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    • 41. 发明申请
    • SUPER-ACTIVATION OF EMULSION POLYMERS
    • 乳液聚合物的超活化
    • WO2016011232A1
    • 2016-01-21
    • PCT/US2015/040714
    • 2015-07-16
    • PARDIKES, Dennis
    • PARDIKES, Dennis
    • B01F3/08B01F5/10
    • C08J3/05C08J2333/26
    • A method for the super-activation of emulsion polymers is provided. The method includes carrying out a one to three-step polymer activation process to form an activated polymer-diluent mixture, the steps selected from (a) - (d): (a) premixing the first polymer-diluent mixture at a predetermined pressure to form a second polymer-diluent mixture; (b) blending the first polymer-diluent mixture or the second polymer-diluent mixture with a blending device to form a blended polymer-diluent mixture; (c) (i) recycling the blended polymer-diluent mixture to be blended as in step (b) or premixed as in step (a) at a predetermined pressure; or (ii) recycling the second polymer-diluent mixture to be premixed as in step (a) at a predetermined pressure; and (d) reducing the pressure in a portion of the blended polymer-diluent mixture or the second polymer-diluent mixture to relax the polymer and form a relaxed polymer-diluent mixture.
    • 提供了乳液聚合物超活化的方法。 该方法包括进行一到三步聚合物活化过程以形成活化的聚合物 - 稀释剂混合物,所述步骤选自(a) - (d):(a)将预定压力下的第一聚合物 - 稀释剂混合物预混合到 形成第二聚合物 - 稀释剂混合物; (b)将第一聚合物稀释剂混合物或第二聚合物 - 稀释剂混合物与共混装置混合以形成混合的聚合物 - 稀释剂混合物; (c)(i)如步骤(b)中所述将待共混的混合的聚合物 - 稀释剂混合物按步骤(a)预定的预定压力循环; 或者(ii)如步骤(a)中那样在预定压力下再循环待混合的第二聚合物 - 稀释剂混合物; 和(d)降低共混的聚合物 - 稀释剂混合物或第二聚合物 - 稀释剂混合物的一部分中的压力以松弛聚合物并形成松弛的聚合物 - 稀释剂混合物。
    • 45. 发明申请
    • PHOTOCURABLE POLYMER WITH A COMB-LIKE STRUCTURE
    • 具有类似结构的可光聚合物
    • WO2015040513A1
    • 2015-03-26
    • PCT/IB2014/063728
    • 2014-08-06
    • FONDAZIONE FILARETE PER LE BIOSCIENZE E L'INNOVAZIONEUNIVERSITA' DEGLI STUDI DI MILANO
    • GERGES, IriniLENARDI, CristinaMARTELLO, FedericoPISTIS, ValentinaTAMPLENIZZA, MargheritaTOCCHIO, Alessandro
    • C08F265/04C08J3/075C08F265/10C08F299/00C12N5/00
    • C08F265/04C08F265/10C08F299/00C08J3/075C08J3/24C08J2333/04C08J2333/26
    • The present invention relates to a synthetic polymeric precursor with a comb-like or hyper- branched structure, which is capable of carrying out an irreversible in situ sol-gel transition by photo- cross-linking, under conditions which are compatible with a biological organism, to produce hydrogels, which is capable of acting as biocompatible and biodegradable tridimensional matrices suitable to the in vitro, and in vivo encapsulation and transport of: cells; drugs; peptides; proteins, and growth factors. In particular, the invention relates to a photocurable polymeric precursor, which can be administered in vivo by injection or minimally invasive surgical approaches, said- polymeric precursor being composed of: (i) an acrylic oligomer of formula (II) : which is obtained by random co-polymerization of an acrylic monomer of formula (III) : CH 2 =C (R 2 ) -CO-OR-R 1 -OH (III) wherein the functional group R 1 is a C 1 -C 6 alkylene, preferably C 2 alkylene; wherein the R 2 functional group is H or a C 1 -C 4 alkylene, preferably C 1 alkylene together with an acrylic co-monomer or acrylamide of formula ( IV) : CH 2 =C(R 3 ) -CO-X-R 4 -YH (IV) wherein the functional group R 3 is H or a C 1 -C 4 alkylene, preferably C 1 alkylene; wherein the R 4 functional group is a C 1 -C 6 alkylene, preferably C3 alkylene; X is 0 or NH; Y is NH or S; such co- polymerization occurs in the presence of a chain transfer agent, preferably 2-mercaptoethanol, on said acrylic oligomer being grafted (ii) side chains composed of linear poly (amidoamine) s, an end of which side chains is bounded to said acrylic oligomer, while the free end terminates with an acrylamide group.
    • 本发明涉及具有梳状或超支化结构的合成聚合物前体,其能够在与生物有机体相容的条件下通过光交联进行不可逆的原位溶胶 - 凝胶转变 ,以产生水凝胶,其能够用作适于体外和体内包封和运输细胞的生物相容性和可生物降解的三维基质; 药物; 肽; 蛋白质和生长因子。 特别地,本发明涉及可以通过注射或微创手术方法在体内施用的光固化聚合物前体,所述聚合物前体由以下组成:(i)式(II)的丙烯酸低聚物:其通过 式(III)的丙烯酸单体的无规共聚:CH2 = C(R2)-CO-OR-R1-OH(Ⅲ)其中官能团R1是C1-C6亚烷基,优选C2亚烷基; 其中R 2官能团是H或C 1 -C 4亚烷基,优选C 1亚烷基与丙烯酸共聚单体或式(Ⅳ)的丙烯酰胺:CH2 = C(R3)-CO-X-R4-YH(Ⅳ),其中 官能团R3是H或C1-C4亚烷基,优选C1亚烷基; 其中R4官能团是C1-C6亚烷基,优选C3亚烷基; X为0或NH; Y是NH或S; 这种共聚发生在链转移剂(优选2-巯基乙醇)存在下,所述丙烯酸低聚物被接枝(ii)由直链聚酰胺胺组成的侧链,其侧链与所述丙烯酸 低聚物,而自由端用丙烯酰胺基团终止。