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51. 发明申请

WO1997021540A1 SPHEROSILOXANE COATINGS 审中-公开
标题翻译：表面活性剂涂料
公开(公告)号：WO1997021540A1
公开(公告)日：1997-06-19
申请号：PCT/US1996020752
申请日：1996-12-12
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , BANASZAK HOLL, Mark, M. , BRIANT, Clyde, L., III , LEE, Sunghee
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
IPC分类号： B32B15/08
CPC分类号： B05D7/54 , B05D7/16 , B05D7/58 , C08G77/12 , Y10T428/31663
摘要： The present invention relates to coating compositions, systems and methods for coating substrates and, more particularly, metallic substrates with spherosiloxane based coating compositions. The spherosiloxane based compositions are applied utilizing conventional techniques such as chemical vapor deposition such that upon application, the spherosiloxane molecules bond with available oxide molecules provided along the substrate.
摘要翻译：本发明涉及用于涂覆基材的涂料组合物，体系和方法，更具体地说，涉及具有基于球烷硅氧烷的涂料组合物的金属基材。使用常规技术（例如化学气相沉积）施加基于球硅氧烷的组合物，使得在施用时，所述球硅氧烷分子与沿着所述基材提供的可用氧化物分子结合。

52. 发明申请

WO1997012602A1 STIMULATION OF HAIR FOLLICLES 审中-公开
标题翻译：刺激毛发
公开(公告)号：WO1997012602A1
公开(公告)日：1997-04-10
申请号：PCT/US1996015686
申请日：1996-09-30
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MICRO-PAK, INC.
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , MICRO-PAK, INC. , WEINER, Norman , WALLACH, Donald, F., H. , EGBARIA, Kamel , CHANDRASEKHARAN, Ramachandran
IPC分类号： A61K09/127
CPC分类号： A61Q7/00 , A61K8/14 , A61K8/4953 , A61K9/127 , A61K9/1272 , A61K31/506 , A61K47/6951 , B82Y5/00 , Y10S514/88 , Y10S514/881
摘要： A novel method and delivery system for therapeutic weak acid or base materials has been developed. The method and delivery system utilize a therapeutic material which is modified to make it more hydrophilic and encapsulated in a lipid vesicle, preferaby a non-phospholipid lipid vesicle. The method and delivery system is paricularly well suited to topical delivery of minoxidil.
摘要翻译：已经开发了用于治疗性弱酸或基础材料的新型方法和递送系统。方法和递送系统利用治疗材料，其被修饰以使其更亲水并且包封在脂质囊泡中，优选非磷脂脂质囊泡。该方法和递送系统特别适用于局部输送米诺地尔。

53. 发明申请

WO1996040585A1 METHOD AND SYSTEM FOR PRODUCING POLARIZED 129Xe GAS 审中-公开
标题翻译：用于生产极化氙气的方法和系统
公开(公告)号：WO1996040585A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009483
申请日：1996-06-06
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , SMITHSONIAN ASTROPHYSICAL OBSERVATORY , CHUPP, Timothy , COULTER, Kevin, P. , OTEIZA, Eduardo , WALSWORTH, Ronald
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , SMITHSONIAN ASTROPHYSICAL OBSERVATORY
IPC分类号： C01B23/00
CPC分类号： A61K49/1815 , C01B23/00
摘要： A method and system for producing polarized Xe gas in an economical manner, allowing the polarized Xe gas to be used commercially in research and clinical applications. The production system of the present invention includes a holding tank (12) for holding an unpolarized xenon gas/nitrogen gas mixture. The holding tank (12) is in communication with a temperature controlled polarization chamber (14). A wide spectrum high power light source (22) such as a diode laser array is in communication with the polarization chamber (14). The alkali metal vapor is optically pumped by the light source (22). The polarization chamber (14), which contains a given quantity of an alkali metal and its associated vapor, receives the gaseous mixture from the holding tank (12). The optically pumped alkali metal vapor atoms then collide with the xenon gas atoms, thus polarizing the xenon atoms. The entire gaseous mixture expands out of the polarization chamber (14) into a device (24) that separates the alkali metal vapor atoms from the polarized Xe atoms. The polarized Xe are then controllably output to a system/user interface (32) for application purposes.
摘要翻译：以经济的方式生产极化的Xe气体的方法和系统，允许极化的129e Xe气体在商业上用于研究和临床应用。本发明的生产系统包括用于保持非极化氙气/氮气混合物的储存罐（12）。保持箱（12）与温度控制的偏振室（14）连通。诸如二极管激光器阵列的宽频高功率光源（22）与偏振室（14）连通。碱金属蒸气由光源（22）光泵浦。含有给定量的碱金属及其相关蒸汽的偏振室（14）从储存罐（12）接收气体混合物。光泵浦的碱金属蒸汽原子然后与氙气原子碰撞，从而使氙原子偏振。整个气态混合物从偏振室（14）中扩展成将碱金属蒸汽原子与极化的Xe原子分离的装置（24）。然后，为了应用目的，极化的Xe被可控地输出到系统/用户界面（32）。

54. 发明申请

WO1996036361A1 DNA BINDING ANTIBODIES 审中-公开
标题翻译： DNA绑定抗体
公开(公告)号：WO1996036361A1
公开(公告)日：1996-11-21
申请号：PCT/US1996007113
申请日：1996-05-16
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GLICK, Gary, D. , SWANSON, Patrick, C.
IPC分类号： A61K39/395
CPC分类号： A61K31/5513 , A61K38/00 , C07K16/18
摘要： This invention provides an antibody with high affinity for single-stranded DNA, low or no affinity for double-stranded DNA, and capable of specifically binding a DNA hairpin. It also provides monoclonal antibodies that having these characteristics as well as the hybridoma cell lines which produce these monoclonal antibodies. A chimeric mouse comprising these hybridoma cell lines and a histocompatible mouse is further provided. A method for screening for an agent which will inhibit anti-DNA antibody-DNA binding. One such agent is a benzodiazepine derivative. This invention therefore provides a method of inhibiting the binding of an anti-DNA antibody to its DNA ligand in a sample by contacting the sample with an effective amount of a benzodiazepine derivative is encompassed by this invention.
摘要翻译：本发明提供对单链DNA具有高亲和力的抗体，对双链DNA具有低亲和力或不具有特异性结合DNA发夹的亲和力。它还提供具有这些特征的单克隆抗体以及产生这些单克隆抗体的杂交瘤细胞系。还提供了包含这些杂交瘤细胞系和组织相容性小鼠的嵌合小鼠。用于筛选将抑制抗DNA抗体-DNA结合的试剂的方法。一种这样的药剂是苯并二氮杂衍生物。因此，本发明提供了通过使样品与有效量的本发明所包含的苯并二氮杂衍生物接触来抑制样品中抗DNA抗体与其DNA配体的结合的方法。

55. 发明申请

WO1995005817A1 NOVEL 1,2-DITHIIN ANTIINFECTIVE AGENTS 审中-公开
标题翻译：新的1,2-DITHIIN抗生素
公开(公告)号：WO1995005817A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009623
申请日：1994-08-24
申请人： SHAMAN PHARMACEUTICALS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： SHAMAN PHARMACEUTICALS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TRUONG, Thien, V. , BIERER, Donald, E. , DENER, Jeffrey, M. , HECTOR, Richard , TEMPESTA, Michael, S. , LOEV, Bernard , YANG, Wu , KOREEDA, Masato
IPC分类号： A61K31/385
CPC分类号： C07C323/14 , A61K31/385 , C07D339/04 , C07D339/08
摘要： This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.
摘要翻译：本发明涉及可用作抗感染剂的新型1,2-二硫素化合物组合物及其制备方法。这些化合物特别有效地治疗真菌感染，特别是由白色念珠菌，新型隐球菌或烟曲霉引起的真菌感染。

56. 发明申请

WO1994028912A1 CD28 PATHWAY IMMUNOSUPPRESSION 审中-公开
标题翻译： CD28路径免疫
公开(公告)号：WO1994028912A1
公开(公告)日：1994-12-22
申请号：PCT/US1994006701
申请日：1994-06-10
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF NAVY
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF NAVY , THOMPSON, Craig, B. , JUNE, Carl, H.
IPC分类号： A61K35/14
CPC分类号： C07K14/70521 , A61K38/00 , C07K16/2818
摘要： The method of immunotherapy of the present invention involves the regulation of the T cell immune response through the activation or suppression/inactivation of the CD28 pathway. Induction of activated T cell lymphokine production occurs upon stimulatory binding of the CD28 surface receptor molecule, even in the presence of conventional immunosuppressants. Inhibition of CD28 receptor binding to an appropriate stimulatory ligand or inactivation of the CD28 signal transduction pathway through other means down-regulates CD28-pathway related T cell lymphokine production and its resulting effects.
摘要翻译：本发明的免疫治疗方法涉及通过激活或抑制/失活CD28途径来调节T细胞免疫应答。活化的T细胞淋巴因子产生的诱导发生在CD28表面受体分子的刺激结合后，即使在常规免疫抑制剂的存在下也是如此。抑制CD28受体结合适当的刺激配体或通过其他方式灭活CD28信号转导通路下调CD28通路相关T细胞淋巴因子的产生及其结果。

57. 发明申请

WO1994026915A1 GENE TRANSFER INTO PANCREATIC AND BILIARY EPITHELIAL CELLS 审中-公开
标题翻译：基因转移到胰腺和双胎上皮细胞中
公开(公告)号：WO1994026915A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005187
申请日：1994-05-10
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WILSON, James, M.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K38/00 , A61K47/6901 , A61K48/00 , C07K14/4712 , C12N2710/10343
摘要： The present invention relates to methods for selective somatic gene transfer into a patient's pancreatic or biliary epithelial cells. The methods of this invention comprise introducing the gene to be transferred, associated with an appropriate transfer vehicle, into the ductal system of either the pancreas or liver. More specifically, the invention relates to using these techniques to treat genetic diseases, such as cystic fibrosis, which are characterized by genetic defects in those epithelial cells.
摘要翻译：本发明涉及选择性体细胞基因转移到患者胰腺或胆管上皮细胞中的方法。本发明的方法包括将与转运载体相关的转运基因导入胰腺或肝脏的导管系统。更具体地，本发明涉及使用这些技术来治疗遗传性疾病，例如囊性纤维化，其特征在于那些上皮细胞中的遗传缺陷。

58. 发明申请

WO1994008456A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：多元苯并咪唑作为抗病毒剂
公开(公告)号：WO1994008456A1
公开(公告)日：1994-04-28
申请号：PCT/US1993010104
申请日：1993-10-20
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TOWNSEND, Leroy, B. , DRACH, John, C.
IPC分类号： A01N43/04
CPC分类号： C07D235/24 , A61K31/4184 , A61K31/52 , A61K31/7056 , C07H19/052 , A61K2300/00
摘要： This invention relates to novel polysubstituted benzimidazoles and compositions and their use in the treatment of viral infections. The polysubstituted benzimidazoles and compositions of the present invention exhibit antiviral properties against viruses of the herpes family, particularly human cytomegalovirus (HCMV) and herpes simplex viruses (HSV).
摘要翻译：本发明涉及新型多取代苯并咪唑及其组合物及其在治疗病毒感染中的用途。本发明的多取代的苯并咪唑和组合物显示抗疱疹家族病毒，特别是人巨细胞病毒（HCMV）和单纯疱疹病毒（HSV）的抗病毒特性。

59. 发明申请

WO1993014188A1 TARGETED VIRUS 审中-公开
标题翻译：目标病毒
公开(公告)号：WO1993014188A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000072
申请日：1993-01-13
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , CLARKE, Michael, F. , EMERSON, Stephen, G. , PALSSON, Bernhard, O.
IPC分类号： C12N05/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/54 , C12N7/00 , C12N2740/16043 , C12N2740/16045 , C12N2740/16222 , C12N2810/6054 , C12N2810/80
摘要： Genetically engineered viruses which comprise a genetically engineered gene and having a chimeric envelope protein which specifically binds to a target cell receptor, to which the naturally occurring envelope protein does not bind, may be used for cell type-specific gene therapy. Transduction of human stem and/or progenitor cells with such viruses containing chimeric envelope proteins which specifically bind to human stem and/or progenitor cells proceeds with high specificity and efficiency, especially when such viruses are incubated with human stem and/or progenitor cells cultured under conditions of rapid medium exchange.
摘要翻译：包含遗传工程改造的基因并具有与天然存在的包膜蛋白不结合的靶细胞受体特异性结合的嵌合包膜蛋白的基因工程病毒可用于细胞型特异性基因治疗。具有特异性结合人干细胞和/或祖细胞的含有嵌合包膜蛋白的病毒的人干细胞和/或祖细胞的转导以高特异性和高效率进行，特别是当这样的病毒与在下培养的人干细胞和/或祖细胞快速介质交换的条件。

60. 发明申请

WO1993000052A1 TREATMENT OF DISEASES BY SITE-SPECIFIC INSTILLATION OF CELLS OR SITE-SPECIFIC TRANSFORMATION OF CELLS AND KITS THEREFOR 审中-公开
标题翻译：通过特异性保护细胞或细胞的位点特异性转化来治疗疾病或病原体
公开(公告)号：WO1993000052A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005243
申请日：1992-06-26
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , NABEL, Elizabeth, G. , NABEL, Gary, J.
IPC分类号： A61F02/06
CPC分类号： A61K9/0024 , A61B17/22 , A61B2017/22082 , A61B2017/22084 , A61K48/00 , A61L29/16 , A61L2300/254 , A61L2300/256 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61L2300/802 , Y02A50/471
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
摘要翻译：公开了一种直接治疗疾病特定部位的方法。该方法基于通过导管插入到使用遗传修饰或正常细胞或其他载体系统的离散血管段的蛋白质递送。表达重组治疗剂或诊断性蛋白质的内皮细胞位于血管壁或患者血管灌注的组织中。该技术提供细胞或载体的转移和体内重组基因的表达，并允许引入用于治疗疾病的治疗或诊断价值的蛋白质。

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