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    • 60. 发明申请
    • COMPOSITIONS AND METHODS FOR AFFECTING MOVEMENT OF CONTAMINANTS, BODILY FLUIDS OR OTHER ENTITIES AND/OR AFFECTING OTHER PHYSIOLOGICAL CONDITIONS
    • 影响污染物,体液或其他物质的运动和/或影响其他生理条件的组合物和方法
    • WO2007142757A3
    • 2008-10-02
    • PCT/US2007010041
    • 2007-04-25
    • MASSACHUSETTS INST TECHNOLOGYELLIS-BEHNKE RUTLEDGELIANG YU-XIANGSCHNEIDER GERALD ESO KWOK-FAITAY DAVID
    • ELLIS-BEHNKE RUTLEDGELIANG YU-XIANGSCHNEIDER GERALD ESO KWOK-FAITAY DAVID
    • A61L15/42A61K38/02A61L24/00
    • A61K38/10A61K31/167A61L15/42A61L26/0061
    • Compositions which self-assemble under physiological conditions are formulate for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may als include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatme such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination wit an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
    • 在生理条件下自组装的组合物适用于伤口。 制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。 制剂可以包括其它治疗剂,预防剂或诊断剂。 可以适当地施用制剂以治疗一种或多种病症或病症。 例如,该制剂可用于修复损伤或手术期间的肺,眼或硬膜,或硬膜外或脊髓抽头后,以阻止血液,间质液或脑脊液的渗漏。 制剂可以施用于烧伤或溃疡。 制剂可以分散在缝合线或粘合剂中,用于在缝合或胶合伤口之后进行给药或作为释放,从而限制出血,组织液或其它流体的损失,例如由实质组织如肝脏产生的那些 ,胰腺和胃肠道。 制剂可以应用于任何出血部位,绷带,纱布,海绵或其他材料,以便立即控制出血,或者如果初始治疗如缝合或压力不足,则稍后释放以控制出血。 在一个实施方案中,制剂作为干燥或冻干粉末提供。 在另一个实施方案中,将材料提供在水中。 在另一个实施方案中,所述材料与油组合提供并形成层压体。 在另一个实施方案中,所述制剂作为涂层提供在装置例如支架或导管上。 该材料也可用于分离组织,用于保存用于随后的移植或再附着的组织,以及作为膨胀,稳定或保湿剂。