一个位置的核密度测量的形成密度的装置和方法
公开(公告)号：WO2013012629A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046181
申请日：2012-07-11
申请人： BAKER HUGHES INCORPORATED , INANC, Feyzi , GILCHRIST, W. Allen , SULLIVAN, Eric , TRINH, Tu Tien , LIU, Yi
发明人： INANC, Feyzi , GILCHRIST, W. Allen , SULLIVAN, Eric , TRINH, Tu Tien , LIU, Yi
IPC分类号： E21B47/01 , G01V5/04 , E21B49/00
CPC分类号： G01V5/08
摘要： In one aspect, the present disclosure provides an apparatus for determining formation density. One embodiment of the apparatus includes a bottomhole assembly having a drill bit attached to end thereof for drilling through a formation, a first sensor in the drill bit configured to provide first signals for determining a first density of the formation proximate to the drill, a second sensor distal from the first sensor configured to provide signals for determining density of a second density of the formation, and a processor configured to determine the formation density from the first density and the second density.
摘要翻译：一方面，本公开提供了一种用于确定地层密度的装置。该装置的一个实施例包括井底组件，其具有附接到其端部的钻头以钻穿地层，钻头中的第一传感器被配置为提供用于确定接近钻头的地层的第一密度的第一信号，第二远离第一传感器的传感器被配置成提供用于确定地层的第二密度的密度的信号，以及处理器，被配置为从第一密度和第二密度确定地层密度。

65. 发明申请

WO2012151562A1 COMBINATION PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：组合药物组合物及其用途
公开(公告)号：WO2012151562A1
公开(公告)日：2012-11-08
申请号：PCT/US2012/036688
申请日：2012-05-04
申请人： INTELLIKINE, LLC , LIU, Yi , REN, Pingda , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian
发明人： LIU, Yi , REN, Pingda , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian
IPC分类号： C40B30/06 , A61K31/535 , C07D487/00 , C07D413/00
CPC分类号： A61K31/519 , A61K31/337 , A61K31/436 , A61K31/52 , C07D473/34 , A61K2300/00
摘要： The present invention provides for methods and pharmaceutical compositions for treating proliferative disorders. In one aspect, the method comprises administration of two cell-cycle suppressors having a synergistic effect. In another aspect, two cell-cycle suppressors having a synergistic effect are provided in a pharmaceutical composition.
摘要翻译：本发明提供了治疗增殖性疾病的方法和药物组合物。一方面，该方法包括施用具有协同作用的两种细胞周期抑制剂。另一方面，在药物组合物中提供具有协同作用的两种细胞周期抑制剂。

66. 发明申请

WO2012149046A1 METHODS AND COMPOSITIONS FOR IMPROVED TISSUE REGENERATION BY SUPPRESSION OF INTERFERON -GAMMA AND TUMOR NECROSIS FACTOR-ALPHA 审中-公开
标题翻译：通过抑制干扰素和肿瘤坏死因子-ATPHA来改善组织再生的方法和组合物
公开(公告)号：WO2012149046A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/035036
申请日：2012-04-25
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , SHI, Songtao , LIU, Yi , WANG, Lei
发明人： SHI, Songtao , LIU, Yi , WANG, Lei
IPC分类号： A01N63/00
CPC分类号： A61K35/28 , A61K31/616 , A61K35/17 , A61K45/06 , A61L27/3834 , A61L27/54 , A61L2300/41 , A61K2300/00
摘要： The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as TNF-α and IFN-γ. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of TNF-α, IFN-γ, or both. Methods for improving tissue regeneration in accordance with this invention will generally have the step of applying a composition or device of the invention to a site in need of the composition or device. Also disclosed are methods for forming composition and devices of the invention and pharmaceutical compositions comprising one or more ants-inflammatory agent(s) effective of inhibiting or reducing the levels of TNF-α, IFN-γ, or both.
摘要翻译：本发明公开了通过抑制TNF-α和IFN-α等几种促炎细胞因子的作用来改善组织再生的方法，组合物和装置。本发明的组合物和装置通常包括能够降低TNF-α，IFN-α或两者的水平的一种或多种抗炎剂。根据本发明的用于改善组织再生的方法通常具有将本发明的组合物或装置应用于需要组合物或装置的部位的步骤。还公开了形成本发明的组合物和装置的方法以及包含一种或多种有效抑制或降低TNF-α，IFN-α或两者的水平的蚂蚁炎症药物的药物组合物。

67. 发明申请

WO2012148540A1 COMBINATION OF KANASE INHIBITORS AND USES THREOF 审中-公开
标题翻译：消费者抑制剂和使用用途的组合
公开(公告)号：WO2012148540A1
公开(公告)日：2012-11-01
申请号：PCT/US2012/026399
申请日：2012-02-23
申请人： INTELLIKINE, LLC , REN, Pingda , LIU, Yi , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian , WILSON, Troy, Edward
发明人： REN, Pingda , LIU, Yi , JESSEN, Katayoun , GUO, Xin , ROMMEL, Christian , WILSON, Troy, Edward
IPC分类号： A61K31/535
CPC分类号： A61K31/5377 , A61K9/0053 , A61K31/4439 , A61K31/4745 , A61K31/498 , A61K31/501 , A61K31/517 , A61K31/519 , A61K31/527 , A61K31/53 , A61K31/541 , A61K31/551 , A61K45/06 , A61K31/4709 , A61K2300/00
摘要： The present invention provides for a method for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3 -kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
摘要翻译：本发明提供了治疗与受试者中PI3激酶a和/或mTOR相关的疾病状况的方法。在另一方面，本发明提供了治疗与受试者中PI3激酶a和/或mTOR相关的疾病状况的方法。另一方面，阐述了抑制细胞中Akt（S473）和Akt（T308）的磷酸化的方法。

68. 发明申请

WO2011133530A4 FORMATION EVALUATION USING A BIT-BASED ACTIVE RADIATION SOURCE AND A GAMMA RAY DETECTOR 审中-公开
标题翻译：使用基于位的有源辐射源和伽马射线探测器的形成评估
公开(公告)号：WO2011133530A4
公开(公告)日：2012-06-07
申请号：PCT/US2011033022
申请日：2011-04-19
申请人： BAKER HUGHES INC , TRINH TU TIEN , SULLIVAN ERIC , CURRY DAVID A , CHENG XIAOMIN C , INANC FEYZI , LIU YI
发明人： TRINH TU TIEN , SULLIVAN ERIC , CURRY DAVID A , CHENG XIAOMIN C , INANC FEYZI , LIU YI
IPC分类号： E21B47/00 , G01V5/10 , G01V5/12
CPC分类号： G01V5/08 , E21B47/00 , E21B47/01 , E21B47/026 , G01V5/125
摘要： A drill bit made according to one embodiment includes a source configured to induce radiation into a formation during drilling of a wellbore and a sensor in the drill bit configured to detect radiation from the formation responsive to the radiation induced by the source. The drill bit may further include a circuit configured to process signals received from the sensor to estimate a property of the formation.
摘要翻译：根据一个实施例制造的钻头包括被配置为在钻井期间将钻井中的辐射诱导到地层中的源，并且钻头中的传感器被配置为响应于由源引起的辐射来检测来自地层的辐射。钻头还可以包括被配置为处理从传感器接收的信号以估计地层的性质的电路。

69. 发明申请

WO2011156469A2 METHOD FOR TREATING AND SEALING PIEZOELECRIC TUNING FORKS 审中-公开
标题翻译：用于处理和密封压克力搅拌机的方法
公开(公告)号：WO2011156469A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039597
申请日：2011-06-08
申请人： BAKER HUGHES INCORPORATED , DIFOGGIO, Rocco , LIU, Yi , PEREZ, Louis , BERGREN, Paul , SANDERLIN, Kerry L.
发明人： DIFOGGIO, Rocco , LIU, Yi , PEREZ, Louis , BERGREN, Paul , SANDERLIN, Kerry L.
IPC分类号： G01V3/18 , E21B47/00 , G01N27/06 , G01N33/18
CPC分类号： G01N29/022 , G01N29/028 , G01N2291/02818 , G01N2291/0289 , G01N2291/0427 , H01L41/0533 , H01L41/23 , Y10T29/42
摘要： Disclosed is an apparatus for estimating a property of a fluid. The apparatus includes: a piezoelectric resonator configured to be disposed in the fluid; an electrode embedded in the piezoelectric resonator and included in a resonator circuit configured to output an electrical signal related to the property; a discontinuity defined by a surface of the piezoelectric resonator, the discontinuity altering an impedance of the resonator circuit if a high-dielectric fluid or a conductive fluid is disposed in the discontinuity; and an insulating material disposed in the discontinuity.
摘要翻译：公开了一种用于估计流体性质的装置。该装置包括：构造成设置在流体中的压电谐振器; 嵌入在所述压电谐振器中并包括在谐振器电路中的电极，所述谐振器电路被配置为输出与所述特性相关的电信号; 由压电谐振器的表面限定的不连续性，如果高介电流体或导电流体被布置在不连续处，则不连续性改变谐振器电路的阻抗; 以及设置在不连续处的绝缘材料。

70. 发明申请

WO2011149937A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：WO2011149937A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037742
申请日：2011-05-24
申请人： INTELLIKINE, INC. , REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina , WILSON, Troy, Edward , CAMPBELL, Simon, Fraser
发明人： REN, Pingda , LIU, Yi , LI, Liansheng , CHAN, Katrina , WILSON, Troy, Edward , CAMPBELL, Simon, Fraser
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.
摘要翻译：本文描述了调节PI3激酶活性的杂环实体，含有所述杂环实体的药物组合物以及使用这些化学实体治疗与PI3激酶活性相关的疾病和病症的方法。

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