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1. 发明申请

WO1995005817A1 NOVEL 1,2-DITHIIN ANTIINFECTIVE AGENTS 审中-公开
标题翻译：新的1,2-DITHIIN抗生素
公开(公告)号：WO1995005817A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009623
申请日：1994-08-24
申请人： SHAMAN PHARMACEUTICALS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： SHAMAN PHARMACEUTICALS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , TRUONG, Thien, V. , BIERER, Donald, E. , DENER, Jeffrey, M. , HECTOR, Richard , TEMPESTA, Michael, S. , LOEV, Bernard , YANG, Wu , KOREEDA, Masato
IPC分类号： A61K31/385
CPC分类号： C07C323/14 , A61K31/385 , C07D339/04 , C07D339/08
摘要： This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.
摘要翻译：本发明涉及可用作抗感染剂的新型1,2-二硫素化合物组合物及其制备方法。这些化合物特别有效地治疗真菌感染，特别是由白色念珠菌，新型隐球菌或烟曲霉引起的真菌感染。

2. 发明申请

WO1995029923A1 PROCESS FOR THE PREPARATION OF MONO- AND BIS(PHOSPHOCHOLINE) DERIVATIVES WHICH HAVE ANTIFUNGAL ACTIVITY 审中-公开
标题翻译：制备具有抗真菌活性的单和双（磷酸基）衍生物的方法
公开(公告)号：WO1995029923A1
公开(公告)日：1995-11-09
申请号：PCT/US1995004676
申请日：1995-04-13
申请人： SHAMAN PHARMACEUTICALS, INC.
发明人： SHAMAN PHARMACEUTICALS, INC. , BIERER, Donald, E. , DENER, Jeffrey, M. , TRUONG, Thien, V.
IPC分类号： C07F09/02
CPC分类号： A01N57/14 , A01N57/16 , A61K31/685 , A61K31/688 , A61K31/70 , A61K47/24 , C07F9/093 , C07F9/10 , C07H15/04 , C07H15/18
摘要： This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be 1,22-bis-[2-(trimethylammonium)ethylphosphatyl] docosane is disclosed. Also disclosed is a synthetic process for obtaining a novel class of mono- and bis(phosphocholine) derivatives which are useful as antiinfective agents. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.
摘要翻译：本发明涉及用于获得已被鉴定为1,22-双 - [2-（三甲基铵）乙基磷酰基]二十二烷的植物伊尔巴比亚植物的叶子中获得的独特的磷酸胆碱衍生物的合成方法。还公开了用于获得可用作抗感染剂的新型一类和双（磷酸胆碱）衍生物的合成方法。这些化合物特别有效地治疗真菌感染，特别是由白色念珠菌，新型隐球菌和烟曲霉引起的真菌感染。

3. 发明申请

WO1995024404A1 PREPARATION OF SYMMETRICAL AND UNSYMMETRICAL DITHIIN COMPOUNDS 审中-公开
标题翻译：对称和非对称性化合物的制备
公开(公告)号：WO1995024404A1
公开(公告)日：1995-09-14
申请号：PCT/US1995003044
申请日：1995-03-10
申请人： SHAMAN PHARMACEUTICALS, INC.
发明人： SHAMAN PHARMACEUTICALS, INC. , BIERER, Donald, E. , DENER, Jeffrey, M. , TRUONG, Thien, V. , LITVAK, Joane , DUBENKO, Larisa, G. , PETERLI-ROTH, Patricia
IPC分类号： C07D339/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D339/08 , C07D409/06 , C07D409/12 , C07D409/14 , C07F7/1804
摘要： Novel 1,2-dithiin compounds useful as antifungal or anti-infective agents, as well as methods for their use as such, are described. The 1,2-dithiin compounds are particularly effective in treating infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Candida krusei, Candida parapsilosis, Candida tropicalis, Trichophyton rubrum, Epidermophyton species, Microsporum species, Sporothrix species, Blastomyces dermatitidis, Coccidiodes immiitis, Histoplasma capsulatum, Herpes virus, Influenza virus, Cytomegalovirus, human immunodeficiency virus, retrovirus, Adenovirus, Papillomavirus, Paravirus, Arenavirus, Bunyavirus, Coronavirus, Paramyxovirus, Picornavirus, Rhabdlovirus, Togavirus, Hepadnavirus, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella pneumoniae, Staphylococcus epidermis, Zanthomonus maltrophilia, Acinetobacter, Enterobacter cloacae, Serratia marscens, Listeria, Monocytogenes, Enterococcus faecalis, Streptococcus pyogenes; Straptococcus pneumonia, Viridans streptococci, Haemophilus influenzae, Proteus mirabilis, proteus vulgaris and Bacterioides fragilis.
摘要翻译：描述了可用作抗真菌剂或抗感染剂的新颖的1,2-二硫素化合物，以及它们如此使用的方法。 1,2-二硫素化合物特别有效地治疗感染，特别是由白色念珠菌，新型隐球菌，烟曲霉，卡尼酵母，热带假丝酵母，热带假丝酵母，红色毛癣菌，表皮癣菌属，微孢子虫种，孢子虫属，皮肤真菌，球孢子虫疫霉菌，囊状绦虫，疱疹病毒，流感病毒，巨细胞病毒，人类免疫缺陷病毒，逆转录病毒，腺病毒，乳头瘤病毒，副病毒，瘟病毒，布尼亚病毒，冠状病毒，副粘病毒，小RNA病毒，犀牛病毒，披头丝病毒，肝炎病毒，金黄色葡萄球菌，粪肠球菌，大肠杆菌大肠杆菌，铜绿假单胞菌，产气肠杆菌，肺炎克雷伯杆菌，表皮葡萄球菌，嗜麦芽寡糖杆菌，不动杆菌，阴沟肠杆菌，沙雷氏菌，李斯特菌，单核细胞增多症，粪肠球菌，化脓链球菌; 肺炎链球菌，维生素链球菌，流感嗜血杆菌，奇异变形杆菌，普通变形杆菌和脆弱杆菌。

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