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51. 发明申请

WO2007061458A2 S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF 审中-公开
标题翻译： S1P受体调节化合物及其用途
公开(公告)号：WO2007061458A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/028657
申请日：2006-07-24
申请人： PREDIX PHARMACEUTICALS HOLDINGS, INC. , SAHA, Ashis, K. , SHARADENDU, Anurag , YU, Xiang, Y. , LIN, Jian , LOBERA, Mercedes , CHERUKU, Srinivasa, Rao , ORBACH, Pini , SHACHAM, Sharon , NOIMAN, Silvia , BECKER, Oren , MARANTZ, Yael , SCHULTZ, Nili , MCCAULEY, Dilara
发明人： SAHA, Ashis, K. , SHARADENDU, Anurag , YU, Xiang, Y. , LIN, Jian , LOBERA, Mercedes , CHERUKU, Srinivasa, Rao , ORBACH, Pini , SHACHAM, Sharon , NOIMAN, Silvia , BECKER, Oren , MARANTZ, Yael , SCHULTZ, Nili , MCCAULEY, Dilara
IPC分类号： A61K31/452 , A61K31/397 , C07D405/02
CPC分类号： C07D405/10 , C07D307/80 , C07D307/81 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/10 , C07D417/14
摘要： The present invention relates to compounds of the general formula (I) that have activity as SlP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate SlP receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behcet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.
摘要翻译：本发明涉及具有作为S1P受体调节剂活性的通式（I）的化合物以及这些化合物用于治疗与不适当的S1P受体活性相关的疾病的用途。所述化合物可以用作免疫调节剂，例如用于治疗或预防诸如自身免疫和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病（例如克罗恩病和溃疡性结肠炎），I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿关节炎，非肾小球肾炎，肝炎，白塞氏病，肾小球肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和Wegner's肉芽肿; 并治疗其他疾病。

52. 发明申请

WO2007018749A2 RADIATION SENSITIVE FILM INCLUDING A MEASURING SCALE 审中-公开
标题翻译：辐射敏感膜，包括测量尺寸
公开(公告)号：WO2007018749A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/023746
申请日：2006-06-16
申请人： ISP INVESTMENTS INC. , LEWIS, David, F. , LISTL, Carl, A. , YU, Xiang
发明人： LEWIS, David, F. , LISTL, Carl, A. , YU, Xiang
IPC分类号： H05G1/28
CPC分类号： G03F7/025 , A61B5/1075 , A61N5/1048
摘要： An article of manufacture comprising a radiation sensitive material, and a measuring scale that is part of the radiation sensitive material. A method of measuring at least one parameter relating to an irradiated material is also described. A radiation sensitive material including a measuring scale is exposed to radiation and at least one parameter relating to one or more exposed areas of the material is measured by reference to the measuring scale on the material.
摘要翻译：包括辐射敏感材料的制品和作为辐射敏感材料的一部分的测量刻度。还描述了测量与被照射材料有关的至少一个参数的方法。包括测量刻度的辐射敏感材料暴露于辐射，并且通过参考材料上的测量刻度测量与材料的一个或多个暴露区域有关的至少一个参数。

53. 发明申请

WO2006116524A1 COMPOSITIONS AND METHODS FOR PROMOTING HEMOSTASIS AND OTHER PHYSIOLOGICAL ACTIVITIES 审中-公开
标题翻译：用于促进HEMOSTASIS和其他生理活动的组合物和方法
公开(公告)号：WO2006116524A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015850
申请日：2006-04-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ELLIS-BEHNKE, Rutledge , ZHANG, Shuguang , SCHNEIDER, Gerald , SO, Kwok-Fai , TAY, David , LIANG, Yu-Xiang
发明人： ELLIS-BEHNKE, Rutledge , ZHANG, Shuguang , SCHNEIDER, Gerald , SO, Kwok-Fai , TAY, David , LIANG, Yu-Xiang
IPC分类号： A61K38/10 , A61P7/04
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
摘要翻译：描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。组合物可以包括其它物质（例如血管收缩剂）。还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物以及抑制除了血液以外的身体物质的运动来去除部位的方法。组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。

54. 发明申请

WO2020092128A1 SYSTEMS AND METHODS FOR ENHANCING LIVE AUDIENCE EXPERIENCE ON ELECTRONIC DEVICE 审中-公开
公开(公告)号：WO2020092128A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/057920
申请日：2019-10-24
申请人： MAYCAS TECHNOLOGY LIMITED , LAM, Pak Kit , YU, Xiang , LO, Ping Tin Cuthbert
发明人： LAM, Pak Kit , YU, Xiang , LO, Ping Tin Cuthbert
IPC分类号： G06T7/246 , G06N20/00 , G06N3/02
摘要： Described herein are methods and systems for receiving a plurality of live video frames; identifying one or more target objects and one or more non-target objects in a first live video frame of the plurality of live video frames, by at least one trained deep neural network; identifying one or more sets of pixels belonging to the one or more target objects; identifying an area on a surface of the one or more target objects, based on the identified one or more sets of pixels belonging to the one or more target objects; overlaying one or more predetermined graphical images onto the area on the surface of the one or more target objects in the plurality of live video frames; and overlaying the one or more non-target objects onto the one or more predetermined graphical images in the plurality of live video frames to form a processed live video.

55. 发明申请

WO2020037332A2 SYSTEMS AND METHODS FOR PERSONALIZED LEARNING AND ATTENTION EVALUATION THROUGH NEURO-FEEDBACK TRAINING 审中-公开
公开(公告)号：WO2020037332A2
公开(公告)日：2020-02-20
申请号：PCT/US2019/054057
申请日：2019-10-01
申请人： SHENZHEN XINLIU TECHNOLOGY CO., LTD. , BRAINCO INC. , NEWLON, Max , SUN, Dongsheng , HAN, Bicheng , ZHENG, Hui , YU, Xiang , YANG, Zhoayi , WANG, Tianhe , DONG, Juewei , LI, Si , FRANCHINI, Lawrence , VARELA, Joshua , A, Disi , SUN, Yue
发明人： NEWLON, Max , SUN, Dongsheng , HAN, Bicheng , ZHENG, Hui , YU, Xiang , YANG, Zhoayi , WANG, Tianhe , DONG, Juewei , LI, Si , FRANCHINI, Lawrence , VARELA, Joshua , A, Disi , SUN, Yue
IPC分类号： A61B5/04
摘要： A method and system for neuro-feedback training are disclosed. The method may include detecting a brainwave signal associated with an electrical activity of a brain of a learner; analyzing a characteristic of the brainwave signal; generating an attention score indicative of a level of engagement of the learner; determining a performance score of the learner; adjusting the stimulus based on a combination of the attention score and the performance score to personalize the educational experience of the learner. An attention evaluation method and system are disclosed. The method comprises obtaining answer data when a user performs a preset attention game and may acquire corresponding EEG data through a wearable device. The answer data and the EEG data may be processed, so that corresponding answer scores and EEG scores can be obtained. The answer scores and the EEG scores may be substituted into an equation to obtain attention scores.

56. 发明申请

WO2012088438A1 COMPOSITIONS AND METHODS USEFUL FOR TREATING DISEASES 审中-公开
标题翻译：用于治疗疾病的组合物和方法
公开(公告)号：WO2012088438A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/066888
申请日：2011-12-22
申请人： EUTROPICS PHARMACEUTICALS, INC. , CARDONE, Michael H. , YU, Xiang Y. , KOLODZIEJ, Andrew F.
发明人： CARDONE, Michael H. , YU, Xiang Y. , KOLODZIEJ, Andrew F.
IPC分类号： C07D233/56 , C07D233/58
CPC分类号： A61K31/498 , A61K31/454 , A61K31/573 , A61K31/69 , A61K45/06 , C07C217/92 , C07C229/18 , C07C229/34 , C07C229/36 , C07C229/48 , C07C229/58 , C07C229/60 , C07C229/64 , C07C311/21 , C07C317/36 , C07C317/44 , C07C2101/08 , C07C2101/14 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/34 , C07D211/46 , C07D211/60 , C07D213/79 , C07D215/48 , C07D231/14 , C07D231/38 , C07D235/26 , C07D239/28 , C07D239/42 , C07D241/46 , C07D261/18 , C07D263/34 , C07D263/48 , C07D309/14
摘要： The present invention relates to a chemotherapeutic cancer treatment in which compounds of Formula la', lb', Ic', or II' (referred to as a group as BH3ls) are administered to a mammal for the treatment of B-cell Lymphoma or other hematopoietic cancers, including diseases associated with MeL-l. In another aspect, the invention provides a method for treating particular types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more compounds selected from the group consisting of compounds of la', lb', Ic', or II' in combination with other therapies, for example, a class of therapeutics known as 26S proteosome inhibitors, such as, for example, Bortezomib. In another aspect the present invention relates to autoimmune treatment with pharmaceutical compositions comprising one or more compounds of Formula la', lb', Ic', or II'.
摘要翻译：本发明涉及化学治疗性癌症治疗，其中将式Ia'，Ib'，Ic'或II'的化合物（称为BH3β的基团）施用于哺乳动物用于治疗B细胞淋巴瘤或其他造血癌，包括与MeL-1有关的疾病。另一方面，本发明提供了一种使用一种或多种选自以下的化合物的组合来治疗特定类型的造血细胞癌例如B细胞淋巴瘤的方法，所述化合物选自Ia'，Ib'，Ic'或 II'与其它疗法组合，例如，一类称为26S蛋白酶抑制剂的治疗剂，例如硼替佐米。另一方面，本发明涉及用包含一种或多种式Ia'，Ib'，Ic'或II'化合物的药物组合物进行自身免疫治疗。

57. 发明申请

WO2011090686A3 COATED ABRASIVE BACKINGS WITH CLOTH TREATED WITH COLLOIDAL SILICON OXIDE 审中-公开
公开(公告)号：WO2011090686A3
公开(公告)日：2011-07-28
申请号：PCT/US2010/062021
申请日：2010-12-23
申请人： SAINT-GOBAIN ABRASIVES, INC. , SAINT-GOBAIN ABRASIFS , YANG, Yu Xiang , SESHU, Adiseshaiah, K. , FENG, Lin, Hua
发明人： YANG, Yu Xiang , SESHU, Adiseshaiah, K. , FENG, Lin, Hua
IPC分类号： B24D3/02 , B24D18/00 , C09K3/14 , C09C1/68
摘要： A cloth backing for an abrasive article is treated by combining a phenolic resin, a latex and a colloidal silicon oxide composition to prepare a colloidal formulation, which is then applied to the cloth backing and cured. Coated abrasive articles are formed by applying a make coat formulation to the treated cloth backing, applying an abrasive and then curing the make coat formulation.

58. 发明申请

WO2009154780A1 S1P1 RECEPTOR AGONISTS AND USE THEREOF 审中-公开
标题翻译： S1P1受体激动剂及其用途
公开(公告)号：WO2009154780A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/003673
申请日：2009-06-18
申请人： AMGEN INC. , EPIX PHARMACEUTICALS , CEE, Victor, J. , LIN, Jian , YU, Xiang, Y. , ZHANG, Zhaoda
发明人： CEE, Victor, J. , LIN, Jian , YU, Xiang, Y. , ZHANG, Zhaoda
IPC分类号： C07D307/78 , C07D405/04 , C07D405/10 , C07D409/10 , A61K31/343 , A61K31/397 , A61P25/00
CPC分类号： C07D513/04 , A61K9/2018 , A61K9/2059 , A61K9/48
摘要： The present invention relates to compounds of Formula (I) that are have activity as S1P receptor modulating agents, more specifically to specifically compounds that are S1P1 receptor agonists. The invention also related to the use of such compounds to treat diseases associated with inappropriate S1P1 receptor activity such as autoimmune diseases.
摘要翻译：本发明涉及具有作为S1P受体调节剂的活性的式（I）化合物，更具体地涉及作为S1P1受体激动剂的具体化合物。本发明还涉及使用这些化合物来治疗与不适当的S1P1受体活性相关的疾病，例如自身免疫性疾病。

59. 发明申请

WO2008148205A1 METHOD AND DEVICE FOR DOWN-SAMPLING A DCT IMAGE IN THE DCT DOMAIN 审中-公开
标题翻译：用于在DCT域中下采样DCT图像的方法和装置
公开(公告)号：WO2008148205A1
公开(公告)日：2008-12-11
申请号：PCT/CA2008/001080
申请日：2008-06-04
申请人： RESEARCH IN MOTION LIMITED , YU, Xiang , YANG, En-hui , WANG, Haiquan
发明人： YU, Xiang , YANG, En-hui , WANG, Haiquan
IPC分类号： G06T3/40 , G06T9/00 , H04N7/50 , H04Q7/32
CPC分类号： G06T3/4084
摘要： A method and device that uses transform matrices to down-sample a DCT image directly in the DCT domain. The transform matrices have been selected to minimize an optimization problem which is a function of the visual quality of down-sampled images obtained using the matrices and the computational complexity associated with using the transform matrices. The transform matrices comprise a row transform matrix and a column transform matrix. A down-sampled image is produced by determining an intermediary matrix as the product of the DCT image and one of either the row transform matrix or the column transform matrix and then determining the down-sampled image as the product of the intermediary matrix and the transform matrix not already used to determine the intermediary matrix.
摘要翻译：一种使用变换矩阵直接在DCT域中对DCT图像进行下采样的方法和装置。已经选择了变换矩阵以最小化优化问题，该优化问题是使用矩阵获得的下采样图像的视觉质量以及与使用变换矩阵相关联的计算复杂度的函数。变换矩阵包括行变换矩阵和列变换矩阵。通过将中间矩阵确定为DCT图像与行变换矩阵或列变换矩阵之一的乘积，然后将下采样图像确定为中间矩阵和变换的乘积来产生下采样图像矩阵尚未用于确定中间矩阵。

60. 发明申请

WO2007142757A3 COMPOSITIONS AND METHODS FOR AFFECTING MOVEMENT OF CONTAMINANTS, BODILY FLUIDS OR OTHER ENTITIES AND/OR AFFECTING OTHER PHYSIOLOGICAL CONDITIONS 审中-公开
标题翻译：影响污染物，体液或其他物质的运动和/或影响其他生理条件的组合物和方法
公开(公告)号：WO2007142757A3
公开(公告)日：2008-10-02
申请号：PCT/US2007010041
申请日：2007-04-25
申请人： MASSACHUSETTS INST TECHNOLOGY , ELLIS-BEHNKE RUTLEDGE , LIANG YU-XIANG , SCHNEIDER GERALD E , SO KWOK-FAI , TAY DAVID
发明人： ELLIS-BEHNKE RUTLEDGE , LIANG YU-XIANG , SCHNEIDER GERALD E , SO KWOK-FAI , TAY DAVID
IPC分类号： A61L15/42 , A61K38/02 , A61L24/00
CPC分类号： A61K38/10 , A61K31/167 , A61L15/42 , A61L26/0061
摘要： Compositions which self-assemble under physiological conditions are formulate for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may als include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatme such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination wit an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
摘要翻译：在生理条件下自组装的组合物适用于伤口。制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。制剂可以包括其它治疗剂，预防剂或诊断剂。可以适当地施用制剂以治疗一种或多种病症或病症。例如，该制剂可用于修复损伤或手术期间的肺，眼或硬膜，或硬膜外或脊髓抽头后，以阻止血液，间质液或脑脊液的渗漏。制剂可以施用于烧伤或溃疡。制剂可以分散在缝合线或粘合剂中，用于在缝合或胶合伤口之后进行给药或作为释放，从而限制出血，组织液或其它流体的损失，例如由实质组织如肝脏产生的那些，胰腺和胃肠道。制剂可以应用于任何出血部位，绷带，纱布，海绵或其他材料，以便立即控制出血，或者如果初始治疗如缝合或压力不足，则稍后释放以控制出血。在一个实施方案中，制剂作为干燥或冻干粉末提供。在另一个实施方案中，将材料提供在水中。在另一个实施方案中，所述材料与油组合提供并形成层压体。在另一个实施方案中，所述制剂作为涂层提供在装置例如支架或导管上。该材料也可用于分离组织，用于保存用于随后的移植或再附着的组织，以及作为膨胀，稳定或保湿剂。

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