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1. 发明申请

WO2006124627A3 METHODS OF TREATING CONDITIONS INVOLVING NEURONAL DEGENERATION 审中-公开
标题翻译：治疗涉及神经衰弱的病症的方法
公开(公告)号：WO2006124627A3
公开(公告)日：2008-10-30
申请号：PCT/US2006018484
申请日：2006-05-12
申请人： BIOGEN IDEC INC , UNIV HONG KONG , LEE DANIEL H S , SAH DINAH W Y , SO KWOK FAI , WU WUTIAN
发明人： LEE DANIEL H S , SAH DINAH W Y , SO KWOK FAI , WU WUTIAN
IPC分类号： A61K38/00 , A01N37/18 , A01N61/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/55 , C07K2317/76
摘要： The invention provides methods for treating conditions of the eye involving death or degeneration of retinal ganglion cells, including glaucoma, by the administration of Nogo receptor-1 antagonists.
摘要翻译：本发明提供了通过施用Nogo受体-1拮抗剂来治疗涉及视网膜神经节细胞（包括青光眼）的死亡或退化的眼睛病症的方法。

2. 发明申请

WO2007142757A3 COMPOSITIONS AND METHODS FOR AFFECTING MOVEMENT OF CONTAMINANTS, BODILY FLUIDS OR OTHER ENTITIES AND/OR AFFECTING OTHER PHYSIOLOGICAL CONDITIONS 审中-公开
标题翻译：影响污染物，体液或其他物质的运动和/或影响其他生理条件的组合物和方法
公开(公告)号：WO2007142757A3
公开(公告)日：2008-10-02
申请号：PCT/US2007010041
申请日：2007-04-25
申请人： MASSACHUSETTS INST TECHNOLOGY , ELLIS-BEHNKE RUTLEDGE , LIANG YU-XIANG , SCHNEIDER GERALD E , SO KWOK-FAI , TAY DAVID
发明人： ELLIS-BEHNKE RUTLEDGE , LIANG YU-XIANG , SCHNEIDER GERALD E , SO KWOK-FAI , TAY DAVID
IPC分类号： A61L15/42 , A61K38/02 , A61L24/00
CPC分类号： A61K38/10 , A61K31/167 , A61L15/42 , A61L26/0061
摘要： Compositions which self-assemble under physiological conditions are formulate for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may als include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatme such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination wit an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
摘要翻译：在生理条件下自组装的组合物适用于伤口。制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。制剂可以包括其它治疗剂，预防剂或诊断剂。可以适当地施用制剂以治疗一种或多种病症或病症。例如，该制剂可用于修复损伤或手术期间的肺，眼或硬膜，或硬膜外或脊髓抽头后，以阻止血液，间质液或脑脊液的渗漏。制剂可以施用于烧伤或溃疡。制剂可以分散在缝合线或粘合剂中，用于在缝合或胶合伤口之后进行给药或作为释放，从而限制出血，组织液或其它流体的损失，例如由实质组织如肝脏产生的那些，胰腺和胃肠道。制剂可以应用于任何出血部位，绷带，纱布，海绵或其他材料，以便立即控制出血，或者如果初始治疗如缝合或压力不足，则稍后释放以控制出血。在一个实施方案中，制剂作为干燥或冻干粉末提供。在另一个实施方案中，将材料提供在水中。在另一个实施方案中，所述材料与油组合提供并形成层压体。在另一个实施方案中，所述制剂作为涂层提供在装置例如支架或导管上。该材料也可用于分离组织，用于保存用于随后的移植或再附着的组织，以及作为膨胀，稳定或保湿剂。

3. 发明申请

WO2006124627A2 METHODS OF TREATING CONDITIONS INVOLVING NEURONAL DEGENERATION 审中-公开
标题翻译：治疗涉及神经衰弱的病症的方法
公开(公告)号：WO2006124627A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/018484
申请日：2006-05-12
申请人： BIOGEN IDEC MA INC. , THE UNIVERSITY OF HONG KONG , LEE, Daniel H.S. , SAH, Dinah W.Y. , SO, Kwok Fai , WU, Wutian
发明人： LEE, Daniel H.S. , SAH, Dinah W.Y. , SO, Kwok Fai , WU, Wutian
IPC分类号： A61K39/395 , C07K16/46
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/55 , C07K2317/76
摘要： The invention provides methods for treating conditions of the eye involving death or degeneration of retinal ganglion cells, including glaucoma, by the administration of Nogo receptor-1 antagonists.
摘要翻译：本发明提供了通过施用Nogo受体-1拮抗剂来治疗涉及视网膜神经节细胞（包括青光眼）的死亡或退化的眼睛病症的方法。

4. 发明申请

WO2006116524A1 COMPOSITIONS AND METHODS FOR PROMOTING HEMOSTASIS AND OTHER PHYSIOLOGICAL ACTIVITIES 审中-公开
标题翻译：用于促进HEMOSTASIS和其他生理活动的组合物和方法
公开(公告)号：WO2006116524A1
公开(公告)日：2006-11-02
申请号：PCT/US2006/015850
申请日：2006-04-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ELLIS-BEHNKE, Rutledge , ZHANG, Shuguang , SCHNEIDER, Gerald , SO, Kwok-Fai , TAY, David , LIANG, Yu-Xiang
发明人： ELLIS-BEHNKE, Rutledge , ZHANG, Shuguang , SCHNEIDER, Gerald , SO, Kwok-Fai , TAY, David , LIANG, Yu-Xiang
IPC分类号： A61K38/10 , A61P7/04
CPC分类号： A61L26/0047 , A61K9/0019 , A61K38/08 , A61K38/10 , A61L26/0066 , A61L2400/04
摘要： Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaiminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
摘要翻译：描述了包括纳米尺度结构材料或其前体（例如，自组装肽）的组合物。组合物可以包括其它物质（例如血管收缩剂）。还描述了使用组合物促进止血，保护皮肤或伤口免受污染，去除先前施用的提供保护性涂层的组合物以及抑制除了血液以外的身体物质的运动来去除部位的方法。组合物还可用于分离组织，去除组织，保存组织（例如，随后的移植或重新连接）以及作为膨胀，稳定或保湿剂。还描述了包括组合物（例如支架或导管），绷带或其他伤口敷料，缝合线和包括组合物的试剂盒的医疗装置。

5. 发明申请

WO2016113605A1 A CERAMIC MATERIAL GRANULATOR 审中-公开
标题翻译：陶瓷材料造粒机
公开(公告)号：WO2016113605A1
公开(公告)日：2016-07-21
申请号：PCT/IB2015/056904
申请日：2015-09-09
申请人： SO, Kwok Fai Edmund
发明人： SO, Kwok Fai Edmund
IPC分类号： B02C4/00 , B02C4/02 , B02C4/32
CPC分类号： B02C4/32 , B02C4/02 , B02C25/00
摘要： A device for pelletizing ceramic raw material comprises a frame, a movable housing, a first rotating unit and a second rotating unit. The movable housing is configured such that detection of a slower movement of the ceramic raw material flow through hole of the first rotating unit and the second rotating unit causes the movable housing to be actuated to move the second rotating unit further away from the first rotating unit. The movement is carried out through the actuator coupled relative to the frame, in order to create more space movement between the first and second rotating units.
摘要翻译：用于造粒陶瓷原料的装置包括框架，可动壳体，第一旋转单元和第二旋转单元。可移动壳体构造成使得检测陶瓷原料流动通过第一旋转单元和第二旋转单元的较慢运动导致可动壳体被致动以使第二旋转单元远离第一旋转单元。运动通过相对于框架联接的致动器进行，以便在第一和第二旋转单元之间产生更多的空间运动。

6. 发明申请

WO2007142757A2 COMPOSITIONS AND METHODS FOR AFFECTING MOVEMENT OF CONTAMINANTS, BODILY FLUIDS OR OTHER ENTITIES AND/OR AFFECTING OTHER PHYSIOLOGICAL CONDITIONS 审中-公开
标题翻译：影响污染物，体液或其他物质的运动和/或影响其他生理条件的组合物和方法
公开(公告)号：WO2007142757A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/010041
申请日：2007-04-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , ELLIS-BEHNKE, Rutledge , LIANG, Yu-xiang , SCHNEIDER, Gerald, E. , SO, Kwok-fai , TAY, David
发明人： ELLIS-BEHNKE, Rutledge , LIANG, Yu-xiang , SCHNEIDER, Gerald, E. , SO, Kwok-fai , TAY, David
IPC分类号： A61L15/42 , A61L26/00
CPC分类号： A61K38/10 , A61K31/167 , A61L15/42 , A61L26/0061
摘要： Compositions which self-assemble under physiological conditions are formulate for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may als include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatme such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination wit an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.
摘要翻译：在生理条件下自组装的组合物适用于伤口。制剂包括药学上可接受的载体或作为医疗装置或涂层的一部分提供。制剂可以包括其它治疗剂，预防剂或诊断剂。可以适当地施用制剂以治疗一种或多种病症或病症。例如，该制剂可用于修复损伤或手术期间的肺，眼或硬膜，或硬膜外或脊髓抽头后，以阻止血液，间质液或脑脊液的渗漏。制剂可以施用于烧伤或溃疡。制剂可以分散在缝合线或粘合剂中，用于在缝合或胶合伤口之后进行给药或作为释放，从而限制出血，组织液或其它流体的损失，例如由实质组织如肝脏产生的那些，胰腺和胃肠道。制剂可以应用于任何出血部位，绷带，纱布，海绵或其他材料，以便立即控制出血，或者如果初始治疗如缝合或压力不足，则稍后释放以控制出血。在一个实施方案中，制剂作为干燥或冻干粉末提供。在另一个实施方案中，将材料提供在水中。在另一个实施方案中，所述材料与油组合提供并形成层压体。在另一个实施方案中，所述制剂作为涂层提供在装置例如支架或导管上。该材料也可用于分离组织，用于保存用于随后的移植或再附着的组织，以及作为膨胀，稳定或保湿剂。

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