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51. 发明申请

WO1995002054A2 PLATELET GLYCOPROTEIN V GENE AND USES 审中-公开
标题翻译： PLATELET GLYCOPROTEIN V基因和用途
公开(公告)号：WO1995002054A2
公开(公告)日：1995-01-19
申请号：PCT/US1994007644
申请日：1994-07-07
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , LANZA, François , PHILLIPS, David, R. , CAZENAVE, Jean-Pierre
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： This invention relates to the glycoprotein v gene. Specifically, this invention discloses the sequence and structure of the glycoprotein v gene and the amino acid sequence of the glycoprotein v polypeptide. In addition, the evolutionary relationship of the glycoprotein v gene with other glycoproteins is described and several uses of the isolated glycoprotein v gene are shown.
摘要翻译：本发明涉及糖蛋白v基因。具体地，本发明公开了糖蛋白v基因的序列和结构以及糖蛋白v多肽的氨基酸序列。此外，描述了糖蛋白v基因与其他糖蛋白的进化关系，并显示了分离的糖蛋白v基因的几种用途。

52. 发明申请

WO1994003479A1 THROMBIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：硫蛋白受体拮抗剂
公开(公告)号：WO1994003479A1
公开(公告)日：1994-02-17
申请号：PCT/US1993006428
申请日：1993-07-08
申请人： COR THERAPEUTICS, INC. , SCARBOROUGH, Robert, M.
发明人： COR THERAPEUTICS, INC.
IPC分类号： C07K05/00
CPC分类号： C07K7/06 , A61K38/00 , C07K5/06078 , C07K5/1016 , C07K7/02
摘要： Peptide derivatives serving as thrombin receptor antagonists are disclosed, which bear specificity for the cellular thrombin receptor without interfering with the catalytic activities of thrombin. The derivatives generally have formula (I) in which R1 and R3 are amide linkages, N-alkylamide linkages, or isosteric replacements of such linkages; R2 is either a neutral amino acid side chain or a hydrophobic radical; R4 is hydrophobic radical; R5 is CO, CH2 or SO; X is either of formula (II) in which R6 and R7 are H, alkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl or arylalkyl, and R8 is a hydrophobic radical, or a hydrophobic residue; Y is alkoxy, hydroxy, amino, alkylamino, dialkylamino, in which any of the alkyl groups may be substituted with a basic moiety; Z is an amino acid or peptide residue; and m is zero or one.
摘要翻译：公开了用作凝血酶受体拮抗剂的肽衍生物，其对细胞凝血酶受体具有特异性，而不干扰凝血酶的催化活性。衍生物通常具有式（I），其中R 1和R 3是酰胺键，N-烷基酰胺键或这种键的等排取代基; R2是中性氨基酸侧链或疏水基团; R4是疏水基; R5是CO，CH2或SO; X为式（Ⅱ）中R6和R7为H，烷基，环烷基烷基，烷氧基烷基，烷硫基烷基或芳基烷基，R8为疏水基团或疏水残基; Y是烷氧基，羟基，氨基，烷基氨基，二烷基氨基，其中任何烷基可被碱部分取代; Z是氨基酸或肽残基; m为0或1。

53. 发明申请

WO1992013867A1 DOMAINS OF EXTRACELLULAR REGION OF HUMAN PLATELET DERIVED GROWTH FACTOR RECEPTOR POLYPEPTIDES 审中-公开
标题翻译：人胎盘衍生生长因子受体多肽的细胞外区域
公开(公告)号：WO1992013867A1
公开(公告)日：1992-08-20
申请号：PCT/US1992000730
申请日：1992-01-28
申请人： COR THERAPEUTICS, INC. , ESCOBEDO, Jaime, A. , WILLIAMS, Lewis, T.
发明人： COR THERAPEUTICS, INC. , WOLF, David , TOMLINSON, James, E. , FRETTO, Larry, J. , GIESE, Neill, A.
IPC分类号： C07H15/12
CPC分类号： C07K16/2863 , A61K38/00 , C07K14/71 , C07K2319/00
摘要： Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening or ligand analogues.
摘要翻译：提供修饰的人血小板衍生生长因子受体多肽的定义构建体。鉴定细胞外区域结构，并提供受体区段的修饰和组合重排。修饰片段的细胞结合和可溶形式均可获得，使用它们的测定方法也可用于筛选或配体类似物。

54. 发明申请

WO1990000178A1 PLATELET BLOCKING PEPTIDES 审中-公开
标题翻译：平板阻滞胶囊
公开(公告)号：WO1990000178A1
公开(公告)日：1990-01-11
申请号：PCT/US1989002893
申请日：1989-06-30
申请人： COR THERAPEUTICS, INC.
发明人： COR THERAPEUTICS, INC. , CHARO, Israel, F. , FITZGERALD, Laurence, A. , PHILLIPS, David, R.
IPC分类号： C07K07/08
CPC分类号： C07K14/70557 , A61K38/00 , C07K2319/00 , C07K2319/33 , Y10S530/806
摘要： Methods and compositions are provided for treating platelet-associated ischemic syndromes utilizing oligopeptides corresponding to regions of the platelet GPIIIa protein. The oligopeptides can be used to block platelet aggregation for numerous applications, and can serve in immunogen to raise receptor-specific antibodies.
摘要翻译：提供了使用对应于血小板GPIIIa蛋白的区域的寡肽来治疗血小板相关缺血综合征的方法和组合物。寡肽可用于阻断多种应用的血小板聚集，并可用于免疫原以产生受体特异性抗体。

55. 发明申请

WO0194331A8 METHODS FOR PRODUCING AMINO-SUBSTITUTED CHROMANES 审中-公开
标题翻译：生产氨基取代的颜料的方法
公开(公告)号：WO0194331A8
公开(公告)日：2003-11-06
申请号：PCT/US0118014
申请日：2001-06-01
申请人： LILLY CO ELI , COR THERAPEUTICS INC , ANTOINE LUC , BOQUEL PASCAL , BORGHESE ALFIA , GORISSEN HUGO , MARTINELLI MICHAEL , MERSCHAERT ALAIN , RUHTER GERD , RYPENS CARINE , SCARBOROUGH ROBERT , SCHOTTEN THEO , VAN HOECK JEAN-PIERRE
发明人： ANTOINE LUC , BOQUEL PASCAL , BORGHESE ALFIA , GORISSEN HUGO , MARTINELLI MICHAEL , MERSCHAERT ALAIN , RUHTER GERD , RYPENS CARINE , SCARBOROUGH ROBERT , SCHOTTEN THEO , VAN HOECK JEAN-PIERRE
IPC分类号： C07D311/58 , C07D311/70 , A61K31/353 , A61P7/02
CPC分类号： C07D311/58
摘要： Disclosed are processes for producing benzopyran compounds, reduced 2-(chroman-2-yl) acetic acid compounds and 2-(6-aminochroman-2-yl)acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
摘要翻译：公开了制备苯并吡喃化合物，还原的2-（色满-2-基）乙酸化合物和2-（6-氨基苯并二氢吡喃-2-基）乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。

56. 发明申请

WO0192249A3 CHIRAL AND ACHIRAL SYNTHESIS OF 2-ACYL SUBSTITUTED CHROMANES AND THEIR DERIVATIVES 审中-公开
标题翻译： 2-ACYL取代的色素及其衍生物的合成和丙烯酸合成
公开(公告)号：WO0192249A3
公开(公告)日：2002-04-11
申请号：PCT/US0118016
申请日：2001-06-01
申请人： COR THERAPEUTICS INC , KANTER JAMES , MARLOWE CHARLES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT , BUTKE GREG , JACOBSEN BARRY , WALKER DERRICK
发明人： KANTER JAMES , MARLOWE CHARLES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT , BUTKE GREG , JACOBSEN BARRY , WALKER DERRICK
IPC分类号： C07D311/20 , C07D311/22 , C07D311/58 , A61K31/35
CPC分类号： C07D311/58 , C07D311/20 , C07D311/22
摘要： Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
摘要翻译：公开了制备（2S）或（2R）-4-氧代 - 苯并二氢吡喃-2-基酰基化合物和色满-2-基酰基化合物，其酯或酰胺及其衍生物的方法。这样的方法可以涉及手性合成或非手性合成，优选与解析程序偶联。这些化合物，特别是（2S）或（2R）乙酸酯是生产血小板聚集抑制剂和/或本身是有效的血小板聚集抑制剂的有用中间体。进一步公开的是制备单一（2R）或（2S）对映异构体中间体的这种基本上纯的或增强的组合物的衍生物的方法或从所需的对映异构体制备最终产物或盐的方法。

57. 发明申请

WO0216599A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO0216599A2
公开(公告)日：2002-02-28
申请号：PCT/US0126510
申请日：2001-08-27
申请人： CURAGEN CORP , COR THERAPEUTICS INC , BURGESS CATHERINE E , CONLEY PAMELA B , GROSSE WILLIAM M , HART MATTHEW , KEKUDA RAMESH , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , SZEKERES EDWARD S JR , TOMLINSON JAMES E , TOPPER JAMES N , YANG RUEY BIN
发明人： BURGESS CATHERINE E , CONLEY PAMELA B , GROSSE WILLIAM M , HART MATTHEW , KEKUDA RAMESH , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , SZEKERES EDWARD S JR , TOMLINSON JAMES E , TOPPER JAMES N , YANG RUEY-BIN
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任何一种相关的病症的治疗，诊断和研究方法。

58. 发明申请

WO0071493A3 INHIBITORS OF FACTOR Xa 审中-公开
标题翻译：因子的抑制剂Xa
公开(公告)号：WO0071493A3
公开(公告)日：2002-01-17
申请号：PCT/US0014138
申请日：2000-05-24
申请人： COR THERAPEUTICS INC
发明人： ZHU BING-YAN , SU TING , ZHAOZHANG JON JIA , SCARBOROUGH ROBERT M , SONG YONGHONG
IPC分类号： A61P7/02 , A61K31/167 , A61K31/18 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/472 , A61K31/4725 , A61P9/00 , A61P9/04 , A61P9/10 , C07C311/16 , C07C311/18 , C07C311/40 , C07C311/44 , C07C311/46 , C07D207/16 , C07D217/22 , C07D401/06
CPC分类号： C07C311/40 , C07C311/16 , C07C311/18 , C07C311/44 , C07C311/46
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其有关的组合物。该化合物在体外或体内可用于预防或治疗凝血障碍。

59. 发明申请

WO0142198A3 METHODS FOR PRODUCING CYANOBENZOIC ACID DERIVATIVES 审中-公开
标题翻译：生产氰基苯甲酸衍生物的方法
公开(公告)号：WO0142198A3
公开(公告)日：2001-12-13
申请号：PCT/US0042819
申请日：2000-12-13
申请人： COR THERAPEUTICS INC
发明人： KANTER JAMES , MULLINS JOHN JASON GENTRY , SCARBOROUGH ROBERT
IPC分类号： C07C253/30 , C07C51/265 , C07C201/12 , C07C209/36 , C07C253/00 , C07C255/57 , C07C257/18 , C07C253/08
CPC分类号： C07C253/00 , C07C255/57
摘要： Novel process steps and novel processes for producing unsubstituted and substituted meta- and para- cyano benzoic acid compounds, as well as salts and derivatives thereof, and intermediates therefor which are useful as intermediates for producing platelet aggregation inhibitors. Further disclosed are processes for producing bicyclic and heterocyclic cyano substituted compounds also having a carboxyl group attached to the same ring structure.
摘要翻译：用于制备未取代和取代的间位和对 - 氰基苯甲酸化合物的新方法步骤和新方法，以及其盐及其衍生物及其中间体，其可用作制备血小板聚集抑制剂的中间体。进一步公开的是还具有连接到相同环结构的羧基的双环和杂环氰基取代的化合物的方法。

60. 发明申请

WO0119788A3 BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa 审中-公开
标题翻译：因子的相关抑制剂Xa
公开(公告)号：WO0119788A3
公开(公告)日：2001-08-09
申请号：PCT/US0025196
申请日：2000-09-15
申请人： COR THERAPEUTICS INC
发明人： ZHU BING-YAN , ZHANG PENGLIE , WANG LINGYAN , HUANG WENRONG , GOLDMAN ERIC , LI WENHAO , ZUCKETT JINGMEI , SONG YONGHONG , SCARBOROUGH ROBERT
IPC分类号： A61K31/18 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/4545 , A61K31/472 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/5513 , A61P7/02 , A61P9/10 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , A61K31/33
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：式A-Q-D-E-G-J-X的化合物，其中D是直链，取代或未取代的苯基或萘基或杂环系; X是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，其公开了与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。

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