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41. 发明申请

WO02006212A2 IMPROVED PROCESS FOR THE PURIFICATION AND RECOVERY OF ACETONITRILE 审中-公开
标题翻译：改进ACETONITRILE的纯化和回收方法
公开(公告)号：WO02006212A2
公开(公告)日：2002-01-24
申请号：PCT/US2001/019709
申请日：2001-06-21
IPC分类号： C07C253/24 , C07C253/26 , C07C253/34 , C07C255/03 , C07C253/00
CPC分类号： C07C253/26 , C07C253/24 , C07C253/34 , Y10S203/20 , C07C255/03
摘要： A method for the purification of crude acetonitrile comprising distilling the crude acetonitrile in a first fractional distillation column at below atmospheric pressure, withdrawing a first side draw fraction comprising acetonitrile, distilling the first side draw fraction in a second fractional distillation column at super atmospheric pressure, and withdrawing from the second distillation a second side draw fraction comprising purified acetonitrile.
摘要翻译：一种用于纯化粗乙腈的方法，包括在低于大气压的第一分馏塔中蒸馏粗乙腈，取出包含乙腈的第一侧馏分，在第二分馏塔中在超大气压下蒸馏第一侧馏分，并从第二次蒸馏中取出包含纯化乙腈的第二侧馏分。

42. 发明申请

WO01042198A2 METHODS FOR PRODUCING 3-CYANO- AND 4-CYANO-BENZOIC ACID DERIVATIVE COMPOUNDS 审中-公开
标题翻译：生产3-氰基和4-氰基苯甲酸衍生化合物的方法
公开(公告)号：WO01042198A2
公开(公告)日：2001-06-14
申请号：PCT/US2000/042819
申请日：2000-12-13
IPC分类号： C07C253/30 , C07C51/265 , C07C201/12 , C07C209/36 , C07C253/00 , C07C255/57 , C07C257/18 , C07C255/00
CPC分类号： C07C253/00 , C07C255/57
摘要： Novel process steps and novel processes for producing unsubstituted and substituted meta- and para- cyano benzoic acid compounds, as well as salts and derivatives thereof, and intermediates therefor which are useful as intermediates for producing platelet aggregation inhibitors. Further disclosed are processes for producing bicyclic and heterocyclic cyano substituted compounds also having a carboxyl group attached to the same ring structure.
摘要翻译：用于制备未取代和取代的间位和对 - 氰基苯甲酸化合物的新方法步骤和新方法，以及其盐及其衍生物及其中间体，其可用作制备血小板聚集抑制剂的中间体。进一步公开的是还具有连接到相同环结构的羧基的双环和杂环氰基取代的化合物的方法。

43. 发明申请

WO01019787A1 OPTICALLY ACTIVE alpha -AMINONITRILE AND PROCESS FOR PRODUCING alpha -AMINO ACID 审中-公开
标题翻译：光活性α-亚胺基和生产α-氨基酸的方法
公开(公告)号：WO01019787A1
公开(公告)日：2001-03-22
申请号：PCT/JP2000/001508
申请日：2000-03-13
IPC分类号： B01J31/18 , B01J31/22 , C07B53/00 , C07B61/00 , C07C227/18 , C07C227/26 , C07C229/08 , C07C253/00 , C07C253/08 , C07C255/24 , C07C255/25 , C07C255/31 , C07C255/33 , C07C255/42 , C07D211/60 , B01J31/02 , C07C227/12 , C07C229/36
CPC分类号： C07D211/60 , B01J31/181 , B01J31/223 , B01J31/2239 , B01J2531/0205 , B01J2531/0266 , B01J2531/48 , C07B2200/07 , C07C227/26 , C07C253/00 , C07C253/08 , C07C2601/14 , C07C255/24 , C07C255/25 , C07C255/31 , C07C255/33 , C07C255/42
摘要： An aldehyde compound is reacted with an amine compound and hydrogen cyanide in the presence of a chiral zirconium catalyst obtained by mixing a zirconium alkoxide with an optically active binaphthol compound.
摘要翻译：在通过将烷氧基锆与光学活性联萘酚化合物混合而获得的手性锆催化剂的存在下，使醛化合物与胺化合物和氰化氢反应。

44. 发明申请

WO0064862A3 PROCESS FOR HYDROGENATING DINITRILES IN AMINONITRILES 审中-公开
标题翻译：氨基甲酸盐加氢处理工艺
公开(公告)号：WO0064862A3
公开(公告)日：2001-02-15
申请号：PCT/US0011045
申请日：2000-04-25
申请人： DU PONT , IONKIN ALEX SERGEY , ZIEMECKI STANISLAW BODGAN , HARPER MARK J , KOCH THEODORE AUGUR , BRYNDZA HENRY EDWARD
发明人： IONKIN ALEX SERGEY , ZIEMECKI STANISLAW BODGAN , HARPER MARK J , KOCH THEODORE AUGUR , BRYNDZA HENRY EDWARD
IPC分类号： B01J23/00 , B01J23/46 , B01J23/74 , B01J25/00 , B01J27/12 , B01J27/185 , B01J27/26 , B01J31/02 , B01J31/20 , B01J35/00 , C07B61/00 , C07C253/00 , C07C253/30 , C07C255/24 , C07C209/48
CPC分类号： C07C253/30 , B01J23/464 , B01J25/00 , B01J27/12 , B01J27/185 , B01J27/26 , B01J31/0239 , B01J31/0268 , B01J31/20 , B01J2231/643 , B01J2531/0211 , B01J2531/822 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/90 , C07C255/24
摘要： Provided is a selective hydrogenation process for producing aminonitriles by contacting the corresponding dinitriles with a hydrogen-containing fluid in the presence of a hydrogenation catalyst, a solvent and an additive for improving the yield of and/or selectivity to the aminonitrile. The additive comprises a carbon monoxide; a tetraalkylammonium hydroxide compound; a tetraalkylphosphonium hydroxide compound; a multi-centered metal carbonyl cluster; an organic isonitrile; a cyanide compound having at least one cyano group bound to other than a carbon atom; and afluoride compound.
摘要翻译：提供了通过在氢化催化剂，溶剂和用于提高氨基腈的产率和/或选择性的添加剂的存在下使相应的二腈与含氢流体接触来制备氨基腈的选择性氢化方法。添加剂包括一氧化碳; 四烷基氢氧化铵化合物; 四烷基鏻氢氧化物化合物; 多中心金属羰基簇; 有机异腈; 具有与碳原子以外的至少一个氰基键合的氰化物化合物; 和氟化物化合物。

45. 发明申请

WO00046186A1 A PROCESS FOR PREPARING (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ESTER 审中-公开
标题翻译：制备（R）-4-氰基-3-羟基丁酸酯的方法
公开(公告)号：WO00046186A1
公开(公告)日：2000-08-10
申请号：PCT/KR2000/000052
申请日：2000-01-24
IPC分类号： C07C253/30 , C07B53/00 , C07C253/00 , C07C255/20
CPC分类号： C07C253/00 , C07B2200/07 , C07C255/20
摘要： The present invention relates to a process for preparing (R)-4-cyano-3-hydroxybutyric acid ester derivatives and more particularly, to a process for preparing optically pure (R)-4-cyano-3-hydroxybutyric acid ester derivatives expressed by formula (1) in high yield by performing cyanation and sequential esterification of (S)-3,4-epoxybutyric acid salt as a starting material. In said formula, R represents linear or branched alkyl group with 1 SIMILAR 5 carbon atoms or benzyl group.
摘要翻译：本发明涉及一种制备（R）-4-氰基-3-羟基丁酸酯衍生物的方法，更具体地说，涉及一种制备光学纯的（R）-4-氰基-3-羟基丁酸酯衍生物的方法，由通过（S）-3,4-环氧丁酸盐作为起始原料进行氰化和连续酯化，高产率的式（1）。在所述式中，R表示具有1〜5个碳原子的直链或支链烷基或苄基。

46. 发明申请

WO00040547A1 alpha -SUBSTITUTION OF UNPROTECTED beta -AMINO ESTER COMPOUNDS 审中-公开
标题翻译：非蛋白质β-氨基酸酯化合物的α-取代
公开(公告)号：WO00040547A1
公开(公告)日：2000-07-13
申请号：PCT/US1999/030366
申请日：1999-12-17
IPC分类号： C07C227/16 , C07B53/00 , C07B61/00 , C07C227/32 , C07C229/00 , C07C229/30 , C07C253/00 , C07C253/30 , C07C255/57 , C07C255/58 , C07C261/00
CPC分类号： C07C253/00 , C07B2200/07 , C07C227/32 , C07C229/30 , C07C255/57
摘要： Methods for stereoselective substitution in which a (mono or un)- alpha -substituted unprotected beta -amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hybride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
摘要翻译：本发明提供了立体选择性取代方法，其中未保护的（单或非）α-取代的β-氨基酯化合物或其盐与脂肪族亲电体在存在选自烷基锂化合物，氢化锂，氨基化锂，二烷基酰胺锂和碱性六甲基二甲硅烷基胺。

47. 发明申请

WO00014055A2 METHOD FOR PRODUCING CYANOVALERIC ACID OR ESTERS THEREOF 审中-公开
标题翻译：用于生产氰基戊酸或酯
公开(公告)号：WO00014055A2
公开(公告)日：2000-03-16
申请号：PCT/EP1999/006463
申请日：1999-09-02
IPC分类号： B01J31/24 , C07B61/00 , C07C253/30 , C07C255/19 , C07F9/6568 , C07F15/00 , C07C253/00
CPC分类号： C07C253/30 , C07F15/0053 , C07C255/19
摘要： The invention relates to a method for producing cyanovaleric acid or esters thereof by reacting 2-, 3- or 4-pentene nitrile or mixtures thereof with carbon monoxide and with a compound containing hydroxyl groups in the presence of a catalyst system. Said catalyst system comprises: (i) a palladium (II) compound, (ii) a bidentate diphosphine ligand and (iii) an anion source. The invention also relates to novel catalyst systems with diphosphine ligands of the bis(phosphinomethyl)amine type.
摘要翻译：公开了用于由2-，3-或4-戊烯腈或与一氧化碳及其混合物中和在催化剂系统，包括存在一个含羟基的化合物反应来制备氰基戊酸或酯的方法：（ⅰ）钯（II）化合物，（ii）双齿二膦配体，和（iii）阴离子源。描述也与双（膦）胺型的二膦配体的新型催化剂体系。

48. 发明申请

WO98047862A1 3-CYANO-2,4,5-TRIFLUORO-BENZOYL FLUORIDE AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译： 3-氰基2,4,5三氟苯甲酰及其生产中间产品
公开(公告)号：WO98047862A1
公开(公告)日：1998-10-29
申请号：PCT/EP1998/002175
申请日：1998-04-14
IPC分类号： B62J99/00 , C07C17/12 , C07C17/14 , C07C25/13 , C07C51/093 , C07C51/373 , C07C65/30 , C07C249/08 , C07C251/48 , C07C253/00 , C07C253/30 , C07C255/57 , G01C21/26 , G01C22/00
CPC分类号： C07C255/57 , C07C17/12 , C07C17/14 , C07C25/13 , C07C251/48 , G01C21/26 , G01C22/002
摘要： The invention relates to 3-cyano-2,4,5-trifluoro-benzoyl fluoride and intermediate products for the production thereof and a method for the production of 3-cyano-2,4,5-trifluoro-benzoyl fluoride starting from 5-fluoro-1,3-xylol (VIII), which is chlorinated twice in the presence of a catalyst with ionic conditions in the nucleus to obtain 2,4-dichloro-5-fluoro-1,3-dymethylbenzol (VII), which is then chlorinated with radical conditions in the side chains to obtain 2,4-dichloro-5-fluoro-3-dichloromethyl-1-trichloromethyl benzol (VI), which is subsequently saponified by the optionally isolatable 2,4-dichloro-5-fluoro-3-dichloromethyl benzoic acid (V) to obtain 2,4-dichloro-5-fluoro-3-formyl-benzoic acid (IV) whose aldehyde group is converted to 2,4-dichloro-5-fluoro-3-N-hydroxyiminomethyl-benzoic acid (III), whereupon water is eliminated using an acid chloride while at the same time converting the carboxyl group into a chlorocarbonyl group to obtain nitrile 2,4-dichloro-3-cyano-5-fluoro-benzoyl-chloride (II), which is finally subjected to a fluorine/chlorine exchange.
摘要翻译：本发明涉及到3-氰基-2,4,5-三氟苯甲酰氟（I）和它的制备的中间体和用于制备3-氰基-2,4,5-三氟苯甲酰氟，5-氟过程 1,3-二甲苯（VIII）进行，其中在催化剂的存在下双氯化离子条件下在核心，得到2,4-二氯-5-氟-1,3-二甲基苯（VII）。这是在侧链自由基条件下氯化，得到2,4-二氯-5-氟-3-二氯-1-三氯甲苯（VI）。这是任选皂化绝缘2,4-二氯-5-氟-3-dichlormethylbenzoesäure（V），得到2,4-二氯-5-氟-3-甲酰基 - 苯甲酸（IV），醛基是2， 2,4-二氯-5-氟 - 3-N-羟基亚 - 苯甲酸（III）反应，并在同一时间将羧基转化成氯基团时，水从这些使用酰氯，得到腈2,4-二氯-3-氰基 - 形成， 5-氟 - 苯甲酰氯（II）被消除。这是最后进行氟/氯交换。

49. 发明申请

WO1996036593A1 PROCESS FOR PRODUCING AROMATIC NITRILES 审中-公开
标题翻译：方法制备芳族腈
公开(公告)号：WO1996036593A1
公开(公告)日：1996-11-21
申请号：PCT/EP1996002127
申请日：1996-05-17
申请人： SKW TROSTBERG AKTIENGESELLSCHAFT , GRAEFE, Jürgen , WERNTHALER, Konrad , ERBEN, Hans-Georg
发明人： SKW TROSTBERG AKTIENGESELLSCHAFT
IPC分类号： C07C253/00
CPC分类号： C07C253/28 , C07C255/50
摘要： The description relates to a process for producing aromatic nitriles from their corresponding aldehydes, in which the latter are caused to react with ammonia at temperatures of 200 to 500 DEG C in the gas phase in the presence of a catalyst based on molybdenum nitride of the general formula MoNxOy in which x = 0.25 to 1.0 and y = 0 to 1.0. It is thus possible to produce aromatic nitriles from the corresponding aldehydes with yields and selectivities of up to 98 % with conversions of up to 100 %.
摘要翻译：本发明提供了一种用于从这些相应的醛制备芳族腈所描述的，与氨在200温度下，在催化剂的存在下根据通式MoNxOy，钼氮化物被反应到500℃，在气相中，其中x = 0.25 和1.0和y = 0〜1.0即可。以这种方式，芳香腈高达100％的可从与收率和选择性高达98％的转化在相应的醛制备。

50. 发明申请

WO1994019317A1 PROCESS FOR THE PREPARATION OF ORTHO-HYDROXY SUBSTITUTED AROMATIC NITRILES VIA DEHYDRATION OF THE CORRESPONDING ALDOXIMES 审中-公开
标题翻译：通过去除对羟基苯甲酸来制备邻羟基取代的芳族硝酸盐的方法
公开(公告)号：WO1994019317A1
公开(公告)日：1994-09-01
申请号：PCT/GB1994000277
申请日：1994-02-11
申请人： ZENECA LIMITED , LEVIN, Daniel
发明人： ZENECA LIMITED
IPC分类号： C07C253/00
CPC分类号： C07C255/53 , C07C253/00
摘要： A method for the preparation of a 2-hydroxybenzonitrile which comprises reacting hydroxylamine with a 2-hydroxyarylaldehyde which is at least partially in the form of a salt and/or complex of a metal of Group II, Group III, Group IVA or Group VIA of the Periodic Table and dehydrating the 2-hydroxyarylaldoxime so formed.
摘要翻译：一种制备2-羟基苄腈的方法，其包括使羟胺与2-羟基芳基醛反应，所述2-羟基芳基醛至少部分为第II族，第III族，第IVA族或第ⅥA族金属的盐和/或络合物形式的盐和/ 周期表和脱水形成的2-羟基芳基醛肟。

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