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61. 发明申请

WO2005028636A3 NOVEL CBH1 HOMOLOGS AND VARIANT CBH1 CELLULASES 审中-公开
标题翻译：新型CBH1 HOMOLOGS和变种CBH1细胞
公开(公告)号：WO2005028636A3
公开(公告)日：2006-08-17
申请号：PCT/US2004008520
申请日：2004-03-19
申请人： GENENCOR INT , GOEDEGEBUUR FRITS , GUALFETTI PETER , MITCHINSON COLIN , NEEFE PAULIEN
发明人： GOEDEGEBUUR FRITS , GUALFETTI PETER , MITCHINSON COLIN , NEEFE PAULIEN
IPC分类号： C12N9/42 , C11D3/386 , C12N15/56
CPC分类号： C12Y302/01091 , C12N9/2437
摘要： Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the same and methods for producing the same. The homologs and variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are substituted and/or deleted.
摘要翻译：公开了许多Hypocrea jecorina Cel7A（以前的里氏木霉纤维二糖水解酶I或CBH1）的同系物和变体，编码它们的核酸及其制备方法。同系物和变体纤维素酶具有7A族糖基水解酶的氨基酸序列，其中一个或多个氨基酸残基被取代和/或缺失。

62. 发明申请

WO2006065556A3 METHOD OF PREVENTING OR REDUCING OFF-FLAVOR IN A BEVERAGE USING SILANE-TREATED SILICA FILTER MEDIA 审中-公开
标题翻译：使用硅烷处理的二氧化硅过滤介质在饮料中预防或减少不利于饮料的方法
公开(公告)号：WO2006065556A3
公开(公告)日：2006-08-03
申请号：PCT/US2005043674
申请日：2005-12-01
申请人： DOW CORNING , GENENCOR INT , BROTHERS HERBERT MARTIN JR , GIBSON GARY L , MATHERLY JAMES E JR , MCIVOR MARGO LYNN , REVIS ANTHONY
发明人： BROTHERS HERBERT MARTIN JR , GIBSON GARY L , MATHERLY JAMES E JR , MCIVOR MARGO LYNN , REVIS ANTHONY
IPC分类号： A23L2/72 , A23L7/20 , C12H1/048
CPC分类号： B01J20/14 , A23L2/80 , B01J20/103 , C12H1/0408
摘要： The present invention provides a method for preventing or reducing off-flavor in a beverage. Silane-treated silica filter media are synthesized. By contacting the beverage with the silane-treated silica filter, one or more off-flavor substances or off-flavor precursors bind to the silane-treated silica filter media and are removed. Beverages that tend to develop off-flavor upon storage such as alcoholic, fruit, and vegetable beverages, are suitable for the present invention. The present invention provides a method that can reduce the level of off-flavor substances such as trans-2-nonenal, diacetyl, and cis-3-nonenal. The present invention also provides a method that can reduce the level of off-flavor precursors such as linoleic acid. The silica filter media useful for the present method include rice hull ash, oat hull ash, or diatomaceous earth.
摘要翻译：本发明提供了一种用于预防或减少饮料中异味的方法。合成硅烷处理的二氧化硅过滤介质。通过将饮料与硅烷处理的二氧化硅过滤器接触，一种或多种非调味物质或异味前体与硅烷处理的二氧化硅过滤介质结合并除去。在酒精，水果和蔬菜饮料等储存时倾向于发出异味的饮料适用于本发明。本发明提供了可以降低反式-2-壬烯醛，二乙酰基和顺式-3-壬烯醛等异味物质的方法。本发明还提供了可以降低异味前体如亚油酸的水平的方法。用于本方法的二氧化硅过滤介质包括稻壳灰，燕麦壳灰，或硅藻土。

63. 发明申请

WO2006055437A3 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：合成和使用糖苷类试剂
公开(公告)号：WO2006055437A3
公开(公告)日：2006-07-13
申请号：PCT/US2005040989
申请日：2005-11-14
申请人： GENENCOR INT , ISIS INNOVATION , UNIV TORONTO , BOTT RICHARD R , DAVIS BENJAMIN G , JONES JOHN BRYAN
发明人： BOTT RICHARD R , DAVIS BENJAMIN G , JONES JOHN BRYAN
IPC分类号： C07H1/00 , C07H15/14
CPC分类号： C08G83/003 , C07H1/00 , C07H15/14
摘要： The present invention relates to synthetic methods for producing glycodendrimer reagents from disaccharides having a sulhydryl group
摘要翻译：本发明涉及由具有磺酰基的二糖制备糖苷配基试剂的合成方法

64. 发明申请

WO2006055644A2 SYNTHESIS AND USE OF GLYCODENDRIMER REAGENTS 审中-公开
标题翻译：甘油二酯试剂的合成和使用
公开(公告)号：WO2006055644A2
公开(公告)日：2006-05-26
申请号：PCT/US2005041549
申请日：2005-11-14
申请人： GENENCOR INT , ISIS INNOVATION , UNIV TORONTO , BOTT RICHARD R , DAVIS BENJAMIN G , JONES JOHN BRYAN
发明人： BOTT RICHARD R , DAVIS BENJAMIN G , JONES JOHN BRYAN
CPC分类号： C07H5/10
摘要： The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.
摘要翻译：本发明涉及化学修饰的突变蛋白质，其包含半胱氨酸残基取代除半胱氨酸之外的残基前体蛋白质，随后通过使半胱氨酸残基与糖基化硫代磺酸盐反应来修饰取代的半胱氨酸残基。还提供了生产化学修饰的突变蛋白的方法。本发明还涉及糖基化的甲硫代磺酸盐。本发明的另一个方面是改变蛋白质的功能特征的方法，包括提供蛋白质并且使蛋白质与糖基化甲硫代磺酸盐试剂在有效产生与蛋白质相比具有改变的功能特性的糖蛋白的条件下反应。另外，本发明涉及确定化学修饰的突变蛋白的结构 - 功能关系的方法。本发明还涉及用于产生硫代糖的合成方法，由此产生的硫代糖，并且涉及用于生产糖代码二聚体试剂的方法。

65. 发明申请

WO2005118795A3 ASPERGILLUS KAWACHI ACID-STABLE ALPHA AMYLASE AND APPLICATIONS IN GRANULAR STARCH HYDROLYSIS 审中-公开
标题翻译： ASPERGILLUS KAWACHI酸稳定的氨基酸和应用于颗粒淀粉水解
公开(公告)号：WO2005118795A3
公开(公告)日：2006-05-26
申请号：PCT/US2005018212
申请日：2005-05-24
申请人： GENENCOR INT , DUNN-COLEMAN NIGEL , FISKE SUSAN M , LANTERO JR ORESTE , LANTZ SUZANNE E , PEPSIN MICHAEL J , SHETTY JAYARAMA K
发明人： DUNN-COLEMAN NIGEL , FISKE SUSAN M , LANTERO JR ORESTE , LANTZ SUZANNE E , PEPSIN MICHAEL J , SHETTY JAYARAMA K
IPC分类号： C12N9/30 , C12N9/00 , C12N9/34 , C12P7/06 , C12P7/10 , C12P19/02 , C12R1/885
CPC分类号： C12N9/242 , C12N9/2417 , C12N9/2428 , C12N15/8245 , C12P7/06 , C12P7/10 , C12P19/02 , C12P19/04 , C12P19/14 , C12P19/22 , C12P21/06 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a method for producing an end product and particularly an alcohol which comprises contacting a granular starch substrate with an acid-stable alpha amylase (asAA) having granular starch hydrolyzing (GSH) activity and a glucoamylase (GA) in a fermentation step which also comprises ethanologenic microorganisms at a temperature between about 25 to 65°C and producing an end-product.
摘要翻译：本发明涉及一种生产最终产品，特别是醇的方法，该方法包括在发酵中使颗粒状淀粉底物与具有颗粒状淀粉水解（GSH）活性的酸稳定性α淀粉酶（asAA）和葡糖淀粉酶（GA）接触步骤，其还包括在约25至65℃之间的温度下产生生物微生物并产生最终产物。

66. 发明申请

WO2005047314A3 FGF-BETA BINDING AND SUPPORTED PEPTIDES 审中-公开
标题翻译： FGF-BETA结合和支持的肽
公开(公告)号：WO2005047314A3
公开(公告)日：2006-04-20
申请号：PCT/US2004036980
申请日：2004-11-06
申请人： GENENCOR INT , DAY ANTHONY G , ESTELL DAVID A , MURRAY CHRISTOPHER J , POWER SCOTT D , TURNQUEST BEVERLY R
发明人： DAY ANTHONY G , ESTELL DAVID A , MURRAY CHRISTOPHER J , POWER SCOTT D , TURNQUEST BEVERLY R
IPC分类号： A61K38/08 , A61K38/54 , A61K38/55 , C07H21/04 , C07K7/06 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/62 , C12N15/74 , C12P21/06 , A61K38/16 , C07K19/00 , C12N15/11
CPC分类号： C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
摘要： The present invention provides peptides and supported peptides that bind to FGF-5.
摘要翻译：本发明提供了结合FGF-5的肽和负载的肽。

67. 发明申请

WO2005121797A3 SCREENING METHOD USING ANTIBODY HEAVY CHAINS 审中-公开
标题翻译：使用抗体重链的筛选方法
公开(公告)号：WO2005121797A3
公开(公告)日：2006-02-09
申请号：PCT/US2005016695
申请日：2005-05-12
申请人： GENENCOR INT , CHEN YIYOU
发明人： CHEN YIYOU
IPC分类号： C07K16/00 , G01N33/543 , G01N33/68 , A61K39/00 , C12P19/34 , G01N33/53
CPC分类号： G01N33/6857 , C07K16/005 , C07K2317/22
摘要： The present invention relates to a method of screening which includes an antibody heavy chain and a reporter gene, such as a camel antibody and beta-lactamase, respectively.
摘要翻译：本发明涉及一种筛选方法，其分别包括抗体重链和报告基因，例如骆驼抗体和β-内酰胺酶。

68. 发明申请

WO2005012486A3 METABOLICALLY ENGINEERED BACTERIAL STRAINS HAVING ENHANCED 2-KETO-D-GLUCONATE ACCUMULATION 审中-公开
标题翻译：具有增强的2-羟色胺-D-葡萄糖酸盐积累的代谢工程细菌菌株
公开(公告)号：WO2005012486A3
公开(公告)日：2006-01-12
申请号：PCT/US2004024203
申请日：2004-07-27
申请人： GENENCOR INT , DODGE TIMOTHY C , VALLE FERNANDO , RASHID M HARUNUR
发明人： DODGE TIMOTHY C , VALLE FERNANDO , RASHID M HARUNUR
IPC分类号： C12N20060101 , C12N1/21 , C12N9/04 , C12N15/74 , C12P7/58 , C12P7/60 , C12P19/02 , C12P1/00 , C07H21/04 , C12P1/04 , C12P7/00 , C12P7/26
CPC分类号： C12P7/60 , C12N9/0006 , C12P19/02
摘要： The present invention relates to a method of altering bacterial host cells to accumulate 2-keto-D-gluconic acid (2-KDG) by inactivating an endogenous membrane bound 2-keto-D-gluconate dehydrogenase (2-KDGDH), which prior to inactivation catalyzed the conversion of 2-KDG to 2,5-diketogluconate (2,5-DKG).
摘要翻译：本发明涉及通过灭活内源性膜结合的2-酮-D-葡萄糖酸脱氢酶（2-KDGDH）来改变细菌宿主细胞以积累2-酮-D-葡萄糖酸（2-KDG）的方法，其在失活催化了2-KDG转化为2,5-二酮葡萄糖酸盐（2,5-DKG）。

69. 发明申请

WO2005123110A2 COMPOSITIONS COMPRISING VARIOUS PROTEORHODOPSINS AND/OR BACTERIORHODOPSINS AND USE THEREOF 审中-公开
标题翻译：包含各种防腐素和/或细菌绒毛的组合物及其用途
公开(公告)号：WO2005123110A2
公开(公告)日：2005-12-29
申请号：PCT/US2005020899
申请日：2005-06-09
申请人： GENENCOR INT , DOW CORNING , BOTT RICHARD R , JENSEN RASMUS B , KELEMEN BRADLEY , WARD II DONALD E , WHITED GREGORY M
发明人： BOTT RICHARD R , JENSEN RASMUS B , KELEMEN BRADLEY , WARD II DONALD E , WHITED GREGORY M
IPC分类号： A61K38/17 , C07K14/215 , C07K14/705
CPC分类号： G11C7/00 , C07K14/215 , C09D11/037 , C09D11/50 , G11B7/242 , Y10S430/146 , Y10T428/249921 , Y10T428/31623 , Y10T428/31685 , Y10T428/31725 , Y10T428/31783
摘要： The present invention provides a solid material comprising an immobilized mixture of two or more proteorhodopsins, two or more bacteriorhodopsins, or one or more bacteriorhodopsin and one or more proteorhodopsins. The proteorhodopsins are selected from the group consisting of all-trans-retinal-containing proteorhodopsins and retinal analog-containing proteorhodopsins; all of which have absorption spectra that do not overlap. The bacteriorhodopsins are selected from the group consisting of all-trans-retinal- containing bacteriorhodopsins and retinal analog-containing bacteriorhodopsins; all of which have absorption spectra that do not overlap. The present invention also provides an optical information carrier, such as an optical data storage material and a fraud-proof optical data carrier, comprising the above-described solid material and a substrate selected from the group consisting of glass, paper, metal, fabric material, and plastic material, wherein said solid material is deposited on said substrate. The present invention further provides security ink comprising one or more hydrophilic polymers and a mixture of various photochromic materials.
摘要翻译：本发明提供了一种固体材料，其包含两种或多种蛋白质视紫红质，两种或更多种细菌视紫红质，或一种或多种细菌视紫红质和一种或多种蛋白质视紫质的固定化混合物。蛋白质视紫红质选自全反式视黄醛的蛋白质视黄素和含视网膜类似物的蛋白质视紫红质; 所有这些都具有不重叠的吸收光谱。细菌视紫红质选自全反式视网膜含细菌视紫红质和视网膜类似物的细菌视紫红质; 所有这些都具有不重叠的吸收光谱。本发明还提供一种光学信息载体，例如光学数据存储材料和防欺诈光学数据载体，其包括上述固体材料和选自玻璃，纸，金属，织物材料的基材和塑料材料，其中所述固体材料沉积在所述基底上。本发明还提供了包含一种或多种亲水聚合物和各种光致变色材料的混合物的安全油墨。

70. 发明申请

WO2005117756A2 ACID-STABLE ALPHA AMYLASES HAVING GRANULAR STARCH HYDROLYZING ACTIVITY AND ENZYME COMPOSITIONS 审中-公开
标题翻译：具有颗粒淀粉水解活性和酶组成的酸稳定的阿拉伯胶囊
公开(公告)号：WO2005117756A2
公开(公告)日：2005-12-15
申请号：PCT/US2005018214
申请日：2005-05-24
申请人： GENENCOR INT , DUNN-COLEMAN NIGEL , FISKE SUSAN M , LANTZ SUZANNE E , NEEFE-KRUITHOF PAULIEN , PEPSIN MICHAEL J , SHETTY JAYARAMA K
发明人： DUNN-COLEMAN NIGEL , FISKE SUSAN M , LANTZ SUZANNE E , NEEFE-KRUITHOF PAULIEN , PEPSIN MICHAEL J , SHETTY JAYARAMA K
IPC分类号： C12N9/00 , C12N9/30 , C12N9/34 , C12P7/06 , C12P7/10 , C12P19/02 , A61F2/06
CPC分类号： C12N9/242 , C12N9/2417 , C12N9/2428 , C12N15/8245 , C12P7/06 , C12P7/10 , C12P19/02 , C12P19/04 , C12P19/14 , C12P19/22 , C12P21/06 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cells and enzyme compositions including the same which optionally include glucoamylase.
摘要翻译：本发明涉及源自川曲霉菌株的酸稳定性α淀粉酶（asAA），其具有颗粒淀粉水解（GSH）活性，在丝状真菌宿主细胞中具有GSH活性的asAA的异源表达和酶组合物，包括其任选地包括葡糖淀粉酶。

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